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The map label for this gene is yciK [H]

Identifier: 114800463

GI number: 114800463

Start: 728752

End: 729468

Strand: Reverse

Name: yciK [H]

Synonym: HNE_0716

Alternate gene names: 114800463

Gene position: 729468-728752 (Counterclockwise)

Preceding gene: 114797301

Following gene: 114799480

Centisome position: 19.69

GC content: 63.88

Gene sequence:

>717_bases
ATGACCTCTACACCTCGCCTTGTTCTCGTTACCGGCGCCTCGCGCGGCATCGGCCGCGCCATCAGCCTTGAGCTTGCCCG
CCAGGGCAATATCGTCGTCGCCATCGCCCGTTCCAAAGCGGCGCTGGAAAAACTCGACGATGAAATCCGCAAGCTCGGCT
CCGAGGCCGTCCTCGTGCCCATGGACCTCAAAGACACCAAGGGCATCGAGACGCTGGGCAAAATCATCGCTGAGAAGTTC
GGCAAGCTGGACGGTTTCGTTGCCAATGCCGGCCTGCTCGGCACGCTTGGTCCGCTGGAAACCTGCGGCCCGCGCAGCTT
TGAGGAAACCATCCAGGTGAACCTCACCGCCAACGCGCATCTCATCCGCGCGCTTGGCCCCTCCCTGCATCGCTCAGAGA
GCCCGCGCGCCGTGTTCATTACCTCTGGCGTGGTACCACGCCCCCGCGCCTTCTGGGGGCCGTATCAGGCCTCCAAGGCA
GGCCTGGAAGCCCTCGTCAAAGCCTGGGCCGATGAGAGCGAGAAGATGGCTCTGCGGGTAAACCTGTTCGATCCCGGCGC
CGTGCGCACAGGTATGCGCGCCGAAGCCATGCCGGGCGAAGACCCGATGACGCTGCCAACGCCCGATGATGTCGCCAAGG
AACTGGTGAAACTTCTGACGCCGGAAGAAACCCGCACGGGTGCCCGCGTGGTCTATCGCGAAGTGGCGGCAAACTAG

Upstream 100 bases:

>100_bases
CTACCCGACCCAGCTGCTCGACCATCAGCGCGCCCAGGCAGACAAAGAGCGTCAGCTCTCCCTGCTGGACGATGTGTGAG
CCCCGCGCTAAAGCCGCGCG

Downstream 100 bases:

>100_bases
ACTATTTGGCGGGCGCGCCGGCTAAGGCTTTTGCCTCGGCGGCTTCTGCCATCGCCACCGCCGCGACCGCGCCATGCGCG
GGCACAGGACTGCGCGCGAG

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTSTPRLVLVTGASRGIGRAISLELARQGNIVVAIARSKAALEKLDDEIRKLGSEAVLVPMDLKDTKGIETLGKIIAEKF
GKLDGFVANAGLLGTLGPLETCGPRSFEETIQVNLTANAHLIRALGPSLHRSESPRAVFITSGVVPRPRAFWGPYQASKA
GLEALVKAWADESEKMALRVNLFDPGAVRTGMRAEAMPGEDPMTLPTPDDVAKELVKLLTPEETRTGARVVYREVAAN

Sequences:

>Translated_238_residues
MTSTPRLVLVTGASRGIGRAISLELARQGNIVVAIARSKAALEKLDDEIRKLGSEAVLVPMDLKDTKGIETLGKIIAEKF
GKLDGFVANAGLLGTLGPLETCGPRSFEETIQVNLTANAHLIRALGPSLHRSESPRAVFITSGVVPRPRAFWGPYQASKA
GLEALVKAWADESEKMALRVNLFDPGAVRTGMRAEAMPGEDPMTLPTPDDVAKELVKLLTPEETRTGARVVYREVAAN
>Mature_237_residues
TSTPRLVLVTGASRGIGRAISLELARQGNIVVAIARSKAALEKLDDEIRKLGSEAVLVPMDLKDTKGIETLGKIIAEKFG
KLDGFVANAGLLGTLGPLETCGPRSFEETIQVNLTANAHLIRALGPSLHRSESPRAVFITSGVVPRPRAFWGPYQASKAG
LEALVKAWADESEKMALRVNLFDPGAVRTGMRAEAMPGEDPMTLPTPDDVAKELVKLLTPEETRTGARVVYREVAAN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=223, Percent_Identity=27.3542600896861, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4557649, Length=222, Percent_Identity=27.9279279279279, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI32483357, Length=188, Percent_Identity=26.5957446808511, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI223718074, Length=241, Percent_Identity=28.2157676348548, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787526, Length=223, Percent_Identity=37.219730941704, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=30.7291666666667, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786701, Length=185, Percent_Identity=32.4324324324324, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787820, Length=216, Percent_Identity=26.3888888888889, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI87082100, Length=219, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI2367175, Length=233, Percent_Identity=27.4678111587983, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=206, Percent_Identity=27.6699029126214, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=212, Percent_Identity=30.6603773584906, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=208, Percent_Identity=33.1730769230769, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193210355, Length=216, Percent_Identity=30.0925925925926, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=190, Percent_Identity=32.1052631578947, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=206, Percent_Identity=30.5825242718447, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=200, Percent_Identity=30.5, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=212, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=203, Percent_Identity=30.5418719211823, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115534660, Length=194, Percent_Identity=27.8350515463918, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=199, Percent_Identity=27.6381909547739, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=204, Percent_Identity=28.4313725490196, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=221, Percent_Identity=30.316742081448, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=220, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=206, Percent_Identity=31.5533980582524, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=215, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=193, Percent_Identity=29.0155440414508, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=189, Percent_Identity=26.984126984127, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=188, Percent_Identity=29.7872340425532, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=191, Percent_Identity=29.3193717277487, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=204, Percent_Identity=27.9411764705882, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=197, Percent_Identity=25.8883248730964, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=224, Percent_Identity=26.3392857142857, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=198, Percent_Identity=31.3131313131313, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322226, Length=203, Percent_Identity=28.0788177339901, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=248, Percent_Identity=29.0322580645161, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=33.6787564766839, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644339, Length=197, Percent_Identity=29.4416243654822, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355319, Length=185, Percent_Identity=28.1081081081081, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=31.9587628865979, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=27.8350515463918, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639444, Length=227, Percent_Identity=27.3127753303965, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28571526, Length=195, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 25478; Mature: 25347

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTPRLVLVTGASRGIGRAISLELARQGNIVVAIARSKAALEKLDDEIRKLGSEAVLVP
CCCCCCEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEE
MDLKDTKGIETLGKIIAEKFGKLDGFVANAGLLGTLGPLETCGPRSFEETIQVNLTANAH
ECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCHH
LIRALGPSLHRSESPRAVFITSGVVPRPRAFWGPYQASKAGLEALVKAWADESEKMALRV
HHHHHCCHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
NLFDPGAVRTGMRAEAMPGEDPMTLPTPDDVAKELVKLLTPEETRTGARVVYREVAAN
EECCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TSTPRLVLVTGASRGIGRAISLELARQGNIVVAIARSKAALEKLDDEIRKLGSEAVLVP
CCCCCEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEE
MDLKDTKGIETLGKIIAEKFGKLDGFVANAGLLGTLGPLETCGPRSFEETIQVNLTANAH
ECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCHH
LIRALGPSLHRSESPRAVFITSGVVPRPRAFWGPYQASKAGLEALVKAWADESEKMALRV
HHHHHCCHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
NLFDPGAVRTGMRAEAMPGEDPMTLPTPDDVAKELVKLLTPEETRTGARVVYREVAAN
EECCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]