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The map label for this gene is pepA [H]

Identifier: 114800349

GI number: 114800349

Start: 2346810

End: 2348351

Strand: Reverse

Name: pepA [H]

Synonym: HNE_2244

Alternate gene names: 114800349

Gene position: 2348351-2346810 (Counterclockwise)

Preceding gene: 114799358

Following gene: 114800524

Centisome position: 63.38

GC content: 62.84

Gene sequence:

>1542_bases
ATGAAAACATGGTTCACCGCAGCTGTATCCGTACTGGCGCTGGCACTGCCCGCCGCCGCGGATCTTCCCGCCATTGAATT
TGCCAAGGCAGAGCGTCCCAACAAGGGCGCGGTCGTGCTGCCCGTGGGCAAGGACGGCGCGCTTGAGGGGCTGTCGAGAG
ATGCTGACCGCGCCGCCAAAGGGGCGATTGCCGAGGCGATCACCATGGCAAGTTTCAAGGGCGAAGCGGGTCAGACCCTG
ACGCTTTATGGCGTTGGCCCCTATAGCGGCGTCCTGCTGGTGGGCACGGGCGCGGGCCTGAAAAGCGCAACAGATATGCA
GACCTACGGCGCCACGGTCGGCAAGGGCACGTCTGCCTGGAAAGCCAATGTGACCGTGGTTGTGCCGGATGCAGCAGATG
TAACCCATGACGCAGCCATTGCGGCGCAAGGCGCGATGCTGGGCGCGTATGATTTTGGAAAATGGCGCAGCGAGCCTGCA
GCGGCAACCGAGCCAACCGTGACACTGACCTTCCTCGCGCCCGATGCAGGCGCGGCGCGGCGCGCCTGGGAAAGCAACGC
CCGCGCGGTCGCGGAAGGCGTTTATTTTGCGCGCGACCTGATCTCCACGCCGTCCAACATCAAAACACCTGCCTGGTTTG
CAGATCAGGTTGTCGCAAAGTTTGACGGTGTACCGAATGTATCGGTGACCGTGCTGGACGAGACGCAGATCGAGGCGCTC
GGCATGGGCGCGCTGTATGGCACCGGGCAGGGCTCAGCCCGCCCGCCGCGCCTGGTGGCGGTTGAATACAAGGGTGGCGC
AGCGGGCGACGCGCCGCTGGCCTTTGTCGGCAAAGGGATCACATTCGACACGGGCGGCATCTCTATCAAGCCGAGCGCGA
ATATGTGGCGTATGCGGATGGATATGTCCGGCGCGGCAGCCTCGGCGGGCGCCGTCCTGACGCTTGCAAAGCGCGAGGCA
AAGCTGAATGCGGTTGCCGTCCTGGCCCTGGCCGAAAACATGCCGGACGGAAATGCGATCCGTCCCGGCGATGTGCTGAC
ATCCATGAGTGGCAAGACGATCGAGATCATGAGCACGGATGCCGAAGGGCGGCTTGTGCTGGCAGATGGCCTGTGGTGGG
CGCAGGAGCAGTACAAGCCCAAGATGGCGGTAACGATCGCGACGCTGACCGGCGCCGTGGTCGGCGCGCTCGGGCCAGAT
TATGCTGGCCTGTTTACGAAGGATGACAAGCTGGCCGGAACTTTCCTGGCCGCGGCGGAGAGCTCGGGTGAAGCGCTTTG
GCGGATGCCGGTTCACCCCAATTCGCGCAAGGCGCTCAATAGCGATGTGGCAGACCTGAAAAATGGTGGTGAAGGCGCGC
CGGGCGCATCGGTTGGCGCAGCCTTTGTGATGGAATGGGCCAAGGAAGAGACGCCGTTCGTGCATCTCGATATTGCCGGG
GTTGCCTGGCAGAATGCCGGCAATGCTGTCGATCCCAAAGGCGCTGTTGGATATGGGGTGCGGCTGTTTGATGAAGTCGC
ACGTACTTACGAATCCAAATAA

Upstream 100 bases:

>100_bases
TTTGTGACCGGAATCTGCAGAGATCTTGCCTCGAAAAGGCTGGACATCCGGGCAGATTTTTCCGAGGCAAATGTAATATT
GAAACAAAGAAGGGGCTCCC

Downstream 100 bases:

>100_bases
TTCGTATAGAGATTAAATAACGAAGCCCGGCCTCATTCTGTGCGGCCGGGCTTTTTGTATAGCAAACCTTTGGAGCGCGC
GCTCAGACAGCGAGCCCCTT

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKTWFTAAVSVLALALPAAADLPAIEFAKAERPNKGAVVLPVGKDGALEGLSRDADRAAKGAIAEAITMASFKGEAGQTL
TLYGVGPYSGVLLVGTGAGLKSATDMQTYGATVGKGTSAWKANVTVVVPDAADVTHDAAIAAQGAMLGAYDFGKWRSEPA
AATEPTVTLTFLAPDAGAARRAWESNARAVAEGVYFARDLISTPSNIKTPAWFADQVVAKFDGVPNVSVTVLDETQIEAL
GMGALYGTGQGSARPPRLVAVEYKGGAAGDAPLAFVGKGITFDTGGISIKPSANMWRMRMDMSGAAASAGAVLTLAKREA
KLNAVAVLALAENMPDGNAIRPGDVLTSMSGKTIEIMSTDAEGRLVLADGLWWAQEQYKPKMAVTIATLTGAVVGALGPD
YAGLFTKDDKLAGTFLAAAESSGEALWRMPVHPNSRKALNSDVADLKNGGEGAPGASVGAAFVMEWAKEETPFVHLDIAG
VAWQNAGNAVDPKGAVGYGVRLFDEVARTYESK

Sequences:

>Translated_513_residues
MKTWFTAAVSVLALALPAAADLPAIEFAKAERPNKGAVVLPVGKDGALEGLSRDADRAAKGAIAEAITMASFKGEAGQTL
TLYGVGPYSGVLLVGTGAGLKSATDMQTYGATVGKGTSAWKANVTVVVPDAADVTHDAAIAAQGAMLGAYDFGKWRSEPA
AATEPTVTLTFLAPDAGAARRAWESNARAVAEGVYFARDLISTPSNIKTPAWFADQVVAKFDGVPNVSVTVLDETQIEAL
GMGALYGTGQGSARPPRLVAVEYKGGAAGDAPLAFVGKGITFDTGGISIKPSANMWRMRMDMSGAAASAGAVLTLAKREA
KLNAVAVLALAENMPDGNAIRPGDVLTSMSGKTIEIMSTDAEGRLVLADGLWWAQEQYKPKMAVTIATLTGAVVGALGPD
YAGLFTKDDKLAGTFLAAAESSGEALWRMPVHPNSRKALNSDVADLKNGGEGAPGASVGAAFVMEWAKEETPFVHLDIAG
VAWQNAGNAVDPKGAVGYGVRLFDEVARTYESK
>Mature_513_residues
MKTWFTAAVSVLALALPAAADLPAIEFAKAERPNKGAVVLPVGKDGALEGLSRDADRAAKGAIAEAITMASFKGEAGQTL
TLYGVGPYSGVLLVGTGAGLKSATDMQTYGATVGKGTSAWKANVTVVVPDAADVTHDAAIAAQGAMLGAYDFGKWRSEPA
AATEPTVTLTFLAPDAGAARRAWESNARAVAEGVYFARDLISTPSNIKTPAWFADQVVAKFDGVPNVSVTVLDETQIEAL
GMGALYGTGQGSARPPRLVAVEYKGGAAGDAPLAFVGKGITFDTGGISIKPSANMWRMRMDMSGAAASAGAVLTLAKREA
KLNAVAVLALAENMPDGNAIRPGDVLTSMSGKTIEIMSTDAEGRLVLADGLWWAQEQYKPKMAVTIATLTGAVVGALGPD
YAGLFTKDDKLAGTFLAAAESSGEALWRMPVHPNSRKALNSDVADLKNGGEGAPGASVGAAFVMEWAKEETPFVHLDIAG
VAWQNAGNAVDPKGAVGYGVRLFDEVARTYESK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=436, Percent_Identity=35.0917431192661, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI47155554, Length=320, Percent_Identity=35, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790710, Length=489, Percent_Identity=35.1738241308793, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI87082123, Length=344, Percent_Identity=38.0813953488372, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=433, Percent_Identity=29.3302540415704, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=330, Percent_Identity=28.1818181818182, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129969, Length=455, Percent_Identity=30.7692307692308, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24662227, Length=438, Percent_Identity=30.1369863013699, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129963, Length=455, Percent_Identity=30.1098901098901, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24661038, Length=475, Percent_Identity=29.2631578947368, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355725, Length=476, Percent_Identity=29.6218487394958, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI161077148, Length=468, Percent_Identity=29.4871794871795, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI20130057, Length=468, Percent_Identity=29.4871794871795, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI19922386, Length=291, Percent_Identity=35.0515463917526, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21355645, Length=343, Percent_Identity=30.3206997084548, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24662223, Length=343, Percent_Identity=30.3206997084548, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221379063, Length=268, Percent_Identity=36.5671641791045, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379062, Length=268, Percent_Identity=36.5671641791045, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357381, Length=268, Percent_Identity=36.5671641791045, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646701, Length=326, Percent_Identity=28.5276073619632, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646703, Length=326, Percent_Identity=28.5276073619632, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358201, Length=326, Percent_Identity=28.5276073619632, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52825; Mature: 52825

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTWFTAAVSVLALALPAAADLPAIEFAKAERPNKGAVVLPVGKDGALEGLSRDADRAAK
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCHHCCCCCHHHHHH
GAIAEAITMASFKGEAGQTLTLYGVGPYSGVLLVGTGAGLKSATDMQTYGATVGKGTSAW
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCE
KANVTVVVPDAADVTHDAAIAAQGAMLGAYDFGKWRSEPAAATEPTVTLTFLAPDAGAAR
EEEEEEEECCCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCHHH
RAWESNARAVAEGVYFARDLISTPSNIKTPAWFADQVVAKFDGVPNVSVTVLDETQIEAL
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEE
GMGALYGTGQGSARPPRLVAVEYKGGAAGDAPLAFVGKGITFDTGGISIKPSANMWRMRM
ECEEEEECCCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCEEEEEE
DMSGAAASAGAVLTLAKREAKLNAVAVLALAENMPDGNAIRPGDVLTSMSGKTIEIMSTD
CCCCCCCCCCEEEEEEHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCEEEEEECC
AEGRLVLADGLWWAQEQYKPKMAVTIATLTGAVVGALGPDYAGLFTKDDKLAGTFLAAAE
CCCCEEEECCCEECHHHCCCEEEEEEEHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECC
SSGEALWRMPVHPNSRKALNSDVADLKNGGEGAPGASVGAAFVMEWAKEETPFVHLDIAG
CCCCEEEEECCCCCCHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
VAWQNAGNAVDPKGAVGYGVRLFDEVARTYESK
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTWFTAAVSVLALALPAAADLPAIEFAKAERPNKGAVVLPVGKDGALEGLSRDADRAAK
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCHHCCCCCHHHHHH
GAIAEAITMASFKGEAGQTLTLYGVGPYSGVLLVGTGAGLKSATDMQTYGATVGKGTSAW
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCE
KANVTVVVPDAADVTHDAAIAAQGAMLGAYDFGKWRSEPAAATEPTVTLTFLAPDAGAAR
EEEEEEEECCCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCHHH
RAWESNARAVAEGVYFARDLISTPSNIKTPAWFADQVVAKFDGVPNVSVTVLDETQIEAL
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEE
GMGALYGTGQGSARPPRLVAVEYKGGAAGDAPLAFVGKGITFDTGGISIKPSANMWRMRM
ECEEEEECCCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCEEEEEE
DMSGAAASAGAVLTLAKREAKLNAVAVLALAENMPDGNAIRPGDVLTSMSGKTIEIMSTD
CCCCCCCCCCEEEEEEHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCEEEEEECC
AEGRLVLADGLWWAQEQYKPKMAVTIATLTGAVVGALGPDYAGLFTKDDKLAGTFLAAAE
CCCCEEEECCCEECHHHCCCEEEEEEEHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECC
SSGEALWRMPVHPNSRKALNSDVADLKNGGEGAPGASVGAAFVMEWAKEETPFVHLDIAG
CCCCEEEEECCCCCCHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
VAWQNAGNAVDPKGAVGYGVRLFDEVARTYESK
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA