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The map label for this gene is fabZ

Identifier: 114800283

GI number: 114800283

Start: 3574690

End: 3575244

Strand: Direct

Name: fabZ

Synonym: HNE_3435

Alternate gene names: 114800283

Gene position: 3574690-3575244 (Clockwise)

Preceding gene: 114797532

Following gene: 114799930

Centisome position: 96.48

GC content: 63.78

Gene sequence:

>555_bases
ATGCAGGGTCCGCACGACTTTCACACGCCCAAATCCTCCTATTCCAAGGAAGACCTGCTCGAATCCGGCAAAGGGGGCTA
TTTCGGCCCCGGCAACGCCCAGCTGCCCGCCCCGCCGATGCTGATGATGGACCGCATCACAGAGATCAGCCTGGATGGCG
GCGCCTTCGGCAAGGGCCATGTTGTCGGCGAGCTCGACATCACACCGGACCTCTGGTTTTTCCAGTGCCACTTCCCCGGC
GATCCCGTCATGCCCGGCTGCCTTGGCCTCGACGCCATGTGGCAGATCGTTGGCTACTGGCTCGGCTGGTCGGGCAGCCC
CGGCAAGGGCCGCGCGCTGGGCGTGGGCGAAGTGAAGTTCACCGGCGAGATCACGCCGGACAAGAAGCTCGTGCGCTATG
AAATCGACATCAAGCGTGTGCGCCGCGGCAAGCTCAATCTGGGCATCGCCGATGGCCGGGTCTATGTCGATGGCGAACAC
GTCTACACCGCGATCGACATGAAAGTCGGCCTCAAGAACGTGCTCGGCGGCGCGGGCGATCTGCCCGCTTCTTGA

Upstream 100 bases:

>100_bases
CCCGGCCGGCAAACCAGCCCCTCAATCAGGCACAAATGGTTGACAAGGCGCGGGGCGTCGGCTCGAAGGCGTGATCCAAA
CTGAATGAGGACACCCCGAC

Downstream 100 bases:

>100_bases
CGAGGGCTTCCGGCGCGCCTAGCCCGGATGCCAGACAAACACACAGCCACCATCAGGGAGTGAGCAATCATGGCCGACGA
CTGGAACATGCCCAAAGGCG

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MQGPHDFHTPKSSYSKEDLLESGKGGYFGPGNAQLPAPPMLMMDRITEISLDGGAFGKGHVVGELDITPDLWFFQCHFPG
DPVMPGCLGLDAMWQIVGYWLGWSGSPGKGRALGVGEVKFTGEITPDKKLVRYEIDIKRVRRGKLNLGIADGRVYVDGEH
VYTAIDMKVGLKNVLGGAGDLPAS

Sequences:

>Translated_184_residues
MQGPHDFHTPKSSYSKEDLLESGKGGYFGPGNAQLPAPPMLMMDRITEISLDGGAFGKGHVVGELDITPDLWFFQCHFPG
DPVMPGCLGLDAMWQIVGYWLGWSGSPGKGRALGVGEVKFTGEITPDKKLVRYEIDIKRVRRGKLNLGIADGRVYVDGEH
VYTAIDMKVGLKNVLGGAGDLPAS
>Mature_184_residues
MQGPHDFHTPKSSYSKEDLLESGKGGYFGPGNAQLPAPPMLMMDRITEISLDGGAFGKGHVVGELDITPDLWFFQCHFPG
DPVMPGCLGLDAMWQIVGYWLGWSGSPGKGRALGVGEVKFTGEITPDKKLVRYEIDIKRVRRGKLNLGIADGRVYVDGEH
VYTAIDMKVGLKNVLGGAGDLPAS

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily

Homologues:

Organism=Escherichia coli, GI1787187, Length=161, Percent_Identity=63.9751552795031, Blast_Score=214, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABA_HYPNA (Q0BWN5)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_762108.1
- ProteinModelPortal:   Q0BWN5
- SMR:   Q0BWN5
- STRING:   Q0BWN5
- GeneID:   4287928
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3435
- NMPDR:   fig|228405.5.peg.3289
- TIGR:   HNE_3435
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   YWLGWSG
- ProtClustDB:   PRK05174
- BioCyc:   HNEP81032:HNE_3435-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00405
- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114
- PANTHER:   PTHR11712
- TIGRFAMs:   TIGR01749

Pfam domain/function: PF07977 FabA

EC number: =4.2.1.60

Molecular weight: Translated: 19861; Mature: 19861

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: ACT_SITE 77-77

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGPHDFHTPKSSYSKEDLLESGKGGYFGPGNAQLPAPPMLMMDRITEISLDGGAFGKGH
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCE
VVGELDITPDLWFFQCHFPGDPVMPGCLGLDAMWQIVGYWLGWSGSPGKGRALGVGEVKF
EEEEEECCCCEEEEEEECCCCCCCCCHHCHHHHHHHHHHHHCCCCCCCCCCEEECCEEEE
TGEITPDKKLVRYEIDIKRVRRGKLNLGIADGRVYVDGEHVYTAIDMKVGLKNVLGGAGD
ECCCCCCCEEEEEEEEHHHHCCCCCEEEEECCEEEECCCEEEEEEEEECCHHHHCCCCCC
LPAS
CCCC
>Mature Secondary Structure
MQGPHDFHTPKSSYSKEDLLESGKGGYFGPGNAQLPAPPMLMMDRITEISLDGGAFGKGH
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCE
VVGELDITPDLWFFQCHFPGDPVMPGCLGLDAMWQIVGYWLGWSGSPGKGRALGVGEVKF
EEEEEECCCCEEEEEEECCCCCCCCCHHCHHHHHHHHHHHHCCCCCCCCCCEEECCEEEE
TGEITPDKKLVRYEIDIKRVRRGKLNLGIADGRVYVDGEHVYTAIDMKVGLKNVLGGAGD
ECCCCCCCEEEEEEEEHHHHCCCCCEEEEECCEEEECCCEEEEEEEEECCHHHHCCCCCC
LPAS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA