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The map label for this gene is trpC

Identifier: 114800153

GI number: 114800153

Start: 1831216

End: 1832013

Strand: Reverse

Name: trpC

Synonym: HNE_1787

Alternate gene names: 114800153

Gene position: 1832013-1831216 (Counterclockwise)

Preceding gene: 114797113

Following gene: 114797550

Centisome position: 49.45

GC content: 57.64

Gene sequence:

>798_bases
ATGAAAACCGCGCTGGACCGGATCATTGACTACAAGCGTGATGAAGTCCGCGCGCTGAAGAAGGATCGCTCCCTTGGCGA
ACTGGAAAATGCGGCGGCTGCGGCTTCTCCAGTTCGCGGATTTGGCTCTGCCCTCTCTGCGATCGCTGATGCAGACCAGA
ATGCGCTTATCTGCGAAATCAAACGCAAGAGCCCGTCCGCGGGCGACATCCTACCGGGAGCCGATCCGGTGGAAATAGCG
CTGGATTATGAACGCGGCGGCGCCGCCTGTCTTTCCGTGCTTACCGACATGCCCAGCTTCGGCGGTAGCCTGGCCGACTT
TGAAACCATCCGCGCTGCGGTAAGCATACCCATGCTCCGCAAGGATTTTATGATAGACCCCATACAGATCATTGAAGCGC
GGGCGCATGGCGCTGACTGCATTCTGATCATCATGTCAGCGATCGATGATACCCTTGCGGGGGAACTTCACGATTGTGCC
TCCCGGCTGGGCATGGATGTTCTGGTTGAGACGCACGATGAGGCGGAAATGGAACGGGCGCTGCGCCTGCCCTCTCCCCT
GATCGGGGTCAACAACCGAGATCTGAAAAAGATGGTTACAGATCTTGGCACGACAGAACGTCTTGCACCGATGCTATCGA
GCGACCGTCAACTCATTGCAGAGAGCGGTATAGCCGACCCGGAAAGCATTATCCGTCTGCGTAAGGTCGGTTCACGGCGT
TTTCTGATCGGCGAGTGGCTGATGAAGCAAGGCACCTCCCGCGCCGAGCAGGTTACCCGTCTGAAACTCGCCTGTTGA

Upstream 100 bases:

>100_bases
TGCCAGCGGGCGTGCAGCGCGCAGCGCAAGCGATTGACAGCGGAGCGGCAAGAGAAACCCTCAACACGCTGGTACGCACA
TCTCGGGAGAGCGATTGAGC

Downstream 100 bases:

>100_bases
GATTGACCCGAACAGGGAACGCTTGTAGAACAAAAGCGAACATAGATTCGCATCGGGAACCGTTCCATGCTCACAACAAA
GCAAAAAGAGCTGCTGCTCT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKTALDRIIDYKRDEVRALKKDRSLGELENAAAAASPVRGFGSALSAIADADQNALICEIKRKSPSAGDILPGADPVEIA
LDYERGGAACLSVLTDMPSFGGSLADFETIRAAVSIPMLRKDFMIDPIQIIEARAHGADCILIIMSAIDDTLAGELHDCA
SRLGMDVLVETHDEAEMERALRLPSPLIGVNNRDLKKMVTDLGTTERLAPMLSSDRQLIAESGIADPESIIRLRKVGSRR
FLIGEWLMKQGTSRAEQVTRLKLAC

Sequences:

>Translated_265_residues
MKTALDRIIDYKRDEVRALKKDRSLGELENAAAAASPVRGFGSALSAIADADQNALICEIKRKSPSAGDILPGADPVEIA
LDYERGGAACLSVLTDMPSFGGSLADFETIRAAVSIPMLRKDFMIDPIQIIEARAHGADCILIIMSAIDDTLAGELHDCA
SRLGMDVLVETHDEAEMERALRLPSPLIGVNNRDLKKMVTDLGTTERLAPMLSSDRQLIAESGIADPESIIRLRKVGSRR
FLIGEWLMKQGTSRAEQVTRLKLAC
>Mature_265_residues
MKTALDRIIDYKRDEVRALKKDRSLGELENAAAAASPVRGFGSALSAIADADQNALICEIKRKSPSAGDILPGADPVEIA
LDYERGGAACLSVLTDMPSFGGSLADFETIRAAVSIPMLRKDFMIDPIQIIEARAHGADCILIIMSAIDDTLAGELHDCA
SRLGMDVLVETHDEAEMERALRLPSPLIGVNNRDLKKMVTDLGTTERLAPMLSSDRQLIAESGIADPESIIRLRKVGSRR
FLIGEWLMKQGTSRAEQVTRLKLAC

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=248, Percent_Identity=37.5, Blast_Score=137, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=223, Percent_Identity=37.6681614349776, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_HYPNA (Q0C1A2)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760491.1
- ProteinModelPortal:   Q0C1A2
- SMR:   Q0C1A2
- STRING:   Q0C1A2
- GeneID:   4290486
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1787
- NMPDR:   fig|228405.5.peg.1720
- TIGR:   HNE_1787
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- PhylomeDB:   Q0C1A2
- ProtClustDB:   CLSK2532115
- BioCyc:   HNEP81032:HNE_1787-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28743; Mature: 28743

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTALDRIIDYKRDEVRALKKDRSLGELENAAAAASPVRGFGSALSAIADADQNALICEI
CCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KRKSPSAGDILPGADPVEIALDYERGGAACLSVLTDMPSFGGSLADFETIRAAVSIPMLR
ECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KDFMIDPIQIIEARAHGADCILIIMSAIDDTLAGELHDCASRLGMDVLVETHDEAEMERA
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
LRLPSPLIGVNNRDLKKMVTDLGTTERLAPMLSSDRQLIAESGIADPESIIRLRKVGSRR
HCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH
FLIGEWLMKQGTSRAEQVTRLKLAC
HHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKTALDRIIDYKRDEVRALKKDRSLGELENAAAAASPVRGFGSALSAIADADQNALICEI
CCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KRKSPSAGDILPGADPVEIALDYERGGAACLSVLTDMPSFGGSLADFETIRAAVSIPMLR
ECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KDFMIDPIQIIEARAHGADCILIIMSAIDDTLAGELHDCASRLGMDVLVETHDEAEMERA
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
LRLPSPLIGVNNRDLKKMVTDLGTTERLAPMLSSDRQLIAESGIADPESIIRLRKVGSRR
HCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH
FLIGEWLMKQGTSRAEQVTRLKLAC
HHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA