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The map label for this gene is era [H]

Identifier: 114799800

GI number: 114799800

Start: 898486

End: 899433

Strand: Direct

Name: era [H]

Synonym: HNE_0878

Alternate gene names: 114799800

Gene position: 898486-899433 (Clockwise)

Preceding gene: 114797101

Following gene: 114799258

Centisome position: 24.25

GC content: 63.61

Gene sequence:

>948_bases
ATGACCGAAACAGAAATCCGCCGGGCAGGTTTTTGCGCCGTTATCGGCGCGCCCAACGCTGGCAAATCCACGCTCACCAA
CCGCCTCGTCGGGGCCAAGGTCGCCATCGTTACCCATAAGGTGCAGACGACCCGCTTCCCCGTGCGCGGCGTGGCGCAGG
TGGGCGACGCGCAGATAGTCATCGTCGACACGCCCGGCATCTTCGCCGCCAAACGCCGGCTCGACCGCGCGATGGTGAAA
GCTGCCTGGGGCGGCGCCGATGAGGCCGATTGCGTGGTCCACCTTGTCGATGCCTCCGCCTGGGTTGCCGAACAAACCGG
CCGGCCCAGCGGCGCCCAACGCCACTCGCTGGAGGACGATCGCCGCGTGATCGAACAGCTCAAGGAAGCGGGCAAACGCG
TCTTCCTCGCGCTCAACAAGATTGATCTCTTCCCGCACGATCAGGTGCTGCCCGTCATCGCCGCGCTCAGCGAGGCAGGC
GTTTATGAGGAGACCTTCCTGATCTCGGCGGAAAACGGTGAAGGCGTTGACAGGCTTGAGGCAGCCATTGCCGCGCGCAT
GCCTGAAGGCCCCGCGCTCTATCCGCCCGATCAGATCGCAGACCTTCCCATGCGCCTCTTGGCGGCGGAAGTGACGCGCG
AGAAGCTGATGCTCCGTCTCCATCAGGAATTGCCCTACCAGCTGATGGTCGATACCGAATCCTGGGAAGAGCGCGGCGAT
GGTTCGGTGCGTATTCAGCAGGTCATCATCGTTGGCCGCGACGGCCACAAGGCGATGGTGCTCGGCAAGGGCGGCAGCCT
GATCAAGGAAATCGGCCGCCTCGCTCGCCTGGACCTTACGCAGATGCTGGAACGCCCGGTACATCTGTTCCTGTTCGTGA
AGGTGGATGAGCGCTGGCAGGAAAAGCGGGAGCGCTATCAGGGCATCGGCCTGGAGTTTGATGTCTGA

Upstream 100 bases:

>100_bases
TCCGCCTTGCCGTCGGCAAGGCAACGGCCACCGGCCCTTCAAAACGAGAGGCGGAGCGTCATGCGGCCGCCCTGATGCTC
AGAACACTGACAGGAACAGA

Downstream 100 bases:

>100_bases
GGGTGCATGAACTGGTCCGATGACGGAATAGTACTGGGAGGGCGCCGCTTCGGGGAAGGCGGCCTGATCCTCGATGTGCT
GACCCGTGAGAAGGGCCGCC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MTETEIRRAGFCAVIGAPNAGKSTLTNRLVGAKVAIVTHKVQTTRFPVRGVAQVGDAQIVIVDTPGIFAAKRRLDRAMVK
AAWGGADEADCVVHLVDASAWVAEQTGRPSGAQRHSLEDDRRVIEQLKEAGKRVFLALNKIDLFPHDQVLPVIAALSEAG
VYEETFLISAENGEGVDRLEAAIAARMPEGPALYPPDQIADLPMRLLAAEVTREKLMLRLHQELPYQLMVDTESWEERGD
GSVRIQQVIIVGRDGHKAMVLGKGGSLIKEIGRLARLDLTQMLERPVHLFLFVKVDERWQEKRERYQGIGLEFDV

Sequences:

>Translated_315_residues
MTETEIRRAGFCAVIGAPNAGKSTLTNRLVGAKVAIVTHKVQTTRFPVRGVAQVGDAQIVIVDTPGIFAAKRRLDRAMVK
AAWGGADEADCVVHLVDASAWVAEQTGRPSGAQRHSLEDDRRVIEQLKEAGKRVFLALNKIDLFPHDQVLPVIAALSEAG
VYEETFLISAENGEGVDRLEAAIAARMPEGPALYPPDQIADLPMRLLAAEVTREKLMLRLHQELPYQLMVDTESWEERGD
GSVRIQQVIIVGRDGHKAMVLGKGGSLIKEIGRLARLDLTQMLERPVHLFLFVKVDERWQEKRERYQGIGLEFDV
>Mature_314_residues
TETEIRRAGFCAVIGAPNAGKSTLTNRLVGAKVAIVTHKVQTTRFPVRGVAQVGDAQIVIVDTPGIFAAKRRLDRAMVKA
AWGGADEADCVVHLVDASAWVAEQTGRPSGAQRHSLEDDRRVIEQLKEAGKRVFLALNKIDLFPHDQVLPVIAALSEAGV
YEETFLISAENGEGVDRLEAAIAARMPEGPALYPPDQIADLPMRLLAAEVTREKLMLRLHQELPYQLMVDTESWEERGDG
SVRIQQVIIVGRDGHKAMVLGKGGSLIKEIGRLARLDLTQMLERPVHLFLFVKVDERWQEKRERYQGIGLEFDV

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=330, Percent_Identity=28.1818181818182, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788919, Length=304, Percent_Identity=36.8421052631579, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI87082120, Length=165, Percent_Identity=29.0909090909091, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34840; Mature: 34708

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETEIRRAGFCAVIGAPNAGKSTLTNRLVGAKVAIVTHKVQTTRFPVRGVAQVGDAQIV
CCCCHHHHCCEEEEEECCCCCHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHCCCEEEE
IVDTPGIFAAKRRLDRAMVKAAWGGADEADCVVHLVDASAWVAEQTGRPSGAQRHSLEDD
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCHH
RRVIEQLKEAGKRVFLALNKIDLFPHDQVLPVIAALSEAGVYEETFLISAENGEGVDRLE
HHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
AAIAARMPEGPALYPPDQIADLPMRLLAAEVTREKLMLRLHQELPYQLMVDTESWEERGD
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHCCC
GSVRIQQVIIVGRDGHKAMVLGKGGSLIKEIGRLARLDLTQMLERPVHLFLFVKVDERWQ
CCEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECHHHH
EKRERYQGIGLEFDV
HHHHHHHCCCCEECC
>Mature Secondary Structure 
TETEIRRAGFCAVIGAPNAGKSTLTNRLVGAKVAIVTHKVQTTRFPVRGVAQVGDAQIV
CCCHHHHCCEEEEEECCCCCHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHCCCEEEE
IVDTPGIFAAKRRLDRAMVKAAWGGADEADCVVHLVDASAWVAEQTGRPSGAQRHSLEDD
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCHH
RRVIEQLKEAGKRVFLALNKIDLFPHDQVLPVIAALSEAGVYEETFLISAENGEGVDRLE
HHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
AAIAARMPEGPALYPPDQIADLPMRLLAAEVTREKLMLRLHQELPYQLMVDTESWEERGD
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHCCC
GSVRIQQVIIVGRDGHKAMVLGKGGSLIKEIGRLARLDLTQMLERPVHLFLFVKVDERWQ
CCEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECHHHH
EKRERYQGIGLEFDV
HHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA