Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 114797101

GI number: 114797101

Start: 897785

End: 898489

Strand: Direct

Name: rnc [H]

Synonym: HNE_0877

Alternate gene names: 114797101

Gene position: 897785-898489 (Clockwise)

Preceding gene: 114798027

Following gene: 114799800

Centisome position: 24.23

GC content: 62.98

Gene sequence:

>705_bases
GTGAAACCGTCTCTGCCGCCCGAAGCGCTGAAGGAAGCCCAGGAGATCATCGGCTTCAAATTCAAGGATGCCGCCATTCT
TGAACGGGCGCTGACCCATCCCAGCGCCATCCCGCCGTCCGGCGATACGGTGAAGCTTTCCAACCAGCGCCTCGAATTCC
TGGGCGACCGGGTGCTGAACCTGATCATCGCCGAACGCCTGATCGAGCGGCGTCAGTCTGACAGCGAGGGCGATCTTGCC
CCGCGCCTCAACCGGCTCGTCAAGAAAGGCGCCTGCGCCGAAGCGATGCGCTTTCTCGGGCTTCAACGGTTCATTCTGCT
GTCGGAAAGCGAAGTCGCCGCCGGCGGCCATGACCGCGAGTCGACACTGGGCGACGCCTGCGAAGCAGTCATCGCCGCGA
TCTATCAGGAAGGCGGGCTCGCCGCTGCGCGCAAGTTCATAGAGCGCGCATGGGCGCCGCAATTTGAAAATGTGCCCGCC
GAAACCAAAGACCCCAAGACGCTGCTTCAGGAATGGGCGCAGGGGCAGGGACATCCGCTCCCGGATTATGTGGTTACTGG
CCGCTCTGGCCCCGACCATGCCCCCCAATATGAGGTGGAAGTCCGCCTTGCCGTCGGCAAGGCAACGGCCACCGGCCCTT
CAAAACGAGAGGCGGAGCGTCATGCGGCCGCCCTGATGCTCAGAACACTGACAGGAACAGAATGA

Upstream 100 bases:

>100_bases
GGGCCGAAGCGCAGGTGATCATCGAGGCCATCCCGGTCGCGGAGCCGTCATGAAGCCCGCCCGCCCCAAACGCACACGCC
AGCGCGCCGCCGTAAAGGCG

Downstream 100 bases:

>100_bases
CCGAAACAGAAATCCGCCGGGCAGGTTTTTGCGCCGTTATCGGCGCGCCCAACGCTGGCAAATCCACGCTCACCAACCGC
CTCGTCGGGGCCAAGGTCGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKPSLPPEALKEAQEIIGFKFKDAAILERALTHPSAIPPSGDTVKLSNQRLEFLGDRVLNLIIAERLIERRQSDSEGDLA
PRLNRLVKKGACAEAMRFLGLQRFILLSESEVAAGGHDRESTLGDACEAVIAAIYQEGGLAAARKFIERAWAPQFENVPA
ETKDPKTLLQEWAQGQGHPLPDYVVTGRSGPDHAPQYEVEVRLAVGKATATGPSKREAERHAAALMLRTLTGTE

Sequences:

>Translated_234_residues
MKPSLPPEALKEAQEIIGFKFKDAAILERALTHPSAIPPSGDTVKLSNQRLEFLGDRVLNLIIAERLIERRQSDSEGDLA
PRLNRLVKKGACAEAMRFLGLQRFILLSESEVAAGGHDRESTLGDACEAVIAAIYQEGGLAAARKFIERAWAPQFENVPA
ETKDPKTLLQEWAQGQGHPLPDYVVTGRSGPDHAPQYEVEVRLAVGKATATGPSKREAERHAAALMLRTLTGTE
>Mature_234_residues
MKPSLPPEALKEAQEIIGFKFKDAAILERALTHPSAIPPSGDTVKLSNQRLEFLGDRVLNLIIAERLIERRQSDSEGDLA
PRLNRLVKKGACAEAMRFLGLQRFILLSESEVAAGGHDRESTLGDACEAVIAAIYQEGGLAAARKFIERAWAPQFENVPA
ETKDPKTLLQEWAQGQGHPLPDYVVTGRSGPDHAPQYEVEVRLAVGKATATGPSKREAERHAAALMLRTLTGTE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=232, Percent_Identity=30.1724137931034, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI155030234, Length=232, Percent_Identity=30.1724137931034, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788920, Length=230, Percent_Identity=32.1739130434783, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=29.0748898678414, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=29.0748898678414, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137682, Length=227, Percent_Identity=32.15859030837, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25509; Mature: 25509

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSLPPEALKEAQEIIGFKFKDAAILERALTHPSAIPPSGDTVKLSNQRLEFLGDRVLN
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHH
LIIAERLIERRQSDSEGDLAPRLNRLVKKGACAEAMRFLGLQRFILLSESEVAAGGHDRE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCH
STLGDACEAVIAAIYQEGGLAAARKFIERAWAPQFENVPAETKDPKTLLQEWAQGQGHPL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
PDYVVTGRSGPDHAPQYEVEVRLAVGKATATGPSKREAERHAAALMLRTLTGTE
CCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKPSLPPEALKEAQEIIGFKFKDAAILERALTHPSAIPPSGDTVKLSNQRLEFLGDRVLN
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHH
LIIAERLIERRQSDSEGDLAPRLNRLVKKGACAEAMRFLGLQRFILLSESEVAAGGHDRE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCH
STLGDACEAVIAAIYQEGGLAAARKFIERAWAPQFENVPAETKDPKTLLQEWAQGQGHPL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
PDYVVTGRSGPDHAPQYEVEVRLAVGKATATGPSKREAERHAAALMLRTLTGTE
CCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA