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The map label for this gene is lpxK

Identifier: 114799558

GI number: 114799558

Start: 711806

End: 712804

Strand: Reverse

Name: lpxK

Synonym: HNE_0700

Alternate gene names: 114799558

Gene position: 712804-711806 (Counterclockwise)

Preceding gene: 114799880

Following gene: 114798797

Centisome position: 19.24

GC content: 67.77

Gene sequence:

>999_bases
GTGAAGGCGCCGTATTTCTGGTCGGCGGATCTCGATCCGAAATCCCGCGAAGCGGCCCCGCTGACCCGTCTGCTGCTGAC
GCCCTTCGCAATGCTCTATCTCTGGGCCTTGCGCCGCAAGCTCGCCAAGGCTCGGCCGGAGGCCGCGCCCGTGCCGGTCG
TCTGCATCGGCAATCTCACTGCCGGCGGGGCGGGCAAGACCCCCGTTACCGAAGCCATCCGTAACCGGATCAGGTCTGCC
GGCCTGCGCGCCGCCAGCCTCTCCCGCGGTCATGGCGGGGCCGAGCCTGGCCCGCTGAAGGTCGATCCCGCCCGGCATAC
GTCCCGCGATGTGGGGGATGAGCCTCTGCTGCTCGCCGGGTCCGGTGAAGCCTGGATCGGGCGCAAACGCCCCGAAGCGG
CGCGCGCCATGGCGGCAGACGGCGCCGAGATCATCCTCATGGATGACGGCCACCAGAACCCGTCTCTGAAGAAAGATCTT
ACCCTGATCGTCATCGATGCGGGTGCCCCCTTCGGCAATGGCCATGTTCTGCCCAAAGGCCCGCTGCGGGAAAAAGTGCC
CGAGGGCCTCGCCCGCGCCGATGCCGTGATCCTTATGGGCGCAGGCCCTGTGCCGCCCGAAGTGACTGCCAGCAGCCTGC
CCGTGCTGCGCGCCCGGCTCGCGCCCCTGGCCGCGCCCCCGCCCGGCCCGCTGGTCGCCTTCGCCGGCATCGGGCGCCCG
CAGAAATTCTTCGATAGTCTTGCGCAGGCAGGCGGCAATGTCTCCGATGCGGTGCCATTTGGGGATCACCATCCTTACAC
CAAGGGCGACGTTCAGTTCCTGCGCAGCCTTGCTCACGATCACGGCGCACGTCTGATCACGACCACCAAAGACCACGTTC
GCCTGCCGCTGGACGCGCAATCAGAAATCCTCGCCTGGCCGGTCACCGCCGTGTTCGAGGACACCGCAGCGCTTGACGCC
GTGCTCGCCCCGATCTTCAAACGCGCTGGCAAACCATGA

Upstream 100 bases:

>100_bases
CGGAGGCCGACGAGCCGATGCTGCTCACGCTGGGCGCGCTGCTGCCCCTCCTGCCCCAACCCCTGCTGGAGGGCAGCGAC
GGCGACTGGGAGCGCCAGCG

Downstream 100 bases:

>100_bases
ACACCCAGCCCCCCCCCTCCAACCCTGGCGGCGCCTATGTCCGCCCGAAGGACATCGATAACCGCGCCACCCTCGGCCAG
CGGATCGCCTGGCGGCTGGA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKAPYFWSADLDPKSREAAPLTRLLLTPFAMLYLWALRRKLAKARPEAAPVPVVCIGNLTAGGAGKTPVTEAIRNRIRSA
GLRAASLSRGHGGAEPGPLKVDPARHTSRDVGDEPLLLAGSGEAWIGRKRPEAARAMAADGAEIILMDDGHQNPSLKKDL
TLIVIDAGAPFGNGHVLPKGPLREKVPEGLARADAVILMGAGPVPPEVTASSLPVLRARLAPLAAPPPGPLVAFAGIGRP
QKFFDSLAQAGGNVSDAVPFGDHHPYTKGDVQFLRSLAHDHGARLITTTKDHVRLPLDAQSEILAWPVTAVFEDTAALDA
VLAPIFKRAGKP

Sequences:

>Translated_332_residues
MKAPYFWSADLDPKSREAAPLTRLLLTPFAMLYLWALRRKLAKARPEAAPVPVVCIGNLTAGGAGKTPVTEAIRNRIRSA
GLRAASLSRGHGGAEPGPLKVDPARHTSRDVGDEPLLLAGSGEAWIGRKRPEAARAMAADGAEIILMDDGHQNPSLKKDL
TLIVIDAGAPFGNGHVLPKGPLREKVPEGLARADAVILMGAGPVPPEVTASSLPVLRARLAPLAAPPPGPLVAFAGIGRP
QKFFDSLAQAGGNVSDAVPFGDHHPYTKGDVQFLRSLAHDHGARLITTTKDHVRLPLDAQSEILAWPVTAVFEDTAALDA
VLAPIFKRAGKP
>Mature_332_residues
MKAPYFWSADLDPKSREAAPLTRLLLTPFAMLYLWALRRKLAKARPEAAPVPVVCIGNLTAGGAGKTPVTEAIRNRIRSA
GLRAASLSRGHGGAEPGPLKVDPARHTSRDVGDEPLLLAGSGEAWIGRKRPEAARAMAADGAEIILMDDGHQNPSLKKDL
TLIVIDAGAPFGNGHVLPKGPLREKVPEGLARADAVILMGAGPVPPEVTASSLPVLRARLAPLAAPPPGPLVAFAGIGRP
QKFFDSLAQAGGNVSDAVPFGDHHPYTKGDVQFLRSLAHDHGARLITTTKDHVRLPLDAQSEILAWPVTAVFEDTAALDA
VLAPIFKRAGKP

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=306, Percent_Identity=38.2352941176471, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_HYPNA (Q0C4B4)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759429.1
- STRING:   Q0C4B4
- GeneID:   4288543
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0700
- NMPDR:   fig|228405.5.peg.686
- TIGR:   HNE_0700
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   Q0C4B4
- ProtClustDB:   CLSK777591
- BioCyc:   HNEP81032:HNE_0700-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 34963; Mature: 34963

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAPYFWSADLDPKSREAAPLTRLLLTPFAMLYLWALRRKLAKARPEAAPVPVVCIGNLT
CCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
AGGAGKTPVTEAIRNRIRSAGLRAASLSRGHGGAEPGPLKVDPARHTSRDVGDEPLLLAG
CCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEC
SGEAWIGRKRPEAARAMAADGAEIILMDDGHQNPSLKKDLTLIVIDAGAPFGNGHVLPKG
CCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
PLREKVPEGLARADAVILMGAGPVPPEVTASSLPVLRARLAPLAAPPPGPLVAFAGIGRP
CHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCH
QKFFDSLAQAGGNVSDAVPFGDHHPYTKGDVQFLRSLAHDHGARLITTTKDHVRLPLDAQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEECCCCCC
SEILAWPVTAVFEDTAALDAVLAPIFKRAGKP
CCEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAPYFWSADLDPKSREAAPLTRLLLTPFAMLYLWALRRKLAKARPEAAPVPVVCIGNLT
CCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
AGGAGKTPVTEAIRNRIRSAGLRAASLSRGHGGAEPGPLKVDPARHTSRDVGDEPLLLAG
CCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEC
SGEAWIGRKRPEAARAMAADGAEIILMDDGHQNPSLKKDLTLIVIDAGAPFGNGHVLPKG
CCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
PLREKVPEGLARADAVILMGAGPVPPEVTASSLPVLRARLAPLAAPPPGPLVAFAGIGRP
CHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCH
QKFFDSLAQAGGNVSDAVPFGDHHPYTKGDVQFLRSLAHDHGARLITTTKDHVRLPLDAQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEECCCCCC
SEILAWPVTAVFEDTAALDAVLAPIFKRAGKP
CCEEECCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA