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The map label for this gene is merR [H]

Identifier: 114798946

GI number: 114798946

Start: 1411034

End: 1411495

Strand: Reverse

Name: merR [H]

Synonym: HNE_1380

Alternate gene names: 114798946

Gene position: 1411495-1411034 (Counterclockwise)

Preceding gene: 114798770

Following gene: 114798241

Centisome position: 38.1

GC content: 58.66

Gene sequence:

>462_bases
GTGCCTCCTTTTCTTCCTTGTCGCGGAGCAGGTCGGCTTACATATAGGTTCCGTACCATAGTACGGAATCAAGAGGAAAA
GATGCTGACCATCGGAAAACTTGCCCAGGCCGGCGGTGTCGGCGTCGAAACCGTCCGCTTCTATCAACGCCGGAACCTGC
TCGGTACGCCTTCGCGGGACGGCGGCATCCGCCGTTATGACACTGAAGATGTTCGCCGCCTCCGCTTTATCCGGAAGGCG
CAGCACGCCGGTTTCACGCTGGAAGAAATCAGGGAATTGATCGAACTGGATTCCGGCCACGATCATCATCGCGCGCGGGA
AATGGCAGAAACGCGCCTGACGAAGCTCGACGAACAGATCGCCGAGCTTCAGCGCGCCAAACAAAGCCTCCAGAGGCTGG
CAACAGAATGCGCTGCGGGTAAGTCCGGCTCCTGCCCGATCCTGGACGCGTTTGAAGTCTGA

Upstream 100 bases:

>100_bases
TGCCTTCAGCCCATAGGGGCATGTGTGTCCCGGCATAATCATCAGGTAGAGGTGCGCCGTTTTCACGGTTTCCAGTTTTT
CAGAACGTTCCGGCATTTGC

Downstream 100 bases:

>100_bases
CGAAACAGATCAGCCGGAATGGCAGCGCAATCAGGAGGCGCGCTTGATCTCGTTGCCTTCGCCGAGCAGCACCACGGTCG
GCGCATGCTGGCGGGCTTTT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MPPFLPCRGAGRLTYRFRTIVRNQEEKMLTIGKLAQAGGVGVETVRFYQRRNLLGTPSRDGGIRRYDTEDVRRLRFIRKA
QHAGFTLEEIRELIELDSGHDHHRAREMAETRLTKLDEQIAELQRAKQSLQRLATECAAGKSGSCPILDAFEV

Sequences:

>Translated_153_residues
MPPFLPCRGAGRLTYRFRTIVRNQEEKMLTIGKLAQAGGVGVETVRFYQRRNLLGTPSRDGGIRRYDTEDVRRLRFIRKA
QHAGFTLEEIRELIELDSGHDHHRAREMAETRLTKLDEQIAELQRAKQSLQRLATECAAGKSGSCPILDAFEV
>Mature_152_residues
PPFLPCRGAGRLTYRFRTIVRNQEEKMLTIGKLAQAGGVGVETVRFYQRRNLLGTPSRDGGIRRYDTEDVRRLRFIRKAQ
HAGFTLEEIRELIELDSGHDHHRAREMAETRLTKLDEQIAELQRAKQSLQRLATECAAGKSGSCPILDAFEV

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=131, Percent_Identity=39.6946564885496, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1786695, Length=126, Percent_Identity=30.1587301587302, Blast_Score=68, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 17466; Mature: 17335

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPFLPCRGAGRLTYRFRTIVRNQEEKMLTIGKLAQAGGVGVETVRFYQRRNLLGTPSRD
CCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
GGIRRYDTEDVRRLRFIRKAQHAGFTLEEIRELIELDSGHDHHRAREMAETRLTKLDEQI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AELQRAKQSLQRLATECAAGKSGSCPILDAFEV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PPFLPCRGAGRLTYRFRTIVRNQEEKMLTIGKLAQAGGVGVETVRFYQRRNLLGTPSRD
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
GGIRRYDTEDVRRLRFIRKAQHAGFTLEEIRELIELDSGHDHHRAREMAETRLTKLDEQI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AELQRAKQSLQRLATECAAGKSGSCPILDAFEV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6091128; 2551364 [H]