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The map label for this gene is cobC [H]

Identifier: 114798819

GI number: 114798819

Start: 1554146

End: 1555138

Strand: Direct

Name: cobC [H]

Synonym: HNE_1520

Alternate gene names: 114798819

Gene position: 1554146-1555138 (Clockwise)

Preceding gene: 114797305

Following gene: 114797196

Centisome position: 41.95

GC content: 59.62

Gene sequence:

>993_bases
GTGAAACCGGATCTTGTTCATGGCGGCGCGCTAGACCGGATGCGTGCGGCCTTCCCTGATGCGCCTGAGCCCTGGATCGA
CCTTTCGACCGGGATCAATCCATGGGCTTACCCGGTTGGAGGCATTCCGGATACGGTATTTCGACAGCTGCCCACTCAAG
AGGCTTATAATGCCTGCCGGCAAGCCTTGGCGGAGAGCCTGCGGAGCCCTGCAGAGAACCTCATTCTCGTCCCCGGCAGC
GAACTTCTCATTCGCCTGTTGCCGATGGTGATCAAGCCAAAGAAAGTTACCATTTTATCTCCGACATATGGCGACCATGC
CGATGCGTGGCGCCGGGCAGGCGGAGAGGTTGTCGAAACTACAGATCCACTGGGCAGGGCCGATCAGGCCGATGCCGTGA
TCATTTGCAATCCCAACAATCCCGACGGTCGTTATTTTGAGCCGGACGCTTTGTTGCAGGCGGCCGCAAGTCTTGCGCGC
CGTAGTGGCTGGTTGATTGTCGACGAAGCCTATGCTGATCTCGATCCGGCGTTCAGCCTGACGCGTTATGGCGGTATGGA
CGGATTGATCGTCTTGCGCTCCTTCGGGAAGTTCTTCGGTCTGGCCGGCCTCCGGCTCGGTGCGCTTATCGCTCCCGAGG
CTACCCGGATGGAAATGCAGAACGTGCTAGGGGTCTGGCCGGTATCCGGCCCGGCTATAGCCATCGGTGCGCAAGCCTGC
GGCGACCTTGCCTGGCAAGCTGAAACCCGCTGCCGGCTCGTTAGGGGCCGAGAGCGTCTGGACCACATTCTTCGATTGTC
AGGCCTGAAAATATGTGGGGGTACGGATCTCTTTCGGCTCGTAATCACAGATAACGCCCGCGCCCTTTGGGAAGGCCTTG
CACATAGGGGGATTTATGTTCGCCGGTTTGCCTGGAGCGACCGGCTTGTGCGGATCGGACTTCCCGAGAACGAGAAGGCC
GAAGATCGCCTGCTGGCTGCCCTCACGACTTGA

Upstream 100 bases:

>100_bases
CCGGCGCCTCTGATATTCAAAGGGCGCTGCGGCTTTACATACTGGCGCTGGCGCTGGTCGGTCTCACACTGATTGGCGTT
GTTCTGTTGGGGGCGTCCAG

Downstream 100 bases:

>100_bases
GGCGCAGCGGCAGGCCCGCAGCGATGAATTCGACAACGTCGCAAACTGAAGCGACACGCTGATTGAGCCGCCCCTGTGCA
TCGCGGAAGGAACGGCCCAG

Product: putative threonine-phosphate decarboxylase CobC

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKPDLVHGGALDRMRAAFPDAPEPWIDLSTGINPWAYPVGGIPDTVFRQLPTQEAYNACRQALAESLRSPAENLILVPGS
ELLIRLLPMVIKPKKVTILSPTYGDHADAWRRAGGEVVETTDPLGRADQADAVIICNPNNPDGRYFEPDALLQAAASLAR
RSGWLIVDEAYADLDPAFSLTRYGGMDGLIVLRSFGKFFGLAGLRLGALIAPEATRMEMQNVLGVWPVSGPAIAIGAQAC
GDLAWQAETRCRLVRGRERLDHILRLSGLKICGGTDLFRLVITDNARALWEGLAHRGIYVRRFAWSDRLVRIGLPENEKA
EDRLLAALTT

Sequences:

>Translated_330_residues
MKPDLVHGGALDRMRAAFPDAPEPWIDLSTGINPWAYPVGGIPDTVFRQLPTQEAYNACRQALAESLRSPAENLILVPGS
ELLIRLLPMVIKPKKVTILSPTYGDHADAWRRAGGEVVETTDPLGRADQADAVIICNPNNPDGRYFEPDALLQAAASLAR
RSGWLIVDEAYADLDPAFSLTRYGGMDGLIVLRSFGKFFGLAGLRLGALIAPEATRMEMQNVLGVWPVSGPAIAIGAQAC
GDLAWQAETRCRLVRGRERLDHILRLSGLKICGGTDLFRLVITDNARALWEGLAHRGIYVRRFAWSDRLVRIGLPENEKA
EDRLLAALTT
>Mature_330_residues
MKPDLVHGGALDRMRAAFPDAPEPWIDLSTGINPWAYPVGGIPDTVFRQLPTQEAYNACRQALAESLRSPAENLILVPGS
ELLIRLLPMVIKPKKVTILSPTYGDHADAWRRAGGEVVETTDPLGRADQADAVIICNPNNPDGRYFEPDALLQAAASLAR
RSGWLIVDEAYADLDPAFSLTRYGGMDGLIVLRSFGKFFGLAGLRLGALIAPEATRMEMQNVLGVWPVSGPAIAIGAQAC
GDLAWQAETRCRLVRGRERLDHILRLSGLKICGGTDLFRLVITDNARALWEGLAHRGIYVRRFAWSDRLVRIGLPENEKA
EDRLLAALTT

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=199, Percent_Identity=33.6683417085427, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36098; Mature: 36098

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDLVHGGALDRMRAAFPDAPEPWIDLSTGINPWAYPVGGIPDTVFRQLPTQEAYNACR
CCCCCCCCCCHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHH
QALAESLRSPAENLILVPGSELLIRLLPMVIKPKKVTILSPTYGDHADAWRRAGGEVVET
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEC
TDPLGRADQADAVIICNPNNPDGRYFEPDALLQAAASLARRSGWLIVDEAYADLDPAFSL
CCCCCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHH
TRYGGMDGLIVLRSFGKFFGLAGLRLGALIAPEATRMEMQNVLGVWPVSGPAIAIGAQAC
HHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHEECCCCCCEEEECHHHH
GDLAWQAETRCRLVRGRERLDHILRLSGLKICGGTDLFRLVITDNARALWEGLAHRGIYV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEECCHHHHHHHHHHCCEEE
RRFAWSDRLVRIGLPENEKAEDRLLAALTT
EEEECCCCEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKPDLVHGGALDRMRAAFPDAPEPWIDLSTGINPWAYPVGGIPDTVFRQLPTQEAYNACR
CCCCCCCCCCHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHH
QALAESLRSPAENLILVPGSELLIRLLPMVIKPKKVTILSPTYGDHADAWRRAGGEVVET
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEC
TDPLGRADQADAVIICNPNNPDGRYFEPDALLQAAASLARRSGWLIVDEAYADLDPAFSL
CCCCCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHH
TRYGGMDGLIVLRSFGKFFGLAGLRLGALIAPEATRMEMQNVLGVWPVSGPAIAIGAQAC
HHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHEECCCCCCEEEECHHHH
GDLAWQAETRCRLVRGRERLDHILRLSGLKICGGTDLFRLVITDNARALWEGLAHRGIYV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEECCHHHHHHHHHHCCEEE
RRFAWSDRLVRIGLPENEKAEDRLLAALTT
EEEECCCCEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]