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The map label for this gene is rsh [H]

Identifier: 114798559

GI number: 114798559

Start: 893746

End: 896013

Strand: Direct

Name: rsh [H]

Synonym: HNE_0873

Alternate gene names: 114798559

Gene position: 893746-896013 (Clockwise)

Preceding gene: 114799587

Following gene: 114797568

Centisome position: 24.12

GC content: 62.48

Gene sequence:

>2268_bases
ATGGACGGCAGCGCCCTTTCCGGACCGGAAAAAGGGGCTGGCACAGGGGCTGGCAAACCAGCTCCTGCCAGCGACGCTGC
GCCTGAACTTCCGCATTTCCTGTCCCGGGAAGAGTTGATCGCGAAAGTTCGCGCCTACCACCCGCGGGTGAGGTCCGAAC
TGCTCGGCCTGGCTTACGACTTCGCCAAGAAGCATCATGGCGAGCAATCCCGCGATTCCGGCGAGGCCTACTATTCCCAC
CCCGTCCAGGTCGCCAGCCTGCTTGCAGAGATAAAGCTCGACGAGGTCACCATCGTGGCCGGCCTCCTGCATGATGTGGT
CGAGGACACCGAGATCGACATCGGCGACATCGAGGTGCGCTTCGGCCCGCAGGTCGCCGAACTCGTCGACGGCGTTACCA
AGCTCGACAAGCTGGAATTCACCTCAAAGGAGGCCGCCCAGGCCGAGAACTTCCAGAAGTTTATCCTCGCCATGACCGGC
GACCTGCGCGTGCTGCTCGTCAAGCTCGCCGACCGAATGCACAACATGGAGACGCTGCACTTCCGCAAGAAGCTGGAAAG
CCGGCAGCGGACGGCGCGCGAAACCATGGACATCTACGCCCCGCTGGCGCGCCGCATCGGTCTTTACGACATGGCCGCCC
GGATGGACGATCTGGCGTTCAAGGAACTGAACCCCGAAGCCCGCCGCGCCATCATCTACCGGCTGGAGGAGCTGGAGCGC
GAAAACAAGGACGACCTCGGACGTATCCGGGCAGACCTGACGCGCATCCTCAACGAGGCAGGGGTGCGCTGCCGGATCAA
GGGCCGCCGCAAGCAGCCCTATTCGCTGTGGCGCAAGCTTGAGCGTAAATCGATTTCCTTCCGCGATGTGGCTGACCTCT
TCGCCTTCCGCATCATTGTGACGGATGTCGCCGATTGCTATCAGGCGCTGGGTGTTCTGCATACGCACTGGGCTTGTATT
CCTGAGCGCTTCCGGGATTTTATATCCGTGCCCAAACCAAACGGTTATGCCAGCCTTCACACAACGGTGCGTGCATCGGG
CAACCGCCGCGTGGAACTTCAGATCCGCACCGAAACCATGGACCTGACGGCAGAATATGGCGTCGCCGCCCACTGGGGTT
ACAAGAACCGCTCCTATGGCTTTGACGTGGATTCTGCCCGCGCGGCAGGTCTCGACCCCGAAGCCAACCTCAACGCCTTT
GCCGAACTCCTGCGGGACGGCGCCGAGCCCGGCGAGTTCCTAGAGCATGCAAAGCTGGAGATGTACCGTGAACACGTCTT
CACCTTCACGCCCAAGGGCAAGCTGATCATCCTGCCGGCCGGCGCCATGCCGCTCGACTTTGCCTATGCCGTCCACTCTG
CCGTCGGCGACACAACCATCGGCGCGCGGATCAATGGCGAGGAGAAATCCCTCCGCCGGCCGCTCAAGAATGGCGATGTG
GTGGACATCATCCGTGGAAAGACGGCTGACCCGATCCGCGGCTGGGAAATGCTGACCCATACCGGCCGGGCGAAATCGGC
GCTGCGCCGGCTGGAGCGCGAGCGGGAGATCGCCGAGTTCCGCCGCCTGGGCGAGGGGCTCATCAATCAGGCCTTGCGCC
GCGCCGGGGCAGACCCGGTGGATGTCATGCTGATGGATGTGGCGAAGAAGTTCGGCTTCAAGACGGTCGACGAGATGCGC
GAAGCGGTCGGGCGTGGCCGATTCAAGACGTCTGTGGTTATCCAGACCGTTTTCCCCGGCTATCAGCCCGAGCGCACCGA
CGACATCGCCAAGACGCCCATCGACAGCGACCATGTTCCGCTGTTCGTCGAGGGCCTCACGCTGACACCAGGCGTGACCC
TGCATCTGAGCACCTGTTGCCACCCGCTGCCCGGCGACCGGATCATCGGCGTCCAGGTGCCAGACAAAGGCTTGATGGTT
CACGTCTCCAGCTGTCCGCGCCTGGCCGAATATGACGACCGGCCAGAGCTTTGGCATGACCTCAAATGGACGGAGCTTGC
GCGCACCGATGCCGTCGCCGTGACGCGTATCCGCATCAACGCGTCCAACCAGCGCGGCGTGCTCGCAAAGCTCTGCGCGG
CGGTCGCCGAATCGAACGGAAACATCATCGGGATTTCCACGGCCTCGCGGCATCCCGATTTCATAGAGCTGATGATGGAT
ATTGAGGTTGAAGACCTGAAGCGTATGACGCAAATCCTTGCGGCACTGCGGTCCTTGGCCGTGGTAGACCGGGCCATACG
CGATCAGGAGGGACAATATGACCAGTGA

Upstream 100 bases:

>100_bases
TCGCCCTTCAGGCTGCGCCTGCAGCGACGGAAGACGATGTTCTGCGCGCCTATCAGGCAGAACTCGAATCCGGGCGCGAC
GACCGGCTCTAGGAGACTCA

Downstream 100 bases:

>100_bases
AGACGTGCTCGCCGTGTTCAAAGAGGCGGGCGCATTGCTGGAGGGGCATTTCATCCTCTCCTCCGGGCGTCGCAGCTCCG
TTTTTTTGCAGAAGGCGCTT

Product: RelA/SpoT family protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MDGSALSGPEKGAGTGAGKPAPASDAAPELPHFLSREELIAKVRAYHPRVRSELLGLAYDFAKKHHGEQSRDSGEAYYSH
PVQVASLLAEIKLDEVTIVAGLLHDVVEDTEIDIGDIEVRFGPQVAELVDGVTKLDKLEFTSKEAAQAENFQKFILAMTG
DLRVLLVKLADRMHNMETLHFRKKLESRQRTARETMDIYAPLARRIGLYDMAARMDDLAFKELNPEARRAIIYRLEELER
ENKDDLGRIRADLTRILNEAGVRCRIKGRRKQPYSLWRKLERKSISFRDVADLFAFRIIVTDVADCYQALGVLHTHWACI
PERFRDFISVPKPNGYASLHTTVRASGNRRVELQIRTETMDLTAEYGVAAHWGYKNRSYGFDVDSARAAGLDPEANLNAF
AELLRDGAEPGEFLEHAKLEMYREHVFTFTPKGKLIILPAGAMPLDFAYAVHSAVGDTTIGARINGEEKSLRRPLKNGDV
VDIIRGKTADPIRGWEMLTHTGRAKSALRRLEREREIAEFRRLGEGLINQALRRAGADPVDVMLMDVAKKFGFKTVDEMR
EAVGRGRFKTSVVIQTVFPGYQPERTDDIAKTPIDSDHVPLFVEGLTLTPGVTLHLSTCCHPLPGDRIIGVQVPDKGLMV
HVSSCPRLAEYDDRPELWHDLKWTELARTDAVAVTRIRINASNQRGVLAKLCAAVAESNGNIIGISTASRHPDFIELMMD
IEVEDLKRMTQILAALRSLAVVDRAIRDQEGQYDQ

Sequences:

>Translated_755_residues
MDGSALSGPEKGAGTGAGKPAPASDAAPELPHFLSREELIAKVRAYHPRVRSELLGLAYDFAKKHHGEQSRDSGEAYYSH
PVQVASLLAEIKLDEVTIVAGLLHDVVEDTEIDIGDIEVRFGPQVAELVDGVTKLDKLEFTSKEAAQAENFQKFILAMTG
DLRVLLVKLADRMHNMETLHFRKKLESRQRTARETMDIYAPLARRIGLYDMAARMDDLAFKELNPEARRAIIYRLEELER
ENKDDLGRIRADLTRILNEAGVRCRIKGRRKQPYSLWRKLERKSISFRDVADLFAFRIIVTDVADCYQALGVLHTHWACI
PERFRDFISVPKPNGYASLHTTVRASGNRRVELQIRTETMDLTAEYGVAAHWGYKNRSYGFDVDSARAAGLDPEANLNAF
AELLRDGAEPGEFLEHAKLEMYREHVFTFTPKGKLIILPAGAMPLDFAYAVHSAVGDTTIGARINGEEKSLRRPLKNGDV
VDIIRGKTADPIRGWEMLTHTGRAKSALRRLEREREIAEFRRLGEGLINQALRRAGADPVDVMLMDVAKKFGFKTVDEMR
EAVGRGRFKTSVVIQTVFPGYQPERTDDIAKTPIDSDHVPLFVEGLTLTPGVTLHLSTCCHPLPGDRIIGVQVPDKGLMV
HVSSCPRLAEYDDRPELWHDLKWTELARTDAVAVTRIRINASNQRGVLAKLCAAVAESNGNIIGISTASRHPDFIELMMD
IEVEDLKRMTQILAALRSLAVVDRAIRDQEGQYDQ
>Mature_755_residues
MDGSALSGPEKGAGTGAGKPAPASDAAPELPHFLSREELIAKVRAYHPRVRSELLGLAYDFAKKHHGEQSRDSGEAYYSH
PVQVASLLAEIKLDEVTIVAGLLHDVVEDTEIDIGDIEVRFGPQVAELVDGVTKLDKLEFTSKEAAQAENFQKFILAMTG
DLRVLLVKLADRMHNMETLHFRKKLESRQRTARETMDIYAPLARRIGLYDMAARMDDLAFKELNPEARRAIIYRLEELER
ENKDDLGRIRADLTRILNEAGVRCRIKGRRKQPYSLWRKLERKSISFRDVADLFAFRIIVTDVADCYQALGVLHTHWACI
PERFRDFISVPKPNGYASLHTTVRASGNRRVELQIRTETMDLTAEYGVAAHWGYKNRSYGFDVDSARAAGLDPEANLNAF
AELLRDGAEPGEFLEHAKLEMYREHVFTFTPKGKLIILPAGAMPLDFAYAVHSAVGDTTIGARINGEEKSLRRPLKNGDV
VDIIRGKTADPIRGWEMLTHTGRAKSALRRLEREREIAEFRRLGEGLINQALRRAGADPVDVMLMDVAKKFGFKTVDEMR
EAVGRGRFKTSVVIQTVFPGYQPERTDDIAKTPIDSDHVPLFVEGLTLTPGVTLHLSTCCHPLPGDRIIGVQVPDKGLMV
HVSSCPRLAEYDDRPELWHDLKWTELARTDAVAVTRIRINASNQRGVLAKLCAAVAESNGNIIGISTASRHPDFIELMMD
IEVEDLKRMTQILAALRSLAVVDRAIRDQEGQYDQ

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=716, Percent_Identity=35.8938547486034, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1789147, Length=695, Percent_Identity=30.7913669064748, Blast_Score=319, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24650996, Length=122, Percent_Identity=36.8852459016393, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84565; Mature: 84565

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSALSGPEKGAGTGAGKPAPASDAAPELPHFLSREELIAKVRAYHPRVRSELLGLAYD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHCHHHHHHHHHHHHH
FAKKHHGEQSRDSGEAYYSHPVQVASLLAEIKLDEVTIVAGLLHDVVEDTEIDIGDIEVR
HHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
FGPQVAELVDGVTKLDKLEFTSKEAAQAENFQKFILAMTGDLRVLLVKLADRMHNMETLH
ECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FRKKLESRQRTARETMDIYAPLARRIGLYDMAARMDDLAFKELNPEARRAIIYRLEELER
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ENKDDLGRIRADLTRILNEAGVRCRIKGRRKQPYSLWRKLERKSISFRDVADLFAFRIIV
CCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TDVADCYQALGVLHTHWACIPERFRDFISVPKPNGYASLHTTVRASGNRRVELQIRTETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCEEEEEEEEECEE
DLTAEYGVAAHWGYKNRSYGFDVDSARAAGLDPEANLNAFAELLRDGAEPGEFLEHAKLE
HHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
MYREHVFTFTPKGKLIILPAGAMPLDFAYAVHSAVGDTTIGARINGEEKSLRRPLKNGDV
HHHHHHEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCEECCCHHHHHCCCCCCCE
VDIIRGKTADPIRGWEMLTHTGRAKSALRRLEREREIAEFRRLGEGLINQALRRAGADPV
EEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
DVMLMDVAKKFGFKTVDEMREAVGRGRFKTSVVIQTVFPGYQPERTDDIAKTPIDSDHVP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCCHHHCCCCCCCCCC
LFVEGLTLTPGVTLHLSTCCHPLPGDRIIGVQVPDKGLMVHVSSCPRLAEYDDRPELWHD
EEEECEEECCCCEEEHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHC
LKWTELARTDAVAVTRIRINASNQRGVLAKLCAAVAESNGNIIGISTASRHPDFIELMMD
CCHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHC
IEVEDLKRMTQILAALRSLAVVDRAIRDQEGQYDQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDGSALSGPEKGAGTGAGKPAPASDAAPELPHFLSREELIAKVRAYHPRVRSELLGLAYD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHCHHHHHHHHHHHHH
FAKKHHGEQSRDSGEAYYSHPVQVASLLAEIKLDEVTIVAGLLHDVVEDTEIDIGDIEVR
HHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
FGPQVAELVDGVTKLDKLEFTSKEAAQAENFQKFILAMTGDLRVLLVKLADRMHNMETLH
ECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FRKKLESRQRTARETMDIYAPLARRIGLYDMAARMDDLAFKELNPEARRAIIYRLEELER
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ENKDDLGRIRADLTRILNEAGVRCRIKGRRKQPYSLWRKLERKSISFRDVADLFAFRIIV
CCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TDVADCYQALGVLHTHWACIPERFRDFISVPKPNGYASLHTTVRASGNRRVELQIRTETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCEEEEEEEEECEE
DLTAEYGVAAHWGYKNRSYGFDVDSARAAGLDPEANLNAFAELLRDGAEPGEFLEHAKLE
HHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
MYREHVFTFTPKGKLIILPAGAMPLDFAYAVHSAVGDTTIGARINGEEKSLRRPLKNGDV
HHHHHHEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCEECCCHHHHHCCCCCCCE
VDIIRGKTADPIRGWEMLTHTGRAKSALRRLEREREIAEFRRLGEGLINQALRRAGADPV
EEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
DVMLMDVAKKFGFKTVDEMREAVGRGRFKTSVVIQTVFPGYQPERTDDIAKTPIDSDHVP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCCHHHCCCCCCCCCC
LFVEGLTLTPGVTLHLSTCCHPLPGDRIIGVQVPDKGLMVHVSSCPRLAEYDDRPELWHD
EEEECEEECCCCEEEHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHC
LKWTELARTDAVAVTRIRINASNQRGVLAKLCAAVAESNGNIIGISTASRHPDFIELMMD
CCHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHC
IEVEDLKRMTQILAALRSLAVVDRAIRDQEGQYDQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA