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The map label for this gene is pyrE

Identifier: 114797568

GI number: 114797568

Start: 896003

End: 896584

Strand: Direct

Name: pyrE

Synonym: HNE_0874

Alternate gene names: 114797568

Gene position: 896003-896584 (Clockwise)

Preceding gene: 114798559

Following gene: 114799252

Centisome position: 24.18

GC content: 63.23

Gene sequence:

>582_bases
ATGACCAGTGAAGACGTGCTCGCCGTGTTCAAAGAGGCGGGCGCATTGCTGGAGGGGCATTTCATCCTCTCCTCCGGGCG
TCGCAGCTCCGTTTTTTTGCAGAAGGCGCTTGTCTTCTCGCGGCCGGACCTTTCAGAGAAACTCTGCAAGGCGCTCGCTG
CCAGGCTGGCGGCAGACTTCGGCAAGATCGATGTGGTCGCCGGCCCCGCCGTGGGCGGCATCATTCCCGGTTATGAGCTT
GCCCGCCATCTGGGCGCACGCGCCATTTTTGCCGAGCGCGTCGATGGCCAGCTCCAGTTCCGCCGCGGCTTTTCGATTGC
GGCGGGCGAGCGGGTGCTGATCGCCGAAGACATTGTCACGACCGGTCTTTCTTTCCGCGAAACGGTCGAGGCGCTTGCAA
AGCTGCCCGGTGAGGTCGTCGGCGGCGCCTGTATCATTGACCGTTCCGGCGGCCGCGCCGATGTCGGCTGCAAGCTGATC
TCGCTCGCCCAGGTAAACTTTCCCGATTATGCGCCTGATGATCTGCCTCCGGAGCTTCAGAAGATCGAAGCCATCAAGCC
CGGCTCGCGGGGGCTTGCCTGA

Upstream 100 bases:

>100_bases
GATATTGAGGTTGAAGACCTGAAGCGTATGACGCAAATCCTTGCGGCACTGCGGTCCTTGGCCGTGGTAGACCGGGCCAT
ACGCGATCAGGAGGGACAAT

Downstream 100 bases:

>100_bases
TGACCAGCCGTCTCCGCCTCGGGGTCAATATTGATCATGTGGCGACCATCCGCAACGCGCGCGGAGGCGCCCATCCTGAT
CCGATGCGCGCCGCTGAAAT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTSEDVLAVFKEAGALLEGHFILSSGRRSSVFLQKALVFSRPDLSEKLCKALAARLAADFGKIDVVAGPAVGGIIPGYEL
ARHLGARAIFAERVDGQLQFRRGFSIAAGERVLIAEDIVTTGLSFRETVEALAKLPGEVVGGACIIDRSGGRADVGCKLI
SLAQVNFPDYAPDDLPPELQKIEAIKPGSRGLA

Sequences:

>Translated_193_residues
MTSEDVLAVFKEAGALLEGHFILSSGRRSSVFLQKALVFSRPDLSEKLCKALAARLAADFGKIDVVAGPAVGGIIPGYEL
ARHLGARAIFAERVDGQLQFRRGFSIAAGERVLIAEDIVTTGLSFRETVEALAKLPGEVVGGACIIDRSGGRADVGCKLI
SLAQVNFPDYAPDDLPPELQKIEAIKPGSRGLA
>Mature_192_residues
TSEDVLAVFKEAGALLEGHFILSSGRRSSVFLQKALVFSRPDLSEKLCKALAARLAADFGKIDVVAGPAVGGIIPGYELA
RHLGARAIFAERVDGQLQFRRGFSIAAGERVLIAEDIVTTGLSFRETVEALAKLPGEVVGGACIIDRSGGRADVGCKLIS
LAQVNFPDYAPDDLPPELQKIEAIKPGSRGLA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_HYPNA (Q0C3U2)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759601.1
- ProteinModelPortal:   Q0C3U2
- SMR:   Q0C3U2
- STRING:   Q0C3U2
- GeneID:   4287286
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0874
- NMPDR:   fig|228405.5.peg.854
- TIGR:   HNE_0874
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- PhylomeDB:   Q0C3U2
- ProtClustDB:   CLSK2531682
- BioCyc:   HNEP81032:HNE_0874-MONOMER
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20388; Mature: 20257

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 120-120 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEDVLAVFKEAGALLEGHFILSSGRRSSVFLQKALVFSRPDLSEKLCKALAARLAADF
CCCHHHHHHHHHHCCHHCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
GKIDVVAGPAVGGIIPGYELARHLGARAIFAERVDGQLQFRRGFSIAAGERVLIAEDIVT
CCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHCCCEEEECCCCEECCCCEEEEEHHHHH
TGLSFRETVEALAKLPGEVVGGACIIDRSGGRADVGCKLISLAQVNFPDYAPDDLPPELQ
CCCCHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHH
KIEAIKPGSRGLA
HHHCCCCCCCCCC
>Mature Secondary Structure 
TSEDVLAVFKEAGALLEGHFILSSGRRSSVFLQKALVFSRPDLSEKLCKALAARLAADF
CCHHHHHHHHHHCCHHCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
GKIDVVAGPAVGGIIPGYELARHLGARAIFAERVDGQLQFRRGFSIAAGERVLIAEDIVT
CCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHCCCEEEECCCCEECCCCEEEEEHHHHH
TGLSFRETVEALAKLPGEVVGGACIIDRSGGRADVGCKLISLAQVNFPDYAPDDLPPELQ
CCCCHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHH
KIEAIKPGSRGLA
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA