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The map label for this gene is uppS [H]

Identifier: 114798355

GI number: 114798355

Start: 1815297

End: 1816055

Strand: Direct

Name: uppS [H]

Synonym: HNE_1772

Alternate gene names: 114798355

Gene position: 1815297-1816055 (Clockwise)

Preceding gene: 114797846

Following gene: 114798911

Centisome position: 49.0

GC content: 54.41

Gene sequence:

>759_bases
ATGTCGCGGGCCTCTGCCCCCCTCAATCCTATTCCGGTGGGCCAACAACCCGTCGTCCCAAAGCATGTGGCAATTATCAT
GGATGGAAATGGCCGCTGGGCGACAGCCAGACATCTGCCCCGTACTGCGGGACATGAACGCGGTGTCGAGGCGCTCCGGC
GTACCGTTGATGCAGCGGGTGATCTTGGTATCCGCTATTTGACGGTCTTTTCTTTTTCGACAGAAAACTGGCGTCGACCT
GCGGCCGAAGTGAACACACTATTCGGTCTCCTGAAGGCTTATGTGCAGAGAGATCTAAGTCGCCTTAAAGATGAGGGAGT
GCGAATCCGGATTATCGGTCAGCGCGCCGGTTTGCCAGCGGACATTGCAAGTCTCGTGTCCAAGGCTGAGGAAGAAACCA
GAACGAATACTGAGTTTAATCTGACAATCGCGTTCAATTACGGATCGCGTGACGAAATTTTGCGGGCTGCTTCCGCTTTA
GCGCGGGATGTTAAATCAGGACTGCGCGATCCGGATATAACAGAAAATGAGTTCGCTGGGTATTTGGATACCGGCGATCT
TCCGGACCCGGACCTTCTTATACGGACGAGTGGAGAATTTCGTATCAGCAACTTTCTGCTTTGGCAGGCGGCCTATGCGG
AGTTCCTGTTTTGTGACGTCCTGTGGCCCGACTTTGGACGCTCCCATCTGGAAGATGCCCTGAAATGCTATAATGAGCGG
GAGCGCAGATATGGCGCTGTCTCTCCGGGAGGGGGCTGA

Upstream 100 bases:

>100_bases
ACCGTGCGCTGACTGAAGAAGTTCAGAAACTGACGGATGCGTTTGTTAAGCGTGTTGACGAAGCCCTGAAGGCCAAAGAA
GCCGAGATCATGCAGGTCTG

Downstream 100 bases:

>100_bases
TGGGTGACTGGACACCGACCGAAAGGCGGTTTTCCGAACTTCCCGTCCGGCTGGTGTCCGCATTTATTCTGATCCCGATG
GCGCTTGCGGCTGTCTGGTT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSRASAPLNPIPVGQQPVVPKHVAIIMDGNGRWATARHLPRTAGHERGVEALRRTVDAAGDLGIRYLTVFSFSTENWRRP
AAEVNTLFGLLKAYVQRDLSRLKDEGVRIRIIGQRAGLPADIASLVSKAEEETRTNTEFNLTIAFNYGSRDEILRAASAL
ARDVKSGLRDPDITENEFAGYLDTGDLPDPDLLIRTSGEFRISNFLLWQAAYAEFLFCDVLWPDFGRSHLEDALKCYNER
ERRYGAVSPGGG

Sequences:

>Translated_252_residues
MSRASAPLNPIPVGQQPVVPKHVAIIMDGNGRWATARHLPRTAGHERGVEALRRTVDAAGDLGIRYLTVFSFSTENWRRP
AAEVNTLFGLLKAYVQRDLSRLKDEGVRIRIIGQRAGLPADIASLVSKAEEETRTNTEFNLTIAFNYGSRDEILRAASAL
ARDVKSGLRDPDITENEFAGYLDTGDLPDPDLLIRTSGEFRISNFLLWQAAYAEFLFCDVLWPDFGRSHLEDALKCYNER
ERRYGAVSPGGG
>Mature_251_residues
SRASAPLNPIPVGQQPVVPKHVAIIMDGNGRWATARHLPRTAGHERGVEALRRTVDAAGDLGIRYLTVFSFSTENWRRPA
AEVNTLFGLLKAYVQRDLSRLKDEGVRIRIIGQRAGLPADIASLVSKAEEETRTNTEFNLTIAFNYGSRDEILRAASALA
RDVKSGLRDPDITENEFAGYLDTGDLPDPDLLIRTSGEFRISNFLLWQAAYAEFLFCDVLWPDFGRSHLEDALKCYNERE
RRYGAVSPGGG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=220, Percent_Identity=39.5454545454545, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI45580742, Length=220, Percent_Identity=39.5454545454545, Blast_Score=161, Evalue=6e-40,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=45.021645021645, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=38.6666666666667, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=37.3831775700935, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=35.8139534883721, Blast_Score=126, Evalue=3e-30,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=39.2070484581498, Blast_Score=160, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28019; Mature: 27888

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRASAPLNPIPVGQQPVVPKHVAIIMDGNGRWATARHLPRTAGHERGVEALRRTVDAAG
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHCCCCCCHHHHHHHHHHHHHHHC
DLGIRYLTVFSFSTENWRRPAAEVNTLFGLLKAYVQRDLSRLKDEGVRIRIIGQRAGLPA
CCCEEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH
DIASLVSKAEEETRTNTEFNLTIAFNYGSRDEILRAASALARDVKSGLRDPDITENEFAG
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCC
YLDTGDLPDPDLLIRTSGEFRISNFLLWQAAYAEFLFCDVLWPDFGRSHLEDALKCYNER
CCCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ERRYGAVSPGGG
HHHCCCCCCCCC
>Mature Secondary Structure 
SRASAPLNPIPVGQQPVVPKHVAIIMDGNGRWATARHLPRTAGHERGVEALRRTVDAAG
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHCCCCCCHHHHHHHHHHHHHHHC
DLGIRYLTVFSFSTENWRRPAAEVNTLFGLLKAYVQRDLSRLKDEGVRIRIIGQRAGLPA
CCCEEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH
DIASLVSKAEEETRTNTEFNLTIAFNYGSRDEILRAASALARDVKSGLRDPDITENEFAG
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCC
YLDTGDLPDPDLLIRTSGEFRISNFLLWQAAYAEFLFCDVLWPDFGRSHLEDALKCYNER
CCCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ERRYGAVSPGGG
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]