Click here to switch to the map view.

The map label for this gene is selA

Identifier: 114797888

GI number: 114797888

Start: 2617673

End: 2619064

Strand: Reverse

Name: selA

Synonym: HNE_2489

Alternate gene names: 114797888

Gene position: 2619064-2617673 (Counterclockwise)

Preceding gene: 114799852

Following gene: 114798311

Centisome position: 70.69

GC content: 62.28

Gene sequence:

>1392_bases
ATGGGCAATCTCTTGAGACATCTGCCTCAGCTGGACGCGCTTCTCAGCACCGCGGCGATGGCGAGTTTGCTGGAGCGCTA
TTCACGCGAAGAAGTCGCCGATGCGCTGCGGGCAGCCTTGCAGGAGGTTCGAAAAGGGGTTCAGGCTGGCCACATGGACA
GCCTGCCGGACTTTGAGAGCGCAGGTTTTGTGAGCGGCGTTATGGCCGGCATCGAAGCGCGGCGAAGGCCAAACCTGGTG
GCCGCAATCAATGCAACCGGCATTATTATCCACACAAATCTCGGCCGGGCCCGTCTGGCGCCTGAGGCGATGGCCGCTGT
GCAGGCCGCTGGCGCGCATGCGTCCAATCTCGAGCTTGATCTTGCCACAGGCAGGCGCGGCTCGCGATACGCGCACGTTG
AAGCGCTGATCTGCGAGCTGACCGGCGCGGAGGCGGCACTGGTCGTGAACAATTGCGCGGCGGCCGTCCTCCTCAGCCTG
ATGGCGACCGCCCAGGGGCGAAAAGTCATCGCATCCCGGGGCGAACTGATCGAGATCGGCGGCTCCTTCCGCTTGCCGGA
TGTGATCCAGCAGAGCGGCGCGACGCTAAAGGAGGTGGGCGCCACCAACAAGACGCGCGCATCCGATTATGCCCAGGCGA
TCGATGCCGAGACGGCTGTACTTCTGAAGAGCCATACCAGCAACTACCAGATCGTCGGATTTACCCATGCGCCGCAGCGC
GAAGAACTTGCTTCGCTGGCGCGTGAGACGGGCACGATCTTGATGGAAGACCTTGGAAGCGGCGTTCTGGTCGACCTGTC
GCCGTATGGTCTGAATGACGAACCGGTTGTTTCTGATGTGCTCAAATCCGGAGTGGATGTCGTGATGTTTTCCGGCGACA
AACTTCTCGGCGGGCCCCAATGCGGGATTATTGCAGGACGCGCTGACATAATTGTCAGCCTTAAAAAACATCCCCTCTGC
CGGGCCGTGCGCATCGACAAGCTTTCGCTCGCAGCGCTGGAGGCAACTTTGCGCCTTTACCGGGCGCCGCATGACCCGTT
TCAGAAAGTGCCGGTTCTGCGCGCCATCTCCCAGCCTGTGGAGGAGATCGAAGCGCGGGCGCGCCGGCTTGCCGGGGAGC
TCACCGTCGCCGGCATCGTGGATGTTATGTGCATTCCGAGCAGGGCCTATGTCGGGGGTGGCTCCCTGCCGCAGCAAAAC
CTCGAGAGCTGTGCGGTTACAGTGATAGTGCCGCATCTCTCGCCCGATGCGCTCGCGGCGGCTCTGCGCGCTGCGCGCCC
GCCCGTCATCGGCATGATCCGGGAAGACCGGTTCGTTATGGATGTTCGTACGCTGATCGATGGAGATCTTCCCGGGATTG
TGGAAGCCTTTCGCCAGGTGGCCCTCCGGTGA

Upstream 100 bases:

>100_bases
AGCGCGCGTGGCTGGCCGGGCCCGGGCGGCGCCCCGGCGTCATGTATTGATCCGGCGCGGTCTGCGCCTACAGTTGGGCT
TGGCAGTGTGAGGGCCGCGC

Downstream 100 bases:

>100_bases
AGTCTTGCCCTGTCATCGTGATCGGGCATGTCGACCATGGCAAGACTTCGCTGGTGGGCGCGCTGACCGGGATAGAAACC
GACAGGCTTCCTGAAGAAAA

Product: L-seryl-tRNA selenium transferase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MGNLLRHLPQLDALLSTAAMASLLERYSREEVADALRAALQEVRKGVQAGHMDSLPDFESAGFVSGVMAGIEARRRPNLV
AAINATGIIIHTNLGRARLAPEAMAAVQAAGAHASNLELDLATGRRGSRYAHVEALICELTGAEAALVVNNCAAAVLLSL
MATAQGRKVIASRGELIEIGGSFRLPDVIQQSGATLKEVGATNKTRASDYAQAIDAETAVLLKSHTSNYQIVGFTHAPQR
EELASLARETGTILMEDLGSGVLVDLSPYGLNDEPVVSDVLKSGVDVVMFSGDKLLGGPQCGIIAGRADIIVSLKKHPLC
RAVRIDKLSLAALEATLRLYRAPHDPFQKVPVLRAISQPVEEIEARARRLAGELTVAGIVDVMCIPSRAYVGGGSLPQQN
LESCAVTVIVPHLSPDALAAALRAARPPVIGMIREDRFVMDVRTLIDGDLPGIVEAFRQVALR

Sequences:

>Translated_463_residues
MGNLLRHLPQLDALLSTAAMASLLERYSREEVADALRAALQEVRKGVQAGHMDSLPDFESAGFVSGVMAGIEARRRPNLV
AAINATGIIIHTNLGRARLAPEAMAAVQAAGAHASNLELDLATGRRGSRYAHVEALICELTGAEAALVVNNCAAAVLLSL
MATAQGRKVIASRGELIEIGGSFRLPDVIQQSGATLKEVGATNKTRASDYAQAIDAETAVLLKSHTSNYQIVGFTHAPQR
EELASLARETGTILMEDLGSGVLVDLSPYGLNDEPVVSDVLKSGVDVVMFSGDKLLGGPQCGIIAGRADIIVSLKKHPLC
RAVRIDKLSLAALEATLRLYRAPHDPFQKVPVLRAISQPVEEIEARARRLAGELTVAGIVDVMCIPSRAYVGGGSLPQQN
LESCAVTVIVPHLSPDALAAALRAARPPVIGMIREDRFVMDVRTLIDGDLPGIVEAFRQVALR
>Mature_462_residues
GNLLRHLPQLDALLSTAAMASLLERYSREEVADALRAALQEVRKGVQAGHMDSLPDFESAGFVSGVMAGIEARRRPNLVA
AINATGIIIHTNLGRARLAPEAMAAVQAAGAHASNLELDLATGRRGSRYAHVEALICELTGAEAALVVNNCAAAVLLSLM
ATAQGRKVIASRGELIEIGGSFRLPDVIQQSGATLKEVGATNKTRASDYAQAIDAETAVLLKSHTSNYQIVGFTHAPQRE
ELASLARETGTILMEDLGSGVLVDLSPYGLNDEPVVSDVLKSGVDVVMFSGDKLLGGPQCGIIAGRADIIVSLKKHPLCR
AVRIDKLSLAALEATLRLYRAPHDPFQKVPVLRAISQPVEEIEARARRLAGELTVAGIVDVMCIPSRAYVGGGSLPQQNL
ESCAVTVIVPHLSPDALAAALRAARPPVIGMIREDRFVMDVRTLIDGDLPGIVEAFRQVALR

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=451, Percent_Identity=45.2328159645233, Blast_Score=321, Evalue=6e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_HYPNA (Q0BZB0)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761183.1
- ProteinModelPortal:   Q0BZB0
- STRING:   Q0BZB0
- GeneID:   4288076
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2489
- NMPDR:   fig|228405.5.peg.2401
- TIGR:   HNE_2489
- eggNOG:   COG1921
- HOGENOM:   HBG564950
- OMA:   KRGDRDD
- PhylomeDB:   Q0BZB0
- BioCyc:   HNEP81032:HNE_2489-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 49070; Mature: 48939

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLLRHLPQLDALLSTAAMASLLERYSREEVADALRAALQEVRKGVQAGHMDSLPDFES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AGFVSGVMAGIEARRRPNLVAAINATGIIIHTNLGRARLAPEAMAAVQAAGAHASNLELD
CHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCHHCCHHHHHHHHHCCCCCCCCEEE
LATGRRGSRYAHVEALICELTGAEAALVVNNCAAAVLLSLMATAQGRKVIASRGELIEIG
ECCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEC
GSFRLPDVIQQSGATLKEVGATNKTRASDYAQAIDAETAVLLKSHTSNYQIVGFTHAPQR
CCCCCCHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCHHHEEEEECCCCEEEEEECCCCCH
EELASLARETGTILMEDLGSGVLVDLSPYGLNDEPVVSDVLKSGVDVVMFSGDKLLGGPQ
HHHHHHHHHHCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCC
CGIIAGRADIIVSLKKHPLCRAVRIDKLSLAALEATLRLYRAPHDPFQKVPVLRAISQPV
CCEEECCHHEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EEIEARARRLAGELTVAGIVDVMCIPSRAYVGGGSLPQQNLESCAVTVIVPHLSPDALAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEEEECCCHHHHHH
ALRAARPPVIGMIREDRFVMDVRTLIDGDLPGIVEAFRQVALR
HHHHCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GNLLRHLPQLDALLSTAAMASLLERYSREEVADALRAALQEVRKGVQAGHMDSLPDFES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AGFVSGVMAGIEARRRPNLVAAINATGIIIHTNLGRARLAPEAMAAVQAAGAHASNLELD
CHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCHHCCHHHHHHHHHCCCCCCCCEEE
LATGRRGSRYAHVEALICELTGAEAALVVNNCAAAVLLSLMATAQGRKVIASRGELIEIG
ECCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEC
GSFRLPDVIQQSGATLKEVGATNKTRASDYAQAIDAETAVLLKSHTSNYQIVGFTHAPQR
CCCCCCHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCHHHEEEEECCCCEEEEEECCCCCH
EELASLARETGTILMEDLGSGVLVDLSPYGLNDEPVVSDVLKSGVDVVMFSGDKLLGGPQ
HHHHHHHHHHCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCC
CGIIAGRADIIVSLKKHPLCRAVRIDKLSLAALEATLRLYRAPHDPFQKVPVLRAISQPV
CCEEECCHHEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EEIEARARRLAGELTVAGIVDVMCIPSRAYVGGGSLPQQNLESCAVTVIVPHLSPDALAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEEEECCCHHHHHH
ALRAARPPVIGMIREDRFVMDVRTLIDGDLPGIVEAFRQVALR
HHHHCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA