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The map label for this gene is hemA [H]

Identifier: 114797766

GI number: 114797766

Start: 2135435

End: 2136652

Strand: Reverse

Name: hemA [H]

Synonym: HNE_2062

Alternate gene names: 114797766

Gene position: 2136652-2135435 (Counterclockwise)

Preceding gene: 114799874

Following gene: 114799314

Centisome position: 57.67

GC content: 61.82

Gene sequence:

>1218_bases
ATGCAGCATCTCAAAGCCTTCGAAGACGCCCTTGGCGCCATTCACAGCGAAGGACGGTATCGGGTCTTTATTGATCTTCA
CCGTCACAAGGGCCGCTTTCCAAAGGCCACCGCCCGGTTTGAAGCGGGCGAGCGCGAAGTCACCATCTGGTGCTCGAACG
ACTATCTGGGCATGGGCCAGGATGACGATGTCATCAAATCCATGCACGAAGCGATCGACAGCTTCGGCGCCGGTTCGGGC
GGCACCCGCAACATCTCCGGCACCACGCGCTTCCACGTCGATCTGGAGCAGGAGCTTGCTGACCTTCACCGCAAGGAAGC
CGCGCTCCTCTTCACCTCAGGTTACGTGTCCAACGAAGCGACCCTGTCGACGCTCGGCAAGATCCTGCCTAACCTGATCA
TCTATTCCGACGCGCTCAACCACGCCTCGATGATCGAGGGTATCCGCCGCTCTGGCGCCGAATACCGCGTCTTCCGCCAT
AACGACGTGGACCATCTGCGTGCGCTTCTGGAGCTCGACGACGCTGACCGTCCCAAGCTGATCGCGTTCGAAAGCGTCTA
TTCCATGGACGGCGACTTTGGCCGCATGGAAGAGATCTGCGACCTCGCCCAGGAATTCAACGCCATCACCTATCTCGATG
AAGTGCATGCCGTCGGCATGTACGGAGAGCAGGGGGCAGGCGTGGCCGAAATGCTCGGGCTGGCTGACCGGATCGACATC
ATGGAAGGCACCCTGGCGAAGGCTTACGGCGTCATGGGCGGCTATATCGCCAGCCATTCCAGCGTCATCGATGCCATCCG
CTCCATGGCCTCGGGCTTCATCTTCACCACTTCGACCTGTCCGGTCATGGCTGCCGGCGCCCTCGCCAGCATCCGCAAGC
TGCGCGCCGATGAAGGCCGCCGCCTGCGCGCTATCCATCAGGACAAGGCCGCCACCCTGAAACAGAAGTTCCGCGATGCG
GGCCTGCCTGTGATGGAGTCGCCCTCGCACATCGTCCCGCTGCTGGTGGGCGATCCCGAACGCTGCAAGGCGCTGTCCGA
CACCCTGCTGTTCGACTTCGGCATCTACGTTCAGCCGATCAACTATCCCACCGTCCCGCGTGGCACCGAGCGCCTGCGCT
TCACGCCCAGCCCCGTGCATGACGAAGTGATGATGGATGAACTGGTCGCCGCCATCCTCGCGGTCTGGAAACAGCTGGGT
CTCGACAAGGCCGCTTAA

Upstream 100 bases:

>100_bases
ATAGGTATTTTCCCTGATTAGACTAAATGGGTTGCCGGAATAAGCCTCCGGTAACCCAAGTTAAACATGGTCATAGTCGA
AAAGAGTTCAGAGTAGCGCC

Downstream 100 bases:

>100_bases
GGGCGCGTTTTGTCCCAAAGTGTCCCGGTTTGTCCTGGAAAGTGCTTAGAGTGGCCCGGTTCTGCCGGGCCATTTTGCGT
TTGAAATCAACGCTTCTTGC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MQHLKAFEDALGAIHSEGRYRVFIDLHRHKGRFPKATARFEAGEREVTIWCSNDYLGMGQDDDVIKSMHEAIDSFGAGSG
GTRNISGTTRFHVDLEQELADLHRKEAALLFTSGYVSNEATLSTLGKILPNLIIYSDALNHASMIEGIRRSGAEYRVFRH
NDVDHLRALLELDDADRPKLIAFESVYSMDGDFGRMEEICDLAQEFNAITYLDEVHAVGMYGEQGAGVAEMLGLADRIDI
MEGTLAKAYGVMGGYIASHSSVIDAIRSMASGFIFTTSTCPVMAAGALASIRKLRADEGRRLRAIHQDKAATLKQKFRDA
GLPVMESPSHIVPLLVGDPERCKALSDTLLFDFGIYVQPINYPTVPRGTERLRFTPSPVHDEVMMDELVAAILAVWKQLG
LDKAA

Sequences:

>Translated_405_residues
MQHLKAFEDALGAIHSEGRYRVFIDLHRHKGRFPKATARFEAGEREVTIWCSNDYLGMGQDDDVIKSMHEAIDSFGAGSG
GTRNISGTTRFHVDLEQELADLHRKEAALLFTSGYVSNEATLSTLGKILPNLIIYSDALNHASMIEGIRRSGAEYRVFRH
NDVDHLRALLELDDADRPKLIAFESVYSMDGDFGRMEEICDLAQEFNAITYLDEVHAVGMYGEQGAGVAEMLGLADRIDI
MEGTLAKAYGVMGGYIASHSSVIDAIRSMASGFIFTTSTCPVMAAGALASIRKLRADEGRRLRAIHQDKAATLKQKFRDA
GLPVMESPSHIVPLLVGDPERCKALSDTLLFDFGIYVQPINYPTVPRGTERLRFTPSPVHDEVMMDELVAAILAVWKQLG
LDKAA
>Mature_405_residues
MQHLKAFEDALGAIHSEGRYRVFIDLHRHKGRFPKATARFEAGEREVTIWCSNDYLGMGQDDDVIKSMHEAIDSFGAGSG
GTRNISGTTRFHVDLEQELADLHRKEAALLFTSGYVSNEATLSTLGKILPNLIIYSDALNHASMIEGIRRSGAEYRVFRH
NDVDHLRALLELDDADRPKLIAFESVYSMDGDFGRMEEICDLAQEFNAITYLDEVHAVGMYGEQGAGVAEMLGLADRIDI
MEGTLAKAYGVMGGYIASHSSVIDAIRSMASGFIFTTSTCPVMAAGALASIRKLRADEGRRLRAIHQDKAATLKQKFRDA
GLPVMESPSHIVPLLVGDPERCKALSDTLLFDFGIYVQPINYPTVPRGTERLRFTPSPVHDEVMMDELVAAILAVWKQLG
LDKAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=397, Percent_Identity=51.6372795969773, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI83977440, Length=397, Percent_Identity=51.6372795969773, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI83977444, Length=397, Percent_Identity=51.6372795969773, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=50.8684863523573, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=50.8684863523573, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI7657118, Length=351, Percent_Identity=34.7578347578348, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI284448556, Length=351, Percent_Identity=34.7578347578348, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=29.1208791208791, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=29.3296089385475, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=27.0161290322581, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1790046, Length=358, Percent_Identity=33.7988826815642, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=34.6590909090909, Blast_Score=171, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=402, Percent_Identity=31.3432835820896, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32566772, Length=380, Percent_Identity=30.5263157894737, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=358, Percent_Identity=29.0502793296089, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=358, Percent_Identity=29.0502793296089, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=291, Percent_Identity=26.8041237113402, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=291, Percent_Identity=27.1477663230241, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=406, Percent_Identity=46.551724137931, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=29.4277929155313, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=255, Percent_Identity=24.3137254901961, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137420, Length=385, Percent_Identity=50.6493506493506, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24662918, Length=364, Percent_Identity=30.7692307692308, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI17136286, Length=383, Percent_Identity=30.2872062663185, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24653280, Length=277, Percent_Identity=25.6317689530686, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653276, Length=277, Percent_Identity=25.6317689530686, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653278, Length=277, Percent_Identity=25.6317689530686, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44666; Mature: 44666

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHLKAFEDALGAIHSEGRYRVFIDLHRHKGRFPKATARFEAGEREVTIWCSNDYLGMGQ
CCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCC
DDDVIKSMHEAIDSFGAGSGGTRNISGTTRFHVDLEQELADLHRKEAALLFTSGYVSNEA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHEEEEECCCCCCCH
TLSTLGKILPNLIIYSDALNHASMIEGIRRSGAEYRVFRHNDVDHLRALLELDDADRPKL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCE
IAFESVYSMDGDFGRMEEICDLAQEFNAITYLDEVHAVGMYGEQGAGVAEMLGLADRIDI
EEEHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MEGTLAKAYGVMGGYIASHSSVIDAIRSMASGFIFTTSTCPVMAAGALASIRKLRADEGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
RLRAIHQDKAATLKQKFRDAGLPVMESPSHIVPLLVGDPERCKALSDTLLFDFGIYVQPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHEECCCEEEEC
NYPTVPRGTERLRFTPSPVHDEVMMDELVAAILAVWKQLGLDKAA
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQHLKAFEDALGAIHSEGRYRVFIDLHRHKGRFPKATARFEAGEREVTIWCSNDYLGMGQ
CCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCC
DDDVIKSMHEAIDSFGAGSGGTRNISGTTRFHVDLEQELADLHRKEAALLFTSGYVSNEA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHEEEEECCCCCCCH
TLSTLGKILPNLIIYSDALNHASMIEGIRRSGAEYRVFRHNDVDHLRALLELDDADRPKL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCE
IAFESVYSMDGDFGRMEEICDLAQEFNAITYLDEVHAVGMYGEQGAGVAEMLGLADRIDI
EEEHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MEGTLAKAYGVMGGYIASHSSVIDAIRSMASGFIFTTSTCPVMAAGALASIRKLRADEGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
RLRAIHQDKAATLKQKFRDAGLPVMESPSHIVPLLVGDPERCKALSDTLLFDFGIYVQPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHEECCCEEEEC
NYPTVPRGTERLRFTPSPVHDEVMMDELVAAILAVWKQLGLDKAA
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2381418; 1904045 [H]