Click here to switch to the map view.

The map label for this gene is fkpA [H]

Identifier: 114797197

GI number: 114797197

Start: 157423

End: 158319

Strand: Reverse

Name: fkpA [H]

Synonym: HNE_0170

Alternate gene names: 114797197

Gene position: 158319-157423 (Counterclockwise)

Preceding gene: 114797934

Following gene: 114799459

Centisome position: 4.27

GC content: 57.3

Gene sequence:

>897_bases
ATGTTTCGCGCCCTACTTGCCGCCGCAGCCGTCAGCCTTTCGCTGGCAGCGTGCGCCCCTCAATCCAGCAGCGCGGATAG
TTCCGCCGAGGACTCTGCCATGACCTCCCCTGTCGACGACTACCTGCCCTGGGACCCGGATGCAAAAGGCATCCAGACCA
CTGACAGCGGTGTCCAGTACATCATCGTGAAAGAGGGCCCTAAAGACGGAAAGAAGCCTGTACCGTCTGACCGGGTGCGC
GTTCATTATGACGGCCGCCTGCCTTCAGGCGAGAAATTCGATTCCTCGATTGACCGGGGTGACCCGTCTGAATTCCGTCT
CAATCAGGTGATCCCCGGCTGGACCATCGGCCTTCAGGAAATGAGCGTGGGTGACGAGTATGTCTTCTACATCCCCAACA
AGCTTGCTTACGGCAATCAGGCTCGCGGCGTCATCAAGGCGGGGGACGATCTGGTATTCTATGTTTCTCTTCTTGAAATC
GTCGAACCCAAGAAATCCGATGCAGCTGCCTGGGCCAAATACTACCCATGGGATGCTGACCTTCCGGAAGTGAAAACGAC
CGAGTCCGGATTACAATACATTGTGCTCAAAAGCGGCGATGCGGAGGGAGAACCTCCTGTTGGCGGCCAACTCGTCGTTG
TCCACTATGAAGGCCGCCTCGCAGAAACAGGAGAGCTTTTTGACTCCTCCTACCAACGCGGGGACCCGGAGGTTTTTCCT
TCAAACGCCCTCATCAGCGGCTGGGTAGAGGCCCTGGCCATGATGAAACCCGGCGATCACTGGATGCTCTACATTCCGTC
TGAACTCGGGTATGGCGAAGAAGGCACTCCCGGCGGACCGATCCCTCCCAACACGGCACTGCAGTTCGAAGTTGAGCTGC
TTGATGTAATGCGCTGA

Upstream 100 bases:

>100_bases
CCCGCCGCGCGCCATCTAGGAACGGCGCGTTACACGTGACTATCACGCTGAACGCGCCTAGAGAGCACGCGACAGTTTTG
CCCCTTCAGGAGGTTGCTCC

Downstream 100 bases:

>100_bases
GCGAGGAGGGCTTCAATGGCAGTCACCGCAGACATTCTCGCCGCTATCGCCCTTGCCGCCGGCAAGGAAATCATGCGCGT
TTATCGCACGGACTTCAGCG

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MFRALLAAAAVSLSLAACAPQSSSADSSAEDSAMTSPVDDYLPWDPDAKGIQTTDSGVQYIIVKEGPKDGKKPVPSDRVR
VHYDGRLPSGEKFDSSIDRGDPSEFRLNQVIPGWTIGLQEMSVGDEYVFYIPNKLAYGNQARGVIKAGDDLVFYVSLLEI
VEPKKSDAAAWAKYYPWDADLPEVKTTESGLQYIVLKSGDAEGEPPVGGQLVVVHYEGRLAETGELFDSSYQRGDPEVFP
SNALISGWVEALAMMKPGDHWMLYIPSELGYGEEGTPGGPIPPNTALQFEVELLDVMR

Sequences:

>Translated_298_residues
MFRALLAAAAVSLSLAACAPQSSSADSSAEDSAMTSPVDDYLPWDPDAKGIQTTDSGVQYIIVKEGPKDGKKPVPSDRVR
VHYDGRLPSGEKFDSSIDRGDPSEFRLNQVIPGWTIGLQEMSVGDEYVFYIPNKLAYGNQARGVIKAGDDLVFYVSLLEI
VEPKKSDAAAWAKYYPWDADLPEVKTTESGLQYIVLKSGDAEGEPPVGGQLVVVHYEGRLAETGELFDSSYQRGDPEVFP
SNALISGWVEALAMMKPGDHWMLYIPSELGYGEEGTPGGPIPPNTALQFEVELLDVMR
>Mature_298_residues
MFRALLAAAAVSLSLAACAPQSSSADSSAEDSAMTSPVDDYLPWDPDAKGIQTTDSGVQYIIVKEGPKDGKKPVPSDRVR
VHYDGRLPSGEKFDSSIDRGDPSEFRLNQVIPGWTIGLQEMSVGDEYVFYIPNKLAYGNQARGVIKAGDDLVFYVSLLEI
VEPKKSDAAAWAKYYPWDADLPEVKTTESGLQYIVLKSGDAEGEPPVGGQLVVVHYEGRLAETGELFDSSYQRGDPEVFP
SNALISGWVEALAMMKPGDHWMLYIPSELGYGEEGTPGGPIPPNTALQFEVELLDVMR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=245, Percent_Identity=30.6122448979592, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI224809327, Length=245, Percent_Identity=30.6122448979592, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4758384, Length=245, Percent_Identity=30.6122448979592, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI33469985, Length=225, Percent_Identity=29.7777777777778, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4503729, Length=244, Percent_Identity=31.1475409836066, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI192448443, Length=223, Percent_Identity=30.0448430493274, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI224809331, Length=111, Percent_Identity=40.5405405405405, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=45.6521739130435, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=45.6521739130435, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=45.6521739130435, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI8923659, Length=93, Percent_Identity=41.9354838709677, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082390, Length=133, Percent_Identity=47.3684210526316, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789745, Length=113, Percent_Identity=48.6725663716814, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17561778, Length=253, Percent_Identity=28.4584980237154, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561782, Length=108, Percent_Identity=41.6666666666667, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=90, Percent_Identity=50, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=98, Percent_Identity=42.8571428571429, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=40.6593406593407, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=40.6593406593407, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583150, Length=251, Percent_Identity=27.4900398406374, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24655568, Length=109, Percent_Identity=40.3669724770642, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32384; Mature: 32384

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRALLAAAAVSLSLAACAPQSSSADSSAEDSAMTSPVDDYLPWDPDAKGIQTTDSGVQY
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEECCCCEEE
IIVKEGPKDGKKPVPSDRVRVHYDGRLPSGEKFDSSIDRGDPSEFRLNQVIPGWTIGLQE
EEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCCEEECCEE
MSVGDEYVFYIPNKLAYGNQARGVIKAGDDLVFYVSLLEIVEPKKSDAAAWAKYYPWDAD
ECCCCCEEEECCCEECCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCHHHHHHCCCCCCC
LPEVKTTESGLQYIVLKSGDAEGEPPVGGQLVVVHYEGRLAETGELFDSSYQRGDPEVFP
CCCCEECCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCC
SNALISGWVEALAMMKPGDHWMLYIPSELGYGEEGTPGGPIPPNTALQFEVELLDVMR
CCHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHCC
>Mature Secondary Structure
MFRALLAAAAVSLSLAACAPQSSSADSSAEDSAMTSPVDDYLPWDPDAKGIQTTDSGVQY
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEECCCCEEE
IIVKEGPKDGKKPVPSDRVRVHYDGRLPSGEKFDSSIDRGDPSEFRLNQVIPGWTIGLQE
EEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCCEEECCEE
MSVGDEYVFYIPNKLAYGNQARGVIKAGDDLVFYVSLLEIVEPKKSDAAAWAKYYPWDAD
ECCCCCEEEECCCEECCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCHHHHHHCCCCCCC
LPEVKTTESGLQYIVLKSGDAEGEPPVGGQLVVVHYEGRLAETGELFDSSYQRGDPEVFP
CCCCEECCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCC
SNALISGWVEALAMMKPGDHWMLYIPSELGYGEEGTPGGPIPPNTALQFEVELLDVMR
CCHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]