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The map label for this gene is cysQ [H]

Identifier: 114799459

GI number: 114799459

Start: 156619

End: 157407

Strand: Reverse

Name: cysQ [H]

Synonym: HNE_0169

Alternate gene names: 114799459

Gene position: 157407-156619 (Counterclockwise)

Preceding gene: 114797197

Following gene: 114800209

Centisome position: 4.25

GC content: 61.34

Gene sequence:

>789_bases
ATGGCAGTCACCGCAGACATTCTCGCCGCTATCGCCCTTGCCGCCGGCAAGGAAATCATGCGCGTTTATCGCACGGACTT
CAGCGTCAGCCACAAGGACGATCATTCCGTACTGACCGAAGCCGATGGCCTTGCCGAAGCAATCATACTGAAAGGCCTCG
CCGAGGCGGAGCCCAGCCTCCAGGTCATCGCCGAAGAGGCGGTCGCGGGCGGACACATGCCCGAACACGGCGCCCGCTTC
GCACTGGTTGACCCGCTGGACGGGACCAAGGAATTCGTCGCAAAGAATGGCGAGTTCACGGTGAATATTGCAATCATCGA
ACATGGCCGTCCGGTCATGGGCGTCGTTTATGTTCCTGCCCAGAACCGTCTTTTTGTCGCCGAAGGCCCTGGCAAAGCCT
GGCATGCAAATGCTGCACCCGACGGGCCGGTTCCCGGCGATCGCACGACGCTCAAGGTACGCCCTGCCCCGGCTGCCGGA
CTAACCGCCGTTGCCTCCAAGTCGCACCGTAGTCCCGAGACGGATGAATGGCTGTCGCAGTATCCGGTTGCCGAAATCAA
AGGGGCTGGCTCTGCCCTGAAATTCTGCCTCGTTGCAGCAGGTGAGGCAGACGTCTACCCCCGTCTCGGCCGCACCATGG
AGTGGGATACTGCTGCTGGACAGGCCGTCGTGGAAGCTGCCGGGGGCCGCGTACTGACTATTTCCGGAGAGCCCCTCCTC
TATGGCAAGCGGGACCGCGGATACGACAATCCCCACTTTGTCGTTTTTGGAGATGTGACGCCGCATTGA

Upstream 100 bases:

>100_bases
TGGCGAAGAAGGCACTCCCGGCGGACCGATCCCTCCCAACACGGCACTGCAGTTCGAAGTTGAGCTGCTTGATGTAATGC
GCTGAGCGAGGAGGGCTTCA

Downstream 100 bases:

>100_bases
ATGGCCGGCGTCGGAGGAAAGACATGGCGCGCCAATATTTTGGAACGGACGGCATTCGCGGACGGGTGAATACAAGTCCG
ATGACGGCAGAAACAGCGCT

Product: 3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MAVTADILAAIALAAGKEIMRVYRTDFSVSHKDDHSVLTEADGLAEAIILKGLAEAEPSLQVIAEEAVAGGHMPEHGARF
ALVDPLDGTKEFVAKNGEFTVNIAIIEHGRPVMGVVYVPAQNRLFVAEGPGKAWHANAAPDGPVPGDRTTLKVRPAPAAG
LTAVASKSHRSPETDEWLSQYPVAEIKGAGSALKFCLVAAGEADVYPRLGRTMEWDTAAGQAVVEAAGGRVLTISGEPLL
YGKRDRGYDNPHFVVFGDVTPH

Sequences:

>Translated_262_residues
MAVTADILAAIALAAGKEIMRVYRTDFSVSHKDDHSVLTEADGLAEAIILKGLAEAEPSLQVIAEEAVAGGHMPEHGARF
ALVDPLDGTKEFVAKNGEFTVNIAIIEHGRPVMGVVYVPAQNRLFVAEGPGKAWHANAAPDGPVPGDRTTLKVRPAPAAG
LTAVASKSHRSPETDEWLSQYPVAEIKGAGSALKFCLVAAGEADVYPRLGRTMEWDTAAGQAVVEAAGGRVLTISGEPLL
YGKRDRGYDNPHFVVFGDVTPH
>Mature_261_residues
AVTADILAAIALAAGKEIMRVYRTDFSVSHKDDHSVLTEADGLAEAIILKGLAEAEPSLQVIAEEAVAGGHMPEHGARFA
LVDPLDGTKEFVAKNGEFTVNIAIIEHGRPVMGVVYVPAQNRLFVAEGPGKAWHANAAPDGPVPGDRTTLKVRPAPAAGL
TAVASKSHRSPETDEWLSQYPVAEIKGAGSALKFCLVAAGEADVYPRLGRTMEWDTAAGQAVVEAAGGRVLTISGEPLLY
GKRDRGYDNPHFVVFGDVTPH

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI221625487, Length=256, Percent_Identity=27.34375, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI5031789, Length=250, Percent_Identity=27.6, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI7657236, Length=244, Percent_Identity=30.327868852459, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1790659, Length=252, Percent_Identity=44.047619047619, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1788882, Length=245, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193202570, Length=228, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193202572, Length=221, Percent_Identity=27.1493212669683, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995905, Length=243, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71995897, Length=241, Percent_Identity=26.1410788381743, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320493, Length=211, Percent_Identity=31.2796208530806, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664926, Length=215, Percent_Identity=26.9767441860465, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357303, Length=240, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24664922, Length=251, Percent_Identity=27.8884462151394, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 27636; Mature: 27504

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTADILAAIALAAGKEIMRVYRTDFSVSHKDDHSVLTEADGLAEAIILKGLAEAEPSL
CCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCH
QVIAEEAVAGGHMPEHGARFALVDPLDGTKEFVAKNGEFTVNIAIIEHGRPVMGVVYVPA
HHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHCCCCEEEEEEEEECCCCEEEEEEECC
QNRLFVAEGPGKAWHANAAPDGPVPGDRTTLKVRPAPAAGLTAVASKSHRSPETDEWLSQ
CCEEEEEECCCCEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHH
YPVAEIKGAGSALKFCLVAAGEADVYPRLGRTMEWDTAAGQAVVEAAGGRVLTISGEPLL
CCHHHHCCCCHHEEEEEEECCCCCCCHHCCCEEECCCCCCHHHEECCCCEEEEEECCEEE
YGKRDRGYDNPHFVVFGDVTPH
EECCCCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
AVTADILAAIALAAGKEIMRVYRTDFSVSHKDDHSVLTEADGLAEAIILKGLAEAEPSL
CCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCH
QVIAEEAVAGGHMPEHGARFALVDPLDGTKEFVAKNGEFTVNIAIIEHGRPVMGVVYVPA
HHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHCCCCEEEEEEEEECCCCEEEEEEECC
QNRLFVAEGPGKAWHANAAPDGPVPGDRTTLKVRPAPAAGLTAVASKSHRSPETDEWLSQ
CCEEEEEECCCCEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHH
YPVAEIKGAGSALKFCLVAAGEADVYPRLGRTMEWDTAAGQAVVEAAGGRVLTISGEPLL
CCHHHHCCCCHHEEEEEEECCCCCCCHHCCCEEECCCCCCHHHEECCCCEEEEEECCEEE
YGKRDRGYDNPHFVVFGDVTPH
EECCCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]