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The map label for this gene is ilvA [H]

Identifier: 114797934

GI number: 114797934

Start: 158401

End: 159627

Strand: Reverse

Name: ilvA [H]

Synonym: HNE_0171

Alternate gene names: 114797934

Gene position: 159627-158401 (Counterclockwise)

Preceding gene: 114797610

Following gene: 114797197

Centisome position: 4.31

GC content: 60.8

Gene sequence:

>1227_bases
ATGCCTGATACATTGCCTCCCGAACTGCCCGTAACCCTGTCCGACATACAGGCCGCCGCCAAGGTGCTGGAGGGGCAAAT
TGAGCGCACAGAGCTCGCCCACTCCAAAACACTGTCGGCAATTACGGGCGCTGAAGTTTGGGTCAAGCTGGAGAACCGGC
AGTACACCGCCGCCTTCAAGGAACGCGGCGCGCTGAACAAGCTCTCCAAGCTTTCCGACAATGAGAAGAAATATGGCGTG
ATTGCCGCTTCGGCCGGCAACCATGCGCAAGGCGTTGCCTATCACGCCCGTCGCCTTGGTATTCCCGCGACCATCGTGAT
GCCGCAGACCACCCCTTTCAACAAGGTTGAGCATACCCGCGATCACGGCGCCCGTGTTCTGTTGGAAGGCATGACATTCG
ATGAGGCCAAGGCCCATGCCTATGCCGTCTGCGAGCGTGAAGGCCTGACATTCGTACATCCTTTCGATGATGCAGACATC
ATCGCTGGCCAGGGCACTATCGCGCTTGAGATGCTGGCGGACAATCCGGGGCTCGATACGCTGGTTGTGCCAATCGGTGG
CGGCGGCCTGATTTCAGGCATAGCCATTGCGGCGAAAGCGCTGAAGCCGGAAATCCGCATCATTGGCGTGCAGACGGCAA
TGTATCCGGCCATGCACGCCGCCATGCGCGGCAAACCCGCAAAAACGGGCGGTGCAACGATCGCAGAAGGCATTGCCGTG
CGCGATGTTGGGGACATCACCCGGCAGATCTGCGAGCGCATGGTGGATGATGTGGTCCTCGTTGAGGAGGAACACCTCGA
ACGCGCCATTACGCTCTTTGTAGAGGTCGAAAAGACGATTGCAGAAGGCGCCGGGGCCGCGGGCCTTGCCGCTCTCCTCG
CCCACCCTTCCCGTTTCTATGGACGCAAGGTTGGCCTCGTACTCTGCGGCGGCAATATCGATACGCGCCTGCTGGCCTCT
GTTTTGACGCGGGCACTGGTCCGCGAGAACCGACTGGCCCGTATCCGCATCGTCGGAGATGACCGGCCGGGCCTGCTCGC
GCTGGTTTCCAAGATCATCGGAGACAATGGCGCCAATATCATGGAAGTCGCCCACAACCGGATTGCGCTGGATGTGCCGG
CGAAAGGCGCCGAGTTCGACATCCTGATGGAGACCCGTGACAGCCAGCACACACAGGAAGTCATCGACGCGCTGGCTCAG
GCTGGCTACCCGCCGCGCGCCATCTAG

Upstream 100 bases:

>100_bases
TTGGGTGGCGGAACATGACCCTGGGAGTGGAACGGCAGGATTGCTTGTAAATTGAACCCCGCCCGCATAGGGTGCGCCCG
CTTCTGACCGGACCCTTCCC

Downstream 100 bases:

>100_bases
GAACGGCGCGTTACACGTGACTATCACGCTGAACGCGCCTAGAGAGCACGCGACAGTTTTGCCCCTTCAGGAGGTTGCTC
CATGTTTCGCGCCCTACTTG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MPDTLPPELPVTLSDIQAAAKVLEGQIERTELAHSKTLSAITGAEVWVKLENRQYTAAFKERGALNKLSKLSDNEKKYGV
IAASAGNHAQGVAYHARRLGIPATIVMPQTTPFNKVEHTRDHGARVLLEGMTFDEAKAHAYAVCEREGLTFVHPFDDADI
IAGQGTIALEMLADNPGLDTLVVPIGGGGLISGIAIAAKALKPEIRIIGVQTAMYPAMHAAMRGKPAKTGGATIAEGIAV
RDVGDITRQICERMVDDVVLVEEEHLERAITLFVEVEKTIAEGAGAAGLAALLAHPSRFYGRKVGLVLCGGNIDTRLLAS
VLTRALVRENRLARIRIVGDDRPGLLALVSKIIGDNGANIMEVAHNRIALDVPAKGAEFDILMETRDSQHTQEVIDALAQ
AGYPPRAI

Sequences:

>Translated_408_residues
MPDTLPPELPVTLSDIQAAAKVLEGQIERTELAHSKTLSAITGAEVWVKLENRQYTAAFKERGALNKLSKLSDNEKKYGV
IAASAGNHAQGVAYHARRLGIPATIVMPQTTPFNKVEHTRDHGARVLLEGMTFDEAKAHAYAVCEREGLTFVHPFDDADI
IAGQGTIALEMLADNPGLDTLVVPIGGGGLISGIAIAAKALKPEIRIIGVQTAMYPAMHAAMRGKPAKTGGATIAEGIAV
RDVGDITRQICERMVDDVVLVEEEHLERAITLFVEVEKTIAEGAGAAGLAALLAHPSRFYGRKVGLVLCGGNIDTRLLAS
VLTRALVRENRLARIRIVGDDRPGLLALVSKIIGDNGANIMEVAHNRIALDVPAKGAEFDILMETRDSQHTQEVIDALAQ
AGYPPRAI
>Mature_407_residues
PDTLPPELPVTLSDIQAAAKVLEGQIERTELAHSKTLSAITGAEVWVKLENRQYTAAFKERGALNKLSKLSDNEKKYGVI
AASAGNHAQGVAYHARRLGIPATIVMPQTTPFNKVEHTRDHGARVLLEGMTFDEAKAHAYAVCEREGLTFVHPFDDADII
AGQGTIALEMLADNPGLDTLVVPIGGGGLISGIAIAAKALKPEIRIIGVQTAMYPAMHAAMRGKPAKTGGATIAEGIAVR
DVGDITRQICERMVDDVVLVEEEHLERAITLFVEVEKTIAEGAGAAGLAALLAHPSRFYGRKVGLVLCGGNIDTRLLASV
LTRALVRENRLARIRIVGDDRPGLLALVSKIIGDNGANIMEVAHNRIALDVPAKGAEFDILMETRDSQHTQEVIDALAQA
GYPPRAI

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=34.5047923322684, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI33469958, Length=273, Percent_Identity=30.4029304029304, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923959, Length=144, Percent_Identity=36.1111111111111, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=42.1383647798742, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1790207, Length=381, Percent_Identity=35.9580052493438, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71991565, Length=404, Percent_Identity=39.3564356435644, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17537387, Length=404, Percent_Identity=33.1683168316832, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=29.2993630573248, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320930, Length=341, Percent_Identity=37.2434017595308, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322631, Length=320, Percent_Identity=35.625, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=267, Percent_Identity=26.2172284644195, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355833, Length=407, Percent_Identity=40.2948402948403, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24645328, Length=301, Percent_Identity=37.2093023255814, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43574; Mature: 43443

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDTLPPELPVTLSDIQAAAKVLEGQIERTELAHSKTLSAITGAEVWVKLENRQYTAAFK
CCCCCCCCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHH
ERGALNKLSKLSDNEKKYGVIAASAGNHAQGVAYHARRLGIPATIVMPQTTPFNKVEHTR
HCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
DHGARVLLEGMTFDEAKAHAYAVCEREGLTFVHPFDDADIIAGQGTIALEMLADNPGLDT
CCCCEEEEECCCCCHHHHHEEEEEECCCCEEECCCCCCCEEECCCCEEEEEEECCCCCCE
LVVPIGGGGLISGIAIAAKALKPEIRIIGVQTAMYPAMHAAMRGKPAKTGGATIAEGIAV
EEEEECCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHHCCEEH
RDVGDITRQICERMVDDVVLVEEEHLERAITLFVEVEKTIAEGAGAAGLAALLAHPSRFY
HHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHC
GRKVGLVLCGGNIDTRLLASVLTRALVRENRLARIRIVGDDRPGLLALVSKIIGDNGANI
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCCHH
MEVAHNRIALDVPAKGAEFDILMETRDSQHTQEVIDALAQAGYPPRAI
HHHCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PDTLPPELPVTLSDIQAAAKVLEGQIERTELAHSKTLSAITGAEVWVKLENRQYTAAFK
CCCCCCCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHH
ERGALNKLSKLSDNEKKYGVIAASAGNHAQGVAYHARRLGIPATIVMPQTTPFNKVEHTR
HCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
DHGARVLLEGMTFDEAKAHAYAVCEREGLTFVHPFDDADIIAGQGTIALEMLADNPGLDT
CCCCEEEEECCCCCHHHHHEEEEEECCCCEEECCCCCCCEEECCCCEEEEEEECCCCCCE
LVVPIGGGGLISGIAIAAKALKPEIRIIGVQTAMYPAMHAAMRGKPAKTGGATIAEGIAV
EEEEECCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHHCCEEH
RDVGDITRQICERMVDDVVLVEEEHLERAITLFVEVEKTIAEGAGAAGLAALLAHPSRFY
HHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHC
GRKVGLVLCGGNIDTRLLASVLTRALVRENRLARIRIVGDDRPGLLALVSKIIGDNGANI
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCCHH
MEVAHNRIALDVPAKGAEFDILMETRDSQHTQEVIDALAQAGYPPRAI
HHHCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA