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The map label for this gene is gpmA

Identifier: 114797148

GI number: 114797148

Start: 21486

End: 22199

Strand: Reverse

Name: gpmA

Synonym: HNE_0031

Alternate gene names: 114797148

Gene position: 22199-21486 (Counterclockwise)

Preceding gene: 114800103

Following gene: 114798109

Centisome position: 0.6

GC content: 61.2

Gene sequence:

>714_bases
ATGACCAAGCTCGCCCTGATCCGGCACGGCCAGTCGGCCTGGAATCTGGAAAACCGTTTCACCGGCTGGTGGGACGCTGA
CCTGACAGCCCAGGGCGAAGCCGAAGCGCGCCATTCGGGCAAGCTGCTGGCGGAAGTCGATGCCGATTTCCGCGCCGGCT
TCACCAGCGTGCAAACCCGCGCCATCCGCACAATGTGGCTGGCACTGACCGAGATGAAGCGCGTGTGGCTGCCGATCGAG
AAAGACTGGCACCTCAACGAACGTCACTATGGCGGCCTGACAGGGCTCAACAAGGCAGAGACCGCTGCCAAGCATGGCGA
AGATCAGGTGCATGTCTGGCGCCGCAGCTATGATATTCCGCCCCCGCCGCTGGAAGTCGGCAGCACGTTCGATCTCTCAA
CCGATCCCCGGTATCGCGGCATCGACATTCCGAACACGGAAAGCCTGAAAACGACCCTCGACCGCGTATTGCCTTACTGG
CAGCAGAAAATTGCGCCGGGGCTGATCGCCGGGACCGACACGATGATCGCCGCGCACGGAAACTCCCTGCGCGCGCTGGT
CAAACACCTGTTCAATGTGCCGGACGAAACAATCACCGGGCTGGAAATTCCTACCGGAAATCCCTTGCTGATCGAGCTTG
ATCCCAATCTCAAGCCGGTATCGGTTCGCTATCTCGACGCAGAGCGCGCCCATAGCCTGCCTGACCTGCCATGA

Upstream 100 bases:

>100_bases
CTTATCCGCGTGATGAACGCTTGATATTCCCGAGATTTGCAGGGAATACAGCCGCGAAACCTGCCTGCCTGCAAGGGCTG
GCCCTGAGATGAGGAATGCC

Downstream 100 bases:

>100_bases
AACGGCCGGGGCGGCGCCGGGACCGCAGGATGATGGGCCGGGCCTTTCAACTGGCGCGTCTCAATCATGGCCTGACCGGC
AAGAACCCATCGGTGGGATG

Product: phosphoglycerate mutase 1 family protein

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTKLALIRHGQSAWNLENRFTGWWDADLTAQGEAEARHSGKLLAEVDADFRAGFTSVQTRAIRTMWLALTEMKRVWLPIE
KDWHLNERHYGGLTGLNKAETAAKHGEDQVHVWRRSYDIPPPPLEVGSTFDLSTDPRYRGIDIPNTESLKTTLDRVLPYW
QQKIAPGLIAGTDTMIAAHGNSLRALVKHLFNVPDETITGLEIPTGNPLLIELDPNLKPVSVRYLDAERAHSLPDLP

Sequences:

>Translated_237_residues
MTKLALIRHGQSAWNLENRFTGWWDADLTAQGEAEARHSGKLLAEVDADFRAGFTSVQTRAIRTMWLALTEMKRVWLPIE
KDWHLNERHYGGLTGLNKAETAAKHGEDQVHVWRRSYDIPPPPLEVGSTFDLSTDPRYRGIDIPNTESLKTTLDRVLPYW
QQKIAPGLIAGTDTMIAAHGNSLRALVKHLFNVPDETITGLEIPTGNPLLIELDPNLKPVSVRYLDAERAHSLPDLP
>Mature_236_residues
TKLALIRHGQSAWNLENRFTGWWDADLTAQGEAEARHSGKLLAEVDADFRAGFTSVQTRAIRTMWLALTEMKRVWLPIEK
DWHLNERHYGGLTGLNKAETAAKHGEDQVHVWRRSYDIPPPPLEVGSTFDLSTDPRYRGIDIPNTESLKTTLDRVLPYWQ
QKIAPGLIAGTDTMIAAHGNSLRALVKHLFNVPDETITGLEIPTGNPLLIELDPNLKPVSVRYLDAERAHSLPDLP

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4505753, Length=224, Percent_Identity=55.8035714285714, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI50593010, Length=224, Percent_Identity=50.4464285714286, Blast_Score=244, Evalue=3e-65,
Organism=Homo sapiens, GI4502445, Length=225, Percent_Identity=48.4444444444444, Blast_Score=234, Evalue=5e-62,
Organism=Homo sapiens, GI40353764, Length=225, Percent_Identity=48.4444444444444, Blast_Score=234, Evalue=5e-62,
Organism=Homo sapiens, GI71274132, Length=223, Percent_Identity=52.4663677130045, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=58.3850931677019, Blast_Score=181, Evalue=5e-46,
Organism=Escherichia coli, GI1786970, Length=228, Percent_Identity=53.0701754385965, Blast_Score=247, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6322697, Length=232, Percent_Identity=51.2931034482759, Blast_Score=237, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6320183, Length=284, Percent_Identity=31.6901408450704, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324516, Length=280, Percent_Identity=31.4285714285714, Blast_Score=122, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646216, Length=225, Percent_Identity=47.5555555555556, Blast_Score=223, Evalue=7e-59,
Organism=Drosophila melanogaster, GI85725270, Length=233, Percent_Identity=49.3562231759657, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI85725272, Length=233, Percent_Identity=49.3562231759657, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24650981, Length=233, Percent_Identity=49.3562231759657, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI28571815, Length=219, Percent_Identity=35.6164383561644, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24648979, Length=219, Percent_Identity=35.6164383561644, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28571817, Length=219, Percent_Identity=35.6164383561644, Blast_Score=156, Evalue=1e-38,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_HYPNA (Q0C678)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_758765.1
- ProteinModelPortal:   Q0C678
- SMR:   Q0C678
- STRING:   Q0C678
- GeneID:   4288365
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0031
- NMPDR:   fig|228405.5.peg.31
- TIGR:   HNE_0031
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   Q0C678
- ProtClustDB:   CLSK2531609
- BioCyc:   HNEP81032:HNE_0031-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 26655; Mature: 26523

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLALIRHGQSAWNLENRFTGWWDADLTAQGEAEARHSGKLLAEVDADFRAGFTSVQTR
CCCEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCHHHCCCEEEEECCHHHCCHHHHHHH
AIRTMWLALTEMKRVWLPIEKDWHLNERHYGGLTGLNKAETAAKHGEDQVHVWRRSYDIP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCC
PPPLEVGSTFDLSTDPRYRGIDIPNTESLKTTLDRVLPYWQQKIAPGLIAGTDTMIAAHG
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECC
NSLRALVKHLFNVPDETITGLEIPTGNPLLIELDPNLKPVSVRYLDAERAHSLPDLP
CHHHHHHHHHHCCCCCCCCCEECCCCCEEEEEECCCCCEEEEEEECHHHHCCCCCCC
>Mature Secondary Structure 
TKLALIRHGQSAWNLENRFTGWWDADLTAQGEAEARHSGKLLAEVDADFRAGFTSVQTR
CCEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCHHHCCCEEEEECCHHHCCHHHHHHH
AIRTMWLALTEMKRVWLPIEKDWHLNERHYGGLTGLNKAETAAKHGEDQVHVWRRSYDIP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCC
PPPLEVGSTFDLSTDPRYRGIDIPNTESLKTTLDRVLPYWQQKIAPGLIAGTDTMIAAHG
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECC
NSLRALVKHLFNVPDETITGLEIPTGNPLLIELDPNLKPVSVRYLDAERAHSLPDLP
CHHHHHHHHHHCCCCCCCCCEECCCCCEEEEEECCCCCEEEEEEECHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA