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The map label for this gene is ribB [H]

Identifier: 114332463

GI number: 114332463

Start: 2644626

End: 2645735

Strand: Direct

Name: ribB [H]

Synonym: Neut_2516

Alternate gene names: 114332463

Gene position: 2644626-2645735 (Clockwise)

Preceding gene: 114332462

Following gene: 114332464

Centisome position: 99.38

GC content: 51.53

Gene sequence:

>1110_bases
ATGACAATCTCATCGATTGAAGAAGTTCTGGCAGACTTCAAAAATGGAAAGATGGTTATCCTCATTGACGAGGAAAATCG
TGAGAATGAGGGCGATCTGGTACTGGCGGCTGATTTTATTACGCCCGAAGCAATCAATTTCATGGCCAGATACGGCAGGG
GATTGATCTGCCTGACATTGACAGAAGAGCGTTGCCGTCAGCTTAAGCTGCCCATGATGGTTGCCGACAATCATTCGCCA
TTGGGCACCAATTTCACTGCCTCCATTGAAGCAGCCAGCGGTGTAACAACCGGAATTTCCGCTGCCGATCGCGCCCGTAC
TGTTCAAACAGCCGTCCAAGCGGATGCTAAACCGGAAGATCTGGTTCAACCCGGCCATATTTTTCCGCTCAAAGCGCAGA
AGGGTGGGGTGCTGGCACGCGCCGGCCATACCGAAGCTGGCTGTGATCTGGCGCGGCTGGCGGGTTTAACCGAGGCCGCA
GTGATTTGCGAGATTCTGAAAGAAAACGGTGAAATGGCAAGGCTGCCAGATCTAATCGAATTCTCCGATGAGCACCATCT
CAAGATCGGGACAATTGCTGATCTCATTCATTATCGCCGTCTCACAGAAAGCCTGGTCACACGAACGACTGAACGTCCCT
TACAAACTGCTCACGGAGAATTCAGACTGATTGCCTACCATGATAAGATTGCCGGCGTCACTCATCTCGCGCTGGTAAAA
GGGACATGGAATACCGGTGAGGAAATACTGGTACGAGTGCACGAACCGCTGACGGTGATTGATCTGCTGGAAATTGATGA
TTACACTCACTCCTGGAGTATTCATGATGCAATGGCAGCCATCACACATGCCGGAAAGGGCGTAGTCGTGCTGCTACAGC
GCAAAAATGATGCCAGCGTGTTAACTGAGCGGATTCTGCAAACCACACCGCATCCAGCGGATAAACCCGTATCGGATCTG
CGCCATCATGGTATCGGTGCGCAGATTCTTAAAGATCTAGGAGTCAGTAAAATGCGCCTGCTGGCAACCCCTCGCAGAAT
GCCTAGTATGACCGGCTTTGGTCTGGAAGTTACCGGGTATCTGGAACCGGAAGATCGCGATCGCGTGTAA

Upstream 100 bases:

>100_bases
CTTTCAAACAGTTTGAGCCCGGCAAAAAAGTGAATCTCGAAACAGATATGATAGCGAAATACGTGGCACGTTTACTCGAT
CAGGCACAAGGCAAGCAATC

Downstream 100 bases:

>100_bases
AAATCTGTTCAAAGTCTCGATCAAGGGATGCAAGGCAAGGCAAAATTGAACGAGAAAGCGGAGCATACTTGAAATATGTG
AGCATTTTGAGTTCAATTTC

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTISSIEEVLADFKNGKMVILIDEENRENEGDLVLAADFITPEAINFMARYGRGLICLTLTEERCRQLKLPMMVADNHSP
LGTNFTASIEAASGVTTGISAADRARTVQTAVQADAKPEDLVQPGHIFPLKAQKGGVLARAGHTEAGCDLARLAGLTEAA
VICEILKENGEMARLPDLIEFSDEHHLKIGTIADLIHYRRLTESLVTRTTERPLQTAHGEFRLIAYHDKIAGVTHLALVK
GTWNTGEEILVRVHEPLTVIDLLEIDDYTHSWSIHDAMAAITHAGKGVVVLLQRKNDASVLTERILQTTPHPADKPVSDL
RHHGIGAQILKDLGVSKMRLLATPRRMPSMTGFGLEVTGYLEPEDRDRV

Sequences:

>Translated_369_residues
MTISSIEEVLADFKNGKMVILIDEENRENEGDLVLAADFITPEAINFMARYGRGLICLTLTEERCRQLKLPMMVADNHSP
LGTNFTASIEAASGVTTGISAADRARTVQTAVQADAKPEDLVQPGHIFPLKAQKGGVLARAGHTEAGCDLARLAGLTEAA
VICEILKENGEMARLPDLIEFSDEHHLKIGTIADLIHYRRLTESLVTRTTERPLQTAHGEFRLIAYHDKIAGVTHLALVK
GTWNTGEEILVRVHEPLTVIDLLEIDDYTHSWSIHDAMAAITHAGKGVVVLLQRKNDASVLTERILQTTPHPADKPVSDL
RHHGIGAQILKDLGVSKMRLLATPRRMPSMTGFGLEVTGYLEPEDRDRV
>Mature_368_residues
TISSIEEVLADFKNGKMVILIDEENRENEGDLVLAADFITPEAINFMARYGRGLICLTLTEERCRQLKLPMMVADNHSPL
GTNFTASIEAASGVTTGISAADRARTVQTAVQADAKPEDLVQPGHIFPLKAQKGGVLARAGHTEAGCDLARLAGLTEAAV
ICEILKENGEMARLPDLIEFSDEHHLKIGTIADLIHYRRLTESLVTRTTERPLQTAHGEFRLIAYHDKIAGVTHLALVKG
TWNTGEEILVRVHEPLTVIDLLEIDDYTHSWSIHDAMAAITHAGKGVVVLLQRKNDASVLTERILQTTPHPADKPVSDLR
HHGIGAQILKDLGVSKMRLLATPRRMPSMTGFGLEVTGYLEPEDRDRV

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=51.5151515151515, Blast_Score=218, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=37.8640776699029, Blast_Score=152, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40499; Mature: 40368

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISSIEEVLADFKNGKMVILIDEENRENEGDLVLAADFITPEAINFMARYGRGLICLTL
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEE
TEERCRQLKLPMMVADNHSPLGTNFTASIEAASGVTTGISAADRARTVQTAVQADAKPED
CHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LVQPGHIFPLKAQKGGVLARAGHTEAGCDLARLAGLTEAAVICEILKENGEMARLPDLIE
HCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCEECCCHHHH
FSDEHHLKIGTIADLIHYRRLTESLVTRTTERPLQTAHGEFRLIAYHDKIAGVTHLALVK
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCCCEEEEEEE
GTWNTGEEILVRVHEPLTVIDLLEIDDYTHSWSIHDAMAAITHAGKGVVVLLQRKNDASV
CCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHH
LTERILQTTPHPADKPVSDLRHHGIGAQILKDLGVSKMRLLATPRRMPSMTGFGLEVTGY
HHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCCCCCCCCCEEEEEE
LEPEDRDRV
ECCCCCCCC
>Mature Secondary Structure 
TISSIEEVLADFKNGKMVILIDEENRENEGDLVLAADFITPEAINFMARYGRGLICLTL
CHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEE
TEERCRQLKLPMMVADNHSPLGTNFTASIEAASGVTTGISAADRARTVQTAVQADAKPED
CHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LVQPGHIFPLKAQKGGVLARAGHTEAGCDLARLAGLTEAAVICEILKENGEMARLPDLIE
HCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCEECCCHHHH
FSDEHHLKIGTIADLIHYRRLTESLVTRTTERPLQTAHGEFRLIAYHDKIAGVTHLALVK
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCCCEEEEEEE
GTWNTGEEILVRVHEPLTVIDLLEIDDYTHSWSIHDAMAAITHAGKGVVVLLQRKNDASV
CCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHH
LTERILQTTPHPADKPVSDLRHHGIGAQILKDLGVSKMRLLATPRRMPSMTGFGLEVTGY
HHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCCCCCCCCCEEEEEE
LEPEDRDRV
ECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]