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The map label for this gene is ribH

Identifier: 114332464

GI number: 114332464

Start: 2645957

End: 2646454

Strand: Direct

Name: ribH

Synonym: Neut_2517

Alternate gene names: 114332464

Gene position: 2645957-2646454 (Clockwise)

Preceding gene: 114332463

Following gene: 114332465

Centisome position: 99.43

GC content: 49.4

Gene sequence:

>498_bases
ATGTCCTACTATGACAATATTCTCGAAATAGATTCAGACCTCAATGGAAACGGGCTGTGCATCGGTATTGTCATGAGCCG
TTTCAATATTGATACGAGTGAAGGGTTGCTTGGCGCCTGCACAACGGAACTTGCCAAACTGGGCGTGCAGGAAGCAGATA
TCGTTCTGGTAACTGTACCCGGTGCGCTGGAGATTCCGCTTGCGCTACAAAAACTCGCCATATCTGACCGGTACGATGCC
CTGATTGCTTTAGGTGCAGTTATTCATGGTGAAACCTATCATTTTGACGTAGTGGCCAATGAATCGGCACGCGGGCTGAT
AGCAGTCGGACTGGAATACGACATCCCCATTGCAAATGGCATTCTTACAACGGATAACGAAGATCAAGCCACTGCCCGTA
TGACCGAAAAAGGGGCTGAAACCGCGCGTGTCGCGGTAGAAATGGCCAATCTGGCATTAACGCTTGGCGAAATGGATCAA
TCCACCACCTCTTCATGA

Upstream 100 bases:

>100_bases
GTGAGCTATTGAACAGGTTCTAAGACACTTTTGCTATCAATTTCCGGCCACAAGGCCAATCAACCAACTTTAAAACAAAG
AGCAGAGAGGTACGTCTTTT

Downstream 100 bases:

>100_bases
TACCAACAGACACTGCTCCACCATCCAAACCAGCACAAGGACACAAAGGCTATAAAAATCGCCGGCGTCTGTCACGTGAA
CTGGCCTTGCAGGGAATTTA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MSYYDNILEIDSDLNGNGLCIGIVMSRFNIDTSEGLLGACTTELAKLGVQEADIVLVTVPGALEIPLALQKLAISDRYDA
LIALGAVIHGETYHFDVVANESARGLIAVGLEYDIPIANGILTTDNEDQATARMTEKGAETARVAVEMANLALTLGEMDQ
STTSS

Sequences:

>Translated_165_residues
MSYYDNILEIDSDLNGNGLCIGIVMSRFNIDTSEGLLGACTTELAKLGVQEADIVLVTVPGALEIPLALQKLAISDRYDA
LIALGAVIHGETYHFDVVANESARGLIAVGLEYDIPIANGILTTDNEDQATARMTEKGAETARVAVEMANLALTLGEMDQ
STTSS
>Mature_164_residues
SYYDNILEIDSDLNGNGLCIGIVMSRFNIDTSEGLLGACTTELAKLGVQEADIVLVTVPGALEIPLALQKLAISDRYDAL
IALGAVIHGETYHFDVVANESARGLIAVGLEYDIPIANGILTTDNEDQATARMTEKGAETARVAVEMANLALTLGEMDQS
TTSS

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=136, Percent_Identity=42.6470588235294, Blast_Score=98, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324429, Length=152, Percent_Identity=29.6052631578947, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_NITEC (Q0AD61)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748686.1
- ProteinModelPortal:   Q0AD61
- SMR:   Q0AD61
- STRING:   Q0AD61
- GeneID:   4273371
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2517
- NMPDR:   fig|335283.3.peg.733
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   DIPIANG
- PhylomeDB:   Q0AD61
- ProtClustDB:   PRK00061
- BioCyc:   NEUT335283:NEUT_2517-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 17463; Mature: 17332

Theoretical pI: Translated: 3.85; Mature: 3.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYYDNILEIDSDLNGNGLCIGIVMSRFNIDTSEGLLGACTTELAKLGVQEADIVLVTVP
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECC
GALEIPLALQKLAISDRYDALIALGAVIHGETYHFDVVANESARGLIAVGLEYDIPIANG
CCEECCHHHHHHHHCCCHHHHHHHHHEECCCEEEEEEEECCCCCEEEEEEEEECCCCCCC
ILTTDNEDQATARMTEKGAETARVAVEMANLALTLGEMDQSTTSS
EEECCCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCCCCC
>Mature Secondary Structure 
SYYDNILEIDSDLNGNGLCIGIVMSRFNIDTSEGLLGACTTELAKLGVQEADIVLVTVP
CCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECC
GALEIPLALQKLAISDRYDALIALGAVIHGETYHFDVVANESARGLIAVGLEYDIPIANG
CCEECCHHHHHHHHCCCHHHHHHHHHEECCCEEEEEEEECCCCCEEEEEEEEECCCCCCC
ILTTDNEDQATARMTEKGAETARVAVEMANLALTLGEMDQSTTSS
EEECCCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA