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The map label for this gene is yqeC [H]

Identifier: 114332384

GI number: 114332384

Start: 2544752

End: 2545807

Strand: Reverse

Name: yqeC [H]

Synonym: Neut_2432

Alternate gene names: 114332384

Gene position: 2545807-2544752 (Counterclockwise)

Preceding gene: 114332385

Following gene: 114332383

Centisome position: 95.67

GC content: 53.22

Gene sequence:

>1056_bases
ATGAATGATTCAACAAATGCTGATCATACGATACAACTCGGTTTTATCGGCTTGGGGCGTATGGGCCTTAATATGGTGGA
GCGATTGCAGAAAGCCGGTATAGGTTGCGTGGTATTTGATACCAATTCTGAAGCATGTATTGCCGCTACAAAATCGGGAG
CAGAGACAGCGATCTCGCTTAATGATCTGGTTAATAAGCTTGCCTTACCTCGTGCAGTATGGCTCATGCTGCCCACCGCA
GTAGTGGATAAAGTGCTCACAGTGTTGACACCCCTTCTCAGTGCCGGCGATGTCGTGATTGATGGGGGAAATTCGCACTA
TGTGGCAGATCTACGCCGTGCTGCATCACTCGCAACCAGACAAATTTATTACCTGGATGTGGGTGTCAGCGGCGGTGTGT
GGGGGCGAGAACGCGGTTATTGCCAGATGATCGGCGGTCCTGATGCGGCCTATCAGCGGCTTGAGCCTGTATTTCGCACA
TTGGCACCTGGTGTGGAAGCCGCGACACGCTCGTCGGGCCGCAGCGGCGAGCCGACACCTGCCGAACATGGCTATTTGCA
TTGCGGGCCGAATGGCGCCGGACATTTCGTCAAGATGGTGCACAACGGCATAGAGTATGGATTAATGGCAGCCTATGCTG
AGGGGTTGAATATACTGCATCAGGCGAACGCTGGAAATGTCCGGCAGGAAATAAATGCCGAAACTGCGCCACTCGAACAT
CCCGCACGCTATCAGTACGATTTTCCGCTCAATGACGTGGTGGAGTTGTGGCGCCGTGGCAGCGTGATTGGTTCCTGGTT
GCTGGATTTGACAGCCATTGAGATGAATGAGGATATGACGCTTTCACGTTATACCGGACGTGTATCTGATTCTGGTGAAG
GCCGCTGGGCGGCACTCGCGGCAATTGAAGAAGGCGTCCCGGTTCCGGTACTTGCCGCAGCACTTTTTGGCCGCTTCACA
TCACGCGGGCATGATGAGTTTGCCGATAAGGTAATGTCTGCGATGCGCCACGGATTTGGGGGGCATGATGAAAAAACCGC
TCCGGATGACAAATAA

Upstream 100 bases:

>100_bases
GGTGGTAACGCACGACTTTTGAAAAAACTACCGACCGGTGTTCGCCGTGGAAAAAACGCCAATGCATTCACTGGTGGTTT
TCGCCTGTGGGAGGATGAGT

Downstream 100 bases:

>100_bases
AAGAAAAAGGAGGAGGTGTGTCTGATACAAACCTTGTGATTCTTGGTGCAACCGGAGACTTGACGCAACGTTTGCTCATG
CCGGCATTGTATCGCCTGCA

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNDSTNADHTIQLGFIGLGRMGLNMVERLQKAGIGCVVFDTNSEACIAATKSGAETAISLNDLVNKLALPRAVWLMLPTA
VVDKVLTVLTPLLSAGDVVIDGGNSHYVADLRRAASLATRQIYYLDVGVSGGVWGRERGYCQMIGGPDAAYQRLEPVFRT
LAPGVEAATRSSGRSGEPTPAEHGYLHCGPNGAGHFVKMVHNGIEYGLMAAYAEGLNILHQANAGNVRQEINAETAPLEH
PARYQYDFPLNDVVELWRRGSVIGSWLLDLTAIEMNEDMTLSRYTGRVSDSGEGRWAALAAIEEGVPVPVLAAALFGRFT
SRGHDEFADKVMSAMRHGFGGHDEKTAPDDK

Sequences:

>Translated_351_residues
MNDSTNADHTIQLGFIGLGRMGLNMVERLQKAGIGCVVFDTNSEACIAATKSGAETAISLNDLVNKLALPRAVWLMLPTA
VVDKVLTVLTPLLSAGDVVIDGGNSHYVADLRRAASLATRQIYYLDVGVSGGVWGRERGYCQMIGGPDAAYQRLEPVFRT
LAPGVEAATRSSGRSGEPTPAEHGYLHCGPNGAGHFVKMVHNGIEYGLMAAYAEGLNILHQANAGNVRQEINAETAPLEH
PARYQYDFPLNDVVELWRRGSVIGSWLLDLTAIEMNEDMTLSRYTGRVSDSGEGRWAALAAIEEGVPVPVLAAALFGRFT
SRGHDEFADKVMSAMRHGFGGHDEKTAPDDK
>Mature_351_residues
MNDSTNADHTIQLGFIGLGRMGLNMVERLQKAGIGCVVFDTNSEACIAATKSGAETAISLNDLVNKLALPRAVWLMLPTA
VVDKVLTVLTPLLSAGDVVIDGGNSHYVADLRRAASLATRQIYYLDVGVSGGVWGRERGYCQMIGGPDAAYQRLEPVFRT
LAPGVEAATRSSGRSGEPTPAEHGYLHCGPNGAGHFVKMVHNGIEYGLMAAYAEGLNILHQANAGNVRQEINAETAPLEH
PARYQYDFPLNDVVELWRRGSVIGSWLLDLTAIEMNEDMTLSRYTGRVSDSGEGRWAALAAIEEGVPVPVLAAALFGRFT
SRGHDEFADKVMSAMRHGFGGHDEKTAPDDK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=352, Percent_Identity=30.6818181818182, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1788341, Length=334, Percent_Identity=28.7425149700599, Blast_Score=127, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17542558, Length=325, Percent_Identity=31.0769230769231, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321695, Length=325, Percent_Identity=31.0769230769231, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321977, Length=325, Percent_Identity=31.0769230769231, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24639279, Length=323, Percent_Identity=32.1981424148607, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 37722; Mature: 37722

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSTNADHTIQLGFIGLGRMGLNMVERLQKAGIGCVVFDTNSEACIAATKSGAETAISL
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCHHEEEH
NDLVNKLALPRAVWLMLPTAVVDKVLTVLTPLLSAGDVVIDGGNSHYVADLRRAASLATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHC
QIYYLDVGVSGGVWGRERGYCQMIGGPDAAYQRLEPVFRTLAPGVEAATRSSGRSGEPTP
EEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC
AEHGYLHCGPNGAGHFVKMVHNGIEYGLMAAYAEGLNILHQANAGNVRQEINAETAPLEH
CCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
PARYQYDFPLNDVVELWRRGSVIGSWLLDLTAIEMNEDMTLSRYTGRVSDSGEGRWAALA
CCCEEECCCHHHHHHHHHCCCHHHHHHHHHHEEECCCCCEEHHHCCCCCCCCCCCEEEEE
AIEEGVPVPVLAAALFGRFTSRGHDEFADKVMSAMRHGFGGHDEKTAPDDK
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDSTNADHTIQLGFIGLGRMGLNMVERLQKAGIGCVVFDTNSEACIAATKSGAETAISL
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCHHEEEH
NDLVNKLALPRAVWLMLPTAVVDKVLTVLTPLLSAGDVVIDGGNSHYVADLRRAASLATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHC
QIYYLDVGVSGGVWGRERGYCQMIGGPDAAYQRLEPVFRTLAPGVEAATRSSGRSGEPTP
EEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC
AEHGYLHCGPNGAGHFVKMVHNGIEYGLMAAYAEGLNILHQANAGNVRQEINAETAPLEH
CCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
PARYQYDFPLNDVVELWRRGSVIGSWLLDLTAIEMNEDMTLSRYTGRVSDSGEGRWAALA
CCCEEECCCHHHHHHHHHCCCHHHHHHHHHHEEECCCCCEEHHHCCCCCCCCCCCEEEEE
AIEEGVPVPVLAAALFGRFTSRGHDEFADKVMSAMRHGFGGHDEKTAPDDK
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]