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The map label for this gene is pgi [H]

Identifier: 114332385

GI number: 114332385

Start: 2545800

End: 2548106

Strand: Reverse

Name: pgi [H]

Synonym: Neut_2433

Alternate gene names: 114332385

Gene position: 2548106-2545800 (Counterclockwise)

Preceding gene: 114332386

Following gene: 114332384

Centisome position: 95.76

GC content: 49.59

Gene sequence:

>2307_bases
GTGAGTACATTACGTGAAACCGGAGTATGGAAGGCGCTGCATTCACACTATCTATCTTTTCAAAGGATACAGTTGCGCGG
GCTGTTTGCGCGAGATAAGAAACGTGCCGAGCGTTACACCGTAGAAGCAGCAGGCTGGCGCCTGGATTACTCCAAGCATC
GTATCAATGACAAAACCCTGAAATTGTTATTTGAGCTGGCACGTGAATGTAGCCTGGAATCGCGGCGTGATGCCATGTTC
TCGGGCAAGGAAGTCAACACCACTGAGCAGCGCGCCGCCCTGCACATCGCGCTACGTGCCCCTGCTGATTCAGTAATAAA
TGTGGCAGGCGTGAATGTAGTACCTGAAGTACAGGCAATACTCAAACGTATGGCTGAATGCGCCGAGTTGATCCGCGCGG
GAGAATGGAAAGGCTACAGTGGCCGACCGATCCGTAACATCGTTAATATTGGTATTGGCGGGTCGGATCTGGGCCCGGTA
ATGGCCTGCGGGGCGCTGTGCCATTATGGCGAACGCAAGTTGAGATTACGCTTCGTTTCCAATGTGGATGGAACGGATTT
TGTAGAGGCAGTACACGGATTGAGGCCGGATGAAACCTTATTCATTATAGCTTCCAAAACGTTTACCACACTCGAAACCA
TGACTAATGCGCACACTGCGCGTCATTGGCTGCAAACCGCTGCAGGACGTGACAGGAAAGCCATCACACCCCACTTTGTA
GCGCTCTCGACCAATGAGAAAGCTGTCAATGATTTTGGTATCCCCTCCAAACAGATGTTTGGTTTCCAGGAATGGGTAGG
TGGGCGTTATTCCATGGATTCTGCTATTGGCTTATCCATTATGATTGCCATCGGGCCGGAAGCTTTCTGCGAAATGCTTG
CTGGTTTTCACGCCATGGACGAACATTTTCGCAGTGCACCACTTGAACAGAATCTGCCTGTCATCATGGGGCTTCTGAAC
GTATGGTATGCGGACTTCTTTGATGCGGGTACCGTCGCAGTATTACCTTATGCACATTCTCTCAAGCGGTTTCCTGCCTA
TCTACAGCAGCTCACCATGGAATCCAACGGCAAGCATGTGACACTTGACGGAAAAAGTGTGGATTACCATACCGGCTCCG
TGTTCTGGGGCGAACCAGGTACCAATGGACAGCATTCGTTTTATCAGTTGATTCATCAGGGCACACATTTGATTCCTTGT
GACTTCATTGCCTTTGCTGAATCGCTCAATCCGGTTGGACGACATCAGGATCTGTTGTTCGCCAACGTAATCGCGCAGGC
CGAGGCGCTTGCCATGGGCAAAACACTTACAGAAGTGCAAAAGGAAGGGGTATCGGCCGAATTGGCACCTCATAAGGTTA
TGAAAGGCAACCAACCGTCGAGTCTATTGTTTGCTAAACGACTTACACCAACATCATTGGGAGCACTAGTAGCACTGTAT
GAGCACAGTGTATTTACACAAGCCACAATATGGGATATCAACCCCTTTGATCAATGGGGGGTGGAATTGGGCAAACGGCT
TGCATCGCGCATAGCAGAGGAAATAGAAACACCGGATGTGACGCTGGCACACGATGCTTCAACTAATGCCTCAATTCGCT
GGTACTGTTACATGCGCGGACAGAATAACAGCCAAGAAAAACAAGAAAAACGCTGTGTACTGGCGCTGGATGTAGGCGGC
AGTAACGTCAAGGCAAGAATAAGCGGCGAGAAATTAAAAATTAAAATCCCATCTGGTTCAGACATGACACCAGAACTTAT
GCTCACGCAGCTGGATAAATGTTTACACGGATGGCATTACGATGCAGTAAGCGTTGGTTTTCCAGCATTGGTTGTACATG
GGCGTATTGCGAACGAACCAGCTAATCTTGGCACTGGTTGGGTAGGGTTCGACTTTGCCAAGGCATTTAGCTGCCCGGTC
AGGATTATGAATGACGCTGCCATGCAGGCACTTGGCAGTTACGAAGGCGGGTACATGCTATTCCTTGGCCTTGGCACCGG
TCTTGGTTCCGCTGTCATTGTGGATGGACGGATTGAGCCAATGGAACTGGCGCACCTTCCATACAAACAGCATACCTATG
AATATTACGTTGGTAAACATGCGCTCCAACGCTTGGGAAAGCGTAAATGGCGAGCTGAAGTGTTCGCAGAAGTTGAAATG
CTGCGCATTGCACTTGAACCTGATTACATCGTACTGGGTGGTGGTAACGCACGACTTTTGAAAAAACTACCGACCGGTGT
TCGCCGTGGAAAAAACGCCAATGCATTCACTGGTGGTTTTCGCCTGTGGGAGGATGAGTATGAATGA

Upstream 100 bases:

>100_bases
CTTGCTTGCCTCCTGATTGATTTGCGTCAAAAAATCAAACCATTCTTAACAGAATGTATGTTGTAATGAGAAAAAATCAT
CACTTCATGGAGTAAGCCAT

Downstream 100 bases:

>100_bases
TTCAACAAATGCTGATCATACGATACAACTCGGTTTTATCGGCTTGGGGCGTATGGGCCTTAATATGGTGGAGCGATTGC
AGAAAGCCGGTATAGGTTGC

Product: phosphoglucose isomerase (PGI)

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MSTLRETGVWKALHSHYLSFQRIQLRGLFARDKKRAERYTVEAAGWRLDYSKHRINDKTLKLLFELARECSLESRRDAMF
SGKEVNTTEQRAALHIALRAPADSVINVAGVNVVPEVQAILKRMAECAELIRAGEWKGYSGRPIRNIVNIGIGGSDLGPV
MACGALCHYGERKLRLRFVSNVDGTDFVEAVHGLRPDETLFIIASKTFTTLETMTNAHTARHWLQTAAGRDRKAITPHFV
ALSTNEKAVNDFGIPSKQMFGFQEWVGGRYSMDSAIGLSIMIAIGPEAFCEMLAGFHAMDEHFRSAPLEQNLPVIMGLLN
VWYADFFDAGTVAVLPYAHSLKRFPAYLQQLTMESNGKHVTLDGKSVDYHTGSVFWGEPGTNGQHSFYQLIHQGTHLIPC
DFIAFAESLNPVGRHQDLLFANVIAQAEALAMGKTLTEVQKEGVSAELAPHKVMKGNQPSSLLFAKRLTPTSLGALVALY
EHSVFTQATIWDINPFDQWGVELGKRLASRIAEEIETPDVTLAHDASTNASIRWYCYMRGQNNSQEKQEKRCVLALDVGG
SNVKARISGEKLKIKIPSGSDMTPELMLTQLDKCLHGWHYDAVSVGFPALVVHGRIANEPANLGTGWVGFDFAKAFSCPV
RIMNDAAMQALGSYEGGYMLFLGLGTGLGSAVIVDGRIEPMELAHLPYKQHTYEYYVGKHALQRLGKRKWRAEVFAEVEM
LRIALEPDYIVLGGGNARLLKKLPTGVRRGKNANAFTGGFRLWEDEYE

Sequences:

>Translated_768_residues
MSTLRETGVWKALHSHYLSFQRIQLRGLFARDKKRAERYTVEAAGWRLDYSKHRINDKTLKLLFELARECSLESRRDAMF
SGKEVNTTEQRAALHIALRAPADSVINVAGVNVVPEVQAILKRMAECAELIRAGEWKGYSGRPIRNIVNIGIGGSDLGPV
MACGALCHYGERKLRLRFVSNVDGTDFVEAVHGLRPDETLFIIASKTFTTLETMTNAHTARHWLQTAAGRDRKAITPHFV
ALSTNEKAVNDFGIPSKQMFGFQEWVGGRYSMDSAIGLSIMIAIGPEAFCEMLAGFHAMDEHFRSAPLEQNLPVIMGLLN
VWYADFFDAGTVAVLPYAHSLKRFPAYLQQLTMESNGKHVTLDGKSVDYHTGSVFWGEPGTNGQHSFYQLIHQGTHLIPC
DFIAFAESLNPVGRHQDLLFANVIAQAEALAMGKTLTEVQKEGVSAELAPHKVMKGNQPSSLLFAKRLTPTSLGALVALY
EHSVFTQATIWDINPFDQWGVELGKRLASRIAEEIETPDVTLAHDASTNASIRWYCYMRGQNNSQEKQEKRCVLALDVGG
SNVKARISGEKLKIKIPSGSDMTPELMLTQLDKCLHGWHYDAVSVGFPALVVHGRIANEPANLGTGWVGFDFAKAFSCPV
RIMNDAAMQALGSYEGGYMLFLGLGTGLGSAVIVDGRIEPMELAHLPYKQHTYEYYVGKHALQRLGKRKWRAEVFAEVEM
LRIALEPDYIVLGGGNARLLKKLPTGVRRGKNANAFTGGFRLWEDEYE
>Mature_767_residues
STLRETGVWKALHSHYLSFQRIQLRGLFARDKKRAERYTVEAAGWRLDYSKHRINDKTLKLLFELARECSLESRRDAMFS
GKEVNTTEQRAALHIALRAPADSVINVAGVNVVPEVQAILKRMAECAELIRAGEWKGYSGRPIRNIVNIGIGGSDLGPVM
ACGALCHYGERKLRLRFVSNVDGTDFVEAVHGLRPDETLFIIASKTFTTLETMTNAHTARHWLQTAAGRDRKAITPHFVA
LSTNEKAVNDFGIPSKQMFGFQEWVGGRYSMDSAIGLSIMIAIGPEAFCEMLAGFHAMDEHFRSAPLEQNLPVIMGLLNV
WYADFFDAGTVAVLPYAHSLKRFPAYLQQLTMESNGKHVTLDGKSVDYHTGSVFWGEPGTNGQHSFYQLIHQGTHLIPCD
FIAFAESLNPVGRHQDLLFANVIAQAEALAMGKTLTEVQKEGVSAELAPHKVMKGNQPSSLLFAKRLTPTSLGALVALYE
HSVFTQATIWDINPFDQWGVELGKRLASRIAEEIETPDVTLAHDASTNASIRWYCYMRGQNNSQEKQEKRCVLALDVGGS
NVKARISGEKLKIKIPSGSDMTPELMLTQLDKCLHGWHYDAVSVGFPALVVHGRIANEPANLGTGWVGFDFAKAFSCPVR
IMNDAAMQALGSYEGGYMLFLGLGTGLGSAVIVDGRIEPMELAHLPYKQHTYEYYVGKHALQRLGKRKWRAEVFAEVEML
RIALEPDYIVLGGGNARLLKKLPTGVRRGKNANAFTGGFRLWEDEYE

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=531, Percent_Identity=48.5875706214689, Blast_Score=517, Evalue=1e-146,
Organism=Homo sapiens, GI296080693, Length=531, Percent_Identity=45.3860640301318, Blast_Score=460, Evalue=1e-129,
Organism=Escherichia coli, GI1790457, Length=544, Percent_Identity=50.9191176470588, Blast_Score=558, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71996708, Length=525, Percent_Identity=49.9047619047619, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71996703, Length=525, Percent_Identity=49.9047619047619, Blast_Score=506, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6319673, Length=538, Percent_Identity=50.9293680297398, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24651916, Length=550, Percent_Identity=49.2727272727273, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24651914, Length=550, Percent_Identity=49.2727272727273, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17737445, Length=550, Percent_Identity=49.2727272727273, Blast_Score=528, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 85263; Mature: 85132

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLRETGVWKALHSHYLSFQRIQLRGLFARDKKRAERYTVEAAGWRLDYSKHRINDKTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEECHHHHCCHHHH
KLLFELARECSLESRRDAMFSGKEVNTTEQRAALHIALRAPADSVINVAGVNVVPEVQAI
HHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHEEEEEEEECCCCHHEEECCCCCCHHHHHH
LKRMAECAELIRAGEWKGYSGRPIRNIVNIGIGGSDLGPVMACGALCHYGERKLRLRFVS
HHHHHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
NVDGTDFVEAVHGLRPDETLFIIASKTFTTLETMTNAHTARHWLQTAAGRDRKAITPHFV
CCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
ALSTNEKAVNDFGIPSKQMFGFQEWVGGRYSMDSAIGLSIMIAIGPEAFCEMLAGFHAMD
EEECCCCHHHHCCCCHHHHCCHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHH
EHFRSAPLEQNLPVIMGLLNVWYADFFDAGTVAVLPYAHSLKRFPAYLQQLTMESNGKHV
HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEE
TLDGKSVDYHTGSVFWGEPGTNGQHSFYQLIHQGTHLIPCDFIAFAESLNPVGRHQDLLF
EECCCEEEEECCEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHH
ANVIAQAEALAMGKTLTEVQKEGVSAELAPHKVMKGNQPSSLLFAKRLTPTSLGALVALY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHEECCCCCHHHHHHHHHH
EHSVFTQATIWDINPFDQWGVELGKRLASRIAEEIETPDVTLAHDASTNASIRWYCYMRG
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEC
QNNSQEKQEKRCVLALDVGGSNVKARISGEKLKIKIPSGSDMTPELMLTQLDKCLHGWHY
CCCCHHHHHCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCC
DAVSVGFPALVVHGRIANEPANLGTGWVGFDFAKAFSCPVRIMNDAAMQALGSYEGGYML
CHHHCCCCEEEEECEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEE
FLGLGTGLGSAVIVDGRIEPMELAHLPYKQHTYEYYVGKHALQRLGKRKWRAEVFAEVEM
EEEECCCCCCEEEECCCCCCHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRIALEPDYIVLGGGNARLLKKLPTGVRRGKNANAFTGGFRLWEDEYE
HEEEECCCEEEEECCCHHHHHHCCHHHHCCCCCCEEECCEEECCCCCC
>Mature Secondary Structure 
STLRETGVWKALHSHYLSFQRIQLRGLFARDKKRAERYTVEAAGWRLDYSKHRINDKTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEECHHHHCCHHHH
KLLFELARECSLESRRDAMFSGKEVNTTEQRAALHIALRAPADSVINVAGVNVVPEVQAI
HHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHEEEEEEEECCCCHHEEECCCCCCHHHHHH
LKRMAECAELIRAGEWKGYSGRPIRNIVNIGIGGSDLGPVMACGALCHYGERKLRLRFVS
HHHHHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
NVDGTDFVEAVHGLRPDETLFIIASKTFTTLETMTNAHTARHWLQTAAGRDRKAITPHFV
CCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
ALSTNEKAVNDFGIPSKQMFGFQEWVGGRYSMDSAIGLSIMIAIGPEAFCEMLAGFHAMD
EEECCCCHHHHCCCCHHHHCCHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHH
EHFRSAPLEQNLPVIMGLLNVWYADFFDAGTVAVLPYAHSLKRFPAYLQQLTMESNGKHV
HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEE
TLDGKSVDYHTGSVFWGEPGTNGQHSFYQLIHQGTHLIPCDFIAFAESLNPVGRHQDLLF
EECCCEEEEECCEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHH
ANVIAQAEALAMGKTLTEVQKEGVSAELAPHKVMKGNQPSSLLFAKRLTPTSLGALVALY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHEECCCCCHHHHHHHHHH
EHSVFTQATIWDINPFDQWGVELGKRLASRIAEEIETPDVTLAHDASTNASIRWYCYMRG
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEC
QNNSQEKQEKRCVLALDVGGSNVKARISGEKLKIKIPSGSDMTPELMLTQLDKCLHGWHY
CCCCHHHHHCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCC
DAVSVGFPALVVHGRIANEPANLGTGWVGFDFAKAFSCPVRIMNDAAMQALGSYEGGYML
CHHHCCCCEEEEECEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEE
FLGLGTGLGSAVIVDGRIEPMELAHLPYKQHTYEYYVGKHALQRLGKRKWRAEVFAEVEM
EEEECCCCCCEEEECCCCCCHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRIALEPDYIVLGGGNARLLKKLPTGVRRGKNANAFTGGFRLWEDEYE
HEEEECCCEEEEECCCHHHHHHCCHHHHCCCCCCEEECCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA