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The map label for this gene is zwf [H]

Identifier: 114332383

GI number: 114332383

Start: 2543292

End: 2544734

Strand: Reverse

Name: zwf [H]

Synonym: Neut_2431

Alternate gene names: 114332383

Gene position: 2544734-2543292 (Counterclockwise)

Preceding gene: 114332384

Following gene: 114332381

Centisome position: 95.63

GC content: 50.87

Gene sequence:

>1443_bases
GTGTCTGATACAAACCTTGTGATTCTTGGTGCAACCGGAGACTTGACGCAACGTTTGCTCATGCCGGCATTGTATCGCCT
GCACCAGTCGGGATATACGCGGGATCTTAAGATTACGGGGTATGCCATTGAGGACTGGAGCAAGGAGCATTTTCGCGATC
ATATTCAAGAGGCATTACGTACATTTGTATCGGATGACAAGATTGAGGATAAACACCAGACAGAATTTTGTGCGGGCCTA
GATTACATTACCGGTAGTCTTGAAGCCGGGCAGATGAAAGAAATCGGGCGTCGCGTGAAAGGGTCGATACTTTTTTACCT
GGCGTTACCTCCACCCTTGTTCGGTGCTGCAGCTGTAGCGCTAGGTGAAGCAGGACTTGCGCAAACTACTGAAGGCTGGC
GACGTCTGGTAATCGAAAAACCTTTTGGTACTGATCTCGCCAGTGCTGAAATGTTGCGTAAACAGATTCACAGTCAATGG
GCCGAGGAAAATGTGTTGCGTATCGACCATTTCCTGGGCAAGGAAACTACGCAGAATCTGATGGTGTTCCGCTTTGCCAA
CCGTTTCCTCGAACCACTCTGGAACAGCGCGCATATTGCGCAAGTGCAGATCAGCTGCCCGGAAACGTTGGGAGTAGAGC
ATCGTGCCGCCTATTACGATCACGCAGGGGCATTACGCGACATGCTGCAAAATCACCTGATGCAATTATTTTGTCTCACC
GCTATGGAGCCGCCGTCAAGCTGGGATGCTGAAGTGTTGCGTGATCACAAAGTCGAAGTATTGCGCGCGGTAGTGCCATT
CAATGAACACACAGTGTGTAACCGAGTTGCGCGCGGCCAATATACTGCTGGCAGCATTGACAGTAAAAATGTACCTGCTT
ATCGTCAGGAATCTGGTATCCCTGTTAACTCAAATACTGAAACTTTCGCGGCACTGCGTTTCGAAATCAACAACTGGCGC
TGGCAAGGTGTTCCCTTCTACCTGCGCAGCGGCAAGCGCATGGCTAGTGATTACTCAGAGATCGCGATACAGTTCAGGCA
AGTGCCAGACGCGCTGCCTGATGGCAGCGCTGCGCCGAATAACTGGATGATATTCCGCCTGCAACCACAGGAAAGTCTCA
ATCTGGTAGCGACAGCCAAAAAGCCCGGTATGGAATTTGCCACGCACACCGTGGTACTTACTGCACCTTATGCACAAGAA
GGTGTCAGAGAATTTTCAGCGTATGAACAGTTGCTGATGGACGCAATCAATGGTAATTGTTCGCACTTCCTGCGTTTTGA
TGAGGTTGAATGGTCATGGCGCTTGCTTGATCCGGTGTTGCATGCGTGGCGCACAGGCAGTCCTGAAGAATATGCTTCCG
GCTCGGAAGGGCCGCCATCACAGAACCAGTTGCTTACAGCTGGCCACAGCTGGCGGCCAGTACAGATGCATTCGGAAAAT
TGA

Upstream 100 bases:

>100_bases
ATGAGTTTGCCGATAAGGTAATGTCTGCGATGCGCCACGGATTTGGGGGGCATGATGAAAAAACCGCTCCGGATGACAAA
TAAAAGAAAAAGGAGGAGGT

Downstream 100 bases:

>100_bases
CTATAAATGTACTTGACTGATCAGAATTCTGATCAGTCAAGTACGAATGCTATTATTGATTTATTGCATAATAAATGGGT
AAATCGGGTTGAATTTTGTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSDTNLVILGATGDLTQRLLMPALYRLHQSGYTRDLKITGYAIEDWSKEHFRDHIQEALRTFVSDDKIEDKHQTEFCAGL
DYITGSLEAGQMKEIGRRVKGSILFYLALPPPLFGAAAVALGEAGLAQTTEGWRRLVIEKPFGTDLASAEMLRKQIHSQW
AEENVLRIDHFLGKETTQNLMVFRFANRFLEPLWNSAHIAQVQISCPETLGVEHRAAYYDHAGALRDMLQNHLMQLFCLT
AMEPPSSWDAEVLRDHKVEVLRAVVPFNEHTVCNRVARGQYTAGSIDSKNVPAYRQESGIPVNSNTETFAALRFEINNWR
WQGVPFYLRSGKRMASDYSEIAIQFRQVPDALPDGSAAPNNWMIFRLQPQESLNLVATAKKPGMEFATHTVVLTAPYAQE
GVREFSAYEQLLMDAINGNCSHFLRFDEVEWSWRLLDPVLHAWRTGSPEEYASGSEGPPSQNQLLTAGHSWRPVQMHSEN

Sequences:

>Translated_480_residues
MSDTNLVILGATGDLTQRLLMPALYRLHQSGYTRDLKITGYAIEDWSKEHFRDHIQEALRTFVSDDKIEDKHQTEFCAGL
DYITGSLEAGQMKEIGRRVKGSILFYLALPPPLFGAAAVALGEAGLAQTTEGWRRLVIEKPFGTDLASAEMLRKQIHSQW
AEENVLRIDHFLGKETTQNLMVFRFANRFLEPLWNSAHIAQVQISCPETLGVEHRAAYYDHAGALRDMLQNHLMQLFCLT
AMEPPSSWDAEVLRDHKVEVLRAVVPFNEHTVCNRVARGQYTAGSIDSKNVPAYRQESGIPVNSNTETFAALRFEINNWR
WQGVPFYLRSGKRMASDYSEIAIQFRQVPDALPDGSAAPNNWMIFRLQPQESLNLVATAKKPGMEFATHTVVLTAPYAQE
GVREFSAYEQLLMDAINGNCSHFLRFDEVEWSWRLLDPVLHAWRTGSPEEYASGSEGPPSQNQLLTAGHSWRPVQMHSEN
>Mature_479_residues
SDTNLVILGATGDLTQRLLMPALYRLHQSGYTRDLKITGYAIEDWSKEHFRDHIQEALRTFVSDDKIEDKHQTEFCAGLD
YITGSLEAGQMKEIGRRVKGSILFYLALPPPLFGAAAVALGEAGLAQTTEGWRRLVIEKPFGTDLASAEMLRKQIHSQWA
EENVLRIDHFLGKETTQNLMVFRFANRFLEPLWNSAHIAQVQISCPETLGVEHRAAYYDHAGALRDMLQNHLMQLFCLTA
MEPPSSWDAEVLRDHKVEVLRAVVPFNEHTVCNRVARGQYTAGSIDSKNVPAYRQESGIPVNSNTETFAALRFEINNWRW
QGVPFYLRSGKRMASDYSEIAIQFRQVPDALPDGSAAPNNWMIFRLQPQESLNLVATAKKPGMEFATHTVVLTAPYAQEG
VREFSAYEQLLMDAINGNCSHFLRFDEVEWSWRLLDPVLHAWRTGSPEEYASGSEGPPSQNQLLTAGHSWRPVQMHSEN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=35.4508196721311, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=35.4508196721311, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI52145310, Length=498, Percent_Identity=27.9116465863454, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1788158, Length=484, Percent_Identity=38.0165289256198, Blast_Score=328, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=36.9609856262834, Blast_Score=295, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=476, Percent_Identity=37.1848739495798, Blast_Score=289, Evalue=8e-79,
Organism=Drosophila melanogaster, GI24643350, Length=469, Percent_Identity=34.5415778251599, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI24643352, Length=469, Percent_Identity=34.5415778251599, Blast_Score=274, Evalue=8e-74,
Organism=Drosophila melanogaster, GI221513548, Length=472, Percent_Identity=27.7542372881356, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54306; Mature: 54175

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTNLVILGATGDLTQRLLMPALYRLHQSGYTRDLKITGYAIEDWSKEHFRDHIQEALR
CCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHCCHHHHHHHHHHHHH
TFVSDDKIEDKHQTEFCAGLDYITGSLEAGQMKEIGRRVKGSILFYLALPPPLFGAAAVA
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
LGEAGLAQTTEGWRRLVIEKPFGTDLASAEMLRKQIHSQWAEENVLRIDHFLGKETTQNL
HCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHH
MVFRFANRFLEPLWNSAHIAQVQISCPETLGVEHRAAYYDHAGALRDMLQNHLMQLFCLT
HHHHHHHHHHHHHCCCCEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMEPPSSWDAEVLRDHKVEVLRAVVPFNEHTVCNRVARGQYTAGSIDSKNVPAYRQESGI
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC
PVNSNTETFAALRFEINNWRWQGVPFYLRSGKRMASDYSEIAIQFRQVPDALPDGSAAPN
CCCCCCCEEEEEEEEECCEEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NWMIFRLQPQESLNLVATAKKPGMEFATHTVVLTAPYAQEGVREFSAYEQLLMDAINGNC
CEEEEEECCCCCCCEEEECCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCH
SHFLRFDEVEWSWRLLDPVLHAWRTGSPEEYASGSEGPPSQNQLLTAGHSWRPVQMHSEN
HHEEEECCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCEEECCCCCCCEEECCCC
>Mature Secondary Structure 
SDTNLVILGATGDLTQRLLMPALYRLHQSGYTRDLKITGYAIEDWSKEHFRDHIQEALR
CCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHCCHHHHHHHHHHHHH
TFVSDDKIEDKHQTEFCAGLDYITGSLEAGQMKEIGRRVKGSILFYLALPPPLFGAAAVA
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
LGEAGLAQTTEGWRRLVIEKPFGTDLASAEMLRKQIHSQWAEENVLRIDHFLGKETTQNL
HCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHH
MVFRFANRFLEPLWNSAHIAQVQISCPETLGVEHRAAYYDHAGALRDMLQNHLMQLFCLT
HHHHHHHHHHHHHCCCCEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMEPPSSWDAEVLRDHKVEVLRAVVPFNEHTVCNRVARGQYTAGSIDSKNVPAYRQESGI
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC
PVNSNTETFAALRFEINNWRWQGVPFYLRSGKRMASDYSEIAIQFRQVPDALPDGSAAPN
CCCCCCCEEEEEEEEECCEEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NWMIFRLQPQESLNLVATAKKPGMEFATHTVVLTAPYAQEGVREFSAYEQLLMDAINGNC
CEEEEEECCCCCCCEEEECCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCH
SHFLRFDEVEWSWRLLDPVLHAWRTGSPEEYASGSEGPPSQNQLLTAGHSWRPVQMHSEN
HHEEEECCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCEEECCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]