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The map label for this gene is bioC [H]

Identifier: 114332100

GI number: 114332100

Start: 2264288

End: 2265184

Strand: Reverse

Name: bioC [H]

Synonym: Neut_2135

Alternate gene names: 114332100

Gene position: 2265184-2264288 (Counterclockwise)

Preceding gene: 114332101

Following gene: 114332099

Centisome position: 85.12

GC content: 50.84

Gene sequence:

>897_bases
ATGCTTTATGATCATGTACTCGACAAGCGCATGTTGCGCCGGTCATTTGAACAGGCGGCGACCAGTTATGACCAGTCTGC
CGTACTGCAGCGGGAAATATGCGACCGTATGTTGTCACGCCTGGAATATATCAAATATGTTCCCGGCAAAATTATCGATG
CAGGCAGTGGAACCGGTTACGGTACGCGCAAGCTGATCGAACGCTATCCTGCGGCAGAAATCATGTCGATGGATATTGCG
CTGACGATGCATGATCGTGCACGTGCAGCCATGCTGGAGAAAATACCTGGTTGGCAGCGCTGGCTACCATTCAAGCATCA
TCAACCCAGAGGCTATATCTGCGCAGACATAGAACAGTTGCCCCTGCGCGAAGCCAGCGTTGGCATGATCTGGTCCAACC
TTGCATTCCAGTGGTGTAATGATCTCAGGCAGACATTTGCAGAAGCGCATCGCGTACTGGAGGATGGTGGTTTGTTGATG
TTCAGCACGTTTGGGCCGGATACACTGAAGGAATTACGGCAAGCCTTCAAGTCAGTGGATCCGTTTAGTCATGTCAATCG
TTTTACGGATATGCATGATGTGGGTGATATGCTGGTGGGTTGTGGCTTTTCATTGCCGGTGATGGATATGGAATATATTA
CATTGACCTACGATGATGTCAAAAGCGCTATGCAGGATCTCAAAGCAATTGGTGCCCGCAATGTGACACAAGGGCGCAGA
CGCGGCTTGATGGGCAAGACGACATGGCAGCAAGTGATCAATCAATATGAAACCTTGCGCAAGGATGGCAGGCTGCCAGC
AACCTACGAAGTAGTTTATGGTCACGCCTGGAAACCGGAGATACGTAAAGTTCAGCTAAAGCCGGAGACGCGGCGCAAGC
TGGGGCTGGATCCGTAA

Upstream 100 bases:

>100_bases
TGGACGCAGCAGCACTTGTCCCAGGCGCAATTGAAGCTGTTTCCTCATTGCGGCCACGCGCCGTTTCTTTCTTTTCCTGA
GCAATTTGTGGGTTGTTTCG

Downstream 100 bases:

>100_bases
TAATGGCAACAGGATTCTTTGTAACGGGTACGGATACCGGAATTGGTAAAACTACAGTGAGTTGTGCGCTGTTGCATGCG
TTTTCGACGAATGGCTATAC

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLYDHVLDKRMLRRSFEQAATSYDQSAVLQREICDRMLSRLEYIKYVPGKIIDAGSGTGYGTRKLIERYPAAEIMSMDIA
LTMHDRARAAMLEKIPGWQRWLPFKHHQPRGYICADIEQLPLREASVGMIWSNLAFQWCNDLRQTFAEAHRVLEDGGLLM
FSTFGPDTLKELRQAFKSVDPFSHVNRFTDMHDVGDMLVGCGFSLPVMDMEYITLTYDDVKSAMQDLKAIGARNVTQGRR
RGLMGKTTWQQVINQYETLRKDGRLPATYEVVYGHAWKPEIRKVQLKPETRRKLGLDP

Sequences:

>Translated_298_residues
MLYDHVLDKRMLRRSFEQAATSYDQSAVLQREICDRMLSRLEYIKYVPGKIIDAGSGTGYGTRKLIERYPAAEIMSMDIA
LTMHDRARAAMLEKIPGWQRWLPFKHHQPRGYICADIEQLPLREASVGMIWSNLAFQWCNDLRQTFAEAHRVLEDGGLLM
FSTFGPDTLKELRQAFKSVDPFSHVNRFTDMHDVGDMLVGCGFSLPVMDMEYITLTYDDVKSAMQDLKAIGARNVTQGRR
RGLMGKTTWQQVINQYETLRKDGRLPATYEVVYGHAWKPEIRKVQLKPETRRKLGLDP
>Mature_298_residues
MLYDHVLDKRMLRRSFEQAATSYDQSAVLQREICDRMLSRLEYIKYVPGKIIDAGSGTGYGTRKLIERYPAAEIMSMDIA
LTMHDRARAAMLEKIPGWQRWLPFKHHQPRGYICADIEQLPLREASVGMIWSNLAFQWCNDLRQTFAEAHRVLEDGGLLM
FSTFGPDTLKELRQAFKSVDPFSHVNRFTDMHDVGDMLVGCGFSLPVMDMEYITLTYDDVKSAMQDLKAIGARNVTQGRR
RGLMGKTTWQQVINQYETLRKDGRLPATYEVVYGHAWKPEIRKVQLKPETRRKLGLDP

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=296, Percent_Identity=25.6756756756757, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI86792933, Length=196, Percent_Identity=29.5918367346939, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786994, Length=252, Percent_Identity=32.9365079365079, Blast_Score=131, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17535003, Length=285, Percent_Identity=23.5087719298246, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922210, Length=287, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 34398; Mature: 34398

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYDHVLDKRMLRRSFEQAATSYDQSAVLQREICDRMLSRLEYIKYVPGKIIDAGSGTGY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
GTRKLIERYPAAEIMSMDIALTMHDRARAAMLEKIPGWQRWLPFKHHQPRGYICADIEQL
HHHHHHHHCCHHHHHHHHHEEEEHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEECCHHHC
PLREASVGMIWSNLAFQWCNDLRQTFAEAHRVLEDGGLLMFSTFGPDTLKELRQAFKSVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCC
PFSHVNRFTDMHDVGDMLVGCGFSLPVMDMEYITLTYDDVKSAMQDLKAIGARNVTQGRR
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHH
RGLMGKTTWQQVINQYETLRKDGRLPATYEVVYGHAWKPEIRKVQLKPETRRKLGLDP
CCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCHHHHCCCCCC
>Mature Secondary Structure
MLYDHVLDKRMLRRSFEQAATSYDQSAVLQREICDRMLSRLEYIKYVPGKIIDAGSGTGY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
GTRKLIERYPAAEIMSMDIALTMHDRARAAMLEKIPGWQRWLPFKHHQPRGYICADIEQL
HHHHHHHHCCHHHHHHHHHEEEEHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEECCHHHC
PLREASVGMIWSNLAFQWCNDLRQTFAEAHRVLEDGGLLMFSTFGPDTLKELRQAFKSVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCC
PFSHVNRFTDMHDVGDMLVGCGFSLPVMDMEYITLTYDDVKSAMQDLKAIGARNVTQGRR
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHH
RGLMGKTTWQQVINQYETLRKDGRLPATYEVVYGHAWKPEIRKVQLKPETRRKLGLDP
CCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]