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The map label for this gene is gph [C]

Identifier: 114332062

GI number: 114332062

Start: 2220822

End: 2221544

Strand: Direct

Name: gph [C]

Synonym: Neut_2097

Alternate gene names: 114332062

Gene position: 2220822-2221544 (Clockwise)

Preceding gene: 114332061

Following gene: 114332063

Centisome position: 83.46

GC content: 51.18

Gene sequence:

>723_bases
ATGACCCAATCTAACATACAACCGTCCAATCGAACCTCGTTTCCGATTCCACTTAAAGCTGTCATCATTGATCTGGATGG
CACTCTGCTTGACACTGCCCAGGATCTCGCGCTAGCGGCCAATGCGATGCTGCGCGAGCTACACATGGCAGAACTGCCGC
TATCCACCATACAAAGTTTTATTGGCAAAGGAGTCCCCAAGCTGGTTAAACGCACGCTTACCAACAGCCCGGATGATGAG
CCGGATCCCGCACTGTTCGAGCAGGCATTGCCGATATACGAACGTTGCTACGCAGAGAACTTGCATGTGTATACACGCCC
CTATCCTGGCGTCATCGAGGGACTCGAACAGCTCAAGCAGAGTGGATTTCGCCTGATTTGCATTACCAATAAAACAGAAA
TCTTTACACTCCCGCTGTTACACAAAACCGGGCTGCGGGATTACTTTGAACTGGTACTGTCCGGTGACAGCCTCCCGAAA
AGAAAGCCGGATCCGCTGCCACTACTGCATGCCTGCAAACATTTTAGTGTTTTACCCAACGCAGCGCTGCTGATCGGTGA
TTCATCCAACGATGCTATTGCCGCACGCGCGGCAGGCTGCCATATCTTCTGTGTACCCTATGGATACAATGAAGGGCATG
ATGTGCACAAACTCGATTGTGACGCGGTTGTTAATTCGATCGTTGAAGCAAACAGTCTGATTACCTGCCAGCGCGATGCC
TGA

Upstream 100 bases:

>100_bases
TTTACAGTGCAGGTAAAGACAGCGATCCTCATCGCTACGATAGCGTTATCGCTGCCATGCGGGCCGAATTAGCAAAAGTT
ACCTGACCAGGAACCAACAT

Downstream 100 bases:

>100_bases
CTGGCAATGAAACACATAAAGCTATACCGGCTTGTCACCGTGATAAACATGCAACAGCCGGTATAACCTCATTCCATCAC
TTTACCATTTTAGTAACACT

Product: phosphoglycolate phosphatase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTQSNIQPSNRTSFPIPLKAVIIDLDGTLLDTAQDLALAANAMLRELHMAELPLSTIQSFIGKGVPKLVKRTLTNSPDDE
PDPALFEQALPIYERCYAENLHVYTRPYPGVIEGLEQLKQSGFRLICITNKTEIFTLPLLHKTGLRDYFELVLSGDSLPK
RKPDPLPLLHACKHFSVLPNAALLIGDSSNDAIAARAAGCHIFCVPYGYNEGHDVHKLDCDAVVNSIVEANSLITCQRDA

Sequences:

>Translated_240_residues
MTQSNIQPSNRTSFPIPLKAVIIDLDGTLLDTAQDLALAANAMLRELHMAELPLSTIQSFIGKGVPKLVKRTLTNSPDDE
PDPALFEQALPIYERCYAENLHVYTRPYPGVIEGLEQLKQSGFRLICITNKTEIFTLPLLHKTGLRDYFELVLSGDSLPK
RKPDPLPLLHACKHFSVLPNAALLIGDSSNDAIAARAAGCHIFCVPYGYNEGHDVHKLDCDAVVNSIVEANSLITCQRDA
>Mature_239_residues
TQSNIQPSNRTSFPIPLKAVIIDLDGTLLDTAQDLALAANAMLRELHMAELPLSTIQSFIGKGVPKLVKRTLTNSPDDEP
DPALFEQALPIYERCYAENLHVYTRPYPGVIEGLEQLKQSGFRLICITNKTEIFTLPLLHKTGLRDYFELVLSGDSLPKR
KPDPLPLLHACKHFSVLPNAALLIGDSSNDAIAARAAGCHIFCVPYGYNEGHDVHKLDCDAVVNSIVEANSLITCQRDA

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1789787, Length=228, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 26387; Mature: 26255

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSNIQPSNRTSFPIPLKAVIIDLDGTLLDTAQDLALAANAMLRELHMAELPLSTIQSF
CCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IGKGVPKLVKRTLTNSPDDEPDPALFEQALPIYERCYAENLHVYTRPYPGVIEGLEQLKQ
HCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHH
SGFRLICITNKTEIFTLPLLHKTGLRDYFELVLSGDSLPKRKPDPLPLLHACKHFSVLPN
CCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
AALLIGDSSNDAIAARAAGCHIFCVPYGYNEGHDVHKLDCDAVVNSIVEANSLITCQRDA
CEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
TQSNIQPSNRTSFPIPLKAVIIDLDGTLLDTAQDLALAANAMLRELHMAELPLSTIQSF
CCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IGKGVPKLVKRTLTNSPDDEPDPALFEQALPIYERCYAENLHVYTRPYPGVIEGLEQLKQ
HCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHH
SGFRLICITNKTEIFTLPLLHKTGLRDYFELVLSGDSLPKRKPDPLPLLHACKHFSVLPN
CCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
AALLIGDSSNDAIAARAAGCHIFCVPYGYNEGHDVHKLDCDAVVNSIVEANSLITCQRDA
CEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA