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The map label for this gene is glcD [H]

Identifier: 114331857

GI number: 114331857

Start: 1996570

End: 1998024

Strand: Direct

Name: glcD [H]

Synonym: Neut_1882

Alternate gene names: 114331857

Gene position: 1996570-1998024 (Clockwise)

Preceding gene: 114331856

Following gene: 114331858

Centisome position: 75.03

GC content: 53.06

Gene sequence:

>1455_bases
ATGAATCGTAAGCAACTGATTACAGCCTTTCTGAAGTTTCTGCCTGAAGAAGCGATACTTTACGAGGCGGAAGATTTAAG
GCCGTATGAATGTGATGCCCTGTCCGCCTACCGGCAGATGCCCATGATTGTCGTGCTGCCGCGCACAGAAGCTGAAATTG
CCGCTATCCTGCAAATCTGTCATGCTGGACAGGTTCCGGTCGTAGCACGCGGCTCCGGCACCGGTCTGTCCGGTGGAGCA
CTACCTCACGCAGAAGGCGTTTTGCTGTCATTGGCCAAACTGAACCGCATTCTGGATATCGATCCTGCTGCCTGCACTGC
ACGTGTTCAACCTGGTGTGCGTAACCTGGCTATCAGCGAAGCCGCTGCAAGCTATGAAATGTATTACGCACCCGATCCTT
CCTCACAGATCGCCTGTAGTATTGGTGGAAATGTGGCGGAAAACTCCGGGGGGGTGCACTGCCTCAAATATGGACTCACC
GTTCATAATATTTTGCGCTTGCGTGTACTGACAATTGAAGGTGACGTGCTGGAAATCGGTGCTGACGCACTCGATAGCCC
CGGTTTTGATTTGCTTGCTCTGATGACAGGCAGCGAAGGCATGCTGGGTATTGTCACCGAAATCACGGTAAAACTGCTTC
CCAAACCGGAAACAGTGAAACTGGTCATGGCCGTGTTCGACGATATCAGCAAAGCCGGGGATGCTGTCGCCAACGTCATT
CAGGCAGGTATTATTCCGGCCGGTATGGAGATGATGGATAAAATTACCATCCACGCCGTTGAGGATTTCGTACACGCAGG
CTACGATCTTGAAGGTGCAGCGATTTTGCTGTGCGAATCTGACGGCATGGCGGAAGAAGTAGCCGATGAAATCAAACAGA
TCCAGACCATTCTGCAAGCCAGTGGCGCTGTCCGGATCAGCCTTGCGCGAGATGAAGCCGAACGGCAGCTTTTCTGGGCC
GGACGGAAAGCCGCCTTTCCGGCAGCCGGCCGGGTTTCACCGGATTACTACTGTATGGACGGCACCATTCCACGCAAGCA
TTTGGCACATGTGCTGGAACAAATTGAGCAACTTTCAGCTGAATACGGTCTGCGCTGCATGAATGTGTTTCACGCGGGAG
ACGGTAATCTGCACCCGCTGATTCTGTACGACGCCAATCAACTGGGCGAACTGGAGAAAGCAGAAGCCTTTGGCGCACGC
ATACTGGAAATCTGCATTCAATCCGGCGGATCATTGACCGGCGAACACGGTGTAGGCATCGAAAAACTCAACCAGATGTG
CCTACAATTCAATGATGCCGAACGTGATCTGTTCCATGCGGTCAAGGCGGCATTCGATCCGCAATCGCTGCTCAATCCAG
GCAAAGCCATTCCCGAACTGCACCGTTGCGCCGAATTCGGGGCGATGCATGTCCATCGAGGCGCTGAAAAATTTCCAGAC
ATACCCAGGTTCTAA

Upstream 100 bases:

>100_bases
TGCGTTGCACAGGAAGACACGATGCTGGATAGCTCAGTCATCGTGCGTATCCTCGAAAAATTGGCCGGACATACTATCAA
TCCATCCACAGCAACCTCTC

Downstream 100 bases:

>100_bases
TCAGACATACCCAAGTTCTAATTTATGCAAGATCAAACCATTCTCGATCAGCTCATCCAGACCGTTACAGAAGCAGCCGA
ATATAAACAGGCGTTATGCA

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MNRKQLITAFLKFLPEEAILYEAEDLRPYECDALSAYRQMPMIVVLPRTEAEIAAILQICHAGQVPVVARGSGTGLSGGA
LPHAEGVLLSLAKLNRILDIDPAACTARVQPGVRNLAISEAAASYEMYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLT
VHNILRLRVLTIEGDVLEIGADALDSPGFDLLALMTGSEGMLGIVTEITVKLLPKPETVKLVMAVFDDISKAGDAVANVI
QAGIIPAGMEMMDKITIHAVEDFVHAGYDLEGAAILLCESDGMAEEVADEIKQIQTILQASGAVRISLARDEAERQLFWA
GRKAAFPAAGRVSPDYYCMDGTIPRKHLAHVLEQIEQLSAEYGLRCMNVFHAGDGNLHPLILYDANQLGELEKAEAFGAR
ILEICIQSGGSLTGEHGVGIEKLNQMCLQFNDAERDLFHAVKAAFDPQSLLNPGKAIPELHRCAEFGAMHVHRGAEKFPD
IPRF

Sequences:

>Translated_484_residues
MNRKQLITAFLKFLPEEAILYEAEDLRPYECDALSAYRQMPMIVVLPRTEAEIAAILQICHAGQVPVVARGSGTGLSGGA
LPHAEGVLLSLAKLNRILDIDPAACTARVQPGVRNLAISEAAASYEMYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLT
VHNILRLRVLTIEGDVLEIGADALDSPGFDLLALMTGSEGMLGIVTEITVKLLPKPETVKLVMAVFDDISKAGDAVANVI
QAGIIPAGMEMMDKITIHAVEDFVHAGYDLEGAAILLCESDGMAEEVADEIKQIQTILQASGAVRISLARDEAERQLFWA
GRKAAFPAAGRVSPDYYCMDGTIPRKHLAHVLEQIEQLSAEYGLRCMNVFHAGDGNLHPLILYDANQLGELEKAEAFGAR
ILEICIQSGGSLTGEHGVGIEKLNQMCLQFNDAERDLFHAVKAAFDPQSLLNPGKAIPELHRCAEFGAMHVHRGAEKFPD
IPRF
>Mature_484_residues
MNRKQLITAFLKFLPEEAILYEAEDLRPYECDALSAYRQMPMIVVLPRTEAEIAAILQICHAGQVPVVARGSGTGLSGGA
LPHAEGVLLSLAKLNRILDIDPAACTARVQPGVRNLAISEAAASYEMYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLT
VHNILRLRVLTIEGDVLEIGADALDSPGFDLLALMTGSEGMLGIVTEITVKLLPKPETVKLVMAVFDDISKAGDAVANVI
QAGIIPAGMEMMDKITIHAVEDFVHAGYDLEGAAILLCESDGMAEEVADEIKQIQTILQASGAVRISLARDEAERQLFWA
GRKAAFPAAGRVSPDYYCMDGTIPRKHLAHVLEQIEQLSAEYGLRCMNVFHAGDGNLHPLILYDANQLGELEKAEAFGAR
ILEICIQSGGSLTGEHGVGIEKLNQMCLQFNDAERDLFHAVKAAFDPQSLLNPGKAIPELHRCAEFGAMHVHRGAEKFPD
IPRF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=423, Percent_Identity=27.8959810874704, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI37595754, Length=446, Percent_Identity=27.1300448430493, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI119964728, Length=463, Percent_Identity=27.645788336933, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI4501993, Length=460, Percent_Identity=21.304347826087, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789351, Length=484, Percent_Identity=62.1900826446281, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1787977, Length=503, Percent_Identity=22.8628230616302, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI48994907, Length=446, Percent_Identity=22.4215246636771, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71992373, Length=473, Percent_Identity=27.906976744186, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71992381, Length=429, Percent_Identity=27.039627039627, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71992392, Length=359, Percent_Identity=28.4122562674095, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17534361, Length=464, Percent_Identity=26.7241379310345, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17556096, Length=220, Percent_Identity=26.3636363636364, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320027, Length=433, Percent_Identity=28.6374133949192, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6320023, Length=479, Percent_Identity=29.6450939457203, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320764, Length=472, Percent_Identity=26.4830508474576, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI18921117, Length=461, Percent_Identity=25.3796095444685, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639277, Length=461, Percent_Identity=25.3796095444685, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639275, Length=461, Percent_Identity=25.3796095444685, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653753, Length=462, Percent_Identity=21.2121212121212, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52160; Mature: 52160

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKQLITAFLKFLPEEAILYEAEDLRPYECDALSAYRQMPMIVVLPRTEAEIAAILQIC
CCHHHHHHHHHHHCCCHHEEEECCCCCCCCCHHHHHHHHCCEEEEECCCHHHHHHHHHHH
HAGQVPVVARGSGTGLSGGALPHAEGVLLSLAKLNRILDIDPAACTARVQPGVRNLAISE
CCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHHH
AAASYEMYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLTVHNILRLRVLTIEGDVLEIG
HHHCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHEEEEEEEEEECCEEEEC
ADALDSPGFDLLALMTGSEGMLGIVTEITVKLLPKPETVKLVMAVFDDISKAGDAVANVI
CHHCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QAGIIPAGMEMMDKITIHAVEDFVHAGYDLEGAAILLCESDGMAEEVADEIKQIQTILQA
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHC
SGAVRISLARDEAERQLFWAGRKAAFPAAGRVSPDYYCMDGTIPRKHLAHVLEQIEQLSA
CCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
EYGLRCMNVFHAGDGNLHPLILYDANQLGELEKAEAFGARILEICIQSGGSLTGEHGVGI
HHCCEEEEEEECCCCCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EKLNQMCLQFNDAERDLFHAVKAAFDPQSLLNPGKAIPELHRCAEFGAMHVHRGAEKFPD
HHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCHHHHCCHHHCCC
IPRF
CCCC
>Mature Secondary Structure
MNRKQLITAFLKFLPEEAILYEAEDLRPYECDALSAYRQMPMIVVLPRTEAEIAAILQIC
CCHHHHHHHHHHHCCCHHEEEECCCCCCCCCHHHHHHHHCCEEEEECCCHHHHHHHHHHH
HAGQVPVVARGSGTGLSGGALPHAEGVLLSLAKLNRILDIDPAACTARVQPGVRNLAISE
CCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHHH
AAASYEMYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLTVHNILRLRVLTIEGDVLEIG
HHHCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHEEEEEEEEEECCEEEEC
ADALDSPGFDLLALMTGSEGMLGIVTEITVKLLPKPETVKLVMAVFDDISKAGDAVANVI
CHHCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QAGIIPAGMEMMDKITIHAVEDFVHAGYDLEGAAILLCESDGMAEEVADEIKQIQTILQA
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHC
SGAVRISLARDEAERQLFWAGRKAAFPAAGRVSPDYYCMDGTIPRKHLAHVLEQIEQLSA
CCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
EYGLRCMNVFHAGDGNLHPLILYDANQLGELEKAEAFGARILEICIQSGGSLTGEHGVGI
HHCCEEEEEEECCCCCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EKLNQMCLQFNDAERDLFHAVKAAFDPQSLLNPGKAIPELHRCAEFGAMHVHRGAEKFPD
HHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCHHHHCCHHHCCC
IPRF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]