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The map label for this gene is glxR [H]

Identifier: 114331856

GI number: 114331856

Start: 1995660

End: 1996580

Strand: Direct

Name: glxR [H]

Synonym: Neut_1881

Alternate gene names: 114331856

Gene position: 1995660-1996580 (Clockwise)

Preceding gene: 114331852

Following gene: 114331857

Centisome position: 75.0

GC content: 52.77

Gene sequence:

>921_bases
ATGAAAAATATCGGTTTTATTGGTCTGGGTATCATGGGAAAACCCATGGTCAGCCATCTTATCCGGGGAGGCTACCCGGC
TTATCTCCATTCCCGCAGTGGCGTGCCCGATGAGTTGACAGCCCTGGGTGGAATTGCTTGTCCTACACCCAAGGCTGTCG
CAGAGCAGACGGATATCATTATTCTGATGTTACCGGATACGCCGGATGTCGAAAAAGTGCTGTTTGCTGAAAACGGTGTC
ATGTCGGGCCTGTCCGCAGATCCAGCCCGATCGAAAATTATCATCGACATGAGTACGATTTCACCAATTAGAACCCGTGA
TTTCGTCAGACGAATCAACCAATCCGGGCATGATTATGCAGATGCCCCCGTATCAGGTGGCGATATCGGCGCCCGGAACG
CCGCGCTAACCATCATGATCGGCGCAACTGAACCGGTTTTTGCAAGAATCAAACCCATCCTGGCGTTAATGGGAAAAACC
GTCACCCGCATCGGCGAGCCAGGTACTGGACAGATCTGCAAGGCAGCCAATCAGATCATTTCCGCCCTGACGCTTGAAGC
AGTGGCCGAAGCGCTGGTATTTGCTTCCAAGGCCGGGGCGGATCCAAACAAGGTCAGACAAGCGTTGCTGGGTGGATTTG
CTGCTTCACGCATTCTGGAAGTACACGGGGAACGTATGCTCAAACATGCCTTCACACCTGGCTTTCGCGTCGATTTGCAT
ATGAAGGATCTGGGGATTGCGCTGGATTGCGCTACGGAGCTGGGCGTCAGCCTGCCGGGTACTGCGCTGACTCAATCGCT
TTATAACGCCTGCGTTGCACAGGAAGACACGATGCTGGATAGCTCAGTCATCGTGCGTATCCTCGAAAAATTGGCCGGAC
ATACTATCAATCCATCCACAGCAACCTCTCATGAATCGTAA

Upstream 100 bases:

>100_bases
CAGACAAATCCGGATGAACCAGCCGGCAAGCAGTTTACCTGTTTTGCCGGAATCACTTAATCGCAGATAAAGACCCATTT
TCTCAGTCACACTGTTCAAC

Downstream 100 bases:

>100_bases
GCAACTGATTACAGCCTTTCTGAAGTTTCTGCCTGAAGAAGCGATACTTTACGAGGCGGAAGATTTAAGGCCGTATGAAT
GTGATGCCCTGTCCGCCTAC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKNIGFIGLGIMGKPMVSHLIRGGYPAYLHSRSGVPDELTALGGIACPTPKAVAEQTDIIILMLPDTPDVEKVLFAENGV
MSGLSADPARSKIIIDMSTISPIRTRDFVRRINQSGHDYADAPVSGGDIGARNAALTIMIGATEPVFARIKPILALMGKT
VTRIGEPGTGQICKAANQIISALTLEAVAEALVFASKAGADPNKVRQALLGGFAASRILEVHGERMLKHAFTPGFRVDLH
MKDLGIALDCATELGVSLPGTALTQSLYNACVAQEDTMLDSSVIVRILEKLAGHTINPSTATSHES

Sequences:

>Translated_306_residues
MKNIGFIGLGIMGKPMVSHLIRGGYPAYLHSRSGVPDELTALGGIACPTPKAVAEQTDIIILMLPDTPDVEKVLFAENGV
MSGLSADPARSKIIIDMSTISPIRTRDFVRRINQSGHDYADAPVSGGDIGARNAALTIMIGATEPVFARIKPILALMGKT
VTRIGEPGTGQICKAANQIISALTLEAVAEALVFASKAGADPNKVRQALLGGFAASRILEVHGERMLKHAFTPGFRVDLH
MKDLGIALDCATELGVSLPGTALTQSLYNACVAQEDTMLDSSVIVRILEKLAGHTINPSTATSHES
>Mature_306_residues
MKNIGFIGLGIMGKPMVSHLIRGGYPAYLHSRSGVPDELTALGGIACPTPKAVAEQTDIIILMLPDTPDVEKVLFAENGV
MSGLSADPARSKIIIDMSTISPIRTRDFVRRINQSGHDYADAPVSGGDIGARNAALTIMIGATEPVFARIKPILALMGKT
VTRIGEPGTGQICKAANQIISALTLEAVAEALVFASKAGADPNKVRQALLGGFAASRILEVHGERMLKHAFTPGFRVDLH
MKDLGIALDCATELGVSLPGTALTQSLYNACVAQEDTMLDSSVIVRILEKLAGHTINPSTATSHES

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=307, Percent_Identity=29.6416938110749, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=24.8251748251748, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786719, Length=293, Percent_Identity=54.2662116040956, Blast_Score=330, Evalue=9e-92,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=40.2730375426621, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1790315, Length=298, Percent_Identity=32.8859060402685, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789092, Length=290, Percent_Identity=29.6551724137931, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=287, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24655230, Length=297, Percent_Identity=32.3232323232323, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI19922568, Length=297, Percent_Identity=32.3232323232323, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574115, Length=268, Percent_Identity=26.1194029850746, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 32231; Mature: 32231

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIGFIGLGIMGKPMVSHLIRGGYPAYLHSRSGVPDELTALGGIACPTPKAVAEQTDII
CCCCCEEEECCCCCHHHHHHHHCCCCCEECCCCCCCHHHHHHCCCCCCCCHHHHCCCCEE
ILMLPDTPDVEKVLFAENGVMSGLSADPARSKIIIDMSTISPIRTRDFVRRINQSGHDYA
EEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCC
DAPVSGGDIGARNAALTIMIGATEPVFARIKPILALMGKTVTRIGEPGTGQICKAANQII
CCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SALTLEAVAEALVFASKAGADPNKVRQALLGGFAASRILEVHGERMLKHAFTPGFRVDLH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
MKDLGIALDCATELGVSLPGTALTQSLYNACVAQEDTMLDSSVIVRILEKLAGHTINPST
HHHHCEEEEHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ATSHES
CCCCCC
>Mature Secondary Structure
MKNIGFIGLGIMGKPMVSHLIRGGYPAYLHSRSGVPDELTALGGIACPTPKAVAEQTDII
CCCCCEEEECCCCCHHHHHHHHCCCCCEECCCCCCCHHHHHHCCCCCCCCHHHHCCCCEE
ILMLPDTPDVEKVLFAENGVMSGLSADPARSKIIIDMSTISPIRTRDFVRRINQSGHDYA
EEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCC
DAPVSGGDIGARNAALTIMIGATEPVFARIKPILALMGKTVTRIGEPGTGQICKAANQII
CCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SALTLEAVAEALVFASKAGADPNKVRQALLGGFAASRILEVHGERMLKHAFTPGFRVDLH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
MKDLGIALDCATELGVSLPGTALTQSLYNACVAQEDTMLDSSVIVRILEKLAGHTINPST
HHHHCEEEEHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ATSHES
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]