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The map label for this gene is era

Identifier: 114331754

GI number: 114331754

Start: 1882354

End: 1883244

Strand: Reverse

Name: era

Synonym: Neut_1777

Alternate gene names: 114331754

Gene position: 1883244-1882354 (Counterclockwise)

Preceding gene: 114331755

Following gene: 114331753

Centisome position: 70.77

GC content: 44.11

Gene sequence:

>891_bases
ATGAGCGCATCTGGTTACAAAGCAGGCTACATATCTATTGTGGGGCGACCCAATGTTGGTAAATCAACCTTGTTGAATCA
TCTGATTAAACAAAAGATCAGCATTACTTCCAGAAAAGCGCAAACCACCCGTCATCGGATTCACGGGATATTGACGGATG
TACAATCACAATTTATTTTTGTAGATACGCCCGGTTTCCAGATGCGCCATCGTAGCCAGCTCAATCAGGTAATGAACCGG
GTTGTTCTGCAAAGTATGCAGGATGTGGATGTCATCTTGTTCGTGCTTGAGGCTGGACGGTTTGGCCGGGAAGATGAGCA
GGTTCTTGAGCAATTGCCCAGGAATCTTCCTGTAATTCTGGTGATAAACAAAATTGATTTGTTACCGGATAAACTGCAAT
TGCTCCCGTTCATGCAAAAAATGGCTGATTTATTCGATTTTGCAGATATTGTCCCGGTAAGTGCATTGCAAAACAGACAA
TTATCAGATCTGACTGAAGTTATTCGTCACTATTTGCCCGAAAATCCTCCGGTGTTTACGGAAGACGAAATTACAGATCG
CAGTGAACGATTTCTGGCAGCAGAATTACTGCGCGAAAAAGTTTTTCGGCAAATTGGTGAGGAGGTACCCTACTCGGTTA
GTGTGATCATCGAGCAGTTCGCTGTGGAAGGCAATTTGCGACGTATCCATGCCTGTATTCTGGTGGAGAGAGAAAATCAG
AAAGCTATCATTATAGGTAAGCAGGGAAAAAAACTGAAGGATATGGCTACACAGGCACGTAAGGATATGGAGGTGCTGTT
TGATGGCAAAGTCTATCTGGAGATATGGGTCAAGGTAAAATCCGGCTGGGCAGATGACGCTATTGCACTGAAGAGTATGG
GGTATGAATAG

Upstream 100 bases:

>100_bases
AACTTGCCGTAGTAAGACATTAAGCAACCTCGTATCCATCGTAACTCTATACAATTCCTTTGATCAACCTGAGTTCTCTT
TATCTAGGCAGAACTTTACT

Downstream 100 bases:

>100_bases
GAATAAAAATTGTCGTGGCAGACTATCTGGCACATACCCCCAACCGGGTTTGTAGATCAGCTGATTTGTAAAAGATTAAA
AAAAGCAATTTAAAACGACT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSASGYKAGYISIVGRPNVGKSTLLNHLIKQKISITSRKAQTTRHRIHGILTDVQSQFIFVDTPGFQMRHRSQLNQVMNR
VVLQSMQDVDVILFVLEAGRFGREDEQVLEQLPRNLPVILVINKIDLLPDKLQLLPFMQKMADLFDFADIVPVSALQNRQ
LSDLTEVIRHYLPENPPVFTEDEITDRSERFLAAELLREKVFRQIGEEVPYSVSVIIEQFAVEGNLRRIHACILVERENQ
KAIIIGKQGKKLKDMATQARKDMEVLFDGKVYLEIWVKVKSGWADDAIALKSMGYE

Sequences:

>Translated_296_residues
MSASGYKAGYISIVGRPNVGKSTLLNHLIKQKISITSRKAQTTRHRIHGILTDVQSQFIFVDTPGFQMRHRSQLNQVMNR
VVLQSMQDVDVILFVLEAGRFGREDEQVLEQLPRNLPVILVINKIDLLPDKLQLLPFMQKMADLFDFADIVPVSALQNRQ
LSDLTEVIRHYLPENPPVFTEDEITDRSERFLAAELLREKVFRQIGEEVPYSVSVIIEQFAVEGNLRRIHACILVERENQ
KAIIIGKQGKKLKDMATQARKDMEVLFDGKVYLEIWVKVKSGWADDAIALKSMGYE
>Mature_295_residues
SASGYKAGYISIVGRPNVGKSTLLNHLIKQKISITSRKAQTTRHRIHGILTDVQSQFIFVDTPGFQMRHRSQLNQVMNRV
VLQSMQDVDVILFVLEAGRFGREDEQVLEQLPRNLPVILVINKIDLLPDKLQLLPFMQKMADLFDFADIVPVSALQNRQL
SDLTEVIRHYLPENPPVFTEDEITDRSERFLAAELLREKVFRQIGEEVPYSVSVIIEQFAVEGNLRRIHACILVERENQK
AIIIGKQGKKLKDMATQARKDMEVLFDGKVYLEIWVKVKSGWADDAIALKSMGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=324, Percent_Identity=25.6172839506173, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788919, Length=297, Percent_Identity=51.1784511784512, Blast_Score=300, Evalue=7e-83,
Organism=Escherichia coli, GI87082120, Length=188, Percent_Identity=30.8510638297872, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532761, Length=151, Percent_Identity=33.112582781457, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646434, Length=302, Percent_Identity=27.1523178807947, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_NITEC (Q0AF71)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747976.1
- ProteinModelPortal:   Q0AF71
- SMR:   Q0AF71
- STRING:   Q0AF71
- GeneID:   4273126
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1777
- NMPDR:   fig|335283.3.peg.2008
- eggNOG:   COG1159
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- PhylomeDB:   Q0AF71
- ProtClustDB:   PRK00089
- BioCyc:   NEUT335283:NEUT_1777-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 33857; Mature: 33726

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASGYKAGYISIVGRPNVGKSTLLNHLIKQKISITSRKAQTTRHRIHGILTDVQSQFIF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VDTPGFQMRHRSQLNQVMNRVVLQSMQDVDVILFVLEAGRFGREDEQVLEQLPRNLPVIL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEE
VINKIDLLPDKLQLLPFMQKMADLFDFADIVPVSALQNRQLSDLTEVIRHYLPENPPVFT
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
EDEITDRSERFLAAELLREKVFRQIGEEVPYSVSVIIEQFAVEGNLRRIHACILVERENQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHEEEEEEEEEECCC
KAIIIGKQGKKLKDMATQARKDMEVLFDGKVYLEIWVKVKSGWADDAIALKSMGYE
EEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SASGYKAGYISIVGRPNVGKSTLLNHLIKQKISITSRKAQTTRHRIHGILTDVQSQFIF
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VDTPGFQMRHRSQLNQVMNRVVLQSMQDVDVILFVLEAGRFGREDEQVLEQLPRNLPVIL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEE
VINKIDLLPDKLQLLPFMQKMADLFDFADIVPVSALQNRQLSDLTEVIRHYLPENPPVFT
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
EDEITDRSERFLAAELLREKVFRQIGEEVPYSVSVIIEQFAVEGNLRRIHACILVERENQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHEEEEEEEEEECCC
KAIIIGKQGKKLKDMATQARKDMEVLFDGKVYLEIWVKVKSGWADDAIALKSMGYE
EEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA