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The map label for this gene is rnc

Identifier: 114331755

GI number: 114331755

Start: 1883322

End: 1884059

Strand: Reverse

Name: rnc

Synonym: Neut_1778

Alternate gene names: 114331755

Gene position: 1884059-1883322 (Counterclockwise)

Preceding gene: 114331756

Following gene: 114331754

Centisome position: 70.8

GC content: 44.31

Gene sequence:

>738_bases
ATGACCAGATCCAAATTTACTTCGCAAGGCATAAAGAGTAAACATGCAAAAAAATTGAAAAAGCAGGATTACACTGTTTT
TTCCCAAAAACTGGGTTATACCTTCAAACAACCTGATTTGCTTCAGGAGGCGCTGACCCATCGCAGCCTCGGTTTTCCGA
ATAATGAACGTCTTGAGTTTCTAGGGGATAGTGTGCTGAACTGTGCGGTATCAACGCTGCTGTTCAAACGTTTCCTGCTA
TTGCCAGAAGGAGATCTGACAAGATTACGTGCAAATTTCGTCAACCAAGACGCCTTGCATCAACTTGCATCTGCTCTGGG
TATTGGCGAATTGATTTTACTTGGTGATGGCGAGCGCAAGAGTGGCGGGCATCAGCGCCCATCTATTCTGGCAAATGCAA
TGGAAGCCATTATCGGGGCAATCTACCTTGAAAGTGGATTTGAAAAAGTTGATCAGGTGATTGTGGCACTCTATGATCCT
TTGTTAAATCAGCTGGATCCTGATCTTTTTGGTAAAGATCCCAAGACTTTGTTACAAGAATATCTACAAAGTCGGAAAGT
AGACTTGCCTGAGTACAGTACGCTATTGACACGTGGTGATGCACATGCACAGGTTTTTCATGTGGAATGCGTCATTCCTG
AATTTGCTATTCGCACAAGTGGTGAAGGAACCAGTCGTCGTCGAGCCGAACAGGAAGCTGCACGCCGAGCTTATAAACTT
GCCGTAGTAAGACATTAA

Upstream 100 bases:

>100_bases
AGCAGGACGAGCAACTAATCTTGAACATTAGTTACGCAGTTAAAAAGCCTTTATTTGCAAACCTTTCGCTACTGATCGAT
TTCGATGCAGCCAGTGATCA

Downstream 100 bases:

>100_bases
GCAACCTCGTATCCATCGTAACTCTATACAATTCCTTTGATCAACCTGAGTTCTCTTTATCTAGGCAGAACTTTACTATG
AGCGCATCTGGTTACAAAGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTRSKFTSQGIKSKHAKKLKKQDYTVFSQKLGYTFKQPDLLQEALTHRSLGFPNNERLEFLGDSVLNCAVSTLLFKRFLL
LPEGDLTRLRANFVNQDALHQLASALGIGELILLGDGERKSGGHQRPSILANAMEAIIGAIYLESGFEKVDQVIVALYDP
LLNQLDPDLFGKDPKTLLQEYLQSRKVDLPEYSTLLTRGDAHAQVFHVECVIPEFAIRTSGEGTSRRRAEQEAARRAYKL
AVVRH

Sequences:

>Translated_245_residues
MTRSKFTSQGIKSKHAKKLKKQDYTVFSQKLGYTFKQPDLLQEALTHRSLGFPNNERLEFLGDSVLNCAVSTLLFKRFLL
LPEGDLTRLRANFVNQDALHQLASALGIGELILLGDGERKSGGHQRPSILANAMEAIIGAIYLESGFEKVDQVIVALYDP
LLNQLDPDLFGKDPKTLLQEYLQSRKVDLPEYSTLLTRGDAHAQVFHVECVIPEFAIRTSGEGTSRRRAEQEAARRAYKL
AVVRH
>Mature_244_residues
TRSKFTSQGIKSKHAKKLKKQDYTVFSQKLGYTFKQPDLLQEALTHRSLGFPNNERLEFLGDSVLNCAVSTLLFKRFLLL
PEGDLTRLRANFVNQDALHQLASALGIGELILLGDGERKSGGHQRPSILANAMEAIIGAIYLESGFEKVDQVIVALYDPL
LNQLDPDLFGKDPKTLLQEYLQSRKVDLPEYSTLLTRGDAHAQVFHVECVIPEFAIRTSGEGTSRRRAEQEAARRAYKLA
VVRH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=31.4159292035398, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=31.4159292035398, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788920, Length=202, Percent_Identity=45.5445544554455, Blast_Score=183, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17506883, Length=202, Percent_Identity=28.7128712871287, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=202, Percent_Identity=28.7128712871287, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137682, Length=224, Percent_Identity=29.4642857142857, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_NITEC (Q0AF70)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747977.1
- ProteinModelPortal:   Q0AF70
- SMR:   Q0AF70
- STRING:   Q0AF70
- GeneID:   4273127
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1778
- NMPDR:   fig|335283.3.peg.2007
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q0AF70
- ProtClustDB:   PRK00102
- BioCyc:   NEUT335283:NEUT_1778-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27495; Mature: 27364

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSKFTSQGIKSKHAKKLKKQDYTVFSQKLGYTFKQPDLLQEALTHRSLGFPNNERLEF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
LGDSVLNCAVSTLLFKRFLLLPEGDLTRLRANFVNQDALHQLASALGIGELILLGDGERK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCC
SGGHQRPSILANAMEAIIGAIYLESGFEKVDQVIVALYDPLLNQLDPDLFGKDPKTLLQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHH
YLQSRKVDLPEYSTLLTRGDAHAQVFHVECVIPEFAIRTSGEGTSRRRAEQEAARRAYKL
HHHHCCCCCCHHHHHHHCCCCCEEEEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVVRH
HHCCC
>Mature Secondary Structure 
TRSKFTSQGIKSKHAKKLKKQDYTVFSQKLGYTFKQPDLLQEALTHRSLGFPNNERLEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
LGDSVLNCAVSTLLFKRFLLLPEGDLTRLRANFVNQDALHQLASALGIGELILLGDGERK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCC
SGGHQRPSILANAMEAIIGAIYLESGFEKVDQVIVALYDPLLNQLDPDLFGKDPKTLLQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHH
YLQSRKVDLPEYSTLLTRGDAHAQVFHVECVIPEFAIRTSGEGTSRRRAEQEAARRAYKL
HHHHCCCCCCHHHHHHHCCCCCEEEEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVVRH
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA