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The map label for this gene is purK [H]

Identifier: 114331199

GI number: 114331199

Start: 1256736

End: 1257866

Strand: Reverse

Name: purK [H]

Synonym: Neut_1201

Alternate gene names: 114331199

Gene position: 1257866-1256736 (Counterclockwise)

Preceding gene: 114331200

Following gene: 114331198

Centisome position: 47.27

GC content: 45.36

Gene sequence:

>1131_bases
ATGTATATAAGACCAGGCACCATGCTGGGCATGCTGGGTGGCGGTCAACTGGGAAGAATGTTTACCATGGCAGCACAACA
AATGGGTTACCGGGTAACTGTACTTGATCCGGCCGCAGAAAGTCCTGCCGCGAACATTGCCGAACGCCATCTGCAAGCAG
ATTATCTGGATTATCGGGCGCTGGATGAATTAGGATCGACTTGTGCCGCGGTCACCATCGAATTTGAAAATGTCCCCGCT
CAGGCACTACGCTATCTGGCGCAACGCTGCATAGTCAGCCCTAATGCCGAAAGTGTCTCAATCGCACAAAACCGTATCCT
TGAGAAACAATTTCTTATGGAAAACGGTTTTCCAGTTGTGCCTTTCGTCGCTATTCGTAGCGAAAAAGATATATCCCGGA
AAATTGATGCATCCTTATTCCCCTGTATACTTAAAATCAGTCAATTTGGTTATGATGGTAAGGGACAAATTCAAATTGAA
AACACGGATATTTTGCCGGAACGATTTGCTGATTTGGGAAGCAGGCCCTGCGTACTGGAAAAACGATTACCGCTTGCCCA
TGAAATTTCCGTTATCCTTGCTCGCGATAATCACAATCGCATTACTTTCTTTCCTGTCCCGGAAAACAGGCATGTGAAAG
GTATCCTTGATACAAGCATTGTACCAGCCGGGTTATCTGACAAGATTATTGAAGAAGCTTGTGAAATTGCCAGACAAGTG
GCTATAAGGCTGAATTATATTGGCGTTCTGTGTGTAGAATTCTTTGTTCTGAATAATGATCAGGTTCTGGTTAATGAAAT
TGCACCACGTCCGCACAACAGCGGACATTATTCGCTTGATGCCTGTATCACCTCACAATTTGAGCAACAAGTTCGCGTAT
TGTGTGGGCTTCCACACGGCAGCACAAAACAGGTACAGGCTGCTGTAATGATTAATATACTCGGGGACCTATGGCAAAAT
GATGAACCTGCCTGGGACCAGATATTACGTCACTCACAAGCCAAGCTGCATTTGTACGGTAAACGTGAAGCAAAACCAGG
CAGGAAAATGGGGCATTTCACTGTACTAGCAGACTCAACTGAAGAAGCTTTTCTGCAAGCTCAGCATATCAGGCATGATC
TTCAATCCTAA

Upstream 100 bases:

>100_bases
TTGCCATGCTGGCCGGGAAAGATACCGTGTTGGCCGAGAAACTTGATCAGTTTCGCAAGGATCAGGCGGATTCCGTTGCT
GCAATGACTCTCCCTGAATC

Downstream 100 bases:

>100_bases
TACAACACACCAGAAATAAGCTCCCCATCAATCAACTATGACAACTGCGACGCTGTTTGAAACCAATATAACAAGCCTCC
CCCTGCTACACCGGGGAAAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MYIRPGTMLGMLGGGQLGRMFTMAAQQMGYRVTVLDPAAESPAANIAERHLQADYLDYRALDELGSTCAAVTIEFENVPA
QALRYLAQRCIVSPNAESVSIAQNRILEKQFLMENGFPVVPFVAIRSEKDISRKIDASLFPCILKISQFGYDGKGQIQIE
NTDILPERFADLGSRPCVLEKRLPLAHEISVILARDNHNRITFFPVPENRHVKGILDTSIVPAGLSDKIIEEACEIARQV
AIRLNYIGVLCVEFFVLNNDQVLVNEIAPRPHNSGHYSLDACITSQFEQQVRVLCGLPHGSTKQVQAAVMINILGDLWQN
DEPAWDQILRHSQAKLHLYGKREAKPGRKMGHFTVLADSTEEAFLQAQHIRHDLQS

Sequences:

>Translated_376_residues
MYIRPGTMLGMLGGGQLGRMFTMAAQQMGYRVTVLDPAAESPAANIAERHLQADYLDYRALDELGSTCAAVTIEFENVPA
QALRYLAQRCIVSPNAESVSIAQNRILEKQFLMENGFPVVPFVAIRSEKDISRKIDASLFPCILKISQFGYDGKGQIQIE
NTDILPERFADLGSRPCVLEKRLPLAHEISVILARDNHNRITFFPVPENRHVKGILDTSIVPAGLSDKIIEEACEIARQV
AIRLNYIGVLCVEFFVLNNDQVLVNEIAPRPHNSGHYSLDACITSQFEQQVRVLCGLPHGSTKQVQAAVMINILGDLWQN
DEPAWDQILRHSQAKLHLYGKREAKPGRKMGHFTVLADSTEEAFLQAQHIRHDLQS
>Mature_376_residues
MYIRPGTMLGMLGGGQLGRMFTMAAQQMGYRVTVLDPAAESPAANIAERHLQADYLDYRALDELGSTCAAVTIEFENVPA
QALRYLAQRCIVSPNAESVSIAQNRILEKQFLMENGFPVVPFVAIRSEKDISRKIDASLFPCILKISQFGYDGKGQIQIE
NTDILPERFADLGSRPCVLEKRLPLAHEISVILARDNHNRITFFPVPENRHVKGILDTSIVPAGLSDKIIEEACEIARQV
AIRLNYIGVLCVEFFVLNNDQVLVNEIAPRPHNSGHYSLDACITSQFEQQVRVLCGLPHGSTKQVQAAVMINILGDLWQN
DEPAWDQILRHSQAKLHLYGKREAKPGRKMGHFTVLADSTEEAFLQAQHIRHDLQS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=352, Percent_Identity=29.8295454545455, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788155, Length=380, Percent_Identity=27.8947368421053, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324702, Length=368, Percent_Identity=32.8804347826087, Blast_Score=210, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR006140
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C; PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41980; Mature: 41980

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIRPGTMLGMLGGGQLGRMFTMAAQQMGYRVTVLDPAAESPAANIAERHLQADYLDYRA
CEECCCCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
LDELGSTCAAVTIEFENVPAQALRYLAQRCIVSPNAESVSIAQNRILEKQFLMENGFPVV
HHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
PFVAIRSEKDISRKIDASLFPCILKISQFGYDGKGQIQIENTDILPERFADLGSRPCVLE
EEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCCEEEC
KRLPLAHEISVILARDNHNRITFFPVPENRHVKGILDTSIVPAGLSDKIIEEACEIARQV
CCCCCHHEEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
AIRLNYIGVLCVEFFVLNNDQVLVNEIAPRPHNSGHYSLDACITSQFEQQVRVLCGLPHG
HHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCC
STKQVQAAVMINILGDLWQNDEPAWDQILRHSQAKLHLYGKREAKPGRKMGHFTVLADST
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCH
EEAFLQAQHIRHDLQS
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYIRPGTMLGMLGGGQLGRMFTMAAQQMGYRVTVLDPAAESPAANIAERHLQADYLDYRA
CEECCCCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
LDELGSTCAAVTIEFENVPAQALRYLAQRCIVSPNAESVSIAQNRILEKQFLMENGFPVV
HHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
PFVAIRSEKDISRKIDASLFPCILKISQFGYDGKGQIQIENTDILPERFADLGSRPCVLE
EEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCCEEEC
KRLPLAHEISVILARDNHNRITFFPVPENRHVKGILDTSIVPAGLSDKIIEEACEIARQV
CCCCCHHEEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
AIRLNYIGVLCVEFFVLNNDQVLVNEIAPRPHNSGHYSLDACITSQFEQQVRVLCGLPHG
HHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCC
STKQVQAAVMINILGDLWQNDEPAWDQILRHSQAKLHLYGKREAKPGRKMGHFTVLADST
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCH
EEAFLQAQHIRHDLQS
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA