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The map label for this gene is purC [H]

Identifier: 114331198

GI number: 114331198

Start: 1255811

End: 1256698

Strand: Reverse

Name: purC [H]

Synonym: Neut_1200

Alternate gene names: 114331198

Gene position: 1256698-1255811 (Counterclockwise)

Preceding gene: 114331199

Following gene: 114331194

Centisome position: 47.23

GC content: 45.05

Gene sequence:

>888_bases
ATGACAACTGCGACGCTGTTTGAAACCAATATAACAAGCCTCCCCCTGCTACACCGGGGAAAGGTACGGGATATTTATGT
GGTAGATGAAAATAACCTACTGATTATACAGACAGATCGCATTTCTGCTTTTGATGTAATATTACCAACCCCGATCCCGG
AAAAAGGTAAGATTCTGACAAAAATTTCCCGTTTCTGGTTCGAGAAACTAGCTCACATTATCCCCAACCACCTTACCGAC
ATACCACCTGAATCCGTTATTCTGCCTGGAGAGCGAGATCAGGTTACAGACCGCGCTTTTGTTGTTAAAAAATTGAAGCC
ACTCCCTGTCGAGGCAATTGTACGCGGTTATATTTCTGGTTCTGGCTGGAGAGATTATCAGCACAGCGGCACCATTTGTG
GCGTTACCCTGCCTGAGGGGTTACGAGAGGCTGACAAAATTCCTGATGGTGCAATTTTTACACCATCAACTAAGGCAGAA
GCAGGATCACATGATGAGAATATTTCATATGCTTCTTGTGAACAAATATTGGGAGCACCGCTTGCTTCAGTTGTCAGCAA
ATATGCAATTGCGCTTTACAGTGCTGCAGCTGACTATGCATTGACACGAAATATCATTATCGCTGATACCAAGTTTGAAT
TTGGCCTGGATGATAACGATCAGCTTTACCTGATCGATGAAGCACTAACCCCGGACTCCTCTCGTTTCTGGCCTGCTGAA
GGCTATCAGCCTGGTAAAACCCCACCCAGTTATGACAAACAGTTTATTCGCGACTGGCTGGAACAAACTGGCTGGAACAA
AACCCCACCTGCTCCTGCTATCCCGGCTGAAATTCTCATGCAAACAGTAGAAAAATATCAGGAAGCATATCAAGTGTTGG
CACAGTAA

Upstream 100 bases:

>100_bases
GCAGACTCAACTGAAGAAGCTTTTCTGCAAGCTCAGCATATCAGGCATGATCTTCAATCCTAATACAACACACCAGAAAT
AAGCTCCCCATCAATCAACT

Downstream 100 bases:

>100_bases
TTAATATACTTGCAACTCATGGTAAGTTGATAGTGGAGCGACTTATGGTTTCAATCGGATGCGGCTGCCCGACAGCAAAT
CCTTGAGCATAATCGATCCC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTTATLFETNITSLPLLHRGKVRDIYVVDENNLLIIQTDRISAFDVILPTPIPEKGKILTKISRFWFEKLAHIIPNHLTD
IPPESVILPGERDQVTDRAFVVKKLKPLPVEAIVRGYISGSGWRDYQHSGTICGVTLPEGLREADKIPDGAIFTPSTKAE
AGSHDENISYASCEQILGAPLASVVSKYAIALYSAAADYALTRNIIIADTKFEFGLDDNDQLYLIDEALTPDSSRFWPAE
GYQPGKTPPSYDKQFIRDWLEQTGWNKTPPAPAIPAEILMQTVEKYQEAYQVLAQ

Sequences:

>Translated_295_residues
MTTATLFETNITSLPLLHRGKVRDIYVVDENNLLIIQTDRISAFDVILPTPIPEKGKILTKISRFWFEKLAHIIPNHLTD
IPPESVILPGERDQVTDRAFVVKKLKPLPVEAIVRGYISGSGWRDYQHSGTICGVTLPEGLREADKIPDGAIFTPSTKAE
AGSHDENISYASCEQILGAPLASVVSKYAIALYSAAADYALTRNIIIADTKFEFGLDDNDQLYLIDEALTPDSSRFWPAE
GYQPGKTPPSYDKQFIRDWLEQTGWNKTPPAPAIPAEILMQTVEKYQEAYQVLAQ
>Mature_294_residues
TTATLFETNITSLPLLHRGKVRDIYVVDENNLLIIQTDRISAFDVILPTPIPEKGKILTKISRFWFEKLAHIIPNHLTDI
PPESVILPGERDQVTDRAFVVKKLKPLPVEAIVRGYISGSGWRDYQHSGTICGVTLPEGLREADKIPDGAIFTPSTKAEA
GSHDENISYASCEQILGAPLASVVSKYAIALYSAAADYALTRNIIIADTKFEFGLDDNDQLYLIDEALTPDSSRFWPAEG
YQPGKTPPSYDKQFIRDWLEQTGWNKTPPAPAIPAEILMQTVEKYQEAYQVLAQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=290, Percent_Identity=49.6551724137931, Blast_Score=283, Evalue=2e-77,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 32860; Mature: 32728

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTATLFETNITSLPLLHRGKVRDIYVVDENNLLIIQTDRISAFDVILPTPIPEKGKILT
CCCEEEEECCCCCCCCEECCCCEEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHH
KISRFWFEKLAHIIPNHLTDIPPESVILPGERDQVTDRAFVVKKLKPLPVEAIVRGYISG
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
SGWRDYQHSGTICGVTLPEGLREADKIPDGAIFTPSTKAEAGSHDENISYASCEQILGAP
CCCCCCCCCCCEEEEECCHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCC
LASVVSKYAIALYSAAADYALTRNIIIADTKFEFGLDDNDQLYLIDEALTPDSSRFWPAE
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECEEEECCCCCCCEEEEECCCCCCCCCCCCCC
GYQPGKTPPSYDKQFIRDWLEQTGWNKTPPAPAIPAEILMQTVEKYQEAYQVLAQ
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTATLFETNITSLPLLHRGKVRDIYVVDENNLLIIQTDRISAFDVILPTPIPEKGKILT
CCEEEEECCCCCCCCEECCCCEEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHH
KISRFWFEKLAHIIPNHLTDIPPESVILPGERDQVTDRAFVVKKLKPLPVEAIVRGYISG
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
SGWRDYQHSGTICGVTLPEGLREADKIPDGAIFTPSTKAEAGSHDENISYASCEQILGAP
CCCCCCCCCCCEEEEECCHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCC
LASVVSKYAIALYSAAADYALTRNIIIADTKFEFGLDDNDQLYLIDEALTPDSSRFWPAE
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECEEEECCCCCCCEEEEECCCCCCCCCCCCCC
GYQPGKTPPSYDKQFIRDWLEQTGWNKTPPAPAIPAEILMQTVEKYQEAYQVLAQ
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]