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The map label for this gene is purE [H]

Identifier: 114331200

GI number: 114331200

Start: 1257857

End: 1258327

Strand: Reverse

Name: purE [H]

Synonym: Neut_1202

Alternate gene names: 114331200

Gene position: 1258327-1257857 (Counterclockwise)

Preceding gene: 114331212

Following gene: 114331199

Centisome position: 47.29

GC content: 50.53

Gene sequence:

>471_bases
ATGGGCAGCAGCAGCGATTGGCATATCATGCAGCATGCTGCAAATATTTTGAAGAAATTCTCTATCCCGCACGAAACTAT
AATTGTCTCAGCGCACCGCACACCCGACAGGATGTTTGATTATGCCGAGACGGCTCGTGACCGTGGAATCAAATGTATTA
TCGCCGGTGCAGGTGGTGCAGCTCACCTGCCAGGGATGATTGCTGCCAAAACCACACTGCCCGTTCTTGGTGTTCCAGTC
ACTTCAAAACACTTACAGGGTATTGATTCACTCCTATCCATTGTACAAATGCCCAAAGGGATACCGGTTGCCACTTTCGC
TATCGGCGAAGCCGGGGCGGTGAATGCTGCGCTGTTTGCTGTTGCCATGCTGGCCGGGAAAGATACCGTGTTGGCCGAGA
AACTTGATCAGTTTCGCAAGGATCAGGCGGATTCCGTTGCTGCAATGACTCTCCCTGAATCATGTATATAA

Upstream 100 bases:

>100_bases
AGTTTATTATTGCCACTTTCACCATGCCTAGGTGTATTTCGAGTTATTCCGGATTTTTGTAAAGGTCTTTCAAGTGGATC
GTCCAGTAATCAGTGTTGTA

Downstream 100 bases:

>100_bases
GACCAGGCACCATGCTGGGCATGCTGGGTGGCGGTCAACTGGGAAGAATGTTTACCATGGCAGCACAACAAATGGGTTAC
CGGGTAACTGTACTTGATCC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MGSSSDWHIMQHAANILKKFSIPHETIIVSAHRTPDRMFDYAETARDRGIKCIIAGAGGAAHLPGMIAAKTTLPVLGVPV
TSKHLQGIDSLLSIVQMPKGIPVATFAIGEAGAVNAALFAVAMLAGKDTVLAEKLDQFRKDQADSVAAMTLPESCI

Sequences:

>Translated_156_residues
MGSSSDWHIMQHAANILKKFSIPHETIIVSAHRTPDRMFDYAETARDRGIKCIIAGAGGAAHLPGMIAAKTTLPVLGVPV
TSKHLQGIDSLLSIVQMPKGIPVATFAIGEAGAVNAALFAVAMLAGKDTVLAEKLDQFRKDQADSVAAMTLPESCI
>Mature_155_residues
GSSSDWHIMQHAANILKKFSIPHETIIVSAHRTPDRMFDYAETARDRGIKCIIAGAGGAAHLPGMIAAKTTLPVLGVPVT
SKHLQGIDSLLSIVQMPKGIPVATFAIGEAGAVNAALFAVAMLAGKDTVLAEKLDQFRKDQADSVAAMTLPESCI

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=146, Percent_Identity=61.6438356164384, Blast_Score=157, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324702, Length=146, Percent_Identity=57.5342465753425, Blast_Score=159, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16417; Mature: 16286

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSSDWHIMQHAANILKKFSIPHETIIVSAHRTPDRMFDYAETARDRGIKCIIAGAGGA
CCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AHLPGMIAAKTTLPVLGVPVTSKHLQGIDSLLSIVQMPKGIPVATFAIGEAGAVNAALFA
HHCCCHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
VAMLAGKDTVLAEKLDQFRKDQADSVAAMTLPESCI
HHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure 
GSSSDWHIMQHAANILKKFSIPHETIIVSAHRTPDRMFDYAETARDRGIKCIIAGAGGA
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AHLPGMIAAKTTLPVLGVPVTSKHLQGIDSLLSIVQMPKGIPVATFAIGEAGAVNAALFA
HHCCCHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
VAMLAGKDTVLAEKLDQFRKDQADSVAAMTLPESCI
HHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]