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The map label for this gene is nuoD

Identifier: 114330928

GI number: 114330928

Start: 950241

End: 951494

Strand: Direct

Name: nuoD

Synonym: Neut_0925

Alternate gene names: 114330928

Gene position: 950241-951494 (Clockwise)

Preceding gene: 114330927

Following gene: 114330929

Centisome position: 35.71

GC content: 44.1

Gene sequence:

>1254_bases
ATGGCTGATATTCGTAATTACACTATGAATTTTGGGCCGCAACATCCCGCAGCGCATGGGGTTTTGCGCTTGGTGATGGA
GCTGGATGGTGAGGTTATTCGGCGTGCTGATCCGCATATCGGATTACTTCATAGGGCGACGGAGAAGCTCGCGGAGAATA
AGACCTATATACAATCTGTGCCCTATATGGATCGGCTGGATTATGTGTCCATGATGGTCAATGAGCATGCGTATGTAATG
GCGATTGAAAAGCTATTGCAGATAGATGTGCCCATAAGAGCGCAATATATTCGTGTTATGTTTGATGAAATAACGCGTAT
TCTCAATCACTTGCTATGGTTAGGCGCCCATGCACTGGATGTTGGGGCAATGACTGTTTTTCTATACACCTTTCGAGAAA
GAGAAGATTTGATGGACTGCTATGAGGCAGTATCAGGCGCTCGGTTACATGCTGCCTATTATCGGCCAGGAGGAGTTTAT
CGGGATCTGCCGGATAGTATGCCGCAGTATCGATCATCAGCAATACACGATGAGAAGACAACGACAGCGCGTAATGAGAA
TCGGCAGGGCTCTTTGTTGGATTTTATTGAGGATTTTACTCATCGATTTCCAGGTTACGTGGATGATTACGAGACATTGC
TGACAGACAATAGAATCTGGAAGCAACGCTTAGTTGATATTGGCGTGGTTTCACCTGATCGCGCTAAAGCTTTGGGATTT
AGTGGGCCGATGTTGCGTGGATCTGGAGTGGCGTGGGACTTACGCAAAAAGCAACCTTATGAAGTTTATGACCAGGTAGA
TTTTGATATACCGGTTGGTGTCAATGGTGATTGCTATGATCGTTATTTGGTACGCATTGAAGAAATGCGTCAATCTAATT
ACATAATTAAGCAGTGTATTGATTGGATGAGAAAAAATCCCGGTCCTGTTATTACCAGTAACTTCAAAGTTGCACCACCT
CCACGGCTGTCCATGAAACAAAATATGGAAGAAATGATTCATCATTTCAAATTATTTACAGAAGGTATGCATGTTCCGAG
AGGGGAGGTCTACGCTGCTGTGGAGCATCCAAAAGGTGAGTTCGGTATTTATATTATTTCGGATGGCGCTAATATGCCTT
ATCGACTAAAAATACGTGCACCCGGGTTCGCACATTTAGCTGCAATGGATGAGATGGCTCGAGGGCATATGATTGCTGAT
CTTGTGGCAATTATTGGTACCCAGGATATAGTGTTTGGTGAAATAGATAGATGA

Upstream 100 bases:

>100_bases
ATATATCATTCGCGAAGAACAATACGGTAAGGAAGAAACATGACACGCTCTATGATTAATCAGCGATCCTCACGAAGTTT
TTGGGAAGGGTGTTTGTGAA

Downstream 100 bases:

>100_bases
GTTCGCTGATGTTAAGCATGGAAGCTCTAAAAAAGATTGATCGGGAAATTGCCAAATATCCCACGGATAAAAAGCAGTCG
GCTGTCATGTCTGCGCTGGC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MADIRNYTMNFGPQHPAAHGVLRLVMELDGEVIRRADPHIGLLHRATEKLAENKTYIQSVPYMDRLDYVSMMVNEHAYVM
AIEKLLQIDVPIRAQYIRVMFDEITRILNHLLWLGAHALDVGAMTVFLYTFREREDLMDCYEAVSGARLHAAYYRPGGVY
RDLPDSMPQYRSSAIHDEKTTTARNENRQGSLLDFIEDFTHRFPGYVDDYETLLTDNRIWKQRLVDIGVVSPDRAKALGF
SGPMLRGSGVAWDLRKKQPYEVYDQVDFDIPVGVNGDCYDRYLVRIEEMRQSNYIIKQCIDWMRKNPGPVITSNFKVAPP
PRLSMKQNMEEMIHHFKLFTEGMHVPRGEVYAAVEHPKGEFGIYIISDGANMPYRLKIRAPGFAHLAAMDEMARGHMIAD
LVAIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MADIRNYTMNFGPQHPAAHGVLRLVMELDGEVIRRADPHIGLLHRATEKLAENKTYIQSVPYMDRLDYVSMMVNEHAYVM
AIEKLLQIDVPIRAQYIRVMFDEITRILNHLLWLGAHALDVGAMTVFLYTFREREDLMDCYEAVSGARLHAAYYRPGGVY
RDLPDSMPQYRSSAIHDEKTTTARNENRQGSLLDFIEDFTHRFPGYVDDYETLLTDNRIWKQRLVDIGVVSPDRAKALGF
SGPMLRGSGVAWDLRKKQPYEVYDQVDFDIPVGVNGDCYDRYLVRIEEMRQSNYIIKQCIDWMRKNPGPVITSNFKVAPP
PRLSMKQNMEEMIHHFKLFTEGMHVPRGEVYAAVEHPKGEFGIYIISDGANMPYRLKIRAPGFAHLAAMDEMARGHMIAD
LVAIIGTQDIVFGEIDR
>Mature_416_residues
ADIRNYTMNFGPQHPAAHGVLRLVMELDGEVIRRADPHIGLLHRATEKLAENKTYIQSVPYMDRLDYVSMMVNEHAYVMA
IEKLLQIDVPIRAQYIRVMFDEITRILNHLLWLGAHALDVGAMTVFLYTFREREDLMDCYEAVSGARLHAAYYRPGGVYR
DLPDSMPQYRSSAIHDEKTTTARNENRQGSLLDFIEDFTHRFPGYVDDYETLLTDNRIWKQRLVDIGVVSPDRAKALGFS
GPMLRGSGVAWDLRKKQPYEVYDQVDFDIPVGVNGDCYDRYLVRIEEMRQSNYIIKQCIDWMRKNPGPVITSNFKVAPPP
RLSMKQNMEEMIHHFKLFTEGMHVPRGEVYAAVEHPKGEFGIYIISDGANMPYRLKIRAPGFAHLAAMDEMARGHMIADL
VAIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=60.3864734299517, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=59.5588235294118, Blast_Score=497, Evalue=1e-141,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=37.0731707317073, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1789076, Length=421, Percent_Identity=28.5035629453682, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788832, Length=407, Percent_Identity=25.5528255528256, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=56.3855421686747, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=55.6626506024096, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=59.7590361445783, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221459469, Length=414, Percent_Identity=55.0724637681159, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_NITEC (Q0AHJ7)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747150.1
- STRING:   Q0AHJ7
- GeneID:   4272804
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0925
- NMPDR:   fig|335283.3.peg.1579
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   MADVITI
- PhylomeDB:   Q0AHJ7
- ProtClustDB:   PRK06075
- BioCyc:   NEUT335283:NEUT_0925-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 47936; Mature: 47805

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIRNYTMNFGPQHPAAHGVLRLVMELDGEVIRRADPHIGLLHRATEKLAENKTYIQSV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHC
PYMDRLDYVSMMVNEHAYVMAIEKLLQIDVPIRAQYIRVMFDEITRILNHLLWLGAHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMTVFLYTFREREDLMDCYEAVSGARLHAAYYRPGGVYRDLPDSMPQYRSSAIHDEKT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHH
TTARNENRQGSLLDFIEDFTHRFPGYVDDYETLLTDNRIWKQRLVDIGVVSPDRAKALGF
HCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCHHHHCCC
SGPMLRGSGVAWDLRKKQPYEVYDQVDFDIPVGVNGDCYDRYLVRIEEMRQSNYIIKQCI
CCCCCCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHH
DWMRKNPGPVITSNFKVAPPPRLSMKQNMEEMIHHFKLFTEGMHVPRGEVYAAVEHPKGE
HHHHCCCCCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYIISDGANMPYRLKIRAPGFAHLAAMDEMARGHMIADLVAIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCC
>Mature Secondary Structure 
ADIRNYTMNFGPQHPAAHGVLRLVMELDGEVIRRADPHIGLLHRATEKLAENKTYIQSV
CCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHC
PYMDRLDYVSMMVNEHAYVMAIEKLLQIDVPIRAQYIRVMFDEITRILNHLLWLGAHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMTVFLYTFREREDLMDCYEAVSGARLHAAYYRPGGVYRDLPDSMPQYRSSAIHDEKT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHH
TTARNENRQGSLLDFIEDFTHRFPGYVDDYETLLTDNRIWKQRLVDIGVVSPDRAKALGF
HCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCHHHHCCC
SGPMLRGSGVAWDLRKKQPYEVYDQVDFDIPVGVNGDCYDRYLVRIEEMRQSNYIIKQCI
CCCCCCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHH
DWMRKNPGPVITSNFKVAPPPRLSMKQNMEEMIHHFKLFTEGMHVPRGEVYAAVEHPKGE
HHHHCCCCCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYIISDGANMPYRLKIRAPGFAHLAAMDEMARGHMIADLVAIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA