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The map label for this gene is tmk

Identifier: 114330554

GI number: 114330554

Start: 558327

End: 558974

Strand: Direct

Name: tmk

Synonym: Neut_0536

Alternate gene names: 114330554

Gene position: 558327-558974 (Clockwise)

Preceding gene: 114330552

Following gene: 114330561

Centisome position: 20.98

GC content: 53.4

Gene sequence:

>648_bases
TTGCAACGCGGAAAATTTATTACTTTTGAAGGGATAGACGGGGCGGGGAAAAGCACCCATCTGGCCTGGCTGGCGAGTTT
CCTGCGTGATAAGGGGCTGGAGGTAATCGTGACGCGTGAACCAGGTAGCACCGCGCTGGGTGAACAATTACGGCAATTGT
TGCTGGATCATCGCCAGGCGATGCACGCTGAAACCGAGACGTTGTTGATGTTTGCCGCGCGGAGAGAGCATCTGGACAAA
GTGATATTGCCAGCATTGGAGCGTGGTGCCTGGGTAATTTCAGATCGTTTTACTGACGCCAGTTTTGCCTACCAGGGCGG
CGGCAGGGGAGTGCCATCAGCCAGGCTGGAAATTCTGGAACAATGGGTGCAGAAAGGGTTTTCTCCTGATCTGACGGTGT
ACTTCGACGTACCGGTGACAATCAGCCGCCAGCGGGTACAATCCGCCAGAACGGCCGATCGCTTTGAGCTGGAACCAGAT
CTGTTTTTTGAGCGTGTGCGACAAGCCTATCTGCAACGCGCCAAACAATTTTCTGAACGGATCAGAGTAGTGGATGGCAG
CTTGTCGCTGGAAGAAGTCAGAACAGCCATGGTGGAAGTTGTAGAGAAATTCTGGTCGGCTCAAGCGAGCTCCGGATACA
GAATGTAA

Upstream 100 bases:

>100_bases
TCGATTAGCATGGATATGATTGAATTGCCGGCATGAGTTCTGAAATTTTAAGGGTGCCGCCATAAAAACGCCCGTTAACC
ATTTTAATTGAGTGATTATC

Downstream 100 bases:

>100_bases
GTTTGGCATGAGTAAACAGCCAGATATCAGAGAGACGCCAGATGGGAAGAATATACTGAAAGACAGTGCTGTCGTTGTAT
TCCTTGCTATTAGATGATTA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MQRGKFITFEGIDGAGKSTHLAWLASFLRDKGLEVIVTREPGSTALGEQLRQLLLDHRQAMHAETETLLMFAARREHLDK
VILPALERGAWVISDRFTDASFAYQGGGRGVPSARLEILEQWVQKGFSPDLTVYFDVPVTISRQRVQSARTADRFELEPD
LFFERVRQAYLQRAKQFSERIRVVDGSLSLEEVRTAMVEVVEKFWSAQASSGYRM

Sequences:

>Translated_215_residues
MQRGKFITFEGIDGAGKSTHLAWLASFLRDKGLEVIVTREPGSTALGEQLRQLLLDHRQAMHAETETLLMFAARREHLDK
VILPALERGAWVISDRFTDASFAYQGGGRGVPSARLEILEQWVQKGFSPDLTVYFDVPVTISRQRVQSARTADRFELEPD
LFFERVRQAYLQRAKQFSERIRVVDGSLSLEEVRTAMVEVVEKFWSAQASSGYRM
>Mature_215_residues
MQRGKFITFEGIDGAGKSTHLAWLASFLRDKGLEVIVTREPGSTALGEQLRQLLLDHRQAMHAETETLLMFAARREHLDK
VILPALERGAWVISDRFTDASFAYQGGGRGVPSARLEILEQWVQKGFSPDLTVYFDVPVTISRQRVQSARTADRFELEPD
LFFERVRQAYLQRAKQFSERIRVVDGSLSLEEVRTAMVEVVEKFWSAQASSGYRM

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=200, Percent_Identity=39.5, Blast_Score=132, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_NITEC (Q0AIL5)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746776.1
- ProteinModelPortal:   Q0AIL5
- STRING:   Q0AIL5
- GeneID:   4273802
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0536
- NMPDR:   fig|335283.3.peg.1413
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q0AIL5
- ProtClustDB:   PRK00698
- BioCyc:   NEUT335283:NEUT_0536-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24481; Mature: 24481

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRGKFITFEGIDGAGKSTHLAWLASFLRDKGLEVIVTREPGSTALGEQLRQLLLDHRQA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
MHAETETLLMFAARREHLDKVILPALERGAWVISDRFTDASFAYQGGGRGVPSARLEILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCCCCHHHHHHHH
QWVQKGFSPDLTVYFDVPVTISRQRVQSARTADRFELEPDLFFERVRQAYLQRAKQFSER
HHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IRVVDGSLSLEEVRTAMVEVVEKFWSAQASSGYRM
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQRGKFITFEGIDGAGKSTHLAWLASFLRDKGLEVIVTREPGSTALGEQLRQLLLDHRQA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
MHAETETLLMFAARREHLDKVILPALERGAWVISDRFTDASFAYQGGGRGVPSARLEILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCCCCHHHHHHHH
QWVQKGFSPDLTVYFDVPVTISRQRVQSARTADRFELEPDLFFERVRQAYLQRAKQFSER
HHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IRVVDGSLSLEEVRTAMVEVVEKFWSAQASSGYRM
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA