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The map label for this gene is aarA [H]

Identifier: 113969173

GI number: 113969173

Start: 973516

End: 975078

Strand: Direct

Name: aarA [H]

Synonym: Shewmr4_0829

Alternate gene names: 113969173

Gene position: 973516-975078 (Clockwise)

Preceding gene: 113969172

Following gene: 113969177

Centisome position: 20.69

GC content: 47.15

Gene sequence:

>1563_bases
ATGCGTGTGGCGTTAATCTTAAAAAAACTCCAGTTGATCTATGTGCCCTTTATACTGCTCTGCCTGCTATTTGTCTCAGG
TTACAGCTTGCTCCATTGGTTGTTGATTATCGAGTTCCAACTACTGAGCATTGACGAATCGATTATCAATTTTTGGTTGC
CGCTGATATTGCCTTGGCCCTTACTGTTTTTCTACTTAAGACCTCGGCTCAAGTTATTCCGCTTTACCAAGAGTAATAGC
CGTTTTATCTATTTTGTGATTGCCGTGCTGTTGCTGGCCGTGCCCACTATCGTGGCGCAGGAATACCTTAATAGCGCAAC
GGGCAAGTTGACTCAACTCGAGTCCATCAATGCACTATTGCATCAGCCGCAGACCAAGTATTACCAATTAAATCAGTTTT
ATATCGACAAAAAACATATAGGGGTGCAGCGCAATATTGAGCCCATAGGCAAGGGCAACAGTGAGCTGCGCATGAGCCTG
TATATTGCGATGCCAATTTTCGCTAAACGTAACGAGAGTTGGCGGGTCGGTGCTAAGGCCTTGGCATGGTATGGCAAAGT
TTATGAGAAAACGATCAGTAATCGACTCGAACAGAAAGAGAAAGAAGCGCTATTTCAAGAGTTTATTCATCATAGCCAGC
AAGAGTTTAATGCCTTAAACCCTGATGACTTTATCTATCTTGACCGTATCGGCCCGTCAAGCCGCTACACTCAGTTACTC
ACCGCAGCCCAAAAAAGCTCAGTCTACTTCGAGGGTTATCGAACCGTCTTGATGCCAGTGAATCAACCCTTCGAGGCGCG
TAATGGTCATAAACTGGCGTGGATTATCGCTTGGCTAAGTTTTGGGGCCATTCTGTGGTTGTTGATGAGTCTGATGTTAA
AGCTGGATGAGACGCAGGCGTCTAAGGCGGCACAGCTAAGCCTAGAAAAACCTAAGGCGGAGCTCTATGGTTTTTTAGCC
GAGTTTAGGCCTCGGCAGGGCTTTGTTATCACGCCTATCTTGCTCTATATCAACAGCTTGATATTTGTATTAATGGCCTT
TGCCAGTCAACACTTTATCGCTTTTCCAAACAGCGTGTTACTCGATTGGGGGGCAAACCTTCGTCAGTTGGTGCTTGAGC
AACAAGTCTGGCGTTTACTCAGTAATGTGTTTTTGCATGGCGGCCTGATGCATTTGGTTTTTAATTTATATGGGCTGTTT
TTTGCGGGGATGTTTTTGGAGCCGTTGCTGGGTAAATGGCGTTTACTCGGGGTCTATTTATGTTGTGGCTTAGTGGCGAG
CCTGGCCAGCATAGGCTGGTATGAGGCGACAATCAGCATCGGGGCATCGGGAGCCATCATGGGGCTATTTGGCGTGTTGA
TTATCTGGATATGGTTGGGCTTGTTGCCCTTGGCGGACAATATGCCACTCGCCCTCAATCTGGCCCTATTCGTCTCTGCC
AGTCTTGTTATGGGGCTCTTTGGCGGCGTGGACAATGCCGCGCACCTTGGCGGTTTAGGTTGTGGATTATTGCTTGGGAG
CTTATTACGGCCAACGCGAAAGGCGGCCATACAGCATAAATAA

Upstream 100 bases:

>100_bases
GATTGATTGGCTTCACTAAAATTCAAGCAATCGTCCTGCTAAAGATGCGTTGCGTGGCGATACGCCGTATCATTGGCGGG
ATTTTTCTCTCAAGGATGAT

Downstream 100 bases:

>100_bases
CAGCCTAAGGTGATTGCTGAAGCTGACCGTAAATAGGCAGCTTCAGCAATCTTTAAACACTGAGGGTTGAATCGAAACGG
TAGGGTAAGCTATTAGAAAT

Product: rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLSIDESIINFWLPLILPWPLLFFYLRPRLKLFRFTKSNS
RFIYFVIAVLLLAVPTIVAQEYLNSATGKLTQLESINALLHQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSL
YIAMPIFAKRNESWRVGAKALAWYGKVYEKTISNRLEQKEKEALFQEFIHHSQQEFNALNPDDFIYLDRIGPSSRYTQLL
TAAQKSSVYFEGYRTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQASKAAQLSLEKPKAELYGFLA
EFRPRQGFVITPILLYINSLIFVLMAFASQHFIAFPNSVLLDWGANLRQLVLEQQVWRLLSNVFLHGGLMHLVFNLYGLF
FAGMFLEPLLGKWRLLGVYLCCGLVASLASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLALFVSA
SLVMGLFGGVDNAAHLGGLGCGLLLGSLLRPTRKAAIQHK

Sequences:

>Translated_520_residues
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLSIDESIINFWLPLILPWPLLFFYLRPRLKLFRFTKSNS
RFIYFVIAVLLLAVPTIVAQEYLNSATGKLTQLESINALLHQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSL
YIAMPIFAKRNESWRVGAKALAWYGKVYEKTISNRLEQKEKEALFQEFIHHSQQEFNALNPDDFIYLDRIGPSSRYTQLL
TAAQKSSVYFEGYRTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQASKAAQLSLEKPKAELYGFLA
EFRPRQGFVITPILLYINSLIFVLMAFASQHFIAFPNSVLLDWGANLRQLVLEQQVWRLLSNVFLHGGLMHLVFNLYGLF
FAGMFLEPLLGKWRLLGVYLCCGLVASLASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLALFVSA
SLVMGLFGGVDNAAHLGGLGCGLLLGSLLRPTRKAAIQHK
>Mature_520_residues
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLSIDESIINFWLPLILPWPLLFFYLRPRLKLFRFTKSNS
RFIYFVIAVLLLAVPTIVAQEYLNSATGKLTQLESINALLHQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSL
YIAMPIFAKRNESWRVGAKALAWYGKVYEKTISNRLEQKEKEALFQEFIHHSQQEFNALNPDDFIYLDRIGPSSRYTQLL
TAAQKSSVYFEGYRTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQASKAAQLSLEKPKAELYGFLA
EFRPRQGFVITPILLYINSLIFVLMAFASQHFIAFPNSVLLDWGANLRQLVLEQQVWRLLSNVFLHGGLMHLVFNLYGLF
FAGMFLEPLLGKWRLLGVYLCCGLVASLASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLALFVSA
SLVMGLFGGVDNAAHLGGLGCGLLLGSLLRPTRKAAIQHK

Specific function: Rhomboid serine protease that catalyzes intramembrane proteolysis. Mediates quorum-sensing and the subsequent regulation of target genes via activation of the Tat protein export system. Catalyzes the proteolytic activation of tatA by removal of its N- ter

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 59069; Mature: 59069

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLSIDESIINFWLPLILPWP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFFYLRPRLKLFRFTKSNSRFIYFVIAVLLLAVPTIVAQEYLNSATGKLTQLESINALL
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSLYIAMPIFAKRNESWRVGAKA
CCCCCHHEEHHHEEEEHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCHHHHHH
LAWYGKVYEKTISNRLEQKEKEALFQEFIHHSQQEFNALNPDDFIYLDRIGPSSRYTQLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHH
TAAQKSSVYFEGYRTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQA
HHHHHCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAAQLSLEKPKAELYGFLAEFRPRQGFVITPILLYINSLIFVLMAFASQHFIAFPNSVL
HHHHHHHCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEECCCCCE
LDWGANLRQLVLEQQVWRLLSNVFLHGGLMHLVFNLYGLFFAGMFLEPLLGKWRLLGVYL
ECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CCGLVASLASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLALFVSA
HHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLVMGLFGGVDNAAHLGGLGCGLLLGSLLRPTRKAAIQHK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCC
>Mature Secondary Structure
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLSIDESIINFWLPLILPWP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFFYLRPRLKLFRFTKSNSRFIYFVIAVLLLAVPTIVAQEYLNSATGKLTQLESINALL
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSLYIAMPIFAKRNESWRVGAKA
CCCCCHHEEHHHEEEEHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCHHHHHH
LAWYGKVYEKTISNRLEQKEKEALFQEFIHHSQQEFNALNPDDFIYLDRIGPSSRYTQLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHH
TAAQKSSVYFEGYRTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQA
HHHHHCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAAQLSLEKPKAELYGFLAEFRPRQGFVITPILLYINSLIFVLMAFASQHFIAFPNSVL
HHHHHHHCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEECCCCCE
LDWGANLRQLVLEQQVWRLLSNVFLHGGLMHLVFNLYGLFFAGMFLEPLLGKWRLLGVYL
ECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CCGLVASLASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLALFVSA
HHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLVMGLFGGVDNAAHLGGLGCGLLLGSLLRPTRKAAIQHK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8051030 [H]