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The map label for this gene is frdB [H]

Identifier: 113968749

GI number: 113968749

Start: 452217

End: 452948

Strand: Direct

Name: frdB [H]

Synonym: Shewmr4_0405

Alternate gene names: 113968749

Gene position: 452217-452948 (Clockwise)

Preceding gene: 113968748

Following gene: 113968752

Centisome position: 9.61

GC content: 50.0

Gene sequence:

>732_bases
ATGAGCCAAGGTCGCCAGCTAACCTTTAATATTTTTCGTTATGATCCGCAGGAGCCAAACGATAAGCCGAAGATGGTGCG
TTATCAGCTCACCGAAACGCCGGGAATGACGGTATTTATCGCACTCAATAAACTTAGAGAAGAGCAAGATACGTCGTTGC
AGTTTGACTTTGTCTGTCGTGCGGGGATCTGCGGTAGTTGCGCCATGGTGATCAATGGTTTCCCTACTTTGGCTTGCCGT
ACTTTAACCGCCAAATATCCTAAGGGCGAGATCACCCTGATGCCACTGCCAGGCTTTGAATTGATTGGTGATTTATCAGT
TAACACGGGTAAGTTTATGCGTGAACTCGCCGAGCGATTAAAGCTGTGGTTACACCCTAAGGCGAATGATATCAGCATCC
ACCGCCTCGAAGAACCGATGGCGCCTGAGGAAGCGGCGCGTCTCTATGAATTAGAGCGCTGCGTCGAGTGTGGGGTTTGT
GTGTCAGCCTGTGCGACTAAGCAAATGCGTGAAACCTTTGTCGGCGCAGTAGGGATGATGAAAATCGCCCGCTTTGAACT
CGATAGCCGCGATGCACGCACGGCTGAAGACTTTTACCATGTGATTGGTAATCAGGATGGCGTGTTTGGTTGCATGACCT
TGCTCGGCTGCCAAGACAACTGTCCGAAGGATTTACCCCATATGCAGCAGATTGCCTATCTGCGCCGTAAAATGGCGATG
ACCTTGGTTTAA

Upstream 100 bases:

>100_bases
TGATGCCCTTCGAGCTGCCGCCTAGCCTGCAAGCAAAAAATGAACGTTTAAGTGATACCTTACAAAGACCATCTGCCAAT
GCGCTAGGAGAAAAATCATA

Downstream 100 bases:

>100_bases
AATCTCTTTAGCTGTTTGATTCAACATAAAAAGCGCCTTCGTAGGCGCTTTTTATGTGTGGGTCTTAACAGGCATAAGTC
TTATGAATATTAACCTGCTT

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSLQFDFVCRAGICGSCAMVINGFPTLACR
TLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKANDISIHRLEEPMAPEEAARLYELERCVECGVC
VSACATKQMRETFVGAVGMMKIARFELDSRDARTAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
TLV

Sequences:

>Translated_243_residues
MSQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSLQFDFVCRAGICGSCAMVINGFPTLACR
TLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKANDISIHRLEEPMAPEEAARLYELERCVECGVC
VSACATKQMRETFVGAVGMMKIARFELDSRDARTAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
TLV
>Mature_242_residues
SQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSLQFDFVCRAGICGSCAMVINGFPTLACRT
LTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKANDISIHRLEEPMAPEEAARLYELERCVECGVCV
SACATKQMRETFVGAVGMMKIARFELDSRDARTAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAMT
LV

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=235, Percent_Identity=31.9148936170213, Blast_Score=110, Evalue=8e-25,
Organism=Escherichia coli, GI1786943, Length=235, Percent_Identity=32.3404255319149, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790596, Length=225, Percent_Identity=27.1111111111111, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=29.0598290598291, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6322987, Length=239, Percent_Identity=30.5439330543933, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=30.2127659574468, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=29.0598290598291, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27520; Mature: 27389

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
10.3 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
9.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSLQFDFVCR
CCCCCEEEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHCCCEEEEEEEC
AGICGSCAMVINGFPTLACRTLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERL
CCCCCHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHH
KLWLHPKANDISIHRLEEPMAPEEAARLYELERCVECGVCVSACATKQMRETFVGAVGMM
HEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIARFELDSRDARTAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
HHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
TLV
HCC
>Mature Secondary Structure 
SQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSLQFDFVCR
CCCCEEEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHCCCEEEEEEEC
AGICGSCAMVINGFPTLACRTLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERL
CCCCCHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHH
KLWLHPKANDISIHRLEEPMAPEEAARLYELERCVECGVCVSACATKQMRETFVGAVGMM
HEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIARFELDSRDARTAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
HHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
TLV
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]