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The map label for this gene is frdA [H]

Identifier: 113968748

GI number: 113968748

Start: 450211

End: 452217

Strand: Direct

Name: frdA [H]

Synonym: Shewmr4_0404

Alternate gene names: 113968748

Gene position: 450211-452217 (Clockwise)

Preceding gene: 113968747

Following gene: 113968749

Centisome position: 9.57

GC content: 53.61

Gene sequence:

>2007_bases
GTGAAACTGATTTATACCGATTCATTAGTGGTTGGTGCCGGATTGGCTGGCCTGAGGGTGGCCATTGCCTCTAAAGAGCG
CGGGTTAGATACCTTAGTGCTTTCGCTTATTCCCGCCAAACGTTCTCACTCCGCTGCAGCGCAGGGGGGAATGCAGGCCA
GTCTTGGCAATGCCGTCAAAGGCATGGGCGATGATGAAGACGTGCATTTTCAAGATACGGTGAAAGGATCGGACTGGGGC
TGCGATCAAGAAGTCGCCAGAATGTTTGCCCATTGTGCACCTAAGGCGGTGCGTGAATTAGCCAACTGGGGCGTGCCTTG
GACACGTGTGACTGCAGGCCCAAGGGAAGTGATTGTTAACGCCCAAAAAGTCACATTGCAGGAAGCCGAAGAAGCCCACG
GTCTGATCAATGCTCGCGACTTTGGCGGCACTAAAAAGTGGCGCACCTGCTATACCGCCGACGGTACAGGTCACTCCTTA
CTCTATGCCATGGATAACAAAGCGATTTCGTTGGATATTCCTGTTCACGAGCGCGTTGAAGCACTGGCGATAATCCACGA
TGGTCAACGCTGTCACGGAGTGATTGCCCGCTGTTTAATCACGGGCGAGCTGCGTGCCTATGTGGCTAAATCGACCACGA
TCGCCACCGGTGGCTATGGCCGTATTTATGAAGTCTCAACCAATGCGATTATCTGCGAGGGTATAGGTCAGGCGCTGGCG
CTCGAAACGGGGGTCGCGACCCTTGGCAACATGGAAGCGGTACAGTTCCACCCAACGGCAATTGTGCCCGTGGGGATTTT
AACCACAGAAGGTTGCCGCGGTGATGGTGGCTTGCTGCGGGATAAAGACGGTTACCGTTTTATGCCGGACTATGAGCCAG
AGAAGAAAGAACTGGCGTCGCGGGACGTGGTGTCTCGCCGCATGACCGAACATATGCGTAAAGGTAAGGGCGTCGATAGT
CCCTATGGCCCACATTTATGGCTCGATATCACCCTGCTTGGGCGCAAGCATATCGAAACCAACCTGCGTGAAGTGCAGGA
GATTTGCGAAAACTTCCTCGGTATCGATCCCGCGAAGGATTGGATCCCCGTTCGTCCAACTCAGCACTATTCCATGGGCG
GGATCCGCACTAAGGCAACGGGCGAGAGTCCGCAGCTTAAGGGCTTATTCAGCGTGGGTGAGGCGGCCTGTTGGGATATG
CATGGCTTTAACCGATTGGGCGGCAACTCGCTCGCCGAAACTGTGGTTGGCGGCATGATTATCGGCAAATATGTGGCTGA
TTTTTGTGAGAATAACAGTCTTGAAATCGACACTCAGCTTGCCGAAAAGTTTATGCGGCAGGTACAGACTGAAATTGACA
CCTTAGTCGATGGTGAAGGTCATGAAAGTCCCTTTGAACTTAAGCGCGAAATGCAGCGGATTATGATGGATTACGTGGGG
ATTTTCCGTAATGGCCCAGAACTCGATAAGGCGGTGACAGAGCTAAAGGTGCTGCTTGAACGCTCACGTAAGCTCGGAGT
TAAGTGTAAGAAACGCCATGCCAATCCTGAGCTAGTAGAAGCACTAAGGGTAAAGCGGATGCTTAAGGTGGCGTTAACGG
TGGCCTGTGGCGCAGCAGCGCGTACCGAGAGCCGTGGTGCCCACGCCCGTGAGGATTATCCGCAGCGTAATGACAGAGAC
TGGCTCAACCGTACTCTCGCAAGTTGGCCCGATGCCGAGGCGTTGGCCCCCGTTTTAAGCTACGAGCCGCTGGATGTGAT
GAAGATGGAGTTGCCGCCGGGATACCGGGGTTACGGTATCGATAATGCCATTGTTCACCCTGATACCGCTAAACGCGAGC
AGCAAATTGCCGAGATTTTGGCCGGGCTGGGTGATGATGCTGACCGTTACCAGCGCCAAACGGCGCTGATGCCCTTCGAG
CTGCCGCCTAGCCTGCAAGCAAAAAATGAACGTTTAAGTGATACCTTACAAAGACCATCTGCCAATGCGCTAGGAGAAAA
ATCATAA

Upstream 100 bases:

>100_bases
ATTGCCTCCTTATTGGCATTTTTACCCCACGCGAGTTAGCGAATATAACAAAAGAGTGTTGTCCTAAAACAATAACAGCA
GTACCCGTTAAGGAGCAGGC

Downstream 100 bases:

>100_bases
TGAGCCAAGGTCGCCAGCTAACCTTTAATATTTTTCGTTATGATCCGCAGGAGCCAAACGATAAGCCGAAGATGGTGCGT
TATCAGCTCACCGAAACGCC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPREVIVNAQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISLDIPVHERVEALAIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
IFRNGPELDKAVTELKVLLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGIDNAIVHPDTAKREQQIAEILAGLGDDADRYQRQTALMPFE
LPPSLQAKNERLSDTLQRPSANALGEKS

Sequences:

>Translated_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPREVIVNAQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISLDIPVHERVEALAIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
IFRNGPELDKAVTELKVLLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGIDNAIVHPDTAKREQQIAEILAGLGDDADRYQRQTALMPFE
LPPSLQAKNERLSDTLQRPSANALGEKS
>Mature_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPREVIVNAQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISLDIPVHERVEALAIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
IFRNGPELDKAVTELKVLLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGIDNAIVHPDTAKREQQIAEILAGLGDDADRYQRQTALMPFE
LPPSLQAKNERLSDTLQRPSANALGEKS

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=607, Percent_Identity=35.4200988467875, Blast_Score=319, Evalue=5e-87,
Organism=Escherichia coli, GI1786942, Length=607, Percent_Identity=36.4085667215816, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=36.6269165247019, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1788928, Length=571, Percent_Identity=28.5464098073555, Blast_Score=170, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=37.6363636363636, Blast_Score=322, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI17550100, Length=545, Percent_Identity=38.348623853211, Blast_Score=314, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6322701, Length=600, Percent_Identity=37, Blast_Score=330, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=36.5935919055649, Blast_Score=324, Evalue=3e-89,
Organism=Drosophila melanogaster, GI17137288, Length=603, Percent_Identity=35.9867330016584, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24655642, Length=603, Percent_Identity=35.9867330016584, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24655647, Length=603, Percent_Identity=35.9867330016584, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24663005, Length=571, Percent_Identity=34.3257443082312, Blast_Score=276, Evalue=3e-74,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73433; Mature: 73433

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPREVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCHHHEEC
AQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISLDIPVHERVE
HHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALAIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
EEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELDKAVTELKVLLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCC
DNAIVHPDTAKREQQIAEILAGLGDDADRYQRQTALMPFELPPSLQAKNERLSDTLQRPS
CCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
ANALGEKS
CCCCCCCC
>Mature Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQEVARMFAHCAPKAVRELANWGVPWTRVTAGPREVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCHHHEEC
AQKVTLQEAEEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISLDIPVHERVE
HHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALAIIHDGQRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
EEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTKATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAEKFMRQVQTEIDTLVDGEGHESPFELKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELDKAVTELKVLLERSRKLGVKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDAEALAPVLSYEPLDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCC
DNAIVHPDTAKREQQIAEILAGLGDDADRYQRQTALMPFELPPSLQAKNERLSDTLQRPS
CCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
ANALGEKS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]