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The map label for this gene is cytR [H]

Identifier: 113968408

GI number: 113968408

Start: 73081

End: 74109

Strand: Direct

Name: cytR [H]

Synonym: Shewmr4_0063

Alternate gene names: 113968408

Gene position: 73081-74109 (Clockwise)

Preceding gene: 113968407

Following gene: 113968410

Centisome position: 1.55

GC content: 47.91

Gene sequence:

>1029_bases
ATGACAACTAAAAACTGGACCTTAAAGAGCATAGCAAACGAGCTAGGTGTCTCTAACGCCACTGTTTCTAATGCTTTTAA
TCGTCCCGATCAGCTATCGGAAAAACGTCGCAACGAGATTTTAGCCGCCTGCTCTAAACTGGGGTATTTTGGCCCAAATA
AGGCGGCGCAGTCCCTACGTAGGGGCAAATTTGATACCGTCGCGCTGGTACTGTCCGATAGTGTTGAATATATGGTGTCC
GATCCTGTCGCCAGTAAGTTTATGAAGGGGGTGGCTTCGGTATTGGAGCGGGAAAAACTCAACTTACTGCTATTTTCTGG
CAGCTCCGACAGTGTGAATGCGGTGGCCGATTTTGTGGATGGGTTTATTTGTTATGGTCGCCCGCGCAATGCCTTGCTCG
CCGAGCAATTAAAACAGGTTAAGAAGAAGGTGGTTACTGTGGATTTTGATATCCACCGCAACGCCTCTGTCAGCATTGAC
AATAAGTTAGCCGCCTATGAGGTGGCAAAATTGGCGTTAAAATCTCCCACCGATCAAGTTGCAATATTGGGATTGAGGCT
ACTCGATACCCATTTAACCTGCCGAGTTTACGATTTGAATTTGCTCGAAATCGATATGTCGATTGCGCACCAGAGGTTGC
AGGGATATTTACAGGCGATTGAGGAAACGGGTGTCACCCTTGGTAATGATCGGATTTGGAATATTCCGGAAAGTAATGCG
GAGTATGCGCGGATTGCGGCCAAGGAGGCATTAAACTCAACCCCAAGACCCAATGTATTTTTATGCATGAGCGACTTAAT
TGCCCTCAGCGTGCTGGGTGAGGCGCAGGCCATGGGATTAGCGATTCCGGAGGATATTCGTGTCGTGGGATTTGATGGTA
TTGATGAGGCGACTCGCTCGAATCCACCACTGACCACGGTTTACCAATACTCGGAACAAAAAGGCCAAATGGCGGCGCAG
ATGTTTATCGACGATGCCGTGCATGCTCAGGTATTAGGGTATGAACTACGTTTAGGCAAAAGCTGTTAA

Upstream 100 bases:

>100_bases
GATCATGAGTAGATTTGTTGGTGCACGACGGATTTAAGCTGTGTAGTATTTGCGGTAGGTTAGCTTCCGCTGTGACCCCA
TTCTTTGCCAGGAATTCTGC

Downstream 100 bases:

>100_bases
TACAATCAGTTTTATATGCAAAAGGCGCTAATTAAGCGCCTTTTGTTTTTGTTCTGCATTAGGCCTGTGCTTGAGTGAGC
AGGTCTGCTAATGCGATTTG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTTKNWTLKSIANELGVSNATVSNAFNRPDQLSEKRRNEILAACSKLGYFGPNKAAQSLRRGKFDTVALVLSDSVEYMVS
DPVASKFMKGVASVLEREKLNLLLFSGSSDSVNAVADFVDGFICYGRPRNALLAEQLKQVKKKVVTVDFDIHRNASVSID
NKLAAYEVAKLALKSPTDQVAILGLRLLDTHLTCRVYDLNLLEIDMSIAHQRLQGYLQAIEETGVTLGNDRIWNIPESNA
EYARIAAKEALNSTPRPNVFLCMSDLIALSVLGEAQAMGLAIPEDIRVVGFDGIDEATRSNPPLTTVYQYSEQKGQMAAQ
MFIDDAVHAQVLGYELRLGKSC

Sequences:

>Translated_342_residues
MTTKNWTLKSIANELGVSNATVSNAFNRPDQLSEKRRNEILAACSKLGYFGPNKAAQSLRRGKFDTVALVLSDSVEYMVS
DPVASKFMKGVASVLEREKLNLLLFSGSSDSVNAVADFVDGFICYGRPRNALLAEQLKQVKKKVVTVDFDIHRNASVSID
NKLAAYEVAKLALKSPTDQVAILGLRLLDTHLTCRVYDLNLLEIDMSIAHQRLQGYLQAIEETGVTLGNDRIWNIPESNA
EYARIAAKEALNSTPRPNVFLCMSDLIALSVLGEAQAMGLAIPEDIRVVGFDGIDEATRSNPPLTTVYQYSEQKGQMAAQ
MFIDDAVHAQVLGYELRLGKSC
>Mature_341_residues
TTKNWTLKSIANELGVSNATVSNAFNRPDQLSEKRRNEILAACSKLGYFGPNKAAQSLRRGKFDTVALVLSDSVEYMVSD
PVASKFMKGVASVLEREKLNLLLFSGSSDSVNAVADFVDGFICYGRPRNALLAEQLKQVKKKVVTVDFDIHRNASVSIDN
KLAAYEVAKLALKSPTDQVAILGLRLLDTHLTCRVYDLNLLEIDMSIAHQRLQGYLQAIEETGVTLGNDRIWNIPESNAE
YARIAAKEALNSTPRPNVFLCMSDLIALSVLGEAQAMGLAIPEDIRVVGFDGIDEATRSNPPLTTVYQYSEQKGQMAAQM
FIDDAVHAQVLGYELRLGKSC

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=344, Percent_Identity=26.7441860465116, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787948, Length=347, Percent_Identity=22.7665706051873, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787580, Length=299, Percent_Identity=23.4113712374582, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994940, Length=351, Percent_Identity=23.6467236467236, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790715, Length=357, Percent_Identity=23.5294117647059, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37551; Mature: 37420

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKNWTLKSIANELGVSNATVSNAFNRPDQLSEKRRNEILAACSKLGYFGPNKAAQSLR
CCCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RGKFDTVALVLSDSVEYMVSDPVASKFMKGVASVLEREKLNLLLFSGSSDSVNAVADFVD
CCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHC
GFICYGRPRNALLAEQLKQVKKKVVTVDFDIHRNASVSIDNKLAAYEVAKLALKSPTDQV
CEEEECCCCCHHHHHHHHHHHHHEEEEEEEECCCCCEEECCHHHHHHHHHHHHCCCCCHH
AILGLRLLDTHLTCRVYDLNLLEIDMSIAHQRLQGYLQAIEETGVTLGNDRIWNIPESNA
HHHHHHHHCCCEEEEEEECEEEEHHHHHHHHHHHHHHHHHHHCCCEECCCEEECCCCCCC
EYARIAAKEALNSTPRPNVFLCMSDLIALSVLGEAQAMGLAIPEDIRVVGFDGIDEATRS
HHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCC
NPPLTTVYQYSEQKGQMAAQMFIDDAVHAQVLGYELRLGKSC
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
>Mature Secondary Structure 
TTKNWTLKSIANELGVSNATVSNAFNRPDQLSEKRRNEILAACSKLGYFGPNKAAQSLR
CCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RGKFDTVALVLSDSVEYMVSDPVASKFMKGVASVLEREKLNLLLFSGSSDSVNAVADFVD
CCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHC
GFICYGRPRNALLAEQLKQVKKKVVTVDFDIHRNASVSIDNKLAAYEVAKLALKSPTDQV
CEEEECCCCCHHHHHHHHHHHHHEEEEEEEECCCCCEEECCHHHHHHHHHHHHCCCCCHH
AILGLRLLDTHLTCRVYDLNLLEIDMSIAHQRLQGYLQAIEETGVTLGNDRIWNIPESNA
HHHHHHHHCCCEEEEEEECEEEEHHHHHHHHHHHHHHHHHHHCCCEECCCEEECCCCCCC
EYARIAAKEALNSTPRPNVFLCMSDLIALSVLGEAQAMGLAIPEDIRVVGFDGIDEATRS
HHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCC
NPPLTTVYQYSEQKGQMAAQMFIDDAVHAQVLGYELRLGKSC
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]