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The map label for this gene is panB

Identifier: 113477823

GI number: 113477823

Start: 6818479

End: 6819270

Strand: Reverse

Name: panB

Synonym: Tery_4423

Alternate gene names: 113477823

Gene position: 6819270-6818479 (Counterclockwise)

Preceding gene: 113477824

Following gene: 113477815

Centisome position: 87.99

GC content: 38.26

Gene sequence:

>792_bases
ATGGCAGTTACAACTAAACAATTAATTCAATGGAAACAAAAAGGTCGCCCAATAGTAGCTCTGACAGCTTATGATTATAC
GATCGCTCAACTTTTAGACAATGCTGGAGTAGATTTAATTCTGGTGGGAGATTCTCTGGGAATGGTAACTTTAGGTTATG
AAACAACTTTACCAGTGACTCTTGAGGAAATGATTCATCATGCTAAAGCAGTACGACGAGCTGTAAAACAAGCTTTAATG
GTGGTAGATTTACCATTTTTAACTTATCAGGAAAGTCCCCAACAAGCTATACATTCAGCAGGAAGAATACTAAAAGAAAC
AGGAGCTCAAGCTGTCAAACTAGAAAGTGGTAATGAAGCGATCGCTCAAACTGTTAAGAAACTAACGTCAATAGGTATTC
CTGTGATGGGTCATATTGGCCTAATTCCCCAATCTGTACATCAATTTGGAGGTTATCCTCAACAAGGCAACGCTCCTGAT
GCTAGTGCGCGTATTTTAACAGAAGCTCTAGCTTTGGCAGAAGCTGGTGCTTTTGCCCTAGTTCTAGAACATATTAAAGC
AGATTTAGCTAAAGAGATTACAGAAAAAGTTTCTATTCCTACTATTGGTATTGGTGCAGGTGCCTATTGTGATGGTCAGA
TATTAGTGATTAATGATGTTTTAGGGCTTTCCCATTGGCAGCCACCTTTTGCTAAACCTTATGTTAACTTGCGAGAGACT
ATTACTCAAGCAGTTAAAGAATATAGTTTAGAAGTAAAGAAAAGAAAATTTCCTCAACCACCATCACCATAG

Upstream 100 bases:

>100_bases
AAAACCTCTGTCGTTTTTGCAAGGTCCTTGATTAATCAATCAAGTCATATGTTTTGATTTTTGATTTTTAACTTCCGCAA
AGCGGTTAACTTAACTGAAA

Downstream 100 bases:

>100_bases
TAGAGCTCAGAAGGTGCGGGTTAACAATTTTGAACTTAATACCATGCACCACTACAGAATATGATAAACTAGATTCGGTA
CTTCCAAACCATCGTGAGTT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAVTTKQLIQWKQKGRPIVALTAYDYTIAQLLDNAGVDLILVGDSLGMVTLGYETTLPVTLEEMIHHAKAVRRAVKQALM
VVDLPFLTYQESPQQAIHSAGRILKETGAQAVKLESGNEAIAQTVKKLTSIGIPVMGHIGLIPQSVHQFGGYPQQGNAPD
ASARILTEALALAEAGAFALVLEHIKADLAKEITEKVSIPTIGIGAGAYCDGQILVINDVLGLSHWQPPFAKPYVNLRET
ITQAVKEYSLEVKKRKFPQPPSP

Sequences:

>Translated_263_residues
MAVTTKQLIQWKQKGRPIVALTAYDYTIAQLLDNAGVDLILVGDSLGMVTLGYETTLPVTLEEMIHHAKAVRRAVKQALM
VVDLPFLTYQESPQQAIHSAGRILKETGAQAVKLESGNEAIAQTVKKLTSIGIPVMGHIGLIPQSVHQFGGYPQQGNAPD
ASARILTEALALAEAGAFALVLEHIKADLAKEITEKVSIPTIGIGAGAYCDGQILVINDVLGLSHWQPPFAKPYVNLRET
ITQAVKEYSLEVKKRKFPQPPSP
>Mature_262_residues
AVTTKQLIQWKQKGRPIVALTAYDYTIAQLLDNAGVDLILVGDSLGMVTLGYETTLPVTLEEMIHHAKAVRRAVKQALMV
VDLPFLTYQESPQQAIHSAGRILKETGAQAVKLESGNEAIAQTVKKLTSIGIPVMGHIGLIPQSVHQFGGYPQQGNAPDA
SARILTEALALAEAGAFALVLEHIKADLAKEITEKVSIPTIGIGAGAYCDGQILVINDVLGLSHWQPPFAKPYVNLRETI
TQAVKEYSLEVKKRKFPQPPSP

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=260, Percent_Identity=45, Blast_Score=216, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6319653, Length=252, Percent_Identity=40.0793650793651, Blast_Score=187, Evalue=1e-48,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_TRIEI (Q10WG3)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_723884.1
- ProteinModelPortal:   Q10WG3
- SMR:   Q10WG3
- STRING:   Q10WG3
- GeneID:   4246076
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_4423
- NMPDR:   fig|203124.1.peg.2987
- eggNOG:   COG0413
- HOGENOM:   HBG299908
- OMA:   DMMIAHG
- PhylomeDB:   Q10WG3
- ProtClustDB:   PRK00311
- BioCyc:   TERY203124:TERY_4423-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 28403; Mature: 28272

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: ACT_SITE 183-183 BINDING 83-83 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTTKQLIQWKQKGRPIVALTAYDYTIAQLLDNAGVDLILVGDSLGMVTLGYETTLPVT
CCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHH
LEEMIHHAKAVRRAVKQALMVVDLPFLTYQESPQQAIHSAGRILKETGAQAVKLESGNEA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHH
IAQTVKKLTSIGIPVMGHIGLIPQSVHQFGGYPQQGNAPDASARILTEALALAEAGAFAL
HHHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHH
VLEHIKADLAKEITEKVSIPTIGIGAGAYCDGQILVINDVLGLSHWQPPFAKPYVNLRET
HHHHHHHHHHHHHHHHHCCCEEECCCCCEECCEEEEEECHHCCCCCCCCCCCHHHHHHHH
ITQAVKEYSLEVKKRKFPQPPSP
HHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AVTTKQLIQWKQKGRPIVALTAYDYTIAQLLDNAGVDLILVGDSLGMVTLGYETTLPVT
CCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHH
LEEMIHHAKAVRRAVKQALMVVDLPFLTYQESPQQAIHSAGRILKETGAQAVKLESGNEA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHH
IAQTVKKLTSIGIPVMGHIGLIPQSVHQFGGYPQQGNAPDASARILTEALALAEAGAFAL
HHHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHH
VLEHIKADLAKEITEKVSIPTIGIGAGAYCDGQILVINDVLGLSHWQPPFAKPYVNLRET
HHHHHHHHHHHHHHHHHCCCEEECCCCCEECCEEEEEECHHCCCCCCCCCCCHHHHHHHH
ITQAVKEYSLEVKKRKFPQPPSP
HHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA