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The map label for this gene is fumC [H]

Identifier: 113475059

GI number: 113475059

Start: 2025743

End: 2027152

Strand: Reverse

Name: fumC [H]

Synonym: Tery_1328

Alternate gene names: 113475059

Gene position: 2027152-2025743 (Counterclockwise)

Preceding gene: 113475061

Following gene: 113475058

Centisome position: 26.16

GC content: 39.29

Gene sequence:

>1410_bases
ATGACAGAATCAAAGCACCCCAAAATGCGACTTGAAAGGGATAGTATGGGAAATATTGAAGTACCAGCAGACCGTTATTG
GGGCGCTCAAACCCAAAGATCGCTTATCTACTTCTCTATTGGGCAAGACTACATTCCACTGGAAGTTATCAAAGCATTTG
CTATCCTCAAAAAAGCAGTTGCCCAAACTAACCAGGAATTTGGTAAACTTCCAGAATACAAAACAAAATTAATCATTCAA
GCAGCAGAAGAAATTATTGCCGGAAAATTAGATAGAAATTTTCCGCTACGAGTTTGGATGACAGGAAGTGGCACTCAATG
CAATATGAATATTAACGAAGTCATAGCTAACCGGGCGATCGAAATTGCTGGTGGAAAAATGGGAAGCAAAAATCCGATAC
ATCCTAATGATCATGTTAATATGTCACAGTCATCTAACGACACATTCCCTACTGCTATGCACATCTCTTCAGCAGTAGCA
TTACATAAACAGTTGCTGCCGAAAGTCAAAAAAATCCGGGATGCACTCCAAGAGAAATCAGTAGAATTTGATGAAATTGT
TAAAATAGGGCGCACTCACCTACAAGATGCGGTTCCACTGACTTTGGGACAAGAATTTTCGGGGTATGTGGCGCAACTAG
ATGCAAATTTGCAACGTATCACTCATACATTGCCAGATTTATATGAATTAGCTATAGGTGGTACTGCAGTGGGAACAGGA
TTAAATACGGTGAAAGGCTTTGCTGAACTTGCTGCGAAACATATTAGTGAAATAACCGGGTTGCCTTTTGTGTCTGCACC
TAATAAGTTTGCTGCTTTAGCTGCTCATGATGGGATAGTGATGGCGAGCGGTGCTTTGAAGACTTTAGCTTGTTCGTTGC
TGAAAATTGCTAACGATATTCGGTGGTTGGGAAGTGGACCTAGATGTGGGTTTGGGGAGTTGATTTTACCTGCAAATGAA
CCGGGATCTTCTATTATGCCAGGAAAAGTTAATCCTACTCAGTGTGAAGCAATGACGATGGTGGCGACTCAGGTGATGGG
TTATGATGCAGCGATCACTTTGGCTGGTGCCCAGGGGAATTTTGAATTGAATACCTATAAACCGATGATGATATTTAATT
TGATTCAGTCGATTAATTTGATTGCTGATAGTTGTAATAATTTTACTGATTTTCTCTTGGTTGATTTGAAACCAAATAGA
AAAAAAATTGAATTTTATTTGGAAAATTCTTTGATGTTAGTGACTGCTTTAAGTCCGAAAATTGGATATGATCGGGCTGC
CGAAGTTGCTCATTTTGCCCATGAAAAAGATTTAACTTTAAAGCAAGCTTGTTTGGAATTAGGTTATGTTTCGGGAAAGG
AATTTGATGAAATTGTGATTCCTGAAAATATGACTCATCCTTCTACTTAG

Upstream 100 bases:

>100_bases
AAGCCTAAAAAGTAAAAAAATAAAAATTTAACTAAGCCCTGGAGATAAAAAGTAATGATATAGGTAAATATAGAGATACA
CTTTACCACAAAGGTTAACT

Downstream 100 bases:

>100_bases
TTTGATAATAAGATGTAGAAAAAATAATGTTCCCAAAGACCATTAGCTGATTATCTAGAGCTTTCTGGTAGCTTCCCGGA
GCGAAATTGCCAATATATAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTESKHPKMRLERDSMGNIEVPADRYWGAQTQRSLIYFSIGQDYIPLEVIKAFAILKKAVAQTNQEFGKLPEYKTKLIIQ
AAEEIIAGKLDRNFPLRVWMTGSGTQCNMNINEVIANRAIEIAGGKMGSKNPIHPNDHVNMSQSSNDTFPTAMHISSAVA
LHKQLLPKVKKIRDALQEKSVEFDEIVKIGRTHLQDAVPLTLGQEFSGYVAQLDANLQRITHTLPDLYELAIGGTAVGTG
LNTVKGFAELAAKHISEITGLPFVSAPNKFAALAAHDGIVMASGALKTLACSLLKIANDIRWLGSGPRCGFGELILPANE
PGSSIMPGKVNPTQCEAMTMVATQVMGYDAAITLAGAQGNFELNTYKPMMIFNLIQSINLIADSCNNFTDFLLVDLKPNR
KKIEFYLENSLMLVTALSPKIGYDRAAEVAHFAHEKDLTLKQACLELGYVSGKEFDEIVIPENMTHPST

Sequences:

>Translated_469_residues
MTESKHPKMRLERDSMGNIEVPADRYWGAQTQRSLIYFSIGQDYIPLEVIKAFAILKKAVAQTNQEFGKLPEYKTKLIIQ
AAEEIIAGKLDRNFPLRVWMTGSGTQCNMNINEVIANRAIEIAGGKMGSKNPIHPNDHVNMSQSSNDTFPTAMHISSAVA
LHKQLLPKVKKIRDALQEKSVEFDEIVKIGRTHLQDAVPLTLGQEFSGYVAQLDANLQRITHTLPDLYELAIGGTAVGTG
LNTVKGFAELAAKHISEITGLPFVSAPNKFAALAAHDGIVMASGALKTLACSLLKIANDIRWLGSGPRCGFGELILPANE
PGSSIMPGKVNPTQCEAMTMVATQVMGYDAAITLAGAQGNFELNTYKPMMIFNLIQSINLIADSCNNFTDFLLVDLKPNR
KKIEFYLENSLMLVTALSPKIGYDRAAEVAHFAHEKDLTLKQACLELGYVSGKEFDEIVIPENMTHPST
>Mature_468_residues
TESKHPKMRLERDSMGNIEVPADRYWGAQTQRSLIYFSIGQDYIPLEVIKAFAILKKAVAQTNQEFGKLPEYKTKLIIQA
AEEIIAGKLDRNFPLRVWMTGSGTQCNMNINEVIANRAIEIAGGKMGSKNPIHPNDHVNMSQSSNDTFPTAMHISSAVAL
HKQLLPKVKKIRDALQEKSVEFDEIVKIGRTHLQDAVPLTLGQEFSGYVAQLDANLQRITHTLPDLYELAIGGTAVGTGL
NTVKGFAELAAKHISEITGLPFVSAPNKFAALAAHDGIVMASGALKTLACSLLKIANDIRWLGSGPRCGFGELILPANEP
GSSIMPGKVNPTQCEAMTMVATQVMGYDAAITLAGAQGNFELNTYKPMMIFNLIQSINLIADSCNNFTDFLLVDLKPNRK
KIEFYLENSLMLVTALSPKIGYDRAAEVAHFAHEKDLTLKQACLELGYVSGKEFDEIVIPENMTHPST

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=60.2173913043478, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=51.9480519480519, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=58.9912280701754, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=38.4449244060475, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=60.8225108225108, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=60.8562691131498, Blast_Score=413, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=60.7375271149675, Blast_Score=561, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24662684, Length=472, Percent_Identity=58.2627118644068, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=58.0993520518359, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=58.0993520518359, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=57.3593073593074, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=50.3225806451613, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51346; Mature: 51215

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESKHPKMRLERDSMGNIEVPADRYWGAQTQRSLIYFSIGQDYIPLEVIKAFAILKKAV
CCCCCCCCCEECCCCCCCEECCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AQTNQEFGKLPEYKTKLIIQAAEEIIAGKLDRNFPLRVWMTGSGTQCNMNINEVIANRAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHHHHHCEE
EIAGGKMGSKNPIHPNDHVNMSQSSNDTFPTAMHISSAVALHKQLLPKVKKIRDALQEKS
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VEFDEIVKIGRTHLQDAVPLTLGQEFSGYVAQLDANLQRITHTLPDLYELAIGGTAVGTG
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
LNTVKGFAELAAKHISEITGLPFVSAPNKFAALAAHDGIVMASGALKTLACSLLKIANDI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHH
RWLGSGPRCGFGELILPANEPGSSIMPGKVNPTQCEAMTMVATQVMGYDAAITLAGAQGN
HCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCC
FELNTYKPMMIFNLIQSINLIADSCNNFTDFLLVDLKPNRKKIEFYLENSLMLVTALSPK
EEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECCEEEEEECCCC
IGYDRAAEVAHFAHEKDLTLKQACLELGYVSGKEFDEIVIPENMTHPST
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
TESKHPKMRLERDSMGNIEVPADRYWGAQTQRSLIYFSIGQDYIPLEVIKAFAILKKAV
CCCCCCCCEECCCCCCCEECCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AQTNQEFGKLPEYKTKLIIQAAEEIIAGKLDRNFPLRVWMTGSGTQCNMNINEVIANRAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHHHHHCEE
EIAGGKMGSKNPIHPNDHVNMSQSSNDTFPTAMHISSAVALHKQLLPKVKKIRDALQEKS
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VEFDEIVKIGRTHLQDAVPLTLGQEFSGYVAQLDANLQRITHTLPDLYELAIGGTAVGTG
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
LNTVKGFAELAAKHISEITGLPFVSAPNKFAALAAHDGIVMASGALKTLACSLLKIANDI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHH
RWLGSGPRCGFGELILPANEPGSSIMPGKVNPTQCEAMTMVATQVMGYDAAITLAGAQGN
HCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCC
FELNTYKPMMIFNLIQSINLIADSCNNFTDFLLVDLKPNRKKIEFYLENSLMLVTALSPK
EEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECCEEEEEECCCC
IGYDRAAEVAHFAHEKDLTLKQACLELGYVSGKEFDEIVIPENMTHPST
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]