Click here to switch to the map view.

The map label for this gene is rffG [H]

Identifier: 113474758

GI number: 113474758

Start: 1509381

End: 1510454

Strand: Reverse

Name: rffG [H]

Synonym: Tery_0957

Alternate gene names: 113474758

Gene position: 1510454-1509381 (Counterclockwise)

Preceding gene: 113474760

Following gene: 113474756

Centisome position: 19.49

GC content: 36.22

Gene sequence:

>1074_bases
ATGGAAACTCGATTGTTGATAACTGGGGGAGCTGGGTTTATTGGTTCTAACTTTACCCATTATTGGTGTCAGACTTATCC
TAATCACCGAGTAGTTGTGTTAGATGCTCTAACTTATGCTGGTAACAAGAAAACTTTAGCTGATTTACAAGACAGATCAA
ATTTTCGTTTTGTCCAAGGAGATATTTGCGATCGCTCTTTAGTAGATAGCTTACTCCAGGAAGAGGATATAGATACAGTA
GCCCACTTAGCAGCAGAATCTCATGTCGATAGGTCTATATTAGGACCAGCAGCTTTTGTTCAAACTAATGTTGTGGGTAC
TTTTACCCTATTAGAGGCATTCAGAAGTCATTATCAGACTCTGGCCCAAAACCCAGACCGTAAGTGTATATTTCTCCATG
TATCAACGGATGAAGTTTATGGCAGTTTAAGTCCTCAAGAGCTTGCTTTTACAGAAACTACACCTTATTCTCCAAATAGT
CCTTACTCAGCATCGAAAGCAGGAAGTGACCATTTTGCTAGAGCTTACTACCATACTTATGGTGTTCCGACAATTATTAC
TAATTGTTCTAATAACTACGGACCATACCATTTTCCTGAGAAGCTAATTCCTTTAATGTGCATCAATATATTATTAGGAA
AAGAATTACCAGTTTATGGAGATGGGCAAAATATTAGAGATTGGTTATATGTAATAGATCATTGTCGGGCATTAGATACG
GTAATTCATAAGGGCAAACCAGGACAAACTTATAATGTTGGTGGAAATAATGAAGTAAAAAATATTAATTTAGTACAAAT
GTTGTGTCAAATTATGGATGAGTTGGCAAATGATTTACCTGTAAAACCTTGTGAAAAATTAATTACTTTTGTCAAGGATA
GACCAGGGCATGATCGACGTTATGCTATTGATGCGACAAAGATTAAAACTGAGTTAGGTTGGCAACCTTCAGTAACTGTT
GAAGAAGGTTTACGTCAAACTGTAAAATGGTTTTTAAATAACCGAGATTGGTGGGAGCCATTATTGTCTGAAGAGTATCA
AGCTTACTATAAACAGGTTTATTCAAGTTCTTAA

Upstream 100 bases:

>100_bases
GTAATGCATAGAAATCAATAACCCCTGCGGCTAAAAGCCTGGGAGTATCAGATAATTAGTTTAATATTTTTGATAATTAC
AGCTTTAGGAGATGAAAATT

Downstream 100 bases:

>100_bases
AAAAAAAATAAAAAAGATTAACAGTAGTCAACAAAAAAAGTCAGTAATTACTTATTTTAATTGACTTTTTTCTCTTCGTA
AAAATAAATTATTTCCTATT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
METRLLITGGAGFIGSNFTHYWCQTYPNHRVVVLDALTYAGNKKTLADLQDRSNFRFVQGDICDRSLVDSLLQEEDIDTV
AHLAAESHVDRSILGPAAFVQTNVVGTFTLLEAFRSHYQTLAQNPDRKCIFLHVSTDEVYGSLSPQELAFTETTPYSPNS
PYSASKAGSDHFARAYYHTYGVPTIITNCSNNYGPYHFPEKLIPLMCINILLGKELPVYGDGQNIRDWLYVIDHCRALDT
VIHKGKPGQTYNVGGNNEVKNINLVQMLCQIMDELANDLPVKPCEKLITFVKDRPGHDRRYAIDATKIKTELGWQPSVTV
EEGLRQTVKWFLNNRDWWEPLLSEEYQAYYKQVYSSS

Sequences:

>Translated_357_residues
METRLLITGGAGFIGSNFTHYWCQTYPNHRVVVLDALTYAGNKKTLADLQDRSNFRFVQGDICDRSLVDSLLQEEDIDTV
AHLAAESHVDRSILGPAAFVQTNVVGTFTLLEAFRSHYQTLAQNPDRKCIFLHVSTDEVYGSLSPQELAFTETTPYSPNS
PYSASKAGSDHFARAYYHTYGVPTIITNCSNNYGPYHFPEKLIPLMCINILLGKELPVYGDGQNIRDWLYVIDHCRALDT
VIHKGKPGQTYNVGGNNEVKNINLVQMLCQIMDELANDLPVKPCEKLITFVKDRPGHDRRYAIDATKIKTELGWQPSVTV
EEGLRQTVKWFLNNRDWWEPLLSEEYQAYYKQVYSSS
>Mature_357_residues
METRLLITGGAGFIGSNFTHYWCQTYPNHRVVVLDALTYAGNKKTLADLQDRSNFRFVQGDICDRSLVDSLLQEEDIDTV
AHLAAESHVDRSILGPAAFVQTNVVGTFTLLEAFRSHYQTLAQNPDRKCIFLHVSTDEVYGSLSPQELAFTETTPYSPNS
PYSASKAGSDHFARAYYHTYGVPTIITNCSNNYGPYHFPEKLIPLMCINILLGKELPVYGDGQNIRDWLYVIDHCRALDT
VIHKGKPGQTYNVGGNNEVKNINLVQMLCQIMDELANDLPVKPCEKLITFVKDRPGHDRRYAIDATKIKTELGWQPSVTV
EEGLRQTVKWFLNNRDWWEPLLSEEYQAYYKQVYSSS

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=336, Percent_Identity=37.797619047619, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI42516563, Length=333, Percent_Identity=25.5255255255255, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4504031, Length=344, Percent_Identity=25, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI48994969, Length=347, Percent_Identity=57.6368876080692, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1788353, Length=359, Percent_Identity=53.7604456824513, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1786974, Length=364, Percent_Identity=27.7472527472527, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788366, Length=299, Percent_Identity=27.7591973244147, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=341, Percent_Identity=35.4838709677419, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=31.8042813455657, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17539532, Length=334, Percent_Identity=25.748502994012, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI133901788, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=292, Percent_Identity=26.3698630136986, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=292, Percent_Identity=26.3698630136986, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=292, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=363, Percent_Identity=25.6198347107438, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356223, Length=335, Percent_Identity=27.1641791044776, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19923002, Length=358, Percent_Identity=27.0949720670391, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 40503; Mature: 40503

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRLLITGGAGFIGSNFTHYWCQTYPNHRVVVLDALTYAGNKKTLADLQDRSNFRFVQG
CCCEEEEECCCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCEEEEC
DICDRSLVDSLLQEEDIDTVAHLAAESHVDRSILGPAAFVQTNVVGTFTLLEAFRSHYQT
CCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAQNPDRKCIFLHVSTDEVYGSLSPQELAFTETTPYSPNSPYSASKAGSDHFARAYYHTY
HHCCCCCEEEEEEEEHHHHHCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GVPTIITNCSNNYGPYHFPEKLIPLMCINILLGKELPVYGDGQNIRDWLYVIDHCRALDT
CCCHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VIHKGKPGQTYNVGGNNEVKNINLVQMLCQIMDELANDLPVKPCEKLITFVKDRPGHDRR
HHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCE
YAIDATKIKTELGWQPSVTVEEGLRQTVKWFLNNRDWWEPLLSEEYQAYYKQVYSSS
EEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METRLLITGGAGFIGSNFTHYWCQTYPNHRVVVLDALTYAGNKKTLADLQDRSNFRFVQG
CCCEEEEECCCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCEEEEC
DICDRSLVDSLLQEEDIDTVAHLAAESHVDRSILGPAAFVQTNVVGTFTLLEAFRSHYQT
CCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAQNPDRKCIFLHVSTDEVYGSLSPQELAFTETTPYSPNSPYSASKAGSDHFARAYYHTY
HHCCCCCEEEEEEEEHHHHHCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GVPTIITNCSNNYGPYHFPEKLIPLMCINILLGKELPVYGDGQNIRDWLYVIDHCRALDT
CCCHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VIHKGKPGQTYNVGGNNEVKNINLVQMLCQIMDELANDLPVKPCEKLITFVKDRPGHDRR
HHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCE
YAIDATKIKTELGWQPSVTVEEGLRQTVKWFLNNRDWWEPLLSEEYQAYYKQVYSSS
EEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]