Click here to switch to the map view.

The map label for this gene is trxB [H]

Identifier: 113474750

GI number: 113474750

Start: 1491215

End: 1491544

Strand: Reverse

Name: trxB [H]

Synonym: Tery_0945

Alternate gene names: 113474750

Gene position: 1491544-1491215 (Counterclockwise)

Preceding gene: 113474755

Following gene: 113474749

Centisome position: 19.25

GC content: 38.48

Gene sequence:

>330_bases
GTGAGTAGCAATGTTGTTGTCATTACTGATTCTGAATTTGAAGGTGAAGTCCTCCAATCAGAAAAACTTGTATTGGCTTA
CTTTTGGGCTAGTTGGTGTGGTCCATGTAAATTAGTATCCCCTTCCGTGGAAAAAGTGGCCACTACGTATAGTGATCGTC
TAAAAGTGGTCAAGATGGAGGTTGATCCTAACCCAGAAACCGTAAAGTCATATAAGGTTGAAGGAGTTCCTGCACTTAGA
CTGTTTGGGAATAAAAAATTATTACTTTCCCATGAAGGAAGCATTACATTGAATAAGTTAGTTGAGAGATTAGAAGCTCA
TTTAGCATGA

Upstream 100 bases:

>100_bases
CTGTTATGTCACTCCGCCAGGTAATTATGATAGAATAGATAAAATCAATAGAAAATATTTGTCAGAAAATTTTAGTAAAT
ATGAGTGAGATAGAAGAAAC

Downstream 100 bases:

>100_bases
ACAAGATATTTTTTATCTATTATCTCTAAATGTTGTGAAAAAACCCACGCTTTCCTAAAAGGAAGCGTCGGGATTAATTA
TAATTAATATTGTGTTTTTT

Product: thioredoxin domain-containing protein

Products: NA

Alternate protein names: Trx-2 [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MSSNVVVITDSEFEGEVLQSEKLVLAYFWASWCGPCKLVSPSVEKVATTYSDRLKVVKMEVDPNPETVKSYKVEGVPALR
LFGNKKLLLSHEGSITLNKLVERLEAHLA

Sequences:

>Translated_109_residues
MSSNVVVITDSEFEGEVLQSEKLVLAYFWASWCGPCKLVSPSVEKVATTYSDRLKVVKMEVDPNPETVKSYKVEGVPALR
LFGNKKLLLSHEGSITLNKLVERLEAHLA
>Mature_108_residues
SSNVVVITDSEFEGEVLQSEKLVLAYFWASWCGPCKLVSPSVEKVATTYSDRLKVVKMEVDPNPETVKSYKVEGVPALRL
FGNKKLLLSHEGSITLNKLVERLEAHLA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=102, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082331, Length=109, Percent_Identity=37.6146788990826, Blast_Score=102, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323072, Length=78, Percent_Identity=38.4615384615385, Blast_Score=62, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=76, Percent_Identity=35.5263157894737, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639826, Length=89, Percent_Identity=38.2022471910112, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=114, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573567, Length=82, Percent_Identity=34.1463414634146, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12123; Mature: 11992

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNVVVITDSEFEGEVLQSEKLVLAYFWASWCGPCKLVSPSVEKVATTYSDRLKVVKME
CCCCEEEEECCCCCCCCCCCCCEEEEEEHHHHCCCCEECCCCHHHHHHHHCCCEEEEEEE
VDPNPETVKSYKVEGVPALRLFGNKKLLLSHEGSITLNKLVERLEAHLA
ECCCCCHHHEEEECCCEEEEEECCEEEEEEECCCEEHHHHHHHHHHHCC
>Mature Secondary Structure 
SSNVVVITDSEFEGEVLQSEKLVLAYFWASWCGPCKLVSPSVEKVATTYSDRLKVVKME
CCCEEEEECCCCCCCCCCCCCEEEEEEHHHHCCCCEECCCCHHHHHHHHCCCEEEEEEE
VDPNPETVKSYKVEGVPALRLFGNKKLLLSHEGSITLNKLVERLEAHLA
ECCCCCHHHEEEECCCEEEEEECCEEEEEEECCCEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492494; 11759840; 8590004 [H]