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The map label for this gene is guaA [H]

Identifier: 113474718

GI number: 113474718

Start: 1432961

End: 1434688

Strand: Direct

Name: guaA [H]

Synonym: Tery_0907

Alternate gene names: 113474718

Gene position: 1432961-1434688 (Clockwise)

Preceding gene: 113474717

Following gene: 113474719

Centisome position: 18.49

GC content: 38.48

Gene sequence:

>1728_bases
GTGTGTCAACAGAAAAATTTTTCTCACAATTATTTATTAGTTTGGCTAATAACTCAGAAAATAATTGTTACTAACACAAG
AAAATTAATCATTAAAGTCCAACACAATAAAATATTAATCGTGACCCTAACAACACAGACACAAAAAAACTCAGATTCTC
TCACTCAATTTAACCGTCAAATGATCGTAATTTTGGATTTTGGTTCTCAATATTCAGAACTAATTGCCCGCCGAATTCGG
GAAACTCAAGTATATTCAGAGGTTATTTCTTACCGCACAACTGCAGCTAAACTGGCAGATATAAACCCCAAGGGAATCAT
TCTTTCTGGTGGGCCAAATTCTGTTTACGATGAAGGGGCACCTCATTGCGATCCCGAAATTTGGAATTTGGGAATACCCA
TTTTGGGTGTATGCTACGGTATGCAGTTAATGGTAAAACAACTGGGCGGAGAAGTTGAACGCACTCAGTTAGCTGAATAT
GGTAAAGCATCTGTATCAATAGATGATCCTACAGATTTGCTAACAAATATAGAAGAAGGTACAACTATGTGGATGAGTCA
TGGAGATTCTGTCACCAAAATGCCTTCTGGTTTTGAAGTATTAGCTCATACAGATAATACTCCTTGTGGAGCAATAGCTG
ACCACAATAAAAAGCTCTATGGTACTCAGTTTCACCCAGAGGTAGTTCATTCTATTGGTGGTCAAGTATTAATTCGGAAT
TTTGTTTACCATATCTGCAAGTGTGAACCAACCTGGACGACAGAAGCTTTTGTAGAAGAAGCGATTCGAGAAATTAGAGC
TAAAGTAGGGGATAAACGAGTATTATTAGCTCTGTCTGGAGGGGTAGACTCTTCGACTTTAGCATTTTTACTCCATCAGG
CCATTGGAGATAAATTAACTTGTATGTTTATTGACCAAGGGTTTATGCGAAAGTATGAACCAGAGAACTTGGTAAAAATA
TTTCACGAATCTTTTCATATATCAGTTAAATATGTGAATGCTCGCGATCGCTTCTTATCTATACTCAAAGGGGTCAGTGA
TCCAGAAGAAAAACGGAAATTAATCGGCCATGAATTTATTCAAGTATTTGAAGAAGAGTCAAAACGTTTGGGACCTTTTG
ATTATCTAGCTCAAGGTACTCTTTATCCAGACGTGATTGAATCTGCTAATACGAATGTTGACCCCAAAACCGGGGAGCGA
GTAGCGGTTAAAATTAAGAGTCATCACAATGTTGGTGGTTTGCCGAAAGATTTGAGATTTAAATTGGTCGAACCTTTGCG
CAAACTATTTAAGGATGAAGTGAGAAACGTTGGTCGTTCTATTGGCTTACCAGAAGAAATTGTGCGACGACATCCTTTTC
CTGGCCCGGGATTAGCAATTCGGATTTTAGGGGAGGTTACAGACAAACGTTTGAAAATATTACGGGATGCTGATTTTATT
GTGCGCGATGAAATTAGGCAGCAAGGTATGTATCATGATTTTTGGCAAGCGTTTGCTGTTTTGTTACCTATTCAAAGTGT
TGGGGTAATGGGGGATCAACGTACTTATGCTTACCCCATTGTTTTGCGGTTTGTTAAGAGTGAGGATGGAATGACTGCTG
ACTGGTCTCGTGTACCTTATGATTTGTTAGAAACTATTTCTAACCGCATTGTGAATGAGGTTAAGGGAGTTAATCGGGTG
GTGTATGATATTACTTCTAAACCTCCAGGTACTATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GGATATGTCTTATGTGACTATATTTTTATGAACTATATACCTATAAAAAACGAATCTACAAGCTTTTGTAGAAAGGCAGA
AATTTTTTTTTACACTGAGA

Downstream 100 bases:

>100_bases
TATAGTACTACGGTTAACTCCTAAGTCGGTAGGGGGTTTGGCTATCAAACCCCCTACTATATTTATTGAATAAATTGGAG
TTGTGGGAGTTAGGAGTAGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MCQQKNFSHNYLLVWLITQKIIVTNTRKLIIKVQHNKILIVTLTTQTQKNSDSLTQFNRQMIVILDFGSQYSELIARRIR
ETQVYSEVISYRTTAAKLADINPKGIILSGGPNSVYDEGAPHCDPEIWNLGIPILGVCYGMQLMVKQLGGEVERTQLAEY
GKASVSIDDPTDLLTNIEEGTTMWMSHGDSVTKMPSGFEVLAHTDNTPCGAIADHNKKLYGTQFHPEVVHSIGGQVLIRN
FVYHICKCEPTWTTEAFVEEAIREIRAKVGDKRVLLALSGGVDSSTLAFLLHQAIGDKLTCMFIDQGFMRKYEPENLVKI
FHESFHISVKYVNARDRFLSILKGVSDPEEKRKLIGHEFIQVFEEESKRLGPFDYLAQGTLYPDVIESANTNVDPKTGER
VAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRNVGRSIGLPEEIVRRHPFPGPGLAIRILGEVTDKRLKILRDADFI
VRDEIRQQGMYHDFWQAFAVLLPIQSVGVMGDQRTYAYPIVLRFVKSEDGMTADWSRVPYDLLETISNRIVNEVKGVNRV
VYDITSKPPGTIEWE

Sequences:

>Translated_575_residues
MCQQKNFSHNYLLVWLITQKIIVTNTRKLIIKVQHNKILIVTLTTQTQKNSDSLTQFNRQMIVILDFGSQYSELIARRIR
ETQVYSEVISYRTTAAKLADINPKGIILSGGPNSVYDEGAPHCDPEIWNLGIPILGVCYGMQLMVKQLGGEVERTQLAEY
GKASVSIDDPTDLLTNIEEGTTMWMSHGDSVTKMPSGFEVLAHTDNTPCGAIADHNKKLYGTQFHPEVVHSIGGQVLIRN
FVYHICKCEPTWTTEAFVEEAIREIRAKVGDKRVLLALSGGVDSSTLAFLLHQAIGDKLTCMFIDQGFMRKYEPENLVKI
FHESFHISVKYVNARDRFLSILKGVSDPEEKRKLIGHEFIQVFEEESKRLGPFDYLAQGTLYPDVIESANTNVDPKTGER
VAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRNVGRSIGLPEEIVRRHPFPGPGLAIRILGEVTDKRLKILRDADFI
VRDEIRQQGMYHDFWQAFAVLLPIQSVGVMGDQRTYAYPIVLRFVKSEDGMTADWSRVPYDLLETISNRIVNEVKGVNRV
VYDITSKPPGTIEWE
>Mature_575_residues
MCQQKNFSHNYLLVWLITQKIIVTNTRKLIIKVQHNKILIVTLTTQTQKNSDSLTQFNRQMIVILDFGSQYSELIARRIR
ETQVYSEVISYRTTAAKLADINPKGIILSGGPNSVYDEGAPHCDPEIWNLGIPILGVCYGMQLMVKQLGGEVERTQLAEY
GKASVSIDDPTDLLTNIEEGTTMWMSHGDSVTKMPSGFEVLAHTDNTPCGAIADHNKKLYGTQFHPEVVHSIGGQVLIRN
FVYHICKCEPTWTTEAFVEEAIREIRAKVGDKRVLLALSGGVDSSTLAFLLHQAIGDKLTCMFIDQGFMRKYEPENLVKI
FHESFHISVKYVNARDRFLSILKGVSDPEEKRKLIGHEFIQVFEEESKRLGPFDYLAQGTLYPDVIESANTNVDPKTGER
VAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRNVGRSIGLPEEIVRRHPFPGPGLAIRILGEVTDKRLKILRDADFI
VRDEIRQQGMYHDFWQAFAVLLPIQSVGVMGDQRTYAYPIVLRFVKSEDGMTADWSRVPYDLLETISNRIVNEVKGVNRV
VYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=552, Percent_Identity=39.1304347826087, Blast_Score=340, Evalue=1e-93,
Organism=Escherichia coli, GI1788854, Length=526, Percent_Identity=50.1901140684411, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1789760, Length=163, Percent_Identity=30.0613496932515, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=574, Percent_Identity=38.1533101045296, Blast_Score=334, Evalue=7e-92,
Organism=Caenorhabditis elegans, GI71992710, Length=574, Percent_Identity=38.1533101045296, Blast_Score=334, Evalue=7e-92,
Organism=Caenorhabditis elegans, GI133901714, Length=574, Percent_Identity=38.1533101045296, Blast_Score=333, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=48.8461538461538, Blast_Score=510, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322638, Length=169, Percent_Identity=28.9940828402367, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281365319, Length=552, Percent_Identity=37.1376811594203, Blast_Score=321, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 65141; Mature: 65141

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCQQKNFSHNYLLVWLITQKIIVTNTRKLIIKVQHNKILIVTLTTQTQKNSDSLTQFNRQ
CCCCCCCCCCEEEEEEECCHHEEECCEEEEEEEECCEEEEEEEECCCCCCCHHHHHHCCC
MIVILDFGSQYSELIARRIRETQVYSEVISYRTTAAKLADINPKGIILSGGPNSVYDEGA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
PHCDPEIWNLGIPILGVCYGMQLMVKQLGGEVERTQLAEYGKASVSIDDPTDLLTNIEEG
CCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEECCCHHHHHHCCCCC
TTMWMSHGDSVTKMPSGFEVLAHTDNTPCGAIADHNKKLYGTQFHPEVVHSIGGQVLIRN
CEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEECCCCCHHHHHHCCHHHHHHH
FVYHICKCEPTWTTEAFVEEAIREIRAKVGDKRVLLALSGGVDSSTLAFLLHQAIGDKLT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEE
CMFIDQGFMRKYEPENLVKIFHESFHISVKYVNARDRFLSILKGVSDPEEKRKLIGHEFI
EEEECCHHHHHCCHHHHHHHHHHCEEEEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHH
QVFEEESKRLGPFDYLAQGTLYPDVIESANTNVDPKTGERVAVKIKSHHNVGGLPKDLRF
HHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHH
KLVEPLRKLFKDEVRNVGRSIGLPEEIVRRHPFPGPGLAIRILGEVTDKRLKILRDADFI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCHH
VRDEIRQQGMYHDFWQAFAVLLPIQSVGVMGDQRTYAYPIVLRFVKSEDGMTADWSRVPY
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCCCCCCHHCCCH
DLLETISNRIVNEVKGVNRVVYDITSKPPGTIEWE
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MCQQKNFSHNYLLVWLITQKIIVTNTRKLIIKVQHNKILIVTLTTQTQKNSDSLTQFNRQ
CCCCCCCCCCEEEEEEECCHHEEECCEEEEEEEECCEEEEEEEECCCCCCCHHHHHHCCC
MIVILDFGSQYSELIARRIRETQVYSEVISYRTTAAKLADINPKGIILSGGPNSVYDEGA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
PHCDPEIWNLGIPILGVCYGMQLMVKQLGGEVERTQLAEYGKASVSIDDPTDLLTNIEEG
CCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEECCCHHHHHHCCCCC
TTMWMSHGDSVTKMPSGFEVLAHTDNTPCGAIADHNKKLYGTQFHPEVVHSIGGQVLIRN
CEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEECCCCCHHHHHHCCHHHHHHH
FVYHICKCEPTWTTEAFVEEAIREIRAKVGDKRVLLALSGGVDSSTLAFLLHQAIGDKLT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEE
CMFIDQGFMRKYEPENLVKIFHESFHISVKYVNARDRFLSILKGVSDPEEKRKLIGHEFI
EEEECCHHHHHCCHHHHHHHHHHCEEEEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHH
QVFEEESKRLGPFDYLAQGTLYPDVIESANTNVDPKTGERVAVKIKSHHNVGGLPKDLRF
HHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHH
KLVEPLRKLFKDEVRNVGRSIGLPEEIVRRHPFPGPGLAIRILGEVTDKRLKILRDADFI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCHH
VRDEIRQQGMYHDFWQAFAVLLPIQSVGVMGDQRTYAYPIVLRFVKSEDGMTADWSRVPY
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCCCCCCHHCCCH
DLLETISNRIVNEVKGVNRVVYDITSKPPGTIEWE
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA