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The map label for this gene is moaA

Identifier: 113474197

GI number: 113474197

Start: 475370

End: 476356

Strand: Reverse

Name: moaA

Synonym: Tery_0308

Alternate gene names: 113474197

Gene position: 476356-475370 (Counterclockwise)

Preceding gene: 113474201

Following gene: 113474196

Centisome position: 6.15

GC content: 33.43

Gene sequence:

>987_bases
ATGAACACAGTTGATTATCTAAGAATTAGTCTGATAGATCGTTGCAATTTTCGGTGTCAATATTGTATGCCAGAAGGTGC
AGAAATAGATTATATCTTAAAACAAGATTTGTTAACTGATAATGAGTTATTAAGTCTGCTTAAAGAGGTGTTTATTCCTG
TAGGTTTTACTCGGTTTCGCTTGACTGGAGGCGAGCCTTTATTACGTCCTAATGTTATAGGTTTGATTGAGGCGATCGCT
TCTTTTCCTGAAACAAAAGATTTATCTATGACTACTAATGGTTTTTTACTATCAAAGATGGCAAAAGATTTATATAAAGC
TGGTTTAAGAAGAATTAATATTAGTTTAGATACTCTTGATTCAGATACTTTTAATTTAATTATTGGAAATAAAAATCGTA
GTCATTGGCAGCTAGTTTGGAATGGTATTCAAGCGGCTTATGAGGTTGGTTTTGATCCTTTAAAGATTAATGTAGTTATT
ATTCCTGGGGTTAATGATCATGAAGTTTTAGATTTAGCTGCTTTAACTATTAACCGTAATTGGCATATTCGATTTATTGA
ATTTATGCCTATAGGTAATGATAAATTGTTTGATAATAAGGGTTGGATTTCTTCTGAAGAATTAAGGCAAATAATTAGGA
AAAAATGGGGGCTAACAGAGTCTTTTGTCCCGGGAAATGGACCGGCGGATATATTTCAAATTCCTGGAGCAAAAGGAACT
TTAGGGTTTATTAGTCAGATGTCTGAATGCTTTTGCGATCGCTGTAATAGAATGCGTCTTTCTGCAGATGGATGGTTAAG
ACCTTGTCTATTAAATGAAATCGGTCAAATAGATTTAAAAAGTAGTTTGCGTAATGGAATTTCTGTGGAAGAGTTACGGC
AGCAGGTGGAATATTTATTAGGTCTAAAACCAGAAATTAATTTTAAGCAAAGAGAGTCTGGCACTACTGGAATTTATAGT
CGAACTATGTCACAAATTGGTGGTTAA

Upstream 100 bases:

>100_bases
TAATATTGAGATAAATTAAAGTTTCAAAAAAGTGGCTATAACTAGCAAATATCTAGCAGGTAAAGTACAATTAAAATTAT
ATTAACAGAATATTTTTAAC

Downstream 100 bases:

>100_bases
TATCCTCCCGAGGCTGCTCCTATGAGGCAGCACGGGATTCCCTAATATGACTTTTCAAGACTTTCTATTTATTAGTATAT
TTACCTCTTTTTTCCACTCC

Product: GTP cyclohydrolase subunit MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MNTVDYLRISLIDRCNFRCQYCMPEGAEIDYILKQDLLTDNELLSLLKEVFIPVGFTRFRLTGGEPLLRPNVIGLIEAIA
SFPETKDLSMTTNGFLLSKMAKDLYKAGLRRINISLDTLDSDTFNLIIGNKNRSHWQLVWNGIQAAYEVGFDPLKINVVI
IPGVNDHEVLDLAALTINRNWHIRFIEFMPIGNDKLFDNKGWISSEELRQIIRKKWGLTESFVPGNGPADIFQIPGAKGT
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNEIGQIDLKSSLRNGISVEELRQQVEYLLGLKPEINFKQRESGTTGIYS
RTMSQIGG

Sequences:

>Translated_328_residues
MNTVDYLRISLIDRCNFRCQYCMPEGAEIDYILKQDLLTDNELLSLLKEVFIPVGFTRFRLTGGEPLLRPNVIGLIEAIA
SFPETKDLSMTTNGFLLSKMAKDLYKAGLRRINISLDTLDSDTFNLIIGNKNRSHWQLVWNGIQAAYEVGFDPLKINVVI
IPGVNDHEVLDLAALTINRNWHIRFIEFMPIGNDKLFDNKGWISSEELRQIIRKKWGLTESFVPGNGPADIFQIPGAKGT
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNEIGQIDLKSSLRNGISVEELRQQVEYLLGLKPEINFKQRESGTTGIYS
RTMSQIGG
>Mature_328_residues
MNTVDYLRISLIDRCNFRCQYCMPEGAEIDYILKQDLLTDNELLSLLKEVFIPVGFTRFRLTGGEPLLRPNVIGLIEAIA
SFPETKDLSMTTNGFLLSKMAKDLYKAGLRRINISLDTLDSDTFNLIIGNKNRSHWQLVWNGIQAAYEVGFDPLKINVVI
IPGVNDHEVLDLAALTINRNWHIRFIEFMPIGNDKLFDNKGWISSEELRQIIRKKWGLTESFVPGNGPADIFQIPGAKGT
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNEIGQIDLKSSLRNGISVEELRQQVEYLLGLKPEINFKQRESGTTGIYS
RTMSQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=329, Percent_Identity=39.8176291793313, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI22027536, Length=329, Percent_Identity=39.8176291793313, Blast_Score=224, Evalue=6e-59,
Organism=Escherichia coli, GI1786999, Length=324, Percent_Identity=33.641975308642, Blast_Score=181, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI32566329, Length=338, Percent_Identity=37.8698224852071, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=304, Percent_Identity=39.1447368421053, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=335, Percent_Identity=37.910447761194, Blast_Score=204, Evalue=4e-53,
Organism=Drosophila melanogaster, GI28574490, Length=292, Percent_Identity=39.7260273972603, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI28574488, Length=329, Percent_Identity=37.9939209726444, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_TRIEI (Q119N9)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720258.1
- ProteinModelPortal:   Q119N9
- SMR:   Q119N9
- STRING:   Q119N9
- GeneID:   4242910
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0308
- NMPDR:   fig|203124.1.peg.2506
- eggNOG:   COG2896
- HOGENOM:   HBG529885
- OMA:   KAIIDAM
- PhylomeDB:   Q119N9
- ProtClustDB:   CLSK896062
- BioCyc:   TERY203124:TERY_0308-MONOMER
- HAMAP:   MF_01225_B
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02666

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 37200; Mature: 37200

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 8-8 BINDING 21-21 BINDING 60-60 BINDING 64-64 BINDING 91-91 BINDING 115-115 BINDING 155-155 BINDING 189-189

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVDYLRISLIDRCNFRCQYCMPEGAEIDYILKQDLLTDNELLSLLKEVFIPVGFTRFR
CCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
LTGGEPLLRPNVIGLIEAIASFPETKDLSMTTNGFLLSKMAKDLYKAGLRRINISLDTLD
EECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEEEEEEECC
SDTFNLIIGNKNRSHWQLVWNGIQAAYEVGFDPLKINVVIIPGVNDHEVLDLAALTINRN
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHEEEEEEEECCC
WHIRFIEFMPIGNDKLFDNKGWISSEELRQIIRKKWGLTESFVPGNGPADIFQIPGAKGT
EEEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCH
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNEIGQIDLKSSLRNGISVEELRQQVEYLL
HHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHH
GLKPEINFKQRESGTTGIYSRTMSQIGG
CCCCCCCCHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNTVDYLRISLIDRCNFRCQYCMPEGAEIDYILKQDLLTDNELLSLLKEVFIPVGFTRFR
CCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
LTGGEPLLRPNVIGLIEAIASFPETKDLSMTTNGFLLSKMAKDLYKAGLRRINISLDTLD
EECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEEEEEEECC
SDTFNLIIGNKNRSHWQLVWNGIQAAYEVGFDPLKINVVIIPGVNDHEVLDLAALTINRN
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHEEEEEEEECCC
WHIRFIEFMPIGNDKLFDNKGWISSEELRQIIRKKWGLTESFVPGNGPADIFQIPGAKGT
EEEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCH
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNEIGQIDLKSSLRNGISVEELRQQVEYLL
HHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHH
GLKPEINFKQRESGTTGIYSRTMSQIGG
CCCCCCCCHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA