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The map label for this gene is glmU

Identifier: 110835585

GI number: 110835585

Start: 3081345

End: 3082703

Strand: Reverse

Name: glmU

Synonym: ABO_2724

Alternate gene names: 110835585

Gene position: 3082703-3081345 (Counterclockwise)

Preceding gene: 110835586

Following gene: 110835584

Centisome position: 98.8

GC content: 53.27

Gene sequence:

>1359_bases
ATGAGTCTAGCAGTAGTGATTCTGGCGGCGGGTAAAGGGACGCGGATGAAGAGCGCTTTGCCAAAGGTGCTTCATGCAGT
GGCCGGCAAGCCAATGGTGCAGCATGTGGTAGACGCGGCAGCGTCGCTGGAACCAGCCAATACCGTCATCGTATACGGCC
ATGGTGGCGAACAGGTGAAAGCCTCGGTCACTGGTGAGCAAGTGGCTTGGGCAGAGCAAGCTGAACAGCTCGGTACTGGC
CATGCGGTTGCGCAAGCCATGCCTTATGTAAAAGAAGACATGGTATTGGTGTTGTACGGTGATGTACCGCTGATTCGCCC
GGAAACACTAAAAGACTTTGTCGCCACGGTGGACGATAGCACCCTGGCGCTGATGACCCTAACCTTGGATGACCCGAACG
GTTACGGCCGTATCGTTCGTGATGGTCAGAACAACGTGCAGCGCATCGTTGAGCAGAAAGACGCCAGCGAAGCTGAGCTG
AGTATTCAGGAAATCAACACGGGCATTCTTGCCTGTTCACGGCGATTCCTAGAAGAAAGCTTGCCCAAGCTTTCCAGTAA
TAATGCCCAGGGCGAATATTACCTTACTGACCTGATCGCAATGGCGTCACAGTCGGGCTTGAATGTGCAAACCCTGCAAC
CCAACGAAGGCTGGGAAGTGGACGGGGTGAATGACAGAGTGCAATTGGCAAGGCTAGAGCGCATTTACCAGCAGGCTCAG
GCTGAAACCTTGATGCGTGACGGGGTAACATTGCTGGACCCTTCTCGTCTGGATATTCGCGGCAGAGTACAGATCGCCAG
TGATGTAATCATTGATGTGAATGTCATTTTAGAGGGAGATGTCACCATCGAAGAAGGTGTGGTGATCGGTCCTAACTGTA
TTCTGCGAGACGCCAACATCGGCGCCGGCACCGTCATAGAAGCGAACACACTCATTGACGGTGCTATTGTGGGTGAACAC
TGTCAGCTAGGCCCCTATGCCCGCTTGCGCCCTGGAACAGAACTGGCCGACAAAGCGAAGATAGGCAACTTTGTTGAAAC
CAAAAAGTCCTACATTGGCGAGGGTTCCAAGGTAAACCACCTGACCTATATCGGCGATAGCAAGATAGGTAAAGGCGTCA
ACGTGGGTGCCGGCACTATTACGTGTAACTATGATGGCGCCAACAAATTTCAGACCGTGCTGAAAGACGGAGCGTTCATT
GGCTCCAATTCCTCTCTAGTTGCTCCAGTCACCATTGGCGTAAATGCCACTGTAGGTGCGGGCAGCACTATTACAAAGGA
TGTGGGCGACAACGGCCTAGCGGTTGCTCGAACGCAACAGCGCAACGTGGCTAATTGGCAGCGCCCCAAGAAAGGGTAA

Upstream 100 bases:

>100_bases
TTCTGTCGTATAGTGAGCGCCCGGTTGGAATAGGTCCTGTGCGAATCAGAGGCGGCACAGTGGTATAACGGTACCGGCAT
GTAAAAGACAAGGATAGGGT

Downstream 100 bases:

>100_bases
GGAAGAGCATTTATGTGCGGAATTGTTGGGGCCATTGGCCAGCGGAATGTGACCAATATTTTGATCACTGGTCTCAAGCG
ACTTGAGTACCGGGGTTACG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase / glucosamine-1-phosphate N-acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSLAVVILAAGKGTRMKSALPKVLHAVAGKPMVQHVVDAAASLEPANTVIVYGHGGEQVKASVTGEQVAWAEQAEQLGTG
HAVAQAMPYVKEDMVLVLYGDVPLIRPETLKDFVATVDDSTLALMTLTLDDPNGYGRIVRDGQNNVQRIVEQKDASEAEL
SIQEINTGILACSRRFLEESLPKLSSNNAQGEYYLTDLIAMASQSGLNVQTLQPNEGWEVDGVNDRVQLARLERIYQQAQ
AETLMRDGVTLLDPSRLDIRGRVQIASDVIIDVNVILEGDVTIEEGVVIGPNCILRDANIGAGTVIEANTLIDGAIVGEH
CQLGPYARLRPGTELADKAKIGNFVETKKSYIGEGSKVNHLTYIGDSKIGKGVNVGAGTITCNYDGANKFQTVLKDGAFI
GSNSSLVAPVTIGVNATVGAGSTITKDVGDNGLAVARTQQRNVANWQRPKKG

Sequences:

>Translated_452_residues
MSLAVVILAAGKGTRMKSALPKVLHAVAGKPMVQHVVDAAASLEPANTVIVYGHGGEQVKASVTGEQVAWAEQAEQLGTG
HAVAQAMPYVKEDMVLVLYGDVPLIRPETLKDFVATVDDSTLALMTLTLDDPNGYGRIVRDGQNNVQRIVEQKDASEAEL
SIQEINTGILACSRRFLEESLPKLSSNNAQGEYYLTDLIAMASQSGLNVQTLQPNEGWEVDGVNDRVQLARLERIYQQAQ
AETLMRDGVTLLDPSRLDIRGRVQIASDVIIDVNVILEGDVTIEEGVVIGPNCILRDANIGAGTVIEANTLIDGAIVGEH
CQLGPYARLRPGTELADKAKIGNFVETKKSYIGEGSKVNHLTYIGDSKIGKGVNVGAGTITCNYDGANKFQTVLKDGAFI
GSNSSLVAPVTIGVNATVGAGSTITKDVGDNGLAVARTQQRNVANWQRPKKG
>Mature_451_residues
SLAVVILAAGKGTRMKSALPKVLHAVAGKPMVQHVVDAAASLEPANTVIVYGHGGEQVKASVTGEQVAWAEQAEQLGTGH
AVAQAMPYVKEDMVLVLYGDVPLIRPETLKDFVATVDDSTLALMTLTLDDPNGYGRIVRDGQNNVQRIVEQKDASEAELS
IQEINTGILACSRRFLEESLPKLSSNNAQGEYYLTDLIAMASQSGLNVQTLQPNEGWEVDGVNDRVQLARLERIYQQAQA
ETLMRDGVTLLDPSRLDIRGRVQIASDVIIDVNVILEGDVTIEEGVVIGPNCILRDANIGAGTVIEANTLIDGAIVGEHC
QLGPYARLRPGTELADKAKIGNFVETKKSYIGEGSKVNHLTYIGDSKIGKGVNVGAGTITCNYDGANKFQTVLKDGAFIG
SNSSLVAPVTIGVNATVGAGSTITKDVGDNGLAVARTQQRNVANWQRPKKG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=52.549889135255, Blast_Score=479, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_ALCBS (Q0VKX6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694444.1
- ProteinModelPortal:   Q0VKX6
- SMR:   Q0VKX6
- STRING:   Q0VKX6
- GeneID:   4211182
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2724
- NMPDR:   fig|393595.12.peg.2733
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q0VKX6
- BioCyc:   ABOR393595:ABO_2724-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48079; Mature: 47948

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 360-360 BINDING 73-73 BINDING 136-136 BINDING 151-151 BINDING 166-166 BINDING 384-384 BINDING 402-402 BINDING 420-420 BINDING 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAVVILAAGKGTRMKSALPKVLHAVAGKPMVQHVVDAAASLEPANTVIVYGHGGEQVK
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
ASVTGEQVAWAEQAEQLGTGHAVAQAMPYVKEDMVLVLYGDVPLIRPETLKDFVATVDDS
EECCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
TLALMTLTLDDPNGYGRIVRDGQNNVQRIVEQKDASEAELSIQEINTGILACSRRFLEES
EEEEEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHH
LPKLSSNNAQGEYYLTDLIAMASQSGLNVQTLQPNEGWEVDGVNDRVQLARLERIYQQAQ
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
AETLMRDGVTLLDPSRLDIRGRVQIASDVIIDVNVILEGDVTIEEGVVIGPNCILRDANI
HHHHHHCCCEEECCCCCCEEEEEEEECEEEEEEEEEEECCEEEECCEEECCCEEEEECCC
GAGTVIEANTLIDGAIVGEHCQLGPYARLRPGTELADKAKIGNFVETKKSYIGEGSKVNH
CCCEEEEECCEECCEEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCEEE
LTYIGDSKIGKGVNVGAGTITCNYDGANKFQTVLKDGAFIGSNSSLVAPVTIGVNATVGA
EEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCEECCCCCEEEEEEEECEEECCC
GSTITKDVGDNGLAVARTQQRNVANWQRPKKG
CCCEECCCCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SLAVVILAAGKGTRMKSALPKVLHAVAGKPMVQHVVDAAASLEPANTVIVYGHGGEQVK
CEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
ASVTGEQVAWAEQAEQLGTGHAVAQAMPYVKEDMVLVLYGDVPLIRPETLKDFVATVDDS
EECCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
TLALMTLTLDDPNGYGRIVRDGQNNVQRIVEQKDASEAELSIQEINTGILACSRRFLEES
EEEEEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHH
LPKLSSNNAQGEYYLTDLIAMASQSGLNVQTLQPNEGWEVDGVNDRVQLARLERIYQQAQ
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
AETLMRDGVTLLDPSRLDIRGRVQIASDVIIDVNVILEGDVTIEEGVVIGPNCILRDANI
HHHHHHCCCEEECCCCCCEEEEEEEECEEEEEEEEEEECCEEEECCEEECCCEEEEECCC
GAGTVIEANTLIDGAIVGEHCQLGPYARLRPGTELADKAKIGNFVETKKSYIGEGSKVNH
CCCEEEEECCEECCEEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCEEE
LTYIGDSKIGKGVNVGAGTITCNYDGANKFQTVLKDGAFIGSNSSLVAPVTIGVNATVGA
EEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCEECCCCCEEEEEEEECEEECCC
GSTITKDVGDNGLAVARTQQRNVANWQRPKKG
CCCEECCCCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA