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The map label for this gene is glmS [H]

Identifier: 110835584

GI number: 110835584

Start: 3079503

End: 3081332

Strand: Reverse

Name: glmS [H]

Synonym: ABO_2723

Alternate gene names: 110835584

Gene position: 3081332-3079503 (Counterclockwise)

Preceding gene: 110835585

Following gene: 110835583

Centisome position: 98.76

GC content: 53.28

Gene sequence:

>1830_bases
ATGTGCGGAATTGTTGGGGCCATTGGCCAGCGGAATGTGACCAATATTTTGATCACTGGTCTCAAGCGACTTGAGTACCG
GGGTTACGACAGTGCGGGAGTCGCGCTGCTCAACGATAAGGGCATCAGTCGTGTCCGTCGTCAGGGAAAAGTGGCCGGGT
TGGAAGAGGCAGTCCTGGAAGCACAAACCCAGGGTTTCACCGGCATTGCCCACACTCGCTGGGCTACCCACGGCAAGCCT
TCGGAGCCTAATTCGCACCCGCATATGTCCGGTGATGATTTGGCCCTGGTGCATAACGGTATCATCGAAAATTTTCAGGC
ACTCAAAGACGAGCTTGAAGCCAGCGGTTATACGTTCAACTCCCAAACCGATACGGAAGTGATTGTGCATCTGGTGCATC
AGGCGCTGGATAACGGGTTGAATCTTTTCGACGCCGTGCAAGCGGTCACAAAGAAACTCGATGGTGCCTACGCACTGGGT
GTTATTCATGCTTCTGAGCCGCACAAGTTGGTTACCGTGCGCTCTGGTAGCCCGCTGGTCATCGGCCTGGGGATTGATGA
AAACTATATCGCCTCCGACCAACTGGCCTTGTTGCCAGTAACCAACCGGTTCATCTTTTTGGAAGAGGGTGACCAGGCAG
AAATTACAACCAATAGCGTGCGTATAGTGGATGCAGCAGGTGAGCCGGTAACACGCGAAGCTCACGAGTTTGATGGCACC
CATGAAGATGCGGAAAAGGGCGAATACCGCCACTATATGCAGAAGGAAATTTTCGAGCAGCCCGCAGCTATTCAGAAAAC
CTTGGAAGATCGCATTGATAGCCCGGCTACCCTGATTGAGTCTTTCGGTGAAAAAGCGCCTGCTATTTTCGATAAGGTTA
AAACCGTTCAAATCGTCGCCTGCGGTACTAGCTATCACGCAGGTATGGTGGCCCGTTATTGGTTAGAGGACATTGCCGGT
ATTCCTTGCCAGGTCGAAGTAGCCAGTGAGTTCCGCTACCGCAAGCACGTGGTGCCAGAAGGCACTCTCTTTGTCACCAT
TTCCCAAAGCGGTGAAACCGCCGATACCTTGGCAGCGCTGCGTGATACTCAGTCACCCAATTATGTGGGTCGCCTGGCTG
TGTGTAACGTGGACAGCTCATCGTTGGTGCGTGAATCAGAACTGGTTTTTCTCACCAAAGCCGGTCCGGAAATCGGGGTA
GCTTCCACCAAGGCCTTCACTACTCAACTGGTTGGGTTGTTGATGCTCGTGTTAGCGCTGGGCCGCCAAAAAGGCCTGGC
CGACAGCGAGATCGAAAAAATTCTGGAAGAACTGCGTCAGCTGCCCAATTTGATCGAGCAGGCGGCGGCGTTAGACAAGC
CCATCGAAAAACTTTCAGAGGCGTTTGTGGAAAAACACCACGCCCTGTTTTTGGGGCGTGGCGTGCAATTTCCGGTGGCT
TTGGAAGGAGCCCTTAAGCTCAAGGAAATTTCCTATATCCACGCCGAAGCCTACGCAGCGGGAGAGCTTAAACACGGCCC
GTTGGCCTTGGTGGACAGCGAAATGCCGGTGGTGTCGGTGGCCCCCAATGATGAATTGTTGGAAAAGCTGAAATCCAATC
TGCAAGAAGTCCGTGCCCGTGGCGGTGAGCTTTATGTGTTTGCTGATAAGAATGCTCACGTAAAAGAAGGGGAAGGGATT
CATGTGTTAAACATGCCCTCAGTGCCCGACACTGTAGCCCCGATCGTTTATACCATACCGCTGCAGCTGCTTAGCTACCA
TGTGGCGGTGCTGCGCGGCACCGATGTGGATCAGCCTCGTAACCTAGCCAAGTCGGTAACGGTGGAATAG

Upstream 100 bases:

>100_bases
TACAAAGGATGTGGGCGACAACGGCCTAGCGGTTGCTCGAACGCAACAGCGCAACGTGGCTAATTGGCAGCGCCCCAAGA
AAGGGTAAGGAAGAGCATTT

Downstream 100 bases:

>100_bases
CCGCCACCCGCAAGGCAATACAAAAAAAGCCCGGCGATCGCCGGGCTTTTTTTGTTGCCGCTTTCTCTCCAGTGCCATTG
CATACCACCACGGGCACGGG

Product: glucosamine 6-phosphate synthase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAIGQRNVTNILITGLKRLEYRGYDSAGVALLNDKGISRVRRQGKVAGLEEAVLEAQTQGFTGIAHTRWATHGKP
SEPNSHPHMSGDDLALVHNGIIENFQALKDELEASGYTFNSQTDTEVIVHLVHQALDNGLNLFDAVQAVTKKLDGAYALG
VIHASEPHKLVTVRSGSPLVIGLGIDENYIASDQLALLPVTNRFIFLEEGDQAEITTNSVRIVDAAGEPVTREAHEFDGT
HEDAEKGEYRHYMQKEIFEQPAAIQKTLEDRIDSPATLIESFGEKAPAIFDKVKTVQIVACGTSYHAGMVARYWLEDIAG
IPCQVEVASEFRYRKHVVPEGTLFVTISQSGETADTLAALRDTQSPNYVGRLAVCNVDSSSLVRESELVFLTKAGPEIGV
ASTKAFTTQLVGLLMLVLALGRQKGLADSEIEKILEELRQLPNLIEQAAALDKPIEKLSEAFVEKHHALFLGRGVQFPVA
LEGALKLKEISYIHAEAYAAGELKHGPLALVDSEMPVVSVAPNDELLEKLKSNLQEVRARGGELYVFADKNAHVKEGEGI
HVLNMPSVPDTVAPIVYTIPLQLLSYHVAVLRGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAIGQRNVTNILITGLKRLEYRGYDSAGVALLNDKGISRVRRQGKVAGLEEAVLEAQTQGFTGIAHTRWATHGKP
SEPNSHPHMSGDDLALVHNGIIENFQALKDELEASGYTFNSQTDTEVIVHLVHQALDNGLNLFDAVQAVTKKLDGAYALG
VIHASEPHKLVTVRSGSPLVIGLGIDENYIASDQLALLPVTNRFIFLEEGDQAEITTNSVRIVDAAGEPVTREAHEFDGT
HEDAEKGEYRHYMQKEIFEQPAAIQKTLEDRIDSPATLIESFGEKAPAIFDKVKTVQIVACGTSYHAGMVARYWLEDIAG
IPCQVEVASEFRYRKHVVPEGTLFVTISQSGETADTLAALRDTQSPNYVGRLAVCNVDSSSLVRESELVFLTKAGPEIGV
ASTKAFTTQLVGLLMLVLALGRQKGLADSEIEKILEELRQLPNLIEQAAALDKPIEKLSEAFVEKHHALFLGRGVQFPVA
LEGALKLKEISYIHAEAYAAGELKHGPLALVDSEMPVVSVAPNDELLEKLKSNLQEVRARGGELYVFADKNAHVKEGEGI
HVLNMPSVPDTVAPIVYTIPLQLLSYHVAVLRGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGAIGQRNVTNILITGLKRLEYRGYDSAGVALLNDKGISRVRRQGKVAGLEEAVLEAQTQGFTGIAHTRWATHGKP
SEPNSHPHMSGDDLALVHNGIIENFQALKDELEASGYTFNSQTDTEVIVHLVHQALDNGLNLFDAVQAVTKKLDGAYALG
VIHASEPHKLVTVRSGSPLVIGLGIDENYIASDQLALLPVTNRFIFLEEGDQAEITTNSVRIVDAAGEPVTREAHEFDGT
HEDAEKGEYRHYMQKEIFEQPAAIQKTLEDRIDSPATLIESFGEKAPAIFDKVKTVQIVACGTSYHAGMVARYWLEDIAG
IPCQVEVASEFRYRKHVVPEGTLFVTISQSGETADTLAALRDTQSPNYVGRLAVCNVDSSSLVRESELVFLTKAGPEIGV
ASTKAFTTQLVGLLMLVLALGRQKGLADSEIEKILEELRQLPNLIEQAAALDKPIEKLSEAFVEKHHALFLGRGVQFPVA
LEGALKLKEISYIHAEAYAAGELKHGPLALVDSEMPVVSVAPNDELLEKLKSNLQEVRARGGELYVFADKNAHVKEGEGI
HVLNMPSVPDTVAPIVYTIPLQLLSYHVAVLRGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=38.7190684133916, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=37.280701754386, Blast_Score=419, Evalue=1e-117,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=61.8032786885246, Blast_Score=752, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=216, Percent_Identity=31.9444444444444, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=41.8604651162791, Blast_Score=296, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=41.4351851851852, Blast_Score=294, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=41.4351851851852, Blast_Score=293, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6322745, Length=449, Percent_Identity=39.6436525612472, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=29.9065420560748, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=221, Percent_Identity=36.6515837104072, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=38.1021897810219, Blast_Score=421, Evalue=1e-117,
Organism=Drosophila melanogaster, GI28573187, Length=260, Percent_Identity=25.3846153846154, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24659598, Length=262, Percent_Identity=24.0458015267176, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66256; Mature: 66256

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAIGQRNVTNILITGLKRLEYRGYDSAGVALLNDKGISRVRRQGKVAGLEEAVLE
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHH
AQTQGFTGIAHTRWATHGKPSEPNSHPHMSGDDLALVHNGIIENFQALKDELEASGYTFN
HHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEC
SQTDTEVIVHLVHQALDNGLNLFDAVQAVTKKLDGAYALGVIHASEPHKLVTVRSGSPLV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEE
IGLGIDENYIASDQLALLPVTNRFIFLEEGDQAEITTNSVRIVDAAGEPVTREAHEFDGT
EEECCCCCCCCCCCEEEEEECCEEEEEECCCCCEEEECCEEEEECCCCCCCCHHHHCCCC
HEDAEKGEYRHYMQKEIFEQPAAIQKTLEDRIDSPATLIESFGEKAPAIFDKVKTVQIVA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHCCCEEEEEE
CGTSYHAGMVARYWLEDIAGIPCQVEVASEFRYRKHVVPEGTLFVTISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHH
RDTQSPNYVGRLAVCNVDSSSLVRESELVFLTKAGPEIGVASTKAFTTQLVGLLMLVLAL
HCCCCCCCEEEEEEEECCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
GRQKGLADSEIEKILEELRQLPNLIEQAAALDKPIEKLSEAFVEKHHALFLGRGVQFPVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEE
LEGALKLKEISYIHAEAYAAGELKHGPLALVDSEMPVVSVAPNDELLEKLKSNLQEVRAR
ECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELYVFADKNAHVKEGEGIHVLNMPSVPDTVAPIVYTIPLQLLSYHVAVLRGTDVDQPR
CCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAIGQRNVTNILITGLKRLEYRGYDSAGVALLNDKGISRVRRQGKVAGLEEAVLE
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHH
AQTQGFTGIAHTRWATHGKPSEPNSHPHMSGDDLALVHNGIIENFQALKDELEASGYTFN
HHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEC
SQTDTEVIVHLVHQALDNGLNLFDAVQAVTKKLDGAYALGVIHASEPHKLVTVRSGSPLV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEE
IGLGIDENYIASDQLALLPVTNRFIFLEEGDQAEITTNSVRIVDAAGEPVTREAHEFDGT
EEECCCCCCCCCCCEEEEEECCEEEEEECCCCCEEEECCEEEEECCCCCCCCHHHHCCCC
HEDAEKGEYRHYMQKEIFEQPAAIQKTLEDRIDSPATLIESFGEKAPAIFDKVKTVQIVA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHCCCEEEEEE
CGTSYHAGMVARYWLEDIAGIPCQVEVASEFRYRKHVVPEGTLFVTISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHH
RDTQSPNYVGRLAVCNVDSSSLVRESELVFLTKAGPEIGVASTKAFTTQLVGLLMLVLAL
HCCCCCCCEEEEEEEECCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
GRQKGLADSEIEKILEELRQLPNLIEQAAALDKPIEKLSEAFVEKHHALFLGRGVQFPVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEE
LEGALKLKEISYIHAEAYAAGELKHGPLALVDSEMPVVSVAPNDELLEKLKSNLQEVRAR
ECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELYVFADKNAHVKEGEGIHVLNMPSVPDTVAPIVYTIPLQLLSYHVAVLRGTDVDQPR
CCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]