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The map label for this gene is zraS [H]

Identifier: 110835381

GI number: 110835381

Start: 2857627

End: 2859078

Strand: Direct

Name: zraS [H]

Synonym: ABO_2520

Alternate gene names: 110835381

Gene position: 2857627-2859078 (Clockwise)

Preceding gene: 110835380

Following gene: 110835382

Centisome position: 91.59

GC content: 47.59

Gene sequence:

>1452_bases
ATGAACAGCTTGCTGGACAAAACGAGTATTGGCTTTGGCATGGAAGCTCAAGGGCTATTTTTAGTGTCCTCTACGGTCAT
CCTGCTGATCATTATTTTCTTTTTGTATAAAACCTACCGCACCTCAATTAACGTGGAAGCTAAACTGACAGAGTTCTCGG
CGTTAACGGATAACCCGTTCGGCCGCAAGCTGCATTTGATCGAGGTAAATGCTGACGAATACAAACTGAACAAAGCTCTA
CTTGGCCCACTGGCGCGGATTATCGACGAATACTGTGTACTGACAACCGACCGCCACGGCACCATAACCTTTGCCAACGG
TAAGTTTCTCGCTCTCAGCGGTCACTCTTTTTCACAACTTATCGGTCAGAACGAAAAGATCAATCATCCTGAAGATGATT
CCCTACCGCTCATGCGTTGCGGGCAGGCGCTATCTGGTGTGTGGAACGGGGAGGTATGCAACCGTCATGCAGACGGTAGC
CGTTACTGGATGAACATGTTCCTATTTCCTCTTTCTTACATTTCCGATGAAGACGACGGCTATATTTATTTCGGCACCGA
TATCACCAACATCAAAACCGAAAACAATAAACTAATGCAGGAGGTGAAAGACAAGAGCCAAAAACTGGATCAGGTGGAAT
CGCTGCTATTACACTCGGAAAAAATGGCCTCATTGGGAACCATATCGGCAGGTATTGCCCACGAAATAAATAATCCTATC
GCCTATATTTCTTCCAATTTGAATCGCAGCCGGGATTACCTCAACTCCATGGCAGGTCTTATTAAGGGACTTAAAAAGCG
TATCAGCAATGATCAGTTCCAGAAATTTCTAAACACTGCAGAAAACCTTAATATAGACACAAAAAAGCTGGCCTTCATGA
TGGAAGATTATCCTGCACTGCTGAATGAAACCGAGGAAGGGATTGAGCGGATCAAGAAAATTATTCGCGACTTAAAGCAC
TTCTCCCATAACCAGCCAGAAGCGTTCTGTCCTACCGATATTCCTGCCTGCCTAGCGATTGCATTGAACCTAGCCAAACA
TGAAATTAAAAATCGGATTACGGTTACTCACACTCTACCCGATTCTCTACCTACGATTAGTGGATCGGCAAGCCAGCTGT
CGCAAGTGTTCATGAATCTGTTCGTCAACGCAGCCCAGGCTATCGAAGACAAAGGTCACATCACTATTGCAGCCCAGTGC
GATGAACAATGGTGCACTCTGACCATTGCCGACGATGGACCAGGCATTGCCGATGAATTCCTACAGCAGATCTTCGAACC
CTTCTTCACCACCAAGCCCATAGGCCAAGGCACCGGTCTTGGGCTGTCCATCTCCCATGACATCATTCAGCACCACGGCG
GCACCATGACCGTGGCAAGCCAACTCGGCGCCGGTACCATTTTTACGATCCGGCTACCGCTAAAGCAGACCGACCGGGCC
GATGCAGCCTGA

Upstream 100 bases:

>100_bases
AGAAACGGTTCGGGAGCAACAAGAAGCCTTGCGTAGTATGGGTTATGAGGGCTAGGCCCTTAACTTTTCGCCCTTCAAAC
AACTAATAACGGCTCGGCGC

Downstream 100 bases:

>100_bases
TTTCGTCTACACTCTGACCACGCCGACGGGGTGGCAACAACGCATCCGTATTTCTCTGTTAGAAGAGCACGGTGCCATTG
CCATTCCCGATACGTTTACC

Product: sensor histidin kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNSLLDKTSIGFGMEAQGLFLVSSTVILLIIIFFLYKTYRTSINVEAKLTEFSALTDNPFGRKLHLIEVNADEYKLNKAL
LGPLARIIDEYCVLTTDRHGTITFANGKFLALSGHSFSQLIGQNEKINHPEDDSLPLMRCGQALSGVWNGEVCNRHADGS
RYWMNMFLFPLSYISDEDDGYIYFGTDITNIKTENNKLMQEVKDKSQKLDQVESLLLHSEKMASLGTISAGIAHEINNPI
AYISSNLNRSRDYLNSMAGLIKGLKKRISNDQFQKFLNTAENLNIDTKKLAFMMEDYPALLNETEEGIERIKKIIRDLKH
FSHNQPEAFCPTDIPACLAIALNLAKHEIKNRITVTHTLPDSLPTISGSASQLSQVFMNLFVNAAQAIEDKGHITIAAQC
DEQWCTLTIADDGPGIADEFLQQIFEPFFTTKPIGQGTGLGLSISHDIIQHHGGTMTVASQLGAGTIFTIRLPLKQTDRA
DAA

Sequences:

>Translated_483_residues
MNSLLDKTSIGFGMEAQGLFLVSSTVILLIIIFFLYKTYRTSINVEAKLTEFSALTDNPFGRKLHLIEVNADEYKLNKAL
LGPLARIIDEYCVLTTDRHGTITFANGKFLALSGHSFSQLIGQNEKINHPEDDSLPLMRCGQALSGVWNGEVCNRHADGS
RYWMNMFLFPLSYISDEDDGYIYFGTDITNIKTENNKLMQEVKDKSQKLDQVESLLLHSEKMASLGTISAGIAHEINNPI
AYISSNLNRSRDYLNSMAGLIKGLKKRISNDQFQKFLNTAENLNIDTKKLAFMMEDYPALLNETEEGIERIKKIIRDLKH
FSHNQPEAFCPTDIPACLAIALNLAKHEIKNRITVTHTLPDSLPTISGSASQLSQVFMNLFVNAAQAIEDKGHITIAAQC
DEQWCTLTIADDGPGIADEFLQQIFEPFFTTKPIGQGTGLGLSISHDIIQHHGGTMTVASQLGAGTIFTIRLPLKQTDRA
DAA
>Mature_483_residues
MNSLLDKTSIGFGMEAQGLFLVSSTVILLIIIFFLYKTYRTSINVEAKLTEFSALTDNPFGRKLHLIEVNADEYKLNKAL
LGPLARIIDEYCVLTTDRHGTITFANGKFLALSGHSFSQLIGQNEKINHPEDDSLPLMRCGQALSGVWNGEVCNRHADGS
RYWMNMFLFPLSYISDEDDGYIYFGTDITNIKTENNKLMQEVKDKSQKLDQVESLLLHSEKMASLGTISAGIAHEINNPI
AYISSNLNRSRDYLNSMAGLIKGLKKRISNDQFQKFLNTAENLNIDTKKLAFMMEDYPALLNETEEGIERIKKIIRDLKH
FSHNQPEAFCPTDIPACLAIALNLAKHEIKNRITVTHTLPDSLPTISGSASQLSQVFMNLFVNAAQAIEDKGHITIAAQC
DEQWCTLTIADDGPGIADEFLQQIFEPFFTTKPIGQGTGLGLSISHDIIQHHGGTMTVASQLGAGTIFTIRLPLKQTDRA
DAA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=276, Percent_Identity=31.5217391304348, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788549, Length=266, Percent_Identity=29.6992481203008, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788393, Length=285, Percent_Identity=25.6140350877193, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081816, Length=152, Percent_Identity=34.2105263157895, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=177, Percent_Identity=29.9435028248588, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786600, Length=147, Percent_Identity=29.2517006802721, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=301, Percent_Identity=25.2491694352159, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=182, Percent_Identity=30.2197802197802, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53653; Mature: 53653

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLLDKTSIGFGMEAQGLFLVSSTVILLIIIFFLYKTYRTSINVEAKLTEFSALTDNPF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCC
GRKLHLIEVNADEYKLNKALLGPLARIIDEYCVLTTDRHGTITFANGKFLALSGHSFSQL
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCEEEEECCCCHHHH
IGQNEKINHPEDDSLPLMRCGQALSGVWNGEVCNRHADGSRYWMNMFLFPLSYISDEDDG
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
YIYFGTDITNIKTENNKLMQEVKDKSQKLDQVESLLLHSEKMASLGTISAGIAHEINNPI
EEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AYISSNLNRSRDYLNSMAGLIKGLKKRISNDQFQKFLNTAENLNIDTKKLAFMMEDYPAL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNETEEGIERIKKIIRDLKHFSHNQPEAFCPTDIPACLAIALNLAKHEIKNRITVTHTLP
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECC
DSLPTISGSASQLSQVFMNLFVNAAQAIEDKGHITIAAQCDEQWCTLTIADDGPGIADEF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCHHHHH
LQQIFEPFFTTKPIGQGTGLGLSISHDIIQHHGGTMTVASQLGAGTIFTIRLPLKQTDRA
HHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCEEEHHHCCCCEEEEEEECCCCCCCC
DAA
CCC
>Mature Secondary Structure
MNSLLDKTSIGFGMEAQGLFLVSSTVILLIIIFFLYKTYRTSINVEAKLTEFSALTDNPF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCC
GRKLHLIEVNADEYKLNKALLGPLARIIDEYCVLTTDRHGTITFANGKFLALSGHSFSQL
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCEEEEECCCCHHHH
IGQNEKINHPEDDSLPLMRCGQALSGVWNGEVCNRHADGSRYWMNMFLFPLSYISDEDDG
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
YIYFGTDITNIKTENNKLMQEVKDKSQKLDQVESLLLHSEKMASLGTISAGIAHEINNPI
EEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AYISSNLNRSRDYLNSMAGLIKGLKKRISNDQFQKFLNTAENLNIDTKKLAFMMEDYPAL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNETEEGIERIKKIIRDLKHFSHNQPEAFCPTDIPACLAIALNLAKHEIKNRITVTHTLP
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECC
DSLPTISGSASQLSQVFMNLFVNAAQAIEDKGHITIAAQCDEQWCTLTIADDGPGIADEF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCHHHHH
LQQIFEPFFTTKPIGQGTGLGLSISHDIIQHHGGTMTVASQLGAGTIFTIRLPLKQTDRA
HHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCEEEHHHCCCCEEEEEEECCCCCCCC
DAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]