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The map label for this gene is hemE

Identifier: 110835088

GI number: 110835088

Start: 2539837

End: 2540898

Strand: Reverse

Name: hemE

Synonym: ABO_2227

Alternate gene names: 110835088

Gene position: 2540898-2539837 (Counterclockwise)

Preceding gene: 110835089

Following gene: 110835081

Centisome position: 81.44

GC content: 54.52

Gene sequence:

>1062_bases
ATGACTTTCGCTCCCCTGCAAAATGATCGCTTTCTTCGTGCACTCAACCGCGAGACGGTGGATCGCACGCCTATCTGGAT
GATGCGCCAAGCGGGGCGTTACCTACCGGAATACCGGGCTGCTCGCGAGCATGCGGGTTCATTTATGGATCTGTGCAAGA
ATGCTGATCTGGCCTGTGAGGTGACGTTACAGCCATTGGAGCGTTACCCGTTGGACGCGGCTATTCTGTTCTCCGACATC
CTGACTATTCCTGATGCTATGGGGCTGGGGCTGTATTTTGAGACGGGAGAGGGGCCCAAATTCAGAAAAGTGGTGCGAAC
CGAAGCGGATGTGGCCGCACTGCCGATACCGGATGCAGAATCCGATCTGGGCTACGTGATGAATGCGGTGAGTACTATTC
GTGGTGCTCTTAATGGACGTGTGCCGCTGATCGGTTTTTCCGGGAGCCCCTGGACGCTGGCGACCTACATGGTAGAGGGC
GGCTCCAGCAAAGATTTCCGTCACCTTAAAGCGATGGTGTACAGCCAGCCCGAGCTGGCTCATGCCATGCTCGACAAACT
GGCTCAGTCCGTGACAGGTTACCTGAATGCACAGATCCGTCATGGAGCCCAGGCTGTGCAAATTTTTGATACTTGGGGCG
GGGCGCTGTCGGCGGAAGCCTATAAAGAATTTTCCCTGCGTTATATGCAGCAAATCGTGGATGGCCTGATTCGTGATAAT
GAGGGTCGCAAGGTACCGGTGATCCTGTTCACTAAAAACGGTGGCCTGTGGCTGGAATCCATGGCTGCCACGGGCTGTGA
TGCTTTAGGGCTGGACTGGACGATTAATATCGGTGACGCGCGCCGTCGTGTGGGTGACAAGGTCGCCCTACAGGGAAATA
TGGATCCGGCAGTGCTGTATGCCTCGCCGCAGGCGATTCGGGCTGAAGTGAAACGTATCCTCGATGATTTTGGTGATCAT
CCTGGGCATATTTTTAATCTAGGGCACGGCATCACCCCGCAAGTGGATCCGGAGCACGCTAAGGTCTTTATTGAAGCTGT
AGTGGAATTGAGTCAGAAATAA

Upstream 100 bases:

>100_bases
GGCCTGCTTTTGCAGGCCCTTTTTCTATATGATGTTGAAGATTTTTATTTTCGCGCGTTGCGTGCAGCGTAGTGCGTGAA
GTGTTTTCAAAGGAACCCAC

Downstream 100 bases:

>100_bases
CCGAGCTGCAAGCTACAACATTGGATAGGGAAAGCAGGGACGCTCCCTCCGATTTTTCTTTTTCATTGTGAACCTGTAAC
GGTATGCCTTGTGCTGGGTG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTFAPLQNDRFLRALNRETVDRTPIWMMRQAGRYLPEYRAAREHAGSFMDLCKNADLACEVTLQPLERYPLDAAILFSDI
LTIPDAMGLGLYFETGEGPKFRKVVRTEADVAALPIPDAESDLGYVMNAVSTIRGALNGRVPLIGFSGSPWTLATYMVEG
GSSKDFRHLKAMVYSQPELAHAMLDKLAQSVTGYLNAQIRHGAQAVQIFDTWGGALSAEAYKEFSLRYMQQIVDGLIRDN
EGRKVPVILFTKNGGLWLESMAATGCDALGLDWTINIGDARRRVGDKVALQGNMDPAVLYASPQAIRAEVKRILDDFGDH
PGHIFNLGHGITPQVDPEHAKVFIEAVVELSQK

Sequences:

>Translated_353_residues
MTFAPLQNDRFLRALNRETVDRTPIWMMRQAGRYLPEYRAAREHAGSFMDLCKNADLACEVTLQPLERYPLDAAILFSDI
LTIPDAMGLGLYFETGEGPKFRKVVRTEADVAALPIPDAESDLGYVMNAVSTIRGALNGRVPLIGFSGSPWTLATYMVEG
GSSKDFRHLKAMVYSQPELAHAMLDKLAQSVTGYLNAQIRHGAQAVQIFDTWGGALSAEAYKEFSLRYMQQIVDGLIRDN
EGRKVPVILFTKNGGLWLESMAATGCDALGLDWTINIGDARRRVGDKVALQGNMDPAVLYASPQAIRAEVKRILDDFGDH
PGHIFNLGHGITPQVDPEHAKVFIEAVVELSQK
>Mature_352_residues
TFAPLQNDRFLRALNRETVDRTPIWMMRQAGRYLPEYRAAREHAGSFMDLCKNADLACEVTLQPLERYPLDAAILFSDIL
TIPDAMGLGLYFETGEGPKFRKVVRTEADVAALPIPDAESDLGYVMNAVSTIRGALNGRVPLIGFSGSPWTLATYMVEGG
SSKDFRHLKAMVYSQPELAHAMLDKLAQSVTGYLNAQIRHGAQAVQIFDTWGGALSAEAYKEFSLRYMQQIVDGLIRDNE
GRKVPVILFTKNGGLWLESMAATGCDALGLDWTINIGDARRRVGDKVALQGNMDPAVLYASPQAIRAEVKRILDDFGDHP
GHIFNLGHGITPQVDPEHAKVFIEAVVELSQK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=46.3276836158192, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI2367337, Length=348, Percent_Identity=71.551724137931, Blast_Score=519, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320252, Length=361, Percent_Identity=38.781163434903, Blast_Score=271, Evalue=8e-74,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=42.5287356321839, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=42.5287356321839, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_ALCBS (Q0VMC3)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693947.1
- ProteinModelPortal:   Q0VMC3
- SMR:   Q0VMC3
- STRING:   Q0VMC3
- GeneID:   4212185
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2227
- NMPDR:   fig|393595.12.peg.2227
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q0VMC3
- BioCyc:   ABOR393595:ABO_2227-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38968; Mature: 38837

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 79-79 BINDING 156-156 BINDING 211-211 BINDING 329-329

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFAPLQNDRFLRALNRETVDRTPIWMMRQAGRYLPEYRAAREHAGSFMDLCKNADLACE
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCCEEE
VTLQPLERYPLDAAILFSDILTIPDAMGLGLYFETGEGPKFRKVVRTEADVAALPIPDAE
EEECHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHCCCCEEEECCCCCC
SDLGYVMNAVSTIRGALNGRVPLIGFSGSPWTLATYMVEGGSSKDFRHLKAMVYSQPELA
CHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHCCHHHH
HAMLDKLAQSVTGYLNAQIRHGAQAVQIFDTWGGALSAEAYKEFSLRYMQQIVDGLIRDN
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EGRKVPVILFTKNGGLWLESMAATGCDALGLDWTINIGDARRRVGDKVALQGNMDPAVLY
CCCEEEEEEEECCCCEEEHHHHHCCCCCCCCCEEEECCHHHHHCCCEEEEECCCCCEEEE
ASPQAIRAEVKRILDDFGDHPGHIFNLGHGITPQVDPEHAKVFIEAVVELSQK
ECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFAPLQNDRFLRALNRETVDRTPIWMMRQAGRYLPEYRAAREHAGSFMDLCKNADLACE
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCCEEE
VTLQPLERYPLDAAILFSDILTIPDAMGLGLYFETGEGPKFRKVVRTEADVAALPIPDAE
EEECHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHCCCCEEEECCCCCC
SDLGYVMNAVSTIRGALNGRVPLIGFSGSPWTLATYMVEGGSSKDFRHLKAMVYSQPELA
CHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHCCHHHH
HAMLDKLAQSVTGYLNAQIRHGAQAVQIFDTWGGALSAEAYKEFSLRYMQQIVDGLIRDN
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EGRKVPVILFTKNGGLWLESMAATGCDALGLDWTINIGDARRRVGDKVALQGNMDPAVLY
CCCEEEEEEEECCCCEEEHHHHHCCCCCCCCCEEEECCHHHHHCCCEEEEECCCCCEEEE
ASPQAIRAEVKRILDDFGDHPGHIFNLGHGITPQVDPEHAKVFIEAVVELSQK
ECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA