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The map label for this gene is mutL [H]

Identifier: 110835066

GI number: 110835066

Start: 2516697

End: 2518565

Strand: Reverse

Name: mutL [H]

Synonym: ABO_2205

Alternate gene names: 110835066

Gene position: 2518565-2516697 (Counterclockwise)

Preceding gene: 110835067

Following gene: 110835065

Centisome position: 80.72

GC content: 60.14

Gene sequence:

>1869_bases
TTGTCCAAAATTCAGCTGCTTGATTCCCGCCTTGCTAACCAGATTGCCGCCGGTGAAGTGGTTGAGCGCCCCGCGTCTGT
GCTCAAAGAGCTGCTGGAGAATGCGCTGGACGCTGGCTCGGAATCCATCAGTGTGGATGTGGAGCAGGGCGGGGTGAAAC
TGCTGCGGGTACGCGACAACGGCAGTGGCATCGAGCGCGATGATTTACCGCTGGCTCTGTCGCGCCATGCCACCAGCAAA
ATCCGGGGGCTTGATGATCTGGAAGCCATTGGCACGTTGGGGTTTCGCGGTGAGGCTCTGGCGGCGATCAGTTCTGTCTC
CCGGTTGAGTCTGGCCAGTAATGTGGAGGGGGAGCCGGAAGGTTGGCAGGTGACCGTGGAGGGGCGTGATATGGCGCCGT
CAGTATCGCCGGCAGGGCATCCCCGTGGCACCACCGTCACCATGCGCGATTTGTTCTTCAATACTCCGGCGCGGCGTCGT
TTCCTGCGCACCGAAAAAACGGAATTCAATCATCTCGAAGAGGTGTTCCGGCGCATTGCCCTGAGCGAATTCAATACCGC
TTTTCGTCTTACCCATAACCAGAAAGTGATTCACCAGCTGCCTGCTGGGTTGGATGACACTTTGCGGGCAGCGCGGGTGG
CCAAGCTGTGTGGCAAGGGCTTCATTGAGCAGGCGGTACCGGTGGATGTGGAGCGTGATGGTTTGCGGCTGCATGGCTGG
ATGGGGCTGCCCACTTTTTCCCGGTCCCAGGCGGACCTACAGTATTTCTATGTAAATGGTCGGGTCATCCGGGACAAGGT
GGTTAGCCATGCGGTGCGTCAGGCTTACTCGGATGTGCTTTATCATGGCCGCCATCCAGCCTATGTGCTGTTTCTGGAAC
TGGATCCGGCCATGGTGGATGTGAATGTTCACCCCACCAAGCACGAAGTGCGTTTCCGCGAGCAGCGCATGGTGCATGGT
TTCTTGTATAGCTCGCTGCACCGTGTCATTGCCGGGGTGCGGCCCGGCCAGGAACTGGCGGGTTCAGTGGCCGATGAAGG
CGGGCCAGCTGCAGGGATGGATGCAGCCATGGCGCCGAGCCAGGGTAATATGTCGCTGACTTCGCCGACGGGCTCGGGGG
GCTCCCTGTCTCATCCTCCCGGGCAGGCTTATCCTTCCACGGGGGGAGGCGTGTTCGGCTATGGCCAGGGCGCACGTCAG
GCGGATGCTTATGGGGCGTTGGTCCGTGGGCATGTAGGTGAGTCGGCGCCGGCGGTAATGCCGCCGGCCAACGAAAATGA
AACGGTACCGCCATTAGGGTATGCGGTGGCGCAATTGCACGGCATTTTTATTTTGGCGGAGAACGAGCAAGGGATGGTGG
TGGTGGATATGCACGCCGCCCACGAACGGATTACCTACGAACGGCTCAAGCAGAGCTGGGCGGAAGACAAGGTGCGTAGC
CAGCCGTTGCTAGTGCCGGTGTCGCTGGCGGTGTCATCCCGGGAGGCGGACTTTGCTGAGCAGCAGCCGGAGGTCTTTTC
CAGGCTGGGGTTTGTGGTTCAGCGTGCTGGGCCGGAGACTCTGGTGGTGCGCGAAGTGCCGGCCCTTCTTCGTAATGGCG
ACAGCGAATCCATGGTGCGAGATGTGCTATCGGACCTGCTGGCCGAAGGCAGCAGCGAACGCATTGCGCAAAAGCTCGAT
GAGCTGCTGTCTACTATGGCCTGCCACGGCAGTGTGCGTGCCAATCGCCGCCTCACCATTGCAGAAATGAACGCGCTGTT
GCGTGATATGGAAGCCACTGAGCGTTCCGGCCAATGCAACCATGGCCGGCCCACCTGGACCCAGATGAGTATTAAGGATC
TGGATCGACTGTTCATGCGGGGGCAATGA

Upstream 100 bases:

>100_bases
GACATTCCGCTTGCACGCAATACGCGCCATGCTGGCACGCTAATTTCCAAACGTGCTGGGTGCGGTGTGGCGGGTCAGAT
AATTTCCTAAAGGGTGTGTT

Downstream 100 bases:

>100_bases
ACCATGACCGCTTGCACGCGACACCCAAGCAGGCAACACGTGGAGGGCACGCGGTCTTTCGCGTGTCAGCGTGATGCCTG
AAGCGTCTCTGCCTATTTTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSKIQLLDSRLANQIAAGEVVERPASVLKELLENALDAGSESISVDVEQGGVKLLRVRDNGSGIERDDLPLALSRHATSK
IRGLDDLEAIGTLGFRGEALAAISSVSRLSLASNVEGEPEGWQVTVEGRDMAPSVSPAGHPRGTTVTMRDLFFNTPARRR
FLRTEKTEFNHLEEVFRRIALSEFNTAFRLTHNQKVIHQLPAGLDDTLRAARVAKLCGKGFIEQAVPVDVERDGLRLHGW
MGLPTFSRSQADLQYFYVNGRVIRDKVVSHAVRQAYSDVLYHGRHPAYVLFLELDPAMVDVNVHPTKHEVRFREQRMVHG
FLYSSLHRVIAGVRPGQELAGSVADEGGPAAGMDAAMAPSQGNMSLTSPTGSGGSLSHPPGQAYPSTGGGVFGYGQGARQ
ADAYGALVRGHVGESAPAVMPPANENETVPPLGYAVAQLHGIFILAENEQGMVVVDMHAAHERITYERLKQSWAEDKVRS
QPLLVPVSLAVSSREADFAEQQPEVFSRLGFVVQRAGPETLVVREVPALLRNGDSESMVRDVLSDLLAEGSSERIAQKLD
ELLSTMACHGSVRANRRLTIAEMNALLRDMEATERSGQCNHGRPTWTQMSIKDLDRLFMRGQ

Sequences:

>Translated_622_residues
MSKIQLLDSRLANQIAAGEVVERPASVLKELLENALDAGSESISVDVEQGGVKLLRVRDNGSGIERDDLPLALSRHATSK
IRGLDDLEAIGTLGFRGEALAAISSVSRLSLASNVEGEPEGWQVTVEGRDMAPSVSPAGHPRGTTVTMRDLFFNTPARRR
FLRTEKTEFNHLEEVFRRIALSEFNTAFRLTHNQKVIHQLPAGLDDTLRAARVAKLCGKGFIEQAVPVDVERDGLRLHGW
MGLPTFSRSQADLQYFYVNGRVIRDKVVSHAVRQAYSDVLYHGRHPAYVLFLELDPAMVDVNVHPTKHEVRFREQRMVHG
FLYSSLHRVIAGVRPGQELAGSVADEGGPAAGMDAAMAPSQGNMSLTSPTGSGGSLSHPPGQAYPSTGGGVFGYGQGARQ
ADAYGALVRGHVGESAPAVMPPANENETVPPLGYAVAQLHGIFILAENEQGMVVVDMHAAHERITYERLKQSWAEDKVRS
QPLLVPVSLAVSSREADFAEQQPEVFSRLGFVVQRAGPETLVVREVPALLRNGDSESMVRDVLSDLLAEGSSERIAQKLD
ELLSTMACHGSVRANRRLTIAEMNALLRDMEATERSGQCNHGRPTWTQMSIKDLDRLFMRGQ
>Mature_621_residues
SKIQLLDSRLANQIAAGEVVERPASVLKELLENALDAGSESISVDVEQGGVKLLRVRDNGSGIERDDLPLALSRHATSKI
RGLDDLEAIGTLGFRGEALAAISSVSRLSLASNVEGEPEGWQVTVEGRDMAPSVSPAGHPRGTTVTMRDLFFNTPARRRF
LRTEKTEFNHLEEVFRRIALSEFNTAFRLTHNQKVIHQLPAGLDDTLRAARVAKLCGKGFIEQAVPVDVERDGLRLHGWM
GLPTFSRSQADLQYFYVNGRVIRDKVVSHAVRQAYSDVLYHGRHPAYVLFLELDPAMVDVNVHPTKHEVRFREQRMVHGF
LYSSLHRVIAGVRPGQELAGSVADEGGPAAGMDAAMAPSQGNMSLTSPTGSGGSLSHPPGQAYPSTGGGVFGYGQGARQA
DAYGALVRGHVGESAPAVMPPANENETVPPLGYAVAQLHGIFILAENEQGMVVVDMHAAHERITYERLKQSWAEDKVRSQ
PLLVPVSLAVSSREADFAEQQPEVFSRLGFVVQRAGPETLVVREVPALLRNGDSESMVRDVLSDLLAEGSSERIAQKLDE
LLSTMACHGSVRANRRLTIAEMNALLRDMEATERSGQCNHGRPTWTQMSIKDLDRLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=316, Percent_Identity=34.4936708860759, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI4505913, Length=352, Percent_Identity=27.2727272727273, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI310128478, Length=352, Percent_Identity=27.2727272727273, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI189458898, Length=423, Percent_Identity=26.241134751773, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4505911, Length=423, Percent_Identity=26.241134751773, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI189458896, Length=416, Percent_Identity=25.7211538461538, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI310128480, Length=305, Percent_Identity=25.9016393442623, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI263191589, Length=228, Percent_Identity=26.7543859649123, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI91992162, Length=270, Percent_Identity=25.5555555555556, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI91992160, Length=270, Percent_Identity=25.5555555555556, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790612, Length=611, Percent_Identity=40.2618657937807, Blast_Score=407, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=34.6749226006192, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=365, Percent_Identity=27.1232876712329, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=353, Percent_Identity=32.5779036827195, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324247, Length=360, Percent_Identity=25, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=710, Percent_Identity=20.9859154929577, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=353, Percent_Identity=25.4957507082153, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136968, Length=316, Percent_Identity=35.7594936708861, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17136970, Length=360, Percent_Identity=27.5, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67888; Mature: 67757

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIQLLDSRLANQIAAGEVVERPASVLKELLENALDAGSESISVDVEQGGVKLLRVRDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECC
GSGIERDDLPLALSRHATSKIRGLDDLEAIGTLGFRGEALAAISSVSRLSLASNVEGEPE
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
GWQVTVEGRDMAPSVSPAGHPRGTTVTMRDLFFNTPARRRFLRTEKTEFNHLEEVFRRIA
CEEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHH
LSEFNTAFRLTHNQKVIHQLPAGLDDTLRAARVAKLCGKGFIEQAVPVDVERDGLRLHGW
HHHCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEE
MGLPTFSRSQADLQYFYVNGRVIRDKVVSHAVRQAYSDVLYHGRHPAYVLFLELDPAMVD
ECCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEE
VNVHPTKHEVRFREQRMVHGFLYSSLHRVIAGVRPGQELAGSVADEGGPAAGMDAAMAPS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
QGNMSLTSPTGSGGSLSHPPGQAYPSTGGGVFGYGQGARQADAYGALVRGHVGESAPAVM
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
PPANENETVPPLGYAVAQLHGIFILAENEQGMVVVDMHAAHERITYERLKQSWAEDKVRS
CCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCC
QPLLVPVSLAVSSREADFAEQQPEVFSRLGFVVQRAGPETLVVREVPALLRNGDSESMVR
CCEEEEEEEEECCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHH
DVLSDLLAEGSSERIAQKLDELLSTMACHGSVRANRRLTIAEMNALLRDMEATERSGQCN
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCC
HGRPTWTQMSIKDLDRLFMRGQ
CCCCCEEECCHHHHHHHHHCCC
>Mature Secondary Structure 
SKIQLLDSRLANQIAAGEVVERPASVLKELLENALDAGSESISVDVEQGGVKLLRVRDN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECC
GSGIERDDLPLALSRHATSKIRGLDDLEAIGTLGFRGEALAAISSVSRLSLASNVEGEPE
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
GWQVTVEGRDMAPSVSPAGHPRGTTVTMRDLFFNTPARRRFLRTEKTEFNHLEEVFRRIA
CEEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHH
LSEFNTAFRLTHNQKVIHQLPAGLDDTLRAARVAKLCGKGFIEQAVPVDVERDGLRLHGW
HHHCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEE
MGLPTFSRSQADLQYFYVNGRVIRDKVVSHAVRQAYSDVLYHGRHPAYVLFLELDPAMVD
ECCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEE
VNVHPTKHEVRFREQRMVHGFLYSSLHRVIAGVRPGQELAGSVADEGGPAAGMDAAMAPS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
QGNMSLTSPTGSGGSLSHPPGQAYPSTGGGVFGYGQGARQADAYGALVRGHVGESAPAVM
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
PPANENETVPPLGYAVAQLHGIFILAENEQGMVVVDMHAAHERITYERLKQSWAEDKVRS
CCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCC
QPLLVPVSLAVSSREADFAEQQPEVFSRLGFVVQRAGPETLVVREVPALLRNGDSESMVR
CCEEEEEEEEECCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHH
DVLSDLLAEGSSERIAQKLDELLSTMACHGSVRANRRLTIAEMNALLRDMEATERSGQCN
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCC
HGRPTWTQMSIKDLDRLFMRGQ
CCCCCEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA