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The map label for this gene is hflK [H]

Identifier: 110835062

GI number: 110835062

Start: 2512236

End: 2513408

Strand: Reverse

Name: hflK [H]

Synonym: ABO_2201

Alternate gene names: 110835062

Gene position: 2513408-2512236 (Counterclockwise)

Preceding gene: 110835063

Following gene: 110835061

Centisome position: 80.55

GC content: 54.39

Gene sequence:

>1173_bases
ATGGCGTGGAATGAACCCGGCGGCAATAAGCCGAAGGACCCTTGGGGTGGTGGTGGCGACCAGGGGCCGCCGGACCTAGA
CGAAGCCCTGAAAAACCTGAAAGACAAGATTAATAATGTTTTCGGCAAAAAAGGTAACAAAGCCGGCGGCGGTGGTAGCC
GCAGTGGCGGAGGGTCGCCTTGGCCGATGCTGGTTATCGCGTTGGTTATTGTCGCCATTGGTTATGGCCTGATGGGCTTT
TTTCAAGTGGACCAGCGTGAACGTGCTGTGGTGCTGCAGTTTGGTAAGTTCGATCGTATCGTGGAGCCGGGTTTGAACTG
GCGAGCGCCTATCTTTGAGCAGTTCGAGAAGGTGGACGTGGGGCAGAACCGTCGCTACGAAATTACCGAAGAAATGCTCA
CCAAGGACACCAATATCGTCAGTGTGACCTTGCAGGTTCAGTATCAGGTGCTTGATCCGCGCCCGTTCCTGTTGAAAGTG
GCGCAGCCTGAAGAAATTCTGCAGCACGCTACCAGCTCGGCGTTACGCCACGTGGTGGGGTCGTCGTCTATGGATGATGT
GCTCAAGGATAATCGTGAGGCGATCCGGGTACAGGTGCGCGAGCGCTTGGATGACTATTTAAACCGTTACGACACTGGCT
TGGTGCTACGCCAAGTGGTACTGGATAAAACCGAAGCGCCGGATGCTGTGCGTGACGCCTTTGATGATGTGTCTAAGGCC
AAGGAAGATGAAGATCGCTTCAAGAAAGAAGCGGAAGCGTACAGCAATGCAGTGATTCCCCAGGCTCGAGGTGAAGCTCA
GCGGATAGAAGAAGAGGCGTTGGCTTATAAACAGCAGGTTATTGATGAAGCCAAAGGTGATGCCAGTCGCTTCACCGATT
TGCTTACTGAGTACCGCAAGGCTCCGGAAGTGACTCGCGAACGTTTGTACCTGGAAACCATGACTCAGGTCTTCAGCAAT
ACCAGCAAGGTAATGGTCGATGTGAACAAGGGCGACAGCCTAATTTACTTGCCATTGGACAAGCTGATGAAGAATAGCGA
CGGCAAGACCAAGGCTCAAAATCCCGGGGCTTCAGCGTCCAGCACCACCTCCAGCGCCGGTGCGGATGACGGCGGCAGCG
GACGTAGTAGCGGCCGCAGCTTGTACAACAACCGTAACCAGGAGCTGCGCTAA

Upstream 100 bases:

>100_bases
GTTGCAGCTGAGGACGCCCCTTCCTACAATTCGGAACACTCGACAAACGCGAGTCATCATTAGGCTGGAGCCCTTTGGCT
TTGGCGGACTGGAGATCTAC

Downstream 100 bases:

>100_bases
TGAATAATCGTGGATGGATGGCGCTACTGGCCTTGGGCGTGCTGGCTCTTTTGGCGATGGACTCTTTTTTCATCGTAAAC
CAGAAAGAAAAGGTCGTGCT

Product: protease subunit HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAWNEPGGNKPKDPWGGGGDQGPPDLDEALKNLKDKINNVFGKKGNKAGGGGSRSGGGSPWPMLVIALVIVAIGYGLMGF
FQVDQRERAVVLQFGKFDRIVEPGLNWRAPIFEQFEKVDVGQNRRYEITEEMLTKDTNIVSVTLQVQYQVLDPRPFLLKV
AQPEEILQHATSSALRHVVGSSSMDDVLKDNREAIRVQVRERLDDYLNRYDTGLVLRQVVLDKTEAPDAVRDAFDDVSKA
KEDEDRFKKEAEAYSNAVIPQARGEAQRIEEEALAYKQQVIDEAKGDASRFTDLLTEYRKAPEVTRERLYLETMTQVFSN
TSKVMVDVNKGDSLIYLPLDKLMKNSDGKTKAQNPGASASSTTSSAGADDGGSGRSSGRSLYNNRNQELR

Sequences:

>Translated_390_residues
MAWNEPGGNKPKDPWGGGGDQGPPDLDEALKNLKDKINNVFGKKGNKAGGGGSRSGGGSPWPMLVIALVIVAIGYGLMGF
FQVDQRERAVVLQFGKFDRIVEPGLNWRAPIFEQFEKVDVGQNRRYEITEEMLTKDTNIVSVTLQVQYQVLDPRPFLLKV
AQPEEILQHATSSALRHVVGSSSMDDVLKDNREAIRVQVRERLDDYLNRYDTGLVLRQVVLDKTEAPDAVRDAFDDVSKA
KEDEDRFKKEAEAYSNAVIPQARGEAQRIEEEALAYKQQVIDEAKGDASRFTDLLTEYRKAPEVTRERLYLETMTQVFSN
TSKVMVDVNKGDSLIYLPLDKLMKNSDGKTKAQNPGASASSTTSSAGADDGGSGRSSGRSLYNNRNQELR
>Mature_389_residues
AWNEPGGNKPKDPWGGGGDQGPPDLDEALKNLKDKINNVFGKKGNKAGGGGSRSGGGSPWPMLVIALVIVAIGYGLMGFF
QVDQRERAVVLQFGKFDRIVEPGLNWRAPIFEQFEKVDVGQNRRYEITEEMLTKDTNIVSVTLQVQYQVLDPRPFLLKVA
QPEEILQHATSSALRHVVGSSSMDDVLKDNREAIRVQVRERLDDYLNRYDTGLVLRQVVLDKTEAPDAVRDAFDDVSKAK
EDEDRFKKEAEAYSNAVIPQARGEAQRIEEEALAYKQQVIDEAKGDASRFTDLLTEYRKAPEVTRERLYLETMTQVFSNT
SKVMVDVNKGDSLIYLPLDKLMKNSDGKTKAQNPGASASSTTSSAGADDGGSGRSSGRSLYNNRNQELR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=378, Percent_Identity=42.8571428571429, Blast_Score=268, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 43250; Mature: 43119

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGGNKPKDPWGGGGDQGPPDLDEALKNLKDKINNVFGKKGNKAGGGGSRSGGGSP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
WPMLVIALVIVAIGYGLMGFFQVDQRERAVVLQFGKFDRIVEPGLNWRAPIFEQFEKVDV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHCC
GQNRRYEITEEMLTKDTNIVSVTLQVQYQVLDPRPFLLKVAQPEEILQHATSSALRHVVG
CCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHC
SSSMDDVLKDNREAIRVQVRERLDDYLNRYDTGLVLRQVVLDKTEAPDAVRDAFDDVSKA
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KEDEDRFKKEAEAYSNAVIPQARGEAQRIEEEALAYKQQVIDEAKGDASRFTDLLTEYRK
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
APEVTRERLYLETMTQVFSNTSKVMVDVNKGDSLIYLPLDKLMKNSDGKTKAQNPGASAS
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCC
STTSSAGADDGGSGRSSGRSLYNNRNQELR
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AWNEPGGNKPKDPWGGGGDQGPPDLDEALKNLKDKINNVFGKKGNKAGGGGSRSGGGSP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
WPMLVIALVIVAIGYGLMGFFQVDQRERAVVLQFGKFDRIVEPGLNWRAPIFEQFEKVDV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHCC
GQNRRYEITEEMLTKDTNIVSVTLQVQYQVLDPRPFLLKVAQPEEILQHATSSALRHVVG
CCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHC
SSSMDDVLKDNREAIRVQVRERLDDYLNRYDTGLVLRQVVLDKTEAPDAVRDAFDDVSKA
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KEDEDRFKKEAEAYSNAVIPQARGEAQRIEEEALAYKQQVIDEAKGDASRFTDLLTEYRK
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
APEVTRERLYLETMTQVFSNTSKVMVDVNKGDSLIYLPLDKLMKNSDGKTKAQNPGASAS
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCC
STTSSAGADDGGSGRSSGRSLYNNRNQELR
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]